| + |
PAK | up-regulates 
phosphorylation
|
MAP2K1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-140039 |
Ser298 |
RTPGRPLsSYGMDSR |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 16129686 |
Inhibition of pak kinase activity dramatically decreased phosphorylation of mek1 at ser(298) in response to either pdgf or egf. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PAK | up-regulates
phosphorylation
|
MEK1/2 |
0.559 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-244920 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 16129686 |
Inhibition of pak kinase activity dramatically decreased phosphorylation of mek1 at ser(298) in response to either pdgf or egf. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PAK | down-regulates activity 
phosphorylation
|
VIM |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269975 |
|
|
in vitro |
|
| pmid |
sentence |
| 11895474 |
In vitro analyses revealed that vimentin served as an excellent substrate for PAK. This phosphorylated vimentin lost the potential to form 10 nm filaments. We identified Ser25, Ser38, Ser50, Ser65 and Ser72 in the amino-terminal head domain as the major phosphorylation sites on vimentin for PAK.  |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
PAK |
phosphorylation
|
SYN1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269974 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 12237306 |
Recombinant PAK2 could also phosphorylate the Ser9 and Ser551 residues. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
CDC42 | up-regulates activity
binding
|
PAK |
0.94 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248259 |
|
|
Mus musculus |
Brain |
| pmid |
sentence |
| 8107774 |
A new brain serine/threonine protein kinase may be a target for the p21ras-related proteins Cdc42 and Rac1. The kinase sequence is related to that of the yeast protein STE20, implicated in pheromone-response pathways. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
PPM1F | down-regulates
dephosphorylation
|
PAK |
0.399 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269882 |
|
|
Homo sapiens |
Breast Cancer Cell, MCF-7 Cell |
| pmid |
sentence |
| 20016286 |
Pop x2, a pp 2c serine/threonine phosphatase, is known to dephosphorylate pak and downregulate its activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RAC1 | up-regulates activity
binding
|
PAK |
0.779 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248256 |
|
|
Mus musculus |
Brain |
| pmid |
sentence |
| 8107774 |
A new brain serine/threonine protein kinase may be a target for the p21ras-related proteins Cdc42 and Rac1. The kinase sequence is related to that of the yeast protein STE20, implicated in pheromone-response pathways. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
PAK | down-regulates activity
phosphorylation
|
MYLK |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269973 |
|
|
in vitro |
|
| pmid |
sentence |
| 10748018 |
PAK2 can directly phosphorylate MLCK, inhibiting its activity and limiting the development of isometric tension. PAK2 catalyzes MLCK phosphorylation on serine residues 439 and 991. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
PAK | down-regulates
phosphorylation
|
NF2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269976 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18071304 |
Merlin contains a c-terminal serine 518, which is phosphorylated both by p21-activated kinase (pak) and protein kinase a (pka) (shaw et al., 2001;kissil et al., 2002;xiao et al., 2002;alfthan et al., 2004). Phosphorylation at this site is predicted to result in a more open conformation incapable of inhibiting cell growth, |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
PAK