Relation Results

Summary

Name HECT E3 ligase
Primary ID SIGNOR-PF104
Type protein family
Formed by AREL1, G2E3, HACE1, HECTD1, HECTD2, HECTD3, HECTD4, HECW1, HECW2, HERC1, HERC2, HERC3, HERC4, HERC5, HERC6, HUWE1, ITCH, NEDD4, NEDD4L, SMURF1, SMURF2, TRIP12, UBE3A, UBE3B, UBE3C, UBR5, WWP1, WWP2
Relations 2
Pathways Ubiquitin activation

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Type: Score: Layout: SPV 
0.20.2Ub:E2HECT E3 ligaseUb:HECT_E3

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Relations
Regulator
Mechanism
target
score ℹ
+ Ub:E2up-regulates activity img/direct-activation.png ubiquitination HECT E3 ligase 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270943 Homo sapiens
pmid sentence
The ubiquitination process is mediated sequentially by three classes of enzymes consisting of a Ub-activating enzyme E1, a Ub-conjugating enzyme E2, and a Ub ligase E3. Ub is first activated by E1 in an adenosine 5′-triphosphate (ATP)-dependent manner t
Publications: 1 Organism: Homo Sapiens
Pathways:Ubiquitin activation
+ HECT E3 ligaseform complex img/form-complex.png binding Ub:HECT_E3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-271376 Homo sapiens
pmid sentence
The ubiquitination process is mediated sequentially by three classes of enzymes consisting of a Ub-activating enzyme E1, a Ub-conjugating enzyme E2, and a Ub ligase E3. Ub is first activated by E1 in an adenosine 5′-triphosphate (ATP)-dependent manner to form a thioester-linked E1‒Ub conjugate. The activated Ub is then delivered to an E2 enzyme via a transthiolation reaction. Finally, an E3 enzyme, which can bind both a substrate and an E2‒Ub conjugate, mediates the covalent linkage of Ub to the target protein as a tag.
Publications: 1 Organism: Homo Sapiens
Pathways:Ubiquitin activation
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