Relation Results

Summary

Name ROBO
Primary ID SIGNOR-PF14
Type protein family
Formed by ROBO1, ROBO2, ROBO3, ROBO4
Relations 9

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Type: Score: Layout: SPV 
0.20.20.20.20.20.9380.893ROBOCDC25CCDC25BCCND2CCND3ATF2SLIT2SLIT1

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ ROBOdown-regulates img/direct_inhibition.png phosphorylation CDC25C 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-124851 Ser216 SGLYRSPsMPENLNR Homo sapiens HeLa Cell, Neuron
pmid sentence
P38 binds and phosphorylates cdc25-b and -c at serines 309 and 361 and at serine 216, respectively, and phosphorylation of these residues is required for binding to 14-3-3 proteinsphosphorylation of cdc25 triggers cell-cycle arrest by the sequestration of cdc25 by 14-3-3
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ ROBOdown-regulates img/direct_inhibition.png phosphorylation CDC25B 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-124843 Ser323 QRLFRSPsMPCSVIR Homo sapiens HeLa Cell, Neuron
pmid sentence
P38 binds and phosphorylates cdc25-b and -c at serines 309 and 361 and at serine 216, respectively, and phosphorylation of these residues is required for binding to 14-3-3 proteinsphosphorylation of cdc25 triggers cell-cycle arrest by the sequestration of cdc25 by 14-3-3
Identifier Residue Sequence Organism Cell Line
SIGNOR-124847 Ser375 ARVLRSKsLCHDEIE Homo sapiens HeLa Cell, Neuron
pmid sentence
P38 binds and phosphorylates cdc25-b and -c at serines 309 and 361 and at serine 216, respectively, and phosphorylation of these residues is required for binding to 14-3-3 proteinsphosphorylation of cdc25 triggers cell-cycle arrest by the sequestration of cdc25 by 14-3-3
Publications: 2 Organism: Homo Sapiens
Tissue: Brain
+ ROBOdown-regulates img/direct_inhibition.png phosphorylation CCND2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-154672 Thr280 DELDQAStPTDVRDI Homo sapiens
pmid sentence
These results indicate that cyclin d2 expression in normal and malignant hematopoietic cells is regulated by ubiquitin/proteasome-dependent degradation that is triggered by thr280 phosphorylation by gsk3beta or p38
Publications: 1 Organism: Homo Sapiens
+ ROBOdown-regulates img/direct_inhibition.png phosphorylation CCND3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-128402 Thr283 QGPSQTStPTDVTAI Homo sapiens T-lymphocyte
pmid sentence
P38sapk2 phosphorylates cyclin d3 at thr-283 and targets it for proteasomal degradation
Publications: 1 Organism: Homo Sapiens
+ ROBOup-regulates img/direct-activation.png phosphorylation ATF2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-137635 Thr69 SVIVADQtPTPTRFL Homo sapiens
pmid sentence
Phosphorylation of atf2 by jnk/p38 on thr69/71 is prerequisite to its transcriptional activities
Identifier Residue Sequence Organism Cell Line
SIGNOR-137639 Thr71 IVADQTPtPTRFLKN Homo sapiens
pmid sentence
Phosphorylation of atf2 by jnk/p38 on thr69/71 is prerequisite to its transcriptional activities
Publications: 2 Organism: Homo Sapiens
+ SLIT2up-regulates img/direct-activation.png binding ROBO 0.938
Identifier Residue Sequence Organism Cell Line
SIGNOR-268377 in vitro
pmid sentence
Here we describe and compare two human robo3 isoforms, robo3a and robo3b, which differ by the insertion of 26 amino acids at the n-terminus, and these forms appear to be evolutionary conserved. We investigated the bioactivity of these isoforms and show that they have different binding properties to slit.
Publications: 1 Organism: In Vitro
+ SLIT1up-regulates img/direct-activation.png binding ROBO 0.893
Identifier Residue Sequence Organism Cell Line
SIGNOR-141111 Homo sapiens
pmid sentence
Here we describe and compare two human robo3 isoforms, robo3a and robo3b, which differ by the insertion of 26 amino acids at the n-terminus, and these forms appear to be evolutionary conserved. We investigated the bioactivity of these isoforms and show that they have different binding properties to slit.
Publications: 1 Organism: Homo Sapiens
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