| + |
JNK | up-regulates 
phosphorylation
|
BCL2L11 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-98384 |
Ser104 |
FSFDTDRsPAPMSCD |
Homo sapiens |
|
| pmid |
sentence |
| 12591950 |
Biml (bim long) was induced and phosphorylated parallel to jnk activitythese data demonstrate that biml is phosphorylated in vivo on thr-56 and that jnk also phosphorylates biml on at least one serine residue (ser-44 and/or ser-58) |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-98388 |
Ser118 |
DKSTQTPsPPCQAFN |
Homo sapiens |
|
| pmid |
sentence |
| 12591950 |
Biml (bim long) was induced and phosphorylated parallel to jnk activitythese data demonstrate that biml is phosphorylated in vivo on thr-56 and that jnk also phosphorylates biml on at least one serine residue (ser-44 and/or ser-58) |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-98392 |
Thr116 |
SCDKSTQtPSPPCQA |
Homo sapiens |
|
| pmid |
sentence |
| 12591950 |
Biml (bim long) was induced and phosphorylated parallel to jnk activitythese data demonstrate that biml is phosphorylated in vivo on thr-56 and that jnk also phosphorylates biml on at least one serine residue (ser-44 and/or ser-58) |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network |
| + |
JNK | up-regulates activity
phosphorylation
|
KIF5C |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264063 |
Ser176 |
CTERFVSsPEEVMDV |
Homo sapiens |
|
| pmid |
sentence |
| 27013971 |
JNK phosphorylates KIF5C on S176 in the motor domain; a site that we show is phosphorylated in brain. In the peroxisome cargo-bound state, S176 phosphorylated KIF5C(1-560) transports to microtubule plus ends, whereas dephosphorylated KIF5C(1-560) is bound tightly to microtubules resulting in an immobile state. As a consequence, phosphorylation of S176 can facilitate plus-end cargo transport by KIF5C(1-560). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain |
| + |
JNK | up-regulates
phosphorylation
|
HNRNPK |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-105758 |
Ser216 |
ILDLISEsPIKGRAQ |
Homo sapiens |
|
| pmid |
sentence |
| 11259409 |
Using modified jnk and its atp analogue enables the detection of novel jnk substrates. Among substrates identified using this approach is heterogeneous nuclear ribonucleoprotein k, which is involved in transcription and post-transcriptional mrna metabolism. The newly identified substrate can be phosphorylated by jnk on amino acids 216 and 353, which contribute to heterogeneous nuclear ribonucleoprotein k mediated transcriptional activities. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-105762 |
Ser353 |
DSAIDTWsPSEWQMA |
Homo sapiens |
|
| pmid |
sentence |
| 11259409 |
Using modified jnk and its atp analogue enables the detection of novel jnk substrates. Among substrates identified using this approach is heterogeneous nuclear ribonucleoprotein k, which is involved in transcription and post-transcriptional mrna metabolism. The newly identified substrate can be phosphorylated by jnk on amino acids 216 and 353, which contribute to heterogeneous nuclear ribonucleoprotein k mediated transcriptional activities. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
JNK | up-regulates
phosphorylation
|
FOXO |
0.706 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252953 |
Ser230 |
PEGATPTsPVGHFAK |
Homo sapiens |
Melanoma Cell |
| pmid |
sentence |
| 20959475 |
Braf(v600e) signaling through mitogen-activated protein kinase/extracellular signal-regulated kinase kinase resulted in increased reactive oxygen species levels and c-jun nh(2) terminal kinase-mediated activation of foxo4 via its phosphorylation on thr(223), ser(226), thr(447), and thr(451). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252954 |
Thr227 |
PAPPEGAtPTSPVGH |
Homo sapiens |
Melanoma Cell |
| pmid |
sentence |
| 20959475 |
Braf(v600e) signaling through mitogen-activated protein kinase/extracellular signal-regulated kinase kinase resulted in increased reactive oxygen species levels and c-jun nh(2) terminal kinase-mediated activation of foxo4 via its phosphorylation on thr(223), ser(226), thr(447), and thr(451). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252955 |
Thr451 |
PIPKALGtPVLTPPT |
Homo sapiens |
Melanoma Cell |
| pmid |
sentence |
| 20959475 |
Braf(v600e) signaling through mitogen-activated protein kinase/extracellular signal-regulated kinase kinase resulted in increased reactive oxygen species levels and c-jun nh(2) terminal kinase-mediated activation of foxo4 via its phosphorylation on thr(223), ser(226), thr(447), and thr(451). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252956 |
Thr455 |
ALGTPVLtPPTEAAS |
Homo sapiens |
Melanoma Cell |
| pmid |
sentence |
| 20959475 |
Braf(v600e) signaling through mitogen-activated protein kinase/extracellular signal-regulated kinase kinase resulted in increased reactive oxygen species levels and c-jun nh(2) terminal kinase-mediated activation of foxo4 via its phosphorylation on thr(223), ser(226), thr(447), and thr(451). |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| Tissue: |
Skin |
| Pathways: | FLT3-ITD signaling |
| + |
JNK | up-regulates
phosphorylation
|
FOXO4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-168754 |
Ser230 |
PEGATPTsPVGHFAK |
Homo sapiens |
Melanoma Cell |
| pmid |
sentence |
| 20959475 |
Braf(v600e) signaling through mitogen-activated protein kinase/extracellular signal-regulated kinase kinase resulted in increased reactive oxygen species levels and c-jun nh(2) terminal kinase-mediated activation of foxo4 via its phosphorylation on thr(223), ser(226), thr(447), and thr(451). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-168758 |
Thr227 |
PAPPEGAtPTSPVGH |
Homo sapiens |
Melanoma Cell |
| pmid |
sentence |
| 20959475 |
Braf(v600e) signaling through mitogen-activated protein kinase/extracellular signal-regulated kinase kinase resulted in increased reactive oxygen species levels and c-jun nh(2) terminal kinase-mediated activation of foxo4 via its phosphorylation on thr(223), ser(226), thr(447), and thr(451). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-168762 |
Thr451 |
PIPKALGtPVLTPPT |
Homo sapiens |
Melanoma Cell |
| pmid |
sentence |
| 20959475 |
Braf(v600e) signaling through mitogen-activated protein kinase/extracellular signal-regulated kinase kinase resulted in increased reactive oxygen species levels and c-jun nh(2) terminal kinase-mediated activation of foxo4 via its phosphorylation on thr(223), ser(226), thr(447), and thr(451). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-168766 |
Thr455 |
ALGTPVLtPPTEAAS |
Homo sapiens |
Melanoma Cell |
| pmid |
sentence |
| 20959475 |
Braf(v600e) signaling through mitogen-activated protein kinase/extracellular signal-regulated kinase kinase resulted in increased reactive oxygen species levels and c-jun nh(2) terminal kinase-mediated activation of foxo4 via its phosphorylation on thr(223), ser(226), thr(447), and thr(451). |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| Tissue: |
Skin |
| + |
JNK | down-regulates quantity by destabilization 
phosphorylation
|
IRS1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235777 |
Ser312 |
TESITATsPASMVGG |
Rattus norvegicus |
H4-II-E-C3 Cell |
| pmid |
sentence |
| 12510059 |
Modulation of insulin-stimulated degradation of human insulin receptor substrate-1 by Serine 312 phosphorylationOne of the specific Ser phosphorylation sites in IRS-1 that has been proposed to negatively modulate the insulin signal is Ser312 (numbered according to the human sequence). Prior studies have demonstrated that IRS-1 associates with and is phosphorylated by JNK in vitro on Ser312 |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
JNK | down-regulates
phosphorylation
|
CTNNB1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-165026 |
Ser37 |
YLDSGIHsGATTTAP |
Homo sapiens |
|
| pmid |
sentence |
| 20419129 |
Specifically, we provide evidence that jnk binds to e-cadherin/beta-catenin complex and phosphorylates beta-catenin at serine 37 and threonine 41, the sites also phosphorylated by gsk-3beta. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-187578 |
Ser37 |
YLDSGIHsGATTTAP |
Homo sapiens |
|
| pmid |
sentence |
| 19667122 |
Specifically, we provide evidence that jnk binds to e-cadherin/beta-catenin complex and phosphorylates beta-catenin at serine 37 and threonine 41, the sites also phosphorylated by gsk-3beta. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-187582 |
Thr41 |
GIHSGATtTAPSLSG |
Homo sapiens |
|
| pmid |
sentence |
| 19667122 |
Specifically, we provide evidence that jnk binds to e-cadherin/beta-catenin complex and phosphorylates beta-catenin at serine 37 and threonine 41, the sites also phosphorylated by gsk-3beta. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| Pathways: | FLT3-ITD signaling |
| + |
JNK | down-regulates
phosphorylation
|
BCL2L1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-99215 |
Ser62 |
PSWHLADsPAVNGAT |
Homo sapiens |
Prostate Gland Cancer Cell |
| pmid |
sentence |
| 12633850 |
We have identified that serine 62 is the necessary site for taxol- or 2-me-induced bcl-xl phosphorylation in summary, our studies suggest that the phosphorylation of bcl-xl by stress response kinase signaling might oppose the anti-apoptotic function of bcl-xl |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-73638 |
Thr115 |
LTSQLHItPGTAYQS |
Homo sapiens |
|
| pmid |
sentence |
| 10617621 |
Sapk phosphorylates bcl-x(l) on threonine 47 (thr-47) and threonine 115 (thr-115) in vitro and in vivo. In contrast to wild-type bcl-x(l), a mutant bcl-x(l) with the two threonines substituted by alanines (ala-47, ala-115) is a more potent inhibitor of ionizing radiation-induced apoptosis |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-73642 |
Thr47 |
GTESEMEtPSAINGN |
Homo sapiens |
|
| pmid |
sentence |
| 10617621 |
Sapk phosphorylates bcl-x(l) on threonine 47 (thr-47) and threonine 115 (thr-115) in vitro and in vivo. In contrast to wild-type bcl-x(l), a mutant bcl-x(l) with the two threonines substituted by alanines (ala-47, ala-115) is a more potent inhibitor of ionizing radiation-induced apoptosis |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network |
| + |
JNK | up-regulates activity
phosphorylation
|
JUN |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-53784 |
Ser63 |
KNSDLLTsPDVGLLK |
Homo sapiens |
|
| pmid |
sentence |
| 17158707 |
The JNK-mediated phosphorylation of both Ser63 and Ser73 within the transactivation domain of c-Jun (Table _(Table1)1) potentiates its transcriptional activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260758 |
Ser63 |
KNSDLLTsPDVGLLK |
Homo sapiens |
HuH-7 Cell |
| pmid |
sentence |
| 21561061 |
3b Induces Phosphorylation of c-Jun (Ser-63) throughActivation of the JNK Pathway.| An enhanced phosphorylation of JNK and MEK4 was observed in cells expressing 3b ascompared to control cells expressing GFP |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236130 |
Ser63 |
KNSDLLTsPDVGLLK |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 12040039 |
Stress in primary cultured cns neurons induces phosphorylation of c-jun serines 63 and 73 and increased c-jun protein. Jnk2/3 activity selectively targets c-jun. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-53788 |
Ser73 |
VGLLKLAsPELERLI |
Homo sapiens |
|
| pmid |
sentence |
| 9405416 |
Phosphorylation by activated jnk protects c-jun from ubiquitination. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236149 |
Ser73 |
VGLLKLAsPELERLI |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 12040039 |
Stress in primary cultured cns neurons induces phosphorylation of c-jun serines 63 and 73 and increased c-jun protein. Thus, neuronal stress selectively activates JNK2/3 in the presence of mechanisms maintaining constitutive JNK1 activity, and this JNK2/3 activity selectively targets c-Jun, which is isolated from constitutive JNK1 activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-36466 |
Ser73 |
VGLLKLAsPELERLI |
Homo sapiens |
|
| pmid |
sentence |
| 17158707 |
The JNK-mediated phosphorylation of both Ser63 and Ser73 within the transactivation domain of c-Jun (Table _(Table1)1) potentiates its transcriptional activity |
|
| Publications: |
6 |
Organism: |
Homo Sapiens |
| Pathways: | TGF-beta Signaling |
| + |
JNK | up-regulates activity
phosphorylation
|
BCL2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261133 |
Ser70 |
RDPVARTsPLQTPAA |
in vitro |
|
| pmid |
sentence |
| 11323415 |
JNK1 directly phosphorylates Bcl2 at Ser70 in vitro and co-localizes with Bcl2 in mitochondrial membranes in vivo. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| Pathways: | COVID-19 Causal Network, FLT3-ITD signaling, SARS-CoV MAPK PERTURBATION |
| + |
JNK | up-regulates
phosphorylation
|
ATF2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-137627 |
Thr69 |
SVIVADQtPTPTRFL |
Homo sapiens |
|
| pmid |
sentence |
| 15916964 |
Phosphorylation of atf2 by jnk/p38 on thr69/71 is prerequisite to its transcriptional activities |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-137631 |
Thr71 |
IVADQTPtPTRFLKN |
Homo sapiens |
|
| pmid |
sentence |
| 15916964 |
Phosphorylation of atf2 by jnk/p38 on thr69/71 is prerequisite to its transcriptional activities |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, SARS-CoV MAPK PERTURBATION, TGF-beta Signaling |
| + |
JNK | up-regulates activity
phosphorylation
|
SMAD3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236113 |
|
|
Homo sapiens |
Mv1Lu Cell |
| pmid |
sentence |
| 10601313 |
JNK-mediated phosphorylation of Smad3 outside the -SSXS motif enhances Smad3 nuclear translocation and potentiates transcriptional activation independent of Smad3 phosphorylation by T_RI. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, TGF-beta Signaling |
| + |
MAP2K4 | up-regulates activity
phosphorylation
|
JNK |
0.735 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236110 |
|
|
Homo sapiens |
COS-7 Cell |
| pmid |
sentence |
| 8974401 |
A MAP kinase kinase kinase (MAPKKK), termed ASK1, was identified that activated two different subgroups of MAP kinase kinases (MAPKK), SEK1 (or MKK4) and MKK3/MAPKK6 (or MKK6), which in turn activated stress-activated protein kinase (SAPK, also known as JNK; c-Jun amino-terminal kinase) and p38 subgroups of MAP kinases, respectively. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-83729 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11062067 |
Here we report that mkk4 shows a striking preference for the tyrosine residue (tyr-185), and mkk7 a striking preference for the threonine residue (thr-183) in three sapk1/jnk1 isoforms tested (jnk1 alpha 1, jnk2 alpha 2 and jnk3 alpha 1). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260759 |
|
|
Homo sapiens |
HuH-7 Cell |
| pmid |
sentence |
| 21561061 |
Activation of JNK pathway components in 3b-expressing cells was assessed by analyzing levels of active phosphorylated formsof JNK and its upstream kinase MEK4. An enhanced phosphor-ylation of JNK and MEK4 was observed in cells expressing 3b ascompared to control cells expressing GFP |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, SARS-CoV MAPK PERTURBATION, TGF-beta Signaling |
| + |
JNK | up-regulates 
|
Apoptosis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260178 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18931691 |
JNKs activate apoptotic signaling by the upregulation pro-apoptotic genes via the transactivation of specific transcription factors or by directly modulating the activities of mitochondrial pro- and anti-apoptotic proteins through distinct phosphorylation events. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, EBV infection, FLT3-ITD signaling, SARS-CoV MAPK PERTURBATION, SARS-CoV ER STRESS |
| + |
TAB3 | up-regulates
binding
|
JNK |
0.377 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-205449 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25290089 |
The irak1/traf6 complex can also activate jnk and p38 signalling through assembly of a catalytically active tab2-tab3-tak1 complex. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
JNK | up-regulates activity
binding
|
AP1 |
0.812 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253340 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24315690 |
In addition to the possible regulation of the transcription factor c-Jun by phosphorylation via the c-Jun N-terminal kinase (JNK) or the kinases ERK1, ERK2 and GSK3β, further signaling pathways lead to an up-regulation of c-Jun protein and thus AP-1 activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, EBV infection, FLT3-ITD signaling, SARS-CoV MAPK PERTURBATION, TGF-beta Signaling |
| + |
JNK | up-regulates
phosphorylation
|
TP53 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269985 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14699954 |
The targets of jnk include the transcription factors p53. P75ntr-mediated apoptosis was shown to be dependent of p53 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | EBV infection, FLT3-ITD signaling |
| + |
JNK | down-regulates
phosphorylation
|
SFN |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269979 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15071501 |
Here we demonstrate that activated jnk promotes bax translocation to mitochondria through phosphorylation of 14-3-3, a cytoplasmic anchor of bax. Phosphorylation of 14-3-3 led to dissociation of bax from this protein.Jnk phosphorylates 14-3-3zeta_ at ser-184 and 14-3-3sigma_ at ser-191 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ANXA3 | up-regulates activity
|
JNK |
0.284 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262214 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26095609 |
ANXA3 Induces a Feed-Forward Loop that Is Mediated by the MKK4/JNK Signaling Cascade. To substantiate the importance of the JNK/AP-1 pathway in ANXA3-driven HCC, we performed rescue experiments using the JNK-specific inhibitor (JNKi) SP600125. JNKi suppressed the oncogenic properties conferred by ANXA3 overexpression, as evidenced by the diminished abilities of HCC cells to form colonies, migrate, invade, induce angiogenesis, form hepatospheres, and resist apoptosis and chemotherapy (Figures 6F–6J). Interestingly, treatment of parental HCC cells or HCC cells overexpressing ANXA3 with JNKi resulted in not only a reduction in JNK activity and modulation of downstream target genes (c-MYC and p21) but also a marked decrease in ANXA3 expression, suggesting that ANXA3 induces a feed-forward loop that is mediated by MKK4/JNK signaling (Figures 6K–6L). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
JNK | down-regulates
phosphorylation
|
PPM1J |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269981 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18553930 |
Specific phosphorylation of pp2czeta at ser (92) by stress-activated jnk attenuates its phosphatase activity in cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP2K7 | up-regulates activity
phosphorylation
|
JNK |
0.682 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-83725 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11062067 |
Here we report that MKK4 shows a striking preference for the tyrosine residue (Tyr-185), and MKK7 a striking preference for the threonine residue (Thr-183) in three SAPK1/JNK1 isoforms tested (JNK1 alpha 1, JNK2 alpha 2 and JNK3 alpha 1). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network |
| + |
JNK | down-regulates activity
phosphorylation
|
ATN1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269978 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12812981 |
Dentatorubral-pallidoluysian atrophy protein is phosphorylated by c-jun nh2-terminal kinase. serine 734 of the drpla protein is a phospho-acceptor site by jnk. The phosphorylation may be coupled to the activation of a protease. The molecular size of drpla protein detected in the rat brain with the specific phosphopeptide antibody was 150_kda, which was slightly smaller than that expected from the sequence and the results with the human protein. The phosphorylated forms of ha-tagged human drpla gradually disappeared after osmotic treatment, |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain |
| + |
MAPK8IP3 | up-regulates
binding
|
JNK |
0.739 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269886 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15767678 |
The c-jun nh2-terminal kinase (jnk)-interacting protein (jip) group of scaffold proteins (jip1, jip2, and jip3) can interact with components of the jnk signaling pathway and potently activate jnk. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LMP1 | up-regulates activity
|
JNK |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267617 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26428373 |
AP1 is a dimeric transcription factor composed of members of the Jun and Fos protooncoprotein families. AP1 was found induced by LMP1 through the JNK signaling cascade, involving JNK1-mediated phosphorylation and activation of c-Jun. JNK1 activation critically relies on CTAR2 and its P379VQLSYY motif. It has long been unclear which signaling mediators at CTAR2 are involved in JNK activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | EBV infection |
| + |
3b | up-regulates activity
|
JNK |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260760 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21561061 |
An enhanced phosphorylation of JNK and MEK4 was observed in cells expressing 3b ascompared to control cells expressing GFP |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, SARS-CoV MAPK PERTURBATION |
| + |
N | up-regulates activity
|
JNK |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261131 |
|
|
Chlorocebus aethiops |
|
| pmid |
sentence |
| 15294014 |
Furthermore, N expression up-regulated the activity of stress-activated protein kinases, namely the JNK and p38 MAPK pathways. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| Pathways: | COVID-19 Causal Network, SARS-CoV MAPK PERTURBATION |
| + |
ERN1 | down-regulates activity 
|
JNK |
0.325 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260177 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31226023 |
The kinase activity of IRE1 also activates a signaling cascade that ultimately activates c-Jun N-terminal kinase (JNK) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, SARS-CoV ER STRESS |
| + |
TLR4 | up-regulates activity
phosphorylation
|
JNK |
0.509 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261929 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28137827 |
Binding of S100A9 to TLR4 stimulates the phosphorylation of JNK, ERK1/2, and p38 MAPK, which leads to the activation of c-Jun, CREB, and NF-κB. Activation of neutrophils by S100A9 also proceeds via p38 MAPK, JNK, and ERK1/2 phosphorylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | FLT3-ITD signaling |
| + |
TAB1 | up-regulates
binding
|
JNK |
0.399 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-205437 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25290089 |
The irak1/traf6 complex can also activate jnk and p38 signalling through assembly of a catalytically active tab2-tab3-tak1 complex. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TNFRSF17 | up-regulates
|
JNK |
0.298 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269887 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10903733 |
Overexpression of bcma activates jnk |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
anthra[1,9-cd]pyrazol-6(2H)-one | down-regulates
chemical inhibition
|
JNK |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269885 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11717429 |
We report the identification of an anthrapyrazolone series with significant jnk1, -2, and -3 (k(i) = 0.19 microm). To determine whether jnk activity is required for stress-induced translocation of bax to the mitochondria, we examined the effect of sp600125, a jnk inhibitor. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
4-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-[(5-nitro-2-thiazolyl)thio]-1H-1,2,4-triazol-5-one | down-regulates
chemical inhibition
|
JNK |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269884 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18922779 |
Bi-78d3, dose-dependently inhibits the phosphorylation of jnk substrates both in vitro and in cell. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL1R1 | up-regulates activity
phosphorylation
|
JNK |
0.395 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269883 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 9625767 |
Il-1 binding to its receptor triggers a cascade of signaling events, including activation of the stress-activated mitogen-activated protein (map) kinases, c-jun nh2-terminal kinase (jnk) and p38 map kinase, as well as transcription factor nuclear factor kappab (nf-kappab |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
JNK | down-regulates
phosphorylation
|
YWHAZ |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269980 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15071501 |
Jnk phosphorylates 14-3-3zetaat ser-184 and 14-3-3sigmaat ser-190 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
JNK | up-regulates
phosphorylation
|
MAPK8IP3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269984 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15767678 |
Phosphoamino acid analysis confirmed that jnk caused thr phosphorylation of jip3 (fig. _(fig.3c).3c). This phosphorylation on thr was markedly decreased when thr266, thr276, and thr287 were replaced with ala. These data indicate that jnk phosphorylated jip3 on thr266, thr276, and thr287 in vitro. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
JNK | down-regulates
phosphorylation
|
CDC25C |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269983 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20220133 |
Here we show that jnk directly phosphorylates cdc25c at serine 168 during g(2) phase of the cell cycle. Cdc25c phosphorylation by jnk negatively regulates its phosphatase activity and thereby cdk1 activation, enabling a timely control of mitosis onset. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
JNK | up-regulates quantity by expression
transcriptional regulation
|
ANXA3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262216 |
|
|
Homo sapiens |
Hepatoma Cell |
| pmid |
sentence |
| 26095609 |
ANXA3 Induces a Feed-Forward Loop that Is Mediated by the MKK4/JNK Signaling Cascade. To substantiate the importance of the JNK/AP-1 pathway in ANXA3-driven HCC, we performed rescue experiments using the JNK-specific inhibitor (JNKi) SP600125. JNKi suppressed the oncogenic properties conferred by ANXA3 overexpression, as evidenced by the diminished abilities of HCC cells to form colonies, migrate, invade, induce angiogenesis, form hepatospheres, and resist apoptosis and chemotherapy (Figures 6F–6J). Interestingly, treatment of parental HCC cells or HCC cells overexpressing ANXA3 with JNKi resulted in not only a reduction in JNK activity and modulation of downstream target genes (c-MYC and p21) but also a marked decrease in ANXA3 expression, suggesting that ANXA3 induces a feed-forward loop that is mediated by MKK4/JNK signaling (Figures 6K–6L). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
JNK | down-regulates
phosphorylation
|
STMN1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269982 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20630875 |
Involved in the regulation of the microtubule (mt) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Here we show that in response to hyperosmotic stress, jnk phosphorylates a key cytoplasmic microtubule regulatory protein, stathmin (stmn), on conserved ser-25 and ser-38 residues. In in vitro biochemical studies, we identified stmn ser-38 as the critical residue required for efficient phosphorylation by jnk and identified a novel kinase interaction domain in stmn required for recognition by jnk. We revealed that jnk was required for microtubule stabilization in response to hyperosmotic stress. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
JNK | up-regulates
|
BAX |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269977 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15071501 |
Demonstrate that jnk-mediated phosphorylation of 14-3-3 induces the release of bax from 14-3-3 and triggers its translocation to the mitochondria; these results strongly indicate that jnk regulates the activity of bax by phosphorylating 14-3-3 proteins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, FLT3-ITD signaling |
| + |
TAB2 | up-regulates
binding
|
JNK |
0.432 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-205443 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25290089 |
The irak1/traf6 complex can also activate jnk and p38 signalling through assembly of a catalytically active tab2-tab3-tak1 complex. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
JNK