| + |
ROBO | down-regulates 
phosphorylation
|
CDC25C |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-124851 |
Ser216 |
SGLYRSPsMPENLNR |
Homo sapiens |
HeLa Cell, Neuron |
| pmid |
sentence |
| 15150265 |
P38 binds and phosphorylates cdc25-b and -c at serines 309 and 361 and at serine 216, respectively, and phosphorylation of these residues is required for binding to 14-3-3 proteinsphosphorylation of cdc25 triggers cell-cycle arrest by the sequestration of cdc25 by 14-3-3 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain |
| + |
ROBO | down-regulates
phosphorylation
|
CDC25B |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-124843 |
Ser323 |
QRLFRSPsMPCSVIR |
Homo sapiens |
HeLa Cell, Neuron |
| pmid |
sentence |
| 15150265 |
P38 binds and phosphorylates cdc25-b and -c at serines 309 and 361 and at serine 216, respectively, and phosphorylation of these residues is required for binding to 14-3-3 proteinsphosphorylation of cdc25 triggers cell-cycle arrest by the sequestration of cdc25 by 14-3-3 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-124847 |
Ser375 |
ARVLRSKsLCHDEIE |
Homo sapiens |
HeLa Cell, Neuron |
| pmid |
sentence |
| 15150265 |
P38 binds and phosphorylates cdc25-b and -c at serines 309 and 361 and at serine 216, respectively, and phosphorylation of these residues is required for binding to 14-3-3 proteinsphosphorylation of cdc25 triggers cell-cycle arrest by the sequestration of cdc25 by 14-3-3 |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain |
| + |
ROBO | down-regulates
phosphorylation
|
CCND2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-154672 |
Thr280 |
DELDQAStPTDVRDI |
Homo sapiens |
|
| pmid |
sentence |
| 17486076 |
These results indicate that cyclin d2 expression in normal and malignant hematopoietic cells is regulated by ubiquitin/proteasome-dependent degradation that is triggered by thr280 phosphorylation by gsk3beta or p38 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ROBO | down-regulates
phosphorylation
|
CCND3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-128402 |
Thr283 |
QGPSQTStPTDVTAI |
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 15326477 |
P38sapk2 phosphorylates cyclin d3 at thr-283 and targets it for proteasomal degradation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ROBO | up-regulates 
phosphorylation
|
ATF2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-137635 |
Thr69 |
SVIVADQtPTPTRFL |
Homo sapiens |
|
| pmid |
sentence |
| 15916964 |
Phosphorylation of atf2 by jnk/p38 on thr69/71 is prerequisite to its transcriptional activities |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-137639 |
Thr71 |
IVADQTPtPTRFLKN |
Homo sapiens |
|
| pmid |
sentence |
| 15916964 |
Phosphorylation of atf2 by jnk/p38 on thr69/71 is prerequisite to its transcriptional activities |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
SLIT2 | up-regulates
binding
|
ROBO |
0.937 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268377 |
|
|
in vitro |
|
| pmid |
sentence |
| 16226035 |
Here we describe and compare two human robo3 isoforms, robo3a and robo3b, which differ by the insertion of 26 amino acids at the n-terminus, and these forms appear to be evolutionary conserved. We investigated the bioactivity of these isoforms and show that they have different binding properties to slit. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
SLIT1 | up-regulates
binding
|
ROBO |
0.893 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-141111 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16226035 |
Here we describe and compare two human robo3 isoforms, robo3a and robo3b, which differ by the insertion of 26 amino acids at the n-terminus, and these forms appear to be evolutionary conserved. We investigated the bioactivity of these isoforms and show that they have different binding properties to slit. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
ROBO