Relation Results

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Type: Score: Layout: SPV 
0.20.20.7P4HA2CollagenP4HBECM_synthesis

Relations

Regulator
Mechanism
target
score
+ up-regulates quantity by stabilization img/direct-activation.png hydroxylation Collagen 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-269733 Homo sapiens
pmid sentence
Prolyl 4-hydroxylase (proline hydroxylase, EC 1.14.11.2) catalyzes the hydroxylation of proline in -Xaa-Pro-Gly- triplets in collagens and other proteins with collagen-like sequences. The enzyme plays a central role in the synthesis of all collagens, as the 4-hydroxyproline residues formed in the reaction are essential for the folding of the newly synthesized collagen polypeptide chains into triple helical molecules. 
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png binding Collagen 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-269731 Homo sapiens
pmid sentence
We also show that PDI associates independently with the C-propeptide of monomeric procollagen chains prior to trimer formation, indicating a role for this protein in coordinating the assembly of heterotrimeric molecules. This demonstrates that PDI has multiple functions in the folding of the same protein, that is, as a catalyst for disulfide bond formation, as a subunit of P4-H during proline hydroxylation, and independently as a molecular chaperone during chain assembly.
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png ECM_synthesis 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-269732 Homo sapiens
pmid sentence
The extracellular matrix is a structure composed of many molecules, including fibrillar (types I, II, III, V, XI, XXIV, XXVII) and non-fibrillar collagens (mainly basement membrane collagens: types IV, VIII, X), non-collagenous glycoproteins (elastin, laminin, fibronectin, thrombospondin, tenascin, osteopontin, osteonectin, entactin, periostin) embedded in a gel of negatively charged water-retaining glycosaminoglycans (GAGs) such as non-sulfated hyaluronic acid (HA) and sulfated GAGs which are linked to a core protein to form proteoglycans (PGs).
Publications: 1 Organism: Homo Sapiens
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