Relation Results

Summary

Name RBR E3 ligase
Primary ID SIGNOR-PF107
Type protein family
Formed by ANKIB1, ARIH1, ARIH2, CUL9, PRKN, RBCK1, RNF14, RNF144A, RNF144B, RNF19A, RNF216, RNF31
Relations 2
Pathways Ubiquitin activation

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Type: Score: Layout: SPV 
0.20.2Ub:E2RBR E3 ligaseUb:RBR_E3

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Relations
Regulator
Mechanism
target
score ℹ
+ Ub:E2up-regulates activity img/direct-activation.png ubiquitination RBR E3 ligase 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270945 Homo sapiens
pmid sentence
The ubiquitination process is mediated sequentially by three classes of enzymes consisting of a Ub-activating enzyme E1, a Ub-conjugating enzyme E2, and a Ub ligase E3. Ub is first activated by E1 in an adenosine 5′-triphosphate (ATP)-dependent manner t
Publications: 1 Organism: Homo Sapiens
Pathways:Ubiquitin activation
+ RBR E3 ligaseform complex img/form-complex.png binding Ub:RBR_E3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-271378 Homo sapiens
pmid sentence
The ubiquitination process is mediated sequentially by three classes of enzymes consisting of a Ub-activating enzyme E1, a Ub-conjugating enzyme E2, and a Ub ligase E3. Ub is first activated by E1 in an adenosine 5′-triphosphate (ATP)-dependent manner to form a thioester-linked E1‒Ub conjugate. The activated Ub is then delivered to an E2 enzyme via a transthiolation reaction. Finally, an E3 enzyme, which can bind both a substrate and an E2‒Ub conjugate, mediates the covalent linkage of Ub to the target protein as a tag.
Publications: 1 Organism: Homo Sapiens
Pathways:Ubiquitin activation
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