Relation Results

Summary

Name p38
Primary ID SIGNOR-PF16
Type protein family
Formed by MAPK11, MAPK12, MAPK13, MAPK14
Relations 46
Pathways Citric acid cycle, COVID-19 Causal Network, Eosinophil: CCL11, SARS-COV APOPTOSIS, SARS-CoV MAPK PERTURBATION

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Type: Score: Layout: SPV 
0.20.20.20.20.20.20.20.20.20.20.20.20.20.7170.2480.20.20.20.2670.20.70.5590.250.5750.6260.7350.2740.440.20.20.20.20.20.20.80.20.4250.821p38CDC25BKRT20HNF4ANFATC4CDC25CFOXC1DROSHACDT1BCL2L11BCL2TP53BP1MAPTFHMAP2K3MFGE8EEF2KDDIT3KRT8TNFRSF17SDCBPActin_cytoskeleton_reorganizationTAB2CCR3MAP2K4DLG1MAP2K6TRIM27TAB3ATF2CACNA2D3N3a7aE(-)-anisomycinTP53TLR4TAB1

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ p38down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation CDC25B 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-276350 Ser101 ASESSLSsESSESSD Homo sapiens HeLa Cell
pmid sentence
 Recently, we showed that Cdc25B is degraded rapidly by non-genotoxic stimuli that activate stress-responsive MAPKs, such as Jun N-terminal kinase (JNK) and p38 (Uchida et al., 2009). Our results suggested that these kinases phosphorylate specific Ser residues in the N-terminal region (S101 and S103) to induce Cdc25B degradation.Here, we report that Cdc25B was ubiquitylated by SCF(βTrCP) E3 ligase upon phosphorylation at two Ser residues in the βTrCP-binding-motif-like sequence D(94)AGLCMDSPSP(104).
Identifier Residue Sequence Organism Cell Line
SIGNOR-276349 Ser103 ESSLSSEsSESSDAG Homo sapiens HeLa Cell
pmid sentence
 Recently, we showed that Cdc25B is degraded rapidly by non-genotoxic stimuli that activate stress-responsive MAPKs, such as Jun N-terminal kinase (JNK) and p38 (Uchida et al., 2009). Our results suggested that these kinases phosphorylate specific Ser residues in the N-terminal region (S101 and S103) to induce Cdc25B degradation.Here, we report that Cdc25B was ubiquitylated by SCF(βTrCP) E3 ligase upon phosphorylation at two Ser residues in the βTrCP-binding-motif-like sequence D(94)AGLCMDSPSP(104).
Publications: 2 Organism: Homo Sapiens
+ p38up-regulates activity img/direct-activation.png phosphorylation KRT20 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-263070 Ser13 RSFHRSLsSSLQAPV in vitro
pmid sentence
P38 phosphorylates the type II keratin, K8 at Ser73, whereas MK2 phosphorylates the binding partners K18 at Ser52 and K20 at Ser13.
Publications: 1 Organism: In Vitro
+ p38up-regulates img/direct-activation.png phosphorylation HNF4A 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-143046 Ser167 VLSRQITsPVSGING Homo sapiens
pmid sentence
Our results indicate that p38 kinase-mediated ser158 phosphorylation is essential for augmentation of the dna binding and transactivation potential of hnf4alpha
Publications: 1 Organism: Homo Sapiens
+ p38down-regulates img/direct_inhibition.png phosphorylation NFATC4 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-87393 Ser168 QGGGAFFsPSPGSSS Homo sapiens
pmid sentence
Phosphorylation of nfatc4 by p38 mitogen-activated protein kinasesthe p38 map kinase phosphorylates multiple residues, including ser(168) and ser(170), in the nfat homology domain of nfatc4. Replacement of ser(168,170) with ala promotes nuclear localization of nfatc4 and increases nfat-mediated transcription activity.
Identifier Residue Sequence Organism Cell Line
SIGNOR-87397 Ser170 GGAFFSPsPGSSSLS Homo sapiens
pmid sentence
Phosphorylation of nfatc4 by p38 mitogen-activated protein kinasesthe p38 map kinase phosphorylates multiple residues, including ser(168) and ser(170), in the nfat homology domain of nfatc4. Replacement of ser(168,170) with ala promotes nuclear localization of nfatc4 and increases nfat-mediated transcription activity.
Publications: 2 Organism: Homo Sapiens
+ p38down-regulates activity img/direct_inhibition.png phosphorylation CDC25C 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-107420 Ser216 SGLYRSPsMPENLNR Homo sapiens
pmid sentence
P38 binds and phosphorylates cdc25-b and -c at serines 309 and 361 and at serine 216, respectively, and phosphorylation of these residues is required for binding to 14-3-3 proteins phosphorylation of cdc25 triggers cell-cycle arrest by the sequestration of cdc25 by 14-3-3
Publications: 1 Organism: Homo Sapiens
+ p38up-regulates quantity by stabilization img/direct-activation.png phosphorylation FOXC1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-275914 Ser241 PSPPQPLsPAAALGS
pmid sentence
P38 interacts with and phosphorylates the Ser241 and ser272 sites of FOXC1 to maintain its stability by inhibiting ubiquitination and degradation.
Identifier Residue Sequence Organism Cell Line
SIGNOR-275912 Ser272 SSLSSGSsPPGSLPS
pmid sentence
P38 interacts with and phosphorylates the Ser241 and ser272 sites of FOXC1 to maintain its stability by inhibiting ubiquitination and degradation.
Publications: 2
+ p38down-regulates activity img/direct_inhibition.png phosphorylation DROSHA 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-264847 Ser300 RHRDNRRsPSLERSY Homo sapiens HEK-293 Cell
pmid sentence
Our findings suggest that phosphorylation of Drosha at multiple sites including S300 promotes its translocation to the cytoplasm. Interestingly, GSK3beta can phosphorylate Drosha at S300 and S302 in vitro. This has been reported to promote the nuclear localization of Drosha under basal condition (Tang et al., 2011). Thus, it appears that phosphorylation of S300 by GSK3beta and p38 MAPK is involved in opposing processes. 
Publications: 1 Organism: Homo Sapiens
+ p38down-regulates activity img/direct_inhibition.png phosphorylation CDC25B 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-107412 Ser323 QRLFRSPsMPCSVIR Homo sapiens
pmid sentence
P38 binds and phosphorylates cdc25-b and -c at serines 309 and 361 and at serine 216, respectively, and phosphorylation of these residues is required for binding to 14-3-3 proteins phosphorylation of cdc25 triggers cell-cycle arrest by the sequestration of cdc25 by 14-3-3
Identifier Residue Sequence Organism Cell Line
SIGNOR-107416 Ser375 ARVLRSKsLCHDEIE Homo sapiens
pmid sentence
P38 binds and phosphorylates cdc25-b and -c at serines 309 and 361 and at serine 216, respectively, and phosphorylation of these residues is required for binding to 14-3-3 proteins phosphorylation of cdc25 triggers cell-cycle arrest by the sequestration of cdc25 by 14-3-3
Publications: 2 Organism: Homo Sapiens
+ p38up-regulates quantity by stabilization img/direct-activation.png phosphorylation CDT1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-276362 Ser391 LRSAAPSsPGSPRPA Homo sapiens HeLa Cell
pmid sentence
 We discovered that human Cdt1, an essential origin licensing protein whose activity must be restricted to G(1) phase, is a substrate of the stress-activated mitogen-activated protein (MAP) kinases p38 and c-Jun N-terminal kinase (JNK). These MAP kinases phosphorylate Cdt1 both during unperturbed G(2) phase and during an acute stress response. Phosphorylation renders Cdt1 resistant to ubiquitin-mediated degradation during S phase and after DNA damage by blocking Cdt1 binding to the Cul4 adaptor, Cdt2. 
Identifier Residue Sequence Organism Cell Line
SIGNOR-276363 Ser491 GSCCTIMsPGEMEKH Homo sapiens HeLa Cell
pmid sentence
 We discovered that human Cdt1, an essential origin licensing protein whose activity must be restricted to G(1) phase, is a substrate of the stress-activated mitogen-activated protein (MAP) kinases p38 and c-Jun N-terminal kinase (JNK). These MAP kinases phosphorylate Cdt1 both during unperturbed G(2) phase and during an acute stress response. Phosphorylation renders Cdt1 resistant to ubiquitin-mediated degradation during S phase and after DNA damage by blocking Cdt1 binding to the Cul4 adaptor, Cdt2. 
Publications: 2 Organism: Homo Sapiens
+ p38down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation BCL2L11 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-260443 Ser69 GPLAPPAsPGPFATR Rattus norvegicus
pmid sentence
Ser69 can also be phosphorylated by JNK and p38MAPK at least in vitro. Phosphorylation of BimEL on Ser69 promotes its ubiquitination.
Publications: 1 Organism: Rattus Norvegicus
Pathways:COVID-19 Causal Network, SARS-COV APOPTOSIS
+ p38down-regulates activity img/direct_inhibition.png phosphorylation BCL2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-260450 Ser87 AAAGPALsPVPPVVH Homo sapiens
pmid sentence
The protein's reduced antiapoptotic capacity was related to phosphorylation of its threonine 56 and serine 87 residues by virally activated p38mapk
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-COV APOPTOSIS, SARS-CoV MAPK PERTURBATION
+ p38down-regulates activity img/direct_inhibition.png phosphorylation TP53BP1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-264445 Thr1609 LGPYEAVtPLTKAAD in vitro
pmid sentence
Here we show that 53BP1 is phosphorylated during mitosis on two residues, T1609 and S1618, located in its well-conserved ubiquitination-dependent recruitment (UDR) motif.|Dephosphorylation enables the recruitment of 53BP1 to double-strand DNA breaks |phosphorylation of T1609 is likely to be mediated by p38 MAPK
Publications: 1 Organism: In Vitro
+ p38down-regulates img/direct_inhibition.png phosphorylation MAPT 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-171062 Thr548 KKVAVVRtPPKSPSS Homo sapiens
pmid sentence
However, other kinases, such as cdk5, p38 and pka, also phosphorylate tau at t231tau phosphorylation at t231, s235 and s262 also contributes to the dissociation of tau from microtubules
Publications: 1 Organism: Homo Sapiens
+ p38up-regulates activity img/direct-activation.png phosphorylation FH 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-266316 Thr90 GVTERMPtPVIKAFG Homo sapiens Non-small Cell Lung Cancer Cell
pmid sentence
In this study, we found that TGFβ induces FH Thr 90 phosphorylation by p38. Upon Notch activation, nuclear NICD promotes the interaction between CSL and p38-phosphorylated FH and thus FH/CSL/p53/Smad complex formation; this facilitates FH recruitment to p53-targed p21 promoter, where FH inhibits KDM2A-mediated demethylation of H3K36me2 through local production of fumarate
Publications: 1 Organism: Homo Sapiens
Pathways:Citric acid cycle
+ MAP2K3up-regulates activity img/direct-activation.png phosphorylation p38 0.717
Identifier Residue Sequence Organism Cell Line
SIGNOR-260723 Chlorocebus aethiops COS-7 Cell
pmid sentence
Two human MAP kinase kinases (MKK3 and MKK4) were cloned that phosphorylate and activate p38 MAP kinase.
Publications: 1 Organism: Chlorocebus Aethiops
Pathways:COVID-19 Causal Network, SARS-CoV MAPK PERTURBATION
+ MFGE8down-regulates activity img/indirect_inhibition.png p38 0.248
Identifier Residue Sequence Organism Cell Line
SIGNOR-260651 Rattus norvegicus
pmid sentence
In our current study, we have shown that after LPS-stimulation, MFG-E8-mediated apoptotic cell phagocytosis suppresses various ERK1/2, p38, JNK, and NFκB activation, resulting in a lower TNF-α release. We also explored whether MFG-E8 helps to suppress the proinflammatory pathway within RPMs. We hence incubated the macrophages with apoptotic cells and stimulated them with LPS and examined the activation of MAP kinase and NFkB pathways after the exogenous addition of recombinant MFG-E8 (rMFG-E8). While apoptotic cells alone had no effect on these pathways, the addition of rMFG-E8 to apoptotic cells prior to phagocytosis and LPS stimulation had a marked suppressive effect on all of the investigated pathways, particularly on the p38 and NFκB pathways that play a key role in the cytokine response of macrophages
Publications: 1 Organism: Rattus Norvegicus
+ p38down-regulates activity img/direct_inhibition.png phosphorylation EEF2K 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270127 in vitro
pmid sentence
Inhibition of eEF2 kinase resulting from phosphorylation of Ser-396 by SAPK2a p38 was approx.25%.
Publications: 1 Organism: In Vitro
+ p38up-regulates activity img/direct-activation.png phosphorylation DDIT3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-260724 in vitro
pmid sentence
Stress-Induced Phosphorylation and Activation of the Transcription Factor CHOP (GADD153) by p38 MAP Kinase
Publications: 1 Organism: In Vitro
Pathways:COVID-19 Causal Network, SARS-CoV MAPK PERTURBATION
+ p38up-regulates img/direct-activation.png phosphorylation KRT8 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270125 Homo sapiens
pmid sentence
Keratin 8 (k8) serine 73 occurs within a relatively conserved type ii keratin motif . Here we show that ser-73 is exclusively phosphorylated in vitro by p38 mitogen-activated protein kinase. The ser-73 --> ala-associated filament reorganization defect is rescued by a ser-73 --> asp mutation. Also, disease-causing keratin mutations can modulate keratin phosphorylation and organization, which may affect disease pathogenesis.
Publications: 1 Organism: Homo Sapiens
+ TNFRSF17up-regulates img/indirect-activation.png p38 0.267
Identifier Residue Sequence Organism Cell Line
SIGNOR-269917 Homo sapiens
pmid sentence
Overexpression of bcma activates the p38 mapk
Publications: 1 Organism: Homo Sapiens
+ SDCBPup-regulates activity img/indirect-activation.png p38 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-260753 Chlorocebus aethiops Vero Cell
pmid sentence
Overall, these results support the hypothesis that the interaction of E protein PBM with syntenin facilitates the recruitment of syntenin in the cytosol and leads to p38 MAPK activation.
Publications: 1 Organism: Chlorocebus Aethiops
Pathways:COVID-19 Causal Network, SARS-CoV MAPK PERTURBATION
+ p38up-regulates img/indirect-activation.png Actin_cytoskeleton_reorganization 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-254360 Homo sapiens
pmid sentence
The p21 G protein Rho and its targets, Rho-associated coiled-coil forming protein kinases (p160ROCK/ROCK I/ROKβ and Rho kinase/ROCK II/ROKα), play a crucial role in actin cytoskeleton reorganization
Publications: 1 Organism: Homo Sapiens
+ TAB2up-regulates img/direct-activation.png binding p38 0.559
Identifier Residue Sequence Organism Cell Line
SIGNOR-205446 Homo sapiens
pmid sentence
The irak1/traf6 complex can also activate jnk and p38 signalling through assembly of a catalytically active tab2-tab3-tak1 complex.
Publications: 1 Organism: Homo Sapiens
+ CCR3up-regulates img/indirect-activation.png p38 0.25
Identifier Residue Sequence Organism Cell Line
SIGNOR-254358 Homo sapiens
pmid sentence
We and others have recently found that eotaxin activates extracellular signal-regulated kinase (ERK)-1/2 and p38 mitogen-activated protein (MAP) kinases in eosinophils, and that these kinases are indispensable for eosinophil chemotaxis and degranulation
Publications: 1 Organism: Homo Sapiens
+ MAP2K4up-regulates activity img/direct-activation.png phosphorylation p38 0.575
Identifier Residue Sequence Organism Cell Line
SIGNOR-260722 Chlorocebus aethiops COS-7 Cell
pmid sentence
Two human MAP kinase kinases (MKK3 and MKK4) were cloned that phosphorylate and activate p38 MAP kinase.
Publications: 1 Organism: Chlorocebus Aethiops
Pathways:COVID-19 Causal Network, SARS-CoV MAPK PERTURBATION
+ DLG1up-regulates activity img/direct-activation.png binding p38 0.626
Identifier Residue Sequence Organism Cell Line
SIGNOR-274143 Homo sapiens T-lymphocyte
pmid sentence
Dlgh1 immunoprecipitates were specifically enriched for activated p38 phosphorylated at Thr180 and Tyr182; phosphorylated p38 was not detected in the unbound fraction from stimulated samples
Publications: 1 Organism: Homo Sapiens
+ MAP2K6up-regulates activity img/direct-activation.png p38 0.735
Identifier Residue Sequence Organism Cell Line
SIGNOR-260720 Homo sapiens
pmid sentence
P38 mitogen-activated protein kinase, and its direct activator MKK6 are rapidly activated in response to TGF-beta.
Identifier Residue Sequence Organism Cell Line
SIGNOR-260721 Chlorocebus aethiops
pmid sentence
The p38 MAP kinase kinase MKK6 is identified as a common activator of p38 alpha, p38 beta 2, and p38 gamma MAP kinase isoforms
Publications: 2 Organism: Homo Sapiens, Chlorocebus Aethiops
Pathways:COVID-19 Causal Network, SARS-CoV MAPK PERTURBATION
+ TRIM27up-regulates img/indirect-activation.png p38 0.274
Identifier Residue Sequence Organism Cell Line
SIGNOR-269915 Homo sapiens
pmid sentence
We found rfp-mediated activation of both exogenous and endogenous forms of the other stress-activated mapk, p38.
Publications: 1 Organism: Homo Sapiens
Tissue: Kidney
+ TAB3up-regulates img/direct-activation.png binding p38 0.44
Identifier Residue Sequence Organism Cell Line
SIGNOR-205452 Homo sapiens
pmid sentence
The irak1/traf6 complex can also activate jnk and p38 signalling through assembly of a catalytically active tab2-tab3-tak1 complex.
Publications: 1 Organism: Homo Sapiens
+ p38up-regulates img/direct-activation.png phosphorylation ATF2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270124 Homo sapiens
pmid sentence
Our results indicate that atf-2 not only directly binds to smad3/4 hetero-oligomers but also that atf-2 is phosphorylated by tgf-beta signaling via tak1 and p38. The two pathways, smad and tak1, synergistically enhance the activity of atf-2 which acts as their common nuclear target
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV MAPK PERTURBATION
+ CACNA2D3up-regulates activity img/indirect-activation.png p38 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-266857 Homo sapiens
pmid sentence
The results indicated that the overexpression of CACNA2D3 induced an increase in intracellular Ca2+ and increased the levels of p-p38 MAPK. These data indicated that the p38 MAPK pathway is activated by overexpression of CACNA2D3 and P4 induction.
Publications: 1 Organism: Homo Sapiens
+ Nup-regulates activity img/indirect-activation.png p38 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-261132 Chlorocebus aethiops COS-7 Cell
pmid sentence
Furthermore, N expression up-regulated the activity of stress-activated protein kinases, namely the JNK and p38 MAPK pathways.
Publications: 1 Organism: Chlorocebus Aethiops
Pathways:COVID-19 Causal Network, SARS-COV APOPTOSIS, SARS-CoV MAPK PERTURBATION
+ 3aup-regulates activity img/indirect-activation.png p38 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-260193 Homo sapiens HuH-7 Cell
pmid sentence
Severe Acute Respiratory Syndrome Coronavirus 3a Protein Activates the Mitochondrial Death Pathway Through p38 MAP Kinase Activation
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-COV APOPTOSIS, SARS-CoV MAPK PERTURBATION
+ 7aup-regulates activity img/indirect-activation.png p38 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-260754 Homo sapiens HEK-293 Cell
pmid sentence
While there is a low level of activated p38 normally found in 293T cells, expression of 7a-protein stimulated larger amounts of activated p38 during the 24-h time course. 
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-COV APOPTOSIS, SARS-CoV MAPK PERTURBATION
+ Eup-regulates activity img/indirect-activation.png p38 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-260751 Mus musculus
pmid sentence
Interestingly, an increase in p38 MAPK activation was observed during infection with viruses containing E protein PBM, similarly to what was observed in the lungs of SARS-CoV-infected mice. These results indicated that the E protein PBM is involved in p38 MAPK activation in response to SARS-CoV infection.
Publications: 1 Organism: Mus Musculus
Tissue: Lung
Pathways:COVID-19 Causal Network, SARS-COV APOPTOSIS, SARS-CoV MAPK PERTURBATION
+ CCR3up-regulates activity img/direct-activation.png p38 0.25
Identifier Residue Sequence Organism Cell Line
SIGNOR-256092 Homo sapiens Eosinophil
pmid sentence
Activation of ERK2 and p38 by eotaxin is mediated through CCR3.
Publications: 1 Organism: Homo Sapiens
+ (-)-anisomycinup-regulates img/direct-activation.png chemical activation p38 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-269916 Homo sapiens
pmid sentence
Publications: 1 Organism: Homo Sapiens
+ p38up-regulates img/direct-activation.png phosphorylation TP53 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270126 Homo sapiens Skin Cancer Cell
pmid sentence
We show that prak activates p53 by direct phosphorylation.
Publications: 1 Organism: Homo Sapiens
+ TLR4up-regulates activity img/direct-activation.png phosphorylation p38 0.425
Identifier Residue Sequence Organism Cell Line
SIGNOR-261928 Homo sapiens
pmid sentence
Binding of S100A9 to TLR4 stimulates the phosphorylation of JNK, ERK1/2, and p38 MAPK, which leads to the activation of c-Jun, CREB, and NF-κB. Activation of neutrophils by S100A9 also proceeds via p38 MAPK, JNK, and ERK1/2 phosphorylation.
Publications: 1 Organism: Homo Sapiens
+ TAB1up-regulates img/direct-activation.png binding p38 0.821
Identifier Residue Sequence Organism Cell Line
SIGNOR-205440 Homo sapiens
pmid sentence
The irak1/traf6 complex can also activate jnk and p38 signalling through assembly of a catalytically active tab2-tab3-tak1 complex.
Publications: 1 Organism: Homo Sapiens
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