Relation Results

Summary

Name Frizzled
Primary ID SIGNOR-PF11
Type protein family
Formed by FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9
Relations 15
Pathways Hepatocellular Tumor, Satellite: WNT, Wnt in cancer, WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis

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Type: Score: Layout: SPV 
0.8020.20.8280.20.7010.7580.20.8340.76WNT3AFrizzledDVL1WNT5AGNASWNT11WNT1CTNNB1WntWNT7A

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Relations
Regulator
Mechanism
target
score ℹ
+ WNT3Aup-regulates activity img/direct-activation.png binding Frizzled 0.802
Identifier Residue Sequence Organism Cell Line
SIGNOR-253128 Homo sapiens
pmid sentence
Ligands such as wnt1, wnt3a, and wnt8 couple the seventransmembrane domain receptor frizzled (fzd) and the single-membrane-spanning low-density receptor-related protein 5/6 (lrp5/6) to activate wnt Beta-catenin signaling.
Identifier Residue Sequence Organism Cell Line
SIGNOR-255650
pmid sentence
Wnt1, Wnt3a and Wnt5a all induced a statistically greater degree of proliferation than control cells
Publications: 2 Organism: Homo Sapiens,
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ Frizzledup-regulates activity img/direct-activation.png binding DVL1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-253124 Homo sapiens
pmid sentence
When canonical wnts bind to their respective fzd receptors, heterotrimeric g-proteins and dsh get activated and lead to the recruitment of axin to the fzd co-receptor lrp.
Publications: 1 Organism: Homo Sapiens
Pathways:Hepatocellular Tumor, Wnt in cancer, WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis
+ WNT5Aup-regulates activity img/direct-activation.png binding Frizzled 0.828
Identifier Residue Sequence Organism Cell Line
SIGNOR-255651
pmid sentence
Wnt1, Wnt3a and Wnt5a all induced a statistically greater degree of proliferation than control cells
Identifier Residue Sequence Organism Cell Line
SIGNOR-253129 Homo sapiens
pmid sentence
Human wnt5a, wnt5b and wnt11 are non-canonical wnt ligands transducing pcp signals through fzd3 or fzd6 receptors.
Publications: 2 Organism: , Homo Sapiens
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ Frizzledup-regulates activity img/direct-activation.png binding GNAS 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-253125 Homo sapiens
pmid sentence
Wnt7a binding to fzd7 activates pi3k through a g protein alpha s- dependent mechanism.
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
Pathways:WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis
+ WNT11up-regulates activity img/direct-activation.png binding Frizzled 0.701
Identifier Residue Sequence Organism Cell Line
SIGNOR-253127 Homo sapiens Lung Cancer Cell, Melanoma Cell
pmid sentence
Human wnt5a, wnt5b and wnt11 are non-canonical wnt ligands transducing pcp signals through fzd3 or fzd6 receptors.
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ WNT1up-regulates activity img/direct-activation.png binding Frizzled 0.758
Identifier Residue Sequence Organism Cell Line
SIGNOR-253126 Mus musculus
pmid sentence
Here, we report that the Wnt signal is transduced in muscle progenitor cells by at least two Frizzled (Fz) receptors (Fz1 and/or Fz6)
Identifier Residue Sequence Organism Cell Line
SIGNOR-255649
pmid sentence
Wnt1, Wnt3a and Wnt5a all induced a statistically greater degree of proliferation than control cells
Publications: 2 Organism: Mus Musculus,
Tissue: Muscle
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ Frizzledup-regulates img/direct-activation.png binding DVL1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-255891
pmid sentence
Wnt signaling is transduced through Fz independent of LRP5/6 leading to the activation of Dsh.
Identifier Residue Sequence Organism Cell Line
SIGNOR-255892
pmid sentence
After binding of Wnt to the receptor complex, the signal is transduced to cytoplasmic phosphoprotein Dishevelled (Dsh/Dvl), and studies have uncovered that Dsh can directly interact with Fz
Publications: 2
Pathways:Hepatocellular Tumor, Wnt in cancer, WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis
+ Frizzledup-regulates img/indirect-activation.png CTNNB1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-255687
pmid sentence
The Wnt–FZD–LRP5/6 trimeric complex recruits Dishevelled (DVL) and Axin through the intracellular domains of FZD and LRP5/6, resulting in inhibition of β-catenin phosphorylation and thus ensuing β-catenin stabilization.
Publications: 1
Tissue: Skeletal Muscle
Pathways:Hepatocellular Tumor, Wnt in cancer, WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis
+ Frizzledup-regulates activity img/indirect-activation.png CTNNB1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-255652
pmid sentence
[…] we suggest that Wnt1, Wnt3a and Wnt5a result in the accumulation of Act-β-Cat
Publications: 1
Pathways:Hepatocellular Tumor, Wnt in cancer, WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis
+ Wntup-regulates activity img/direct-activation.png binding Frizzled 0.834
Identifier Residue Sequence Organism Cell Line
SIGNOR-256173 Homo sapiens
pmid sentence
Wnt proteins bind to the frizzled receptors and lrp5/6 co-receptors, and through stabilizing the critical mediator betBeta-catenin, initiate a complex signaling cascade that plays an important role in regulating cell proliferation and differentiation.
Publications: 1 Organism: Homo Sapiens
Pathways:Hepatocellular Tumor, Wnt in cancer, WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis
+ WNT7Aup-regulates activity img/direct-activation.png binding Frizzled 0.76
Identifier Residue Sequence Organism Cell Line
SIGNOR-253130 Homo sapiens
pmid sentence
Wnt proteins bind to the frizzled receptors and lrp5/6 co-receptors, and through stabilizing the critical mediator betBeta-catenin, initiate a complex signaling cascade that plays an important role in regulating cell proliferation and differentiation.
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT Signaling and Myogenesis
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