Relation Results

Summary

Name Protocadherin_beta
Primary ID SIGNOR-PF102
Type protein family
Formed by PCDHB1, PCDHB10, PCDHB11, PCDHB12, PCDHB13, PCDHB14, PCDHB15, PCDHB16, PCDHB18P, PCDHB2, PCDHB3, PCDHB4, PCDHB5, PCDHB6, PCDHB7, PCDHB8, PCDHB9
Relations 2

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Type: Score: Layout: SPV 
0.20.2Protocadherin_betaITGB1Protocadherin_alpha

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Relations
Regulator
Mechanism
target
score ℹ
+ Protocadherin_betaup-regulates activity img/direct-activation.png binding ITGB1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-269039 Homo sapiens
pmid sentence
The clustered protocadherins comprise the largest subfamily of the cadherin superfamily and are predominantly expressed in the nervous system. Pcdh-alpha proteins interact with beta1-integrin to promote cell adhesion.
Publications: 1 Organism: Homo Sapiens
Tissue: Central Nervous System
+ Protocadherin_alphaup-regulates activity img/direct-activation.png binding Protocadherin_beta 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-269036 Homo sapiens HEK-293 Cell
pmid sentence
We analyzed the expression of CNR/Pcdhalpha and Pcdhgamma in HEK293T cells and found that they formed a protein complex and that Pcdhgamma enhanced the surface expression of CNR/Pcdhalpha. This enhanced surface expression was confirmed by flow cytometry analysis and by marking cell surface proteins with biotin. The enhancement was observed using different combinations of CNR/Pcdhalpha and Pcdhgamma proteins. The surface expression activity was enhanced by the extracellular domains of the proteins, which could bind each other. Their cytoplasmic domains also had binding activity and influenced their localization. Their protein-protein interaction was also detected in extracts of mouse brain and two neuroblastoma cell lines. Thus, interactions between CNR/Pcdhalpha and Pcdhgamma regulate their surface expression and contribute to the combinatorial diversity of cell recognition proteins in the brain.
Publications: 1 Organism: Homo Sapiens
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