Relation Results

Summary

Name PAK
Primary ID SIGNOR-PF13
Type protein family
Formed by PAK1, PAK2
Relations 9

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Type: Score: Layout: SPV 
0.20.9410.5650.20.20.20.20.3990.782PAKMAP2K1CDC42MEK1/2VIMMYLKNF2SYN1PPM1FRAC1

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ PAKup-regulates img/direct-activation.png phosphorylation MAP2K1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-140039 Ser298 RTPGRPLsSYGMDSR Homo sapiens HeLa Cell
pmid sentence
Inhibition of pak kinase activity dramatically decreased phosphorylation of mek1 at ser(298) in response to either pdgf or egf.
Publications: 1 Organism: Homo Sapiens
+ CDC42up-regulates activity img/direct-activation.png binding PAK 0.941
Identifier Residue Sequence Organism Cell Line
SIGNOR-248259 Mus musculus Brain
pmid sentence
A new brain serine/threonine protein kinase may be a target for the p21ras-related proteins Cdc42 and Rac1. The kinase sequence is related to that of the yeast protein STE20, implicated in pheromone-response pathways.
Publications: 1 Organism: Mus Musculus
+ PAKup-regulates img/direct-activation.png phosphorylation MEK1/2 0.565
Identifier Residue Sequence Organism Cell Line
SIGNOR-244920 Homo sapiens HeLa Cell
pmid sentence
Inhibition of pak kinase activity dramatically decreased phosphorylation of mek1 at ser(298) in response to either pdgf or egf.
Publications: 1 Organism: Homo Sapiens
+ PAKdown-regulates activity img/direct_inhibition.png phosphorylation VIM 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-269975 in vitro
pmid sentence
In vitro analyses revealed that vimentin served as an excellent substrate for PAK. This phosphorylated vimentin lost the potential to form 10 nm filaments. We identified Ser25, Ser38, Ser50, Ser65 and Ser72 in the amino-terminal head domain as the major phosphorylation sites on vimentin for PAK. 
Publications: 1 Organism: In Vitro
+ PAKdown-regulates activity img/direct_inhibition.png phosphorylation MYLK 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-269973 in vitro
pmid sentence
PAK2 can directly phosphorylate MLCK, inhibiting its activity and limiting the development of isometric tension. PAK2 catalyzes MLCK phosphorylation on serine residues 439 and 991.
Publications: 1 Organism: In Vitro
+ PAKdown-regulates img/direct_inhibition.png phosphorylation NF2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-269976 Homo sapiens
pmid sentence
Merlin contains a c-terminal serine 518, which is phosphorylated both by p21-activated kinase (pak) and protein kinase a (pka) (shaw et al., 2001;kissil et al., 2002;xiao et al., 2002;alfthan et al., 2004). Phosphorylation at this site is predicted to result in a more open conformation incapable of inhibiting cell growth,
Publications: 1 Organism: Homo Sapiens
+ PAK img/unknown.png phosphorylation SYN1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-269974 Rattus norvegicus
pmid sentence
Recombinant PAK2 could also phosphorylate the Ser9 and Ser551 residues.
Publications: 1 Organism: Rattus Norvegicus
+ PPM1Fdown-regulates img/direct_inhibition.png dephosphorylation PAK 0.399
Identifier Residue Sequence Organism Cell Line
SIGNOR-269882 Homo sapiens Breast Cancer Cell, MCF-7 Cell
pmid sentence
Pop x2, a pp 2c serine/threonine phosphatase, is known to dephosphorylate pak and downregulate its activity.
Publications: 1 Organism: Homo Sapiens
+ RAC1up-regulates activity img/direct-activation.png binding PAK 0.782
Identifier Residue Sequence Organism Cell Line
SIGNOR-248256 Mus musculus Brain
pmid sentence
A new brain serine/threonine protein kinase may be a target for the p21ras-related proteins Cdc42 and Rac1. The kinase sequence is related to that of the yeast protein STE20, implicated in pheromone-response pathways.
Publications: 1 Organism: Mus Musculus
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