Relation Results

Summary

Name PP2B
Primary ID SIGNOR-PF18
Type protein family
Formed by PPP3CA, PPP3CB, PPP3CC
Relations 24

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Type: Score: Layout: SPV 
0.20.20.20.7640.660.2780.20.20.20.20.20.20.20.80.20.80.6040.20.20.2PP2BJUNMAPTNFATC2CALM1CALM3IGF1MEF2CBADFLNAPPP1R1ANFATC1DLL3IL6cyclosporin ADNM2tacrolimus (anhydrous)CALM2DLL4DLL1DNM1L

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ PP2Bup-regulates img/direct-activation.png dephosphorylation JUN 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-152006 Ser243 PGETPPLsPIDMESQ Homo sapiens Neuron, A-431 Cell
pmid sentence
Importantly, pp2b not only dephosphorylates the c-jun at ser-243 but also interacts with c-jun in pma-treated cells. Pma stimulates the association of the pp2b/c-jun/sp1 complex with the promoter. These findings indicate the dephosphorylation of c-jun c terminus is required for the c-jun/sp1 interaction
Publications: 1 Organism: Homo Sapiens
+ PP2Bup-regulates img/direct-activation.png dephosphorylation MAPT 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-164659 Ser516 GDRSGYSsPGSPGTP Homo sapiens
pmid sentence
Among the sites studied, thr205, thr212, ser214, and ser262 were the most favorable sites, and ser199 and ser404 were the least favorable sites for pp2a in vitro.
Identifier Residue Sequence Organism Cell Line
SIGNOR-164663 Ser579 NVKSKIGsTENLKHQ Homo sapiens
pmid sentence
Among the sites studied, thr205, thr212, ser214, and ser262 were the most favorable sites, and ser199 and ser404 were the least favorable sites for pp2a in vitro.
Identifier Residue Sequence Organism Cell Line
SIGNOR-164667 Ser721 PVVSGDTsPRHLSNV Homo sapiens
pmid sentence
Among the sites studied, thr205, thr212, ser214, and ser262 were the most favorable sites, and ser199 and ser404 were the least favorable sites for pp2a in vitro.
Identifier Residue Sequence Organism Cell Line
SIGNOR-164671 Thr522 SSPGSPGtPGSRSRT Homo sapiens
pmid sentence
Among the sites studied, thr205, thr212, ser214, and ser262 were the most favorable sites, and ser199 and ser404 were the least favorable sites for pp2a in vitro.
Identifier Residue Sequence Organism Cell Line
SIGNOR-164675 Thr529 TPGSRSRtPSLPTPP Homo sapiens
pmid sentence
Among the sites studied, thr205, thr212, ser214, and ser262 were the most favorable sites, and ser199 and ser404 were the least favorable sites for pp2a in vitro.
Publications: 5 Organism: Homo Sapiens
Tissue: Brain
+ PP2Bup-regulates img/direct-activation.png dephosphorylation NFATC2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-269988 Homo sapiens
pmid sentence
Calcineurin dephosphorylates members of the nuclear factor of activated T cells (NFAT)2 transcription factor family, allowing NFAT to translocate to the nucleus where it cooperates with other transcription factors to induce transcription of target genes.
Publications: 1 Organism: Homo Sapiens
+ CALM1up-regulates img/direct-activation.png binding PP2B 0.764
Identifier Residue Sequence Organism Cell Line
SIGNOR-269892 Homo sapiens
pmid sentence
Calcium-bound calmodulin associates with calcineurin (cn), releasing the phosphatase from the repressive effects on an autoinhibitory domain.
Publications: 1 Organism: Homo Sapiens
+ CALM3up-regulates img/direct-activation.png binding PP2B 0.66
Identifier Residue Sequence Organism Cell Line
SIGNOR-269891 Homo sapiens
pmid sentence
Calcium-bound calmodulin associates with calcineurin (cn), releasing the phosphatase from the repressive effects on an autoinhibitory domain.
Publications: 1 Organism: Homo Sapiens
+ IGF1up-regulates img/indirect-activation.png PP2B 0.278
Identifier Residue Sequence Organism Cell Line
SIGNOR-269890 Mus musculus C2C12 Cell, Satellite Cell
pmid sentence
Treatment with igf-1 or insulin and dexamethasone mobilizes intracellular calcium, activates the ca2+/calmodulin-dependent phosphatase calcineurin, and induces the nuclear translocation of the transcription factor nf-atc1.
Publications: 1 Organism: Mus Musculus
Tissue: Muscle, Skeletal Muscle, Myotube
+ PP2Bup-regulates img/indirect-activation.png MEF2C 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-269993 Homo sapiens
pmid sentence
The ca2+ dependent phosphatase calcineurin induces cardiac and skeletal muscle hypertrophy by a process that involves nf-at nuclear translocation, and activation of mef2c.
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
+ PP2Bup-regulates activity img/direct-activation.png dephosphorylation BAD 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-269992 Homo sapiens HEK-293 Cell
pmid sentence
Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD|Calcineurin was found to dephosphorylate BAD, a pro-apoptotic member of the Bcl-2 family, thus enhancing BAD heterodimerization with Bcl-xL and promoting apoptosis.
Publications: 1 Organism: Homo Sapiens
+ PP2Bdown-regulates quantity by destabilization img/direct_inhibition.png dephosphorylation FLNA 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-269986 Homo sapiens
pmid sentence
Filamin is a phosphoprotein that organizes actin filaments into networks. We report that a purified C-terminal recombinant region of filamin is a suitable substrate for calcineurin |Mutagenesis analysis showed that a dephosphorylation step occurred in Ser 2152, which was previously shown to provide resistance to calpain cleavage when endogenous PKA is activated. In contrast, phosphorylation of Ser 2152 was recently reported to be necessary for membrane dynamic changes. In this regard, we found that CsA protects filamin in platelets from calpain degradation.
Publications: 1 Organism: Homo Sapiens
+ PP2B img/unknown.png dephosphorylation PPP1R1A 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-269991 Rattus norvegicus
pmid sentence
In vitro and in vivo studies indicated that phospho-Ser-67 inhibitor-1 was dephosphorylated by protein phosphatases-2A and -2B. | However, inhibitor-1 phosphorylated at Ser-67 was a less efficient substrate for cAMP-dependent protein kinase. These results demonstrate regulation of a Cdk5-dependent phosphorylation site in inhibitor-1 and suggest a role for this site in modulating the amplitude of signal transduction events that involve cAMP-dependent protein kinase activation.
Publications: 1 Organism: Rattus Norvegicus
+ PP2Bup-regulates img/direct-activation.png relocalization NFATC1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-269989 Homo sapiens
pmid sentence
The ca2+ dependent phosphatase calcineurin induces cardiac and skeletal muscle hypertrophy by a process that involves nf-at nuclear translocation, and activation of mef2c.
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
+ DLL3up-regulates activity img/direct-activation.png binding PP2B 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-209747 Homo sapiens B-lymphocyte
pmid sentence
Notch signaling is a highly conserved pathway involved in cell fate choice during development with Delta and Jagged constituting the two evolutionary conserved families of Notch ligands. These ligands are transmembrane proteins with conserved biochemical structure that share their receptors and signal through a common mechanism. Upon ligand binding Notch receptors are proteoliticaly cleaved, the intracellular domain of Notch (NICD) is released and translocated to the nucleus, where it activates target genes. In mammals, four receptors and five ligands have been described. Delta-1, Delta-3 and Delta-4 are homologues to Drosophila Delta and Jagged-1 and Jagged-2 to Drosophila Serrate.
Publications: 1 Organism: Homo Sapiens
+ PP2Bup-regulates quantity by expression img/indirect-activation.png transcriptional regulation IL6 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-269987 Mus musculus
pmid sentence
Interestingly, since IL-6 production by nerve-mediated skeletal muscle contraction has recently been shown to be partly dependent on the activation of the calcineurin pathway |The fact that IL-6 is produced not only by proliferating satellite cells but also by growing myofibers during hypertrophy
Publications: 1 Organism: Mus Musculus
+ cyclosporin Adown-regulates img/direct_inhibition.png chemical inhibition PP2B 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-269889 Homo sapiens
pmid sentence
Calcineurin catalytic activity is inhibited by the immunosuppressive drugs cyclosporine and fk506 through complexes with immunophilin proteins.
Publications: 1 Organism: Homo Sapiens
+ PP2B img/unknown.png dephosphorylation DNM2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-269990 Rattus norvegicus
pmid sentence
CaN is activated, targeting a set of proteins for dephosphorylation, including dynamin II |We have recently discovered that the ubiquitously expressed dynamin isoform, dynII, is phosphorylated at S764 specifically during mitosis (unpublished data). We now show that S764 is phosphorylated throughout mitosis and is dephosphorylated at the time of cytokinesis(dynII).
Publications: 1 Organism: Rattus Norvegicus
+ tacrolimus (anhydrous)down-regulates img/direct_inhibition.png chemical inhibition PP2B 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-269893 Homo sapiens
pmid sentence
Calcineurin catalytic activity is inhibited by the immunosuppressive drugs cyclosporine and fk506 through complexes with immunophilin proteins.
Publications: 1 Organism: Homo Sapiens
+ CALM2up-regulates img/direct-activation.png binding PP2B 0.604
Identifier Residue Sequence Organism Cell Line
SIGNOR-269888 Homo sapiens
pmid sentence
Calcium-bound calmodulin associates with calcineurin (cn), releasing the phosphatase from the repressive effects on an autoinhibitory domain.
Publications: 1 Organism: Homo Sapiens
+ DLL4up-regulates activity img/direct-activation.png binding PP2B 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-209744 Homo sapiens B-lymphocyte
pmid sentence
Notch signaling is a highly conserved pathway involved in cell fate choice during development with Delta and Jagged constituting the two evolutionary conserved families of Notch ligands. These ligands are transmembrane proteins with conserved biochemical structure that share their receptors and signal through a common mechanism. Upon ligand binding Notch receptors are proteoliticaly cleaved, the intracellular domain of Notch (NICD) is released and translocated to the nucleus, where it activates target genes. In mammals, four receptors and five ligands have been described. Delta-1, Delta-3 and Delta-4 are homologues to Drosophila Delta and Jagged-1 and Jagged-2 to Drosophila Serrate.
Publications: 1 Organism: Homo Sapiens
+ DLL1up-regulates activity img/direct-activation.png binding PP2B 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-209741 Homo sapiens B-lymphocyte
pmid sentence
Notch signaling is a highly conserved pathway involved in cell fate choice during development with Delta and Jagged constituting the two evolutionary conserved families of Notch ligands. These ligands are transmembrane proteins with conserved biochemical structure that share their receptors and signal through a common mechanism. Upon ligand binding Notch receptors are proteoliticaly cleaved, the intracellular domain of Notch (NICD) is released and translocated to the nucleus, where it activates target genes. In mammals, four receptors and five ligands have been described. Delta-1, Delta-3 and Delta-4 are homologues to Drosophila Delta and Jagged-1 and Jagged-2 to Drosophila Serrate.
Publications: 1 Organism: Homo Sapiens
+ PP2Bup-regulates activity img/direct-activation.png dephosphorylation DNM1L 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-269994 Homo sapiens
pmid sentence
When mitochondrial depolarization is associated with sustained cytosolic Ca(2+) rise, it activates the cytosolic phosphatase calcineurin that normally interacts with Drp1. Calcineurin-dependent dephosphorylation of Drp1, and in particular of its conserved serine 637, regulates its translocation to mitochondria as substantiated by site directed mutagenesis.
Publications: 1 Organism: Homo Sapiens
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