Relation Results

Summary

Name ERK1/2
Primary ID SIGNOR-PF1
Type protein family
Formed by MAPK1, MAPK3
Relations 350
Pathways Adipogenesis, Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, KIT in AML, AML_TRIPLETS, AMPK Signaling, B-cell activation, COVID-19 Causal Network, Colorectal Carcinoma, EGFR Signaling, Eosinophil: IL5, ErbB receptors in cancer, FAP: PDGFR alpha, FLT3-ITD in AML, FLT3-ITD signaling, Glioblastoma Multiforme, Hepatocellular Tumor, iCAF signaling in PDAC, IL6 Signaling, Insulin Signaling, Inhibition of Apoptosis, Integrin Signaling, Luminal Breast Cancer, Leptin Signaling, Mast cell: SCF, Mitochondrial dynamics in T cell exhaustion, Malignant Melanoma, Monocyte: IL10 transcriptional regulation, Monocyte: Macrophage differentiation, MTOR Signaling, Nucleotide Biosynthesis, Triple mutant AML, NPM1_new, Noonan syndrome, Non-small-cell lung cancer (NSCLC), Oxytocin signaling, Pancreatic ductal adenocarcinoma (PDA), PI3K/AKT Signaling, Rett syndrome, Rhabdomyosarcoma, RTKs in cancer, SARS-CoV MAPK PERTURBATION, Satellite: CCR2, Thyroid cancer, T cell activation, Toll like receptors, T-Lymphocyte: IL6, T-Lymphocyte: TGF beta, VEGF Signaling, WNT/FLT3

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ ERK1/2up-regulates img/direct-activation.png phosphorylation CDKN1B 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-244622 Ser10 NVRVSNGsPSLERMD Homo sapiens
pmid sentence
Phosphorylation on ser-10 of kip1 is the major site of phosphorylation in resting cells, takes place at the g(0)-g1 phase and leads to protein stability.
Identifier Residue Sequence Organism Cell Line
SIGNOR-244517 Ser178 EENVSDGsPNAGSVE Homo sapiens
pmid sentence
Indeed, p27kip1 was phosphorylated by p42 mapk (erk2) in vitrothese results suggest that ser(10) is the major site of phosphorylation of p27(kip1) and that phosphorylation at this site, like that at thr(187), contributes to regulation of p27(kip1) stability.
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, Integrin Signaling
+ ERK1/2up-regulates img/direct-activation.png phosphorylation HDAC6 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-244545 Ser1035 DHQTPPTsPVQGTTP Homo sapiens
pmid sentence
Histone deacetylase 6 (hdac6) is well known for its ability to promote cell migrationextracellular signal-regulated kinase (erk) phosphorylates histone deacetylase 6 (hdac6) at serine 1035 to stimulate cell migrationwe have identified two novel erk-mediated phosphorylation sites: threonine 1031 and serine 1035 in hdac6. Both sites were phosphorylated by erk1
Identifier Residue Sequence Organism Cell Line
SIGNOR-244549 Thr1031 ASSTDHQtPPTSPVQ Homo sapiens
pmid sentence
Histone deacetylase 6 (hdac6) is well known for its ability to promote cell migrationextracellular signal-regulated kinase (erk) phosphorylates histone deacetylase 6 (hdac6) at serine 1035 to stimulate cell migrationwe have identified two novel erk-mediated phosphorylation sites: threonine 1031 and serine 1035 in hdac6. Both sites were phosphorylated by erk1
Publications: 2 Organism: Homo Sapiens
+ ERK1/2down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation EP300 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-276455 Ser1038 STSATQSsPAPGQSK Homo sapiens Lung Cancer Cell
pmid sentence
In this study, we found that p300 was highly phosphorylated and its level was decreased during mitosis and tumorigenesis. In vitro and in vivo experiments aimed showed that cyclin-dependent kinase 1 (CDK1) and ERK1/2 phosphorylated p300 on Ser1038 and Ser2039. Mutations of Ser1038 and Ser2039 increased p300 protein stability and levels. 
Identifier Residue Sequence Organism Cell Line
SIGNOR-276458 Ser2039 GLGQVGIsPLKPGTV Homo sapiens Lung Cancer Cell
pmid sentence
In this study, we found that p300 was highly phosphorylated and its level was decreased during mitosis and tumorigenesis. In vitro and in vivo experiments aimed showed that cyclin-dependent kinase 1 (CDK1) and ERK1/2 phosphorylated p300 on Ser1038 and Ser2039. Mutations of Ser1038 and Ser2039 increased p300 protein stability and levels. 
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3 in AML, COVID-19 Causal Network
+ ERK1/2up-regulates img/direct-activation.png phosphorylation ESR1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-244647 Ser104 FPPLNSVsPSPLMLL Homo sapiens HeLa Cell
pmid sentence
In several estrogen response element-containing genes, the s118a mutation strongly reduced induction by e(2), and u0126 did not further reduce expression. Here, we show that serines 104 (s104) and 106 (s106) are also phosphorylated by mapk in vitro and upon stimulation of mapk activity in vivo.Phosphorylation at serines 104 and 106 by erk1/2 mapk is important for estrogen receptor-alpha activity
Identifier Residue Sequence Organism Cell Line
SIGNOR-244651 Ser106 PLNSVSPsPLMLLHP Homo sapiens HeLa Cell
pmid sentence
In several estrogen response element-containing genes, the s118a mutation strongly reduced induction by e(2), and u0126 did not further reduce expression. Here, we show that serines 104 (s104) and 106 (s106) are also phosphorylated by mapk in vitro and upon stimulation of mapk activity in vivo.Phosphorylation at serines 104 and 106 by erk1/2 mapk is important for estrogen receptor-alpha activity
Identifier Residue Sequence Organism Cell Line
SIGNOR-244655 Ser118 LHPPPQLsPFLQPHG Homo sapiens HeLa Cell
pmid sentence
In several estrogen response element-containing genes, the s118a mutation strongly reduced induction by e(2), and u0126 did not further reduce expression. Here, we show that serines 104 (s104) and 106 (s106) are also phosphorylated by mapk in vitro and upon stimulation of mapk activity in vivo.
Publications: 3 Organism: Homo Sapiens
Pathways:Luminal Breast Cancer, Oxytocin signaling
+ ERK1/2up-regulates activity img/direct-activation.png phosphorylation PPARG 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-232236 Ser112 AIKVEPAsPPYYSEK Homo sapiens
pmid sentence
Moreover, the inhibition of erks 1 and 2 with a mek inhibitor, u1026, lead to an inhibition in the decay of ppargamma proteins, indicating that serine phosphorylation influences the degradation of ppargamma in fat cells.
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis, Leptin Signaling, MTOR Signaling, Rett syndrome, Thyroid cancer
+ ERK1/2down-regulates activity img/direct_inhibition.png phosphorylation SOS1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-244580 Ser1132 TLPHGPRsASVSSIS Chlorocebus aethiops COS Cell
pmid sentence
In this report, we describe the identification of five map kinase sites (s-1137, s-1167, s-1178, s-1193, and s-1197) on hsos1Replacing the MAP kinase phosphorylation sites with alanine residues results in an increase in the binding affinity of Grb2 to hSos1
Identifier Residue Sequence Organism Cell Line
SIGNOR-244584 Ser1167 ESAPAESsPSKIMSK Chlorocebus aethiops COS Cell
pmid sentence
In this report, we describe the identification of five map kinase sites (s-1137, s-1167, s-1178, s-1193, and s-1197) on hsos1Replacing the MAP kinase phosphorylation sites with alanine residues results in an increase in the binding affinity of Grb2 to hSos1
Identifier Residue Sequence Organism Cell Line
SIGNOR-244588 Ser1197 KAYSPRYsISDRTSI Chlorocebus aethiops COS Cell
pmid sentence
In this report, we describe the identification of five map kinase sites (s-1137, s-1167, s-1178, s-1193, and s-1197) on hsos1Replacing the MAP kinase phosphorylation sites with alanine residues results in an increase in the binding affinity of Grb2 to hSos1
Identifier Residue Sequence Organism Cell Line
SIGNOR-244591 Homo sapiens
pmid sentence
ERK activation was sufficient for the SOS1 phosphorylation and resulting inhibition of EGF-induced Ras activation. This result also showed that SOS1 could be phosphorylated by ERK in the absence of association with EGFR at the plasma membrane, which is a phosphotyrosine-dependent process.
Publications: 4 Organism: Chlorocebus Aethiops, Homo Sapiens
Tissue: Lung, Breast
Pathways:Adipogenesis, Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, KIT in AML, COVID-19 Causal Network, Colorectal Carcinoma, EGFR Signaling, ErbB receptors in cancer, Glioblastoma Multiforme, Hepatocellular Tumor, IL6 Signaling, Insulin Signaling, Inhibition of Apoptosis, Integrin Signaling, Luminal Breast Cancer, Malignant Melanoma, Noonan syndrome, Non-small-cell lung cancer (NSCLC), PI3K/AKT Signaling, Rett syndrome, Rhabdomyosarcoma, RTKs in cancer, SARS-CoV MAPK PERTURBATION, Thyroid cancer, T cell activation, VEGF Signaling
+ ERK1/2up-regulates img/direct-activation.png phosphorylation SREBF1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-244754 Ser117 YPSMPAFsPGPGIKE Homo sapiens
pmid sentence
Map kinases erk1/2 phosphorylate sterol regulatory element-binding protein (srebp)-1a at serine 117 in vitro. mutation of serine 117 to alanine abolished erk2-mediated phosphorylation in vitro and the map kinase-related transcriptional activation of srebp-1a by insulin and platelet-derived growth factor in vivo.
Publications: 1 Organism: Homo Sapiens
Pathways:Insulin Signaling, MTOR Signaling
+ ERK1/2down-regulates img/direct_inhibition.png phosphorylation SOS1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-244743 Ser1178 IMSKHLDsPPAIPPR Homo sapiens
pmid sentence
ERK activation was sufficient for the SOS1 phosphorylation and resulting inhibition of EGF-induced Ras activation. This result also showed that SOS1 could be phosphorylated by ERK in the absence of association with EGFR at the plasma membrane, which is a phosphotyrosine-dependent process.
Identifier Residue Sequence Organism Cell Line
SIGNOR-244747 Ser1193 QPTSKAYsPRYSISD Homo sapiens
pmid sentence
ERK activation was sufficient for the SOS1 phosphorylation and resulting inhibition of EGF-induced Ras activation. This result also showed that SOS1 could be phosphorylated by ERK in the absence of association with EGFR at the plasma membrane, which is a phosphotyrosine-dependent process.
Publications: 2 Organism: Homo Sapiens
Pathways:Adipogenesis, Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, KIT in AML, COVID-19 Causal Network, Colorectal Carcinoma, EGFR Signaling, ErbB receptors in cancer, Glioblastoma Multiforme, Hepatocellular Tumor, IL6 Signaling, Insulin Signaling, Inhibition of Apoptosis, Integrin Signaling, Luminal Breast Cancer, Malignant Melanoma, Noonan syndrome, Non-small-cell lung cancer (NSCLC), PI3K/AKT Signaling, Rett syndrome, Rhabdomyosarcoma, RTKs in cancer, SARS-CoV MAPK PERTURBATION, Thyroid cancer, T cell activation, VEGF Signaling
+ ERK1/2down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation CDKN1A 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-244618 Ser130 SGEQAEGsPGGPGDS Homo sapiens
pmid sentence
Extracellular signal-regulated kinase 2-dependent phosphorylation induces cytoplasmic localization and degradation of p21cip1.|Phosphopeptide analysis of in vitro ERK2-phosphorylated p21(Cip1) revealed two phosphorylation sites, Thr57 and Ser130.
Identifier Residue Sequence Organism Cell Line
SIGNOR-244513 Thr57 NFDFVTEtPLEGDFA Homo sapiens
pmid sentence
We have shown that erk2 interacts with and phosphorylates p21cip1, promoting p21cip1_ubiquitination. We identified two erk2 phosphorylation sites, thr57 and ser130, in p21cip1_and showed that phosphorylation of these residues increases p21cip1_cytoplasmic distribution and proteasome-dependent degradation.
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML, FLT3-ITD signaling, Rhabdomyosarcoma
+ ERK1/2up-regulates activity img/direct-activation.png phosphorylation ARRB2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-274018 Ser14 TRVFKKSsPNCKLTV Mus musculus MEF Cell
pmid sentence
ERK1/2-dependent βarr2 phosphorylation on S14 and T276 induces CXCR4 intracellular sequestration.
Identifier Residue Sequence Organism Cell Line
SIGNOR-274019 Thr276 FCKVYTItPLLSDNR Mus musculus MEF Cell
pmid sentence
ERK1/2-dependent βarr2 phosphorylation on S14 and T276 induces CXCR4 intracellular sequestration.
Publications: 2 Organism: Mus Musculus
+ ERK1/2down-regulates img/direct_inhibition.png phosphorylation CIC 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-244630 Ser1409 SAPEDPTsPKRKMRR Homo sapiens Melanoma Cell
pmid sentence
Specifically, 14-3-3 binds to p90(rsk)-phosphorylated ser?_??_ Of capic?_A thereby modulating dna binding to its hmg (high-mobility group) box, whereas erk phosphorylations prevent binding of a c-terminal nls (nuclear localization sequence) to importin ?4 (kpna3)[...] These results suggest that erk phosphorylation of ser1382 and ser1409 masks the nls and prevents its binding to kpna3
Publications: 1 Organism: Homo Sapiens
+ ERK1/2 img/unknown.png phosphorylation SCRIB 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-263064 Ser1448 TSRQSPAsPPPLGGG Homo sapiens HEK-293 Cell
pmid sentence
HScrib is a substrate of ERK and PKA. Under normal growth conditions, hScrib is phosphorylated at S853, most likely by ERK, and at S1445 by PKA. Interestingly, stimulation of MAPK by osmotic stress results in a marked loss of phosphorylation at the PKA site S1445, but a concomitant increase in phosphorylation at S1448, presumably also by ERK. At present, we have no information as to what are the functional consequences of ERK or PKA phosphorylation of hScrib. However, we can speculate that this will most likely affect the ability of hScrib to interact with some of its cellular partners, and studies are currently in progress to investigate these aspects further.
Identifier Residue Sequence Organism Cell Line
SIGNOR-263065 Ser853 LPLLPPEsPGPLRQR Homo sapiens HEK-293 Cell
pmid sentence
HScrib is a substrate of ERK and PKA. Under normal growth conditions, hScrib is phosphorylated at S853, most likely by ERK, and at S1445 by PKA. Interestingly, stimulation of MAPK by osmotic stress results in a marked loss of phosphorylation at the PKA site S1445, but a concomitant increase in phosphorylation at S1448, presumably also by ERK. At present, we have no information as to what are the functional consequences of ERK or PKA phosphorylation of hScrib. However, we can speculate that this will most likely affect the ability of hScrib to interact with some of its cellular partners, and studies are currently in progress to investigate these aspects further.
Publications: 2 Organism: Homo Sapiens
+ ERK1/2down-regulates activity img/direct_inhibition.png phosphorylation BRAF 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-259919 Ser151 VARSNPKsPQKPIVR Homo sapiens Melanoma Cell
pmid sentence
We show that overactivation of the MAPK pathway, induced by the oncogenic Ras in melanoma, induces constitutive phosphorylation of BRAF on Ser151 by ERK, which inhibits NRAS-BRAF interaction
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, KIT in AML, AML_TRIPLETS, Colorectal Carcinoma, EGFR Signaling, ErbB receptors in cancer, FLT3-ITD signaling, Glioblastoma Multiforme, Hepatocellular Tumor, IL6 Signaling, Inhibition of Apoptosis, Luminal Breast Cancer, Malignant Melanoma, NPM1_new, Noonan syndrome, Non-small-cell lung cancer (NSCLC), Pancreatic ductal adenocarcinoma (PDA), PI3K/AKT Signaling, Rett syndrome, Rhabdomyosarcoma, RTKs in cancer, Thyroid cancer, T cell activation, VEGF Signaling
+ ERK1/2up-regulates activity img/direct-activation.png phosphorylation CACNB1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-262966 Ser161 CEVGFIPsPVKLDSL Chlorocebus aethiops COS-7 Cell
pmid sentence
Thus, Ser-447 on Ca(v)2.2 and Ser-161 and Ser-348 of Ca(v)beta1b appear to be both necessary and sufficient for ERK-dependent modulation of these channels. Together, our data strongly suggest that modulation of neuronal N-type VDCCs by ERK involves phosphorylation of Ca(v)2.2alpha1 and to a lesser extent possibly also Ca(v)beta subunits. On the basis of the evidence presented here, it is therefore suggested that ERK-dependent up-regulation of Cav2.2 channels is primarily mediated by phosphorylation of Ser-447 on the I–II loop of Cav2.2 and possibly also the two SP sites conserved on Cavβs.
Identifier Residue Sequence Organism Cell Line
SIGNOR-262965 Ser348 IVYIKITsPKVLQRL Chlorocebus aethiops COS-7 Cell
pmid sentence
Thus, Ser-447 on Ca(v)2.2 and Ser-161 and Ser-348 of Ca(v)beta1b appear to be both necessary and sufficient for ERK-dependent modulation of these channels. Together, our data strongly suggest that modulation of neuronal N-type VDCCs by ERK involves phosphorylation of Ca(v)2.2alpha1 and to a lesser extent possibly also Ca(v)beta subunits. On the basis of the evidence presented here, it is therefore suggested that ERK-dependent up-regulation of Cav2.2 channels is primarily mediated by phosphorylation of Ser-447 on the I–II loop of Cav2.2 and possibly also the two SP sites conserved on Cavβs.
Publications: 2 Organism: Chlorocebus Aethiops
+ ERK1/2up-regulates quantity by stabilization img/direct-activation.png phosphorylation PCBP2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-262668 Ser173 MLETLSQsPPKGVTI Mus musculus K-562 Cell
pmid sentence
All together, these data indicate that ERK-dependent phosphorylation of hnRNP-E2 at serines 173, 189, and 272, and threonine 213 is responsible for increased hnRNP-E2 protein stability in BCR/ABL-transformed cells.
Publications: 1 Organism: Mus Musculus
+ ERK1/2down-regulates img/direct_inhibition.png phosphorylation MITF 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-249575 Ser180 PGSSAPNsPMAMLTL Homo sapiens
pmid sentence
The current study reveals that c-kit signaling triggers two phosphorylation events on mi, which up-regulate transactivation potential yet simultaneously target mi for ubiquitin-dependent proteolysis. The specific activation/degradation signals derive from mapk/erk targeting of serine 73the results suggested that s1p reduced melanin synthesis via s1p(3) receptor-mediated erk and rsk-1 activation, and subsequent mitf dual phosphorylation and degradation.
Publications: 1 Organism: Homo Sapiens
Pathways:Malignant Melanoma
+ ERK1/2down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation XBP1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-276439 Ser181 QQVQAQLsPLQNISP Homo sapiens HCT-116 Cell
pmid sentence
Phosphorylation of XBP-1u by ERK is critical for the increased interaction of XBP-1u and FoxO1.
Identifier Residue Sequence Organism Cell Line
SIGNOR-276438 Ser68 RQRLTHLsPEEKALR Homo sapiens HCT-116 Cell
pmid sentence
Phosphorylation of XBP-1u by ERK is critical for the increased interaction of XBP-1u and FoxO1.
Publications: 2 Organism: Homo Sapiens
+ ERK1/2up-regulates activity img/direct-activation.png phosphorylation RRAS 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-277220 Ser186 S-->L Homo sapiens HEK-293T Cell
pmid sentence
 In this study, we report that TC21 and R-Ras are phosphorylated on a conserved serine, Ser186 and Ser201, respectively, in intact cells. This residue is located in the C-terminal hypervariable region of the proteins and is not conserved in M-Ras. We show that the MAP kinases ERK1/2 phosphorylate TC21 and R-Ras on this C-terminal serine residue both in vitro and in vivo. 
Identifier Residue Sequence Organism Cell Line
SIGNOR-277219 Ser201 QEQELPPsPPSAPRK Homo sapiens HEK-293T Cell
pmid sentence
 In this study, we report that TC21 and R-Ras are phosphorylated on a conserved serine, Ser186 and Ser201, respectively, in intact cells. This residue is located in the C-terminal hypervariable region of the proteins and is not conserved in M-Ras. We show that the MAP kinases ERK1/2 phosphorylate TC21 and R-Ras on this C-terminal serine residue both in vitro and in vivo. 
Publications: 2 Organism: Homo Sapiens
+ ERK1/2down-regulates activity img/direct_inhibition.png phosphorylation PAX5 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-269088 Ser189
Ser283		 SGILGITsPSADTNK
DMKANLAsPTPADIG		 Homo sapiens RAMOS (RA.1) Cell
pmid sentence
In this study, we demonstrated that PAX5 was phosphorylated by ERK1/2 in vitro and in vivo at serines 189 and 283. This phosphorylation attenuated the transcriptional repression of BLIMP1 by PAX5.
Publications: 1 Organism: Homo Sapiens
+ ERK1/2up-regulates activity img/direct-activation.png phosphorylation MARS1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-276671 Ser209 LQKQPQPsPAEGRAV Homo sapiens HeLa Cell
pmid sentence
Here, we report that methionyl-tRNA synthetase (MRS) is phosphorylated at Ser209 and Ser825 by extracellular signal-related kinase (ERK1/2) under conditions of stress caused by reactive oxygen species (ROS), and that this phosphorylated MRS shows increased affinity for non-cognate tRNAs with lower affinity for tRNA(Met), leading to an increase in Met residues in cellular proteins. 
Identifier Residue Sequence Organism Cell Line
SIGNOR-277834 Ser209 LQKQPQPsPAEGRAV Homo sapiens HeLa Cell
pmid sentence
Here, we report that methionyl-tRNA synthetase (MRS) is phosphorylated at Ser209 and Ser825 by extracellular signal-related kinase (ERK1/2) under conditions of stress caused by reactive oxygen species (ROS), and that this phosphorylated MRS shows increased affinity for non-cognate tRNAs with lower affinity for tRNA(Met), leading to an increase in Met residues in cellular proteins.
Identifier Residue Sequence Organism Cell Line
SIGNOR-277833 Ser825 GGGQAKTsPKPAVVE Homo sapiens HeLa Cell
pmid sentence
Here, we report that methionyl-tRNA synthetase (MRS) is phosphorylated at Ser209 and Ser825 by extracellular signal-related kinase (ERK1/2) under conditions of stress caused by reactive oxygen species (ROS), and that this phosphorylated MRS shows increased affinity for non-cognate tRNAs with lower affinity for tRNA(Met), leading to an increase in Met residues in cellular proteins.
Identifier Residue Sequence Organism Cell Line
SIGNOR-276670 Ser825 GGGQAKTsPKPAVVE Homo sapiens HeLa Cell
pmid sentence
Here, we report that methionyl-tRNA synthetase (MRS) is phosphorylated at Ser209 and Ser825 by extracellular signal-related kinase (ERK1/2) under conditions of stress caused by reactive oxygen species (ROS), and that this phosphorylated MRS shows increased affinity for non-cognate tRNAs with lower affinity for tRNA(Met), leading to an increase in Met residues in cellular proteins. 
Publications: 4 Organism: Homo Sapiens
+ ERK1/2up-regulates activity img/direct-activation.png phosphorylation CDCA5 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-262968 Ser209 DMTLPGIsPPPEKQK Homo sapiens HeLa Cell
pmid sentence
Phosphorylation and activation of cell division cycle associated 5 by mitogen-activated protein kinase play a crucial role in human lung carcinogenesis. Our data suggest that transactivation of CDCA5 and its phosphorylation at Ser209 by ERK play an important role in lung cancer proliferation, and that the selective suppression of the ERK-CDCA5 pathway could be a promising strategy for cancer therapy.
Identifier Residue Sequence Organism Cell Line
SIGNOR-262969 Ser79 AVQSPRRsPRISFFL Homo sapiens HeLa Cell
pmid sentence
Phosphorylation and activation of cell division cycle associated 5 by mitogen-activated protein kinase play a crucial role in human lung carcinogenesis. Our data suggest that transactivation of CDCA5 and its phosphorylation at Ser209 by ERK play an important role in lung cancer proliferation, and that the selective suppression of the ERK-CDCA5 pathway could be a promising strategy for cancer therapy.
Publications: 2 Organism: Homo Sapiens
+ ERK1/2down-regulates img/direct_inhibition.png phosphorylation ETV6 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-260084 Ser213 DNMIRRLsPAERAQG Mus musculus NIH-3T3 Cell
pmid sentence
Leukemia-related transcription factor TEL is negatively regulated through extracellular signal-regulated kinase-induced phosphorylation. Overexpressed TEL becomes phosphorylated in vivo by activated ERK. TEL is also directly phosphorylated in vitro by ERK. The inducible phosphorylation sites are Ser(213) and Ser(257).
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, KIT in AML, AML_TRIPLETS, Triple mutant AML
+ ERK1/2down-regulates activity img/direct_inhibition.png phosphorylation NUP50 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-188131 Ser221 KVAAETQsPSLFGST Homo sapiens
pmid sentence
Erk phosphorylates nup50 at ser221 and ser315 erk phosphorylation of the fg repeat region of nup50 reduced its affinity for importin-beta family proteins, importin-beta and transportin.
Identifier Residue Sequence Organism Cell Line
SIGNOR-263043 Ser315 TQSKPVSsPFPTKPL Homo sapiens
pmid sentence
Erk phosphorylates nup50 at ser221 and ser315 phosphorylation of nup50 reduces affinity for importin-beta
Publications: 2 Organism: Homo Sapiens
+ ERK1/2up-regulates activity img/direct-activation.png phosphorylation RPS6K 0.756
Identifier Residue Sequence Organism Cell Line
SIGNOR-252741 Ser221 DHEKKAYsFCGTVEY Chlorocebus aethiops COS Cell
pmid sentence
Several lines of evidence indicate that the mapkap-k1 isoforms are also activated by mapks in vivo via the ras-dependent protein kinase cascade that is triggered by growth factors or tumor-promoting phorbol esters, such as phorbol 12-myristate 13-acetate (pma). here we identify six sites in mapkap-k1a that become phosphorylated in transfected cos-1 cells. The inactive form of mapkap-k1a in unstimulated cells is partially phosphorylated at ser222 and ser733. Stimulation with phorbol 12-myristate 13-acetate induces the phosphorylation of thr360, ser364, thr574, and ser381 and increases the phosphorylation of ser222 and ser733.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252742 Ser363 TSRTPKDsPGIPPSA Chlorocebus aethiops COS Cell
pmid sentence
Several lines of evidence indicate that the mapkap-k1 isoforms are also activated by mapks in vivo via the ras-dependent protein kinase cascade that is triggered by growth factors or tumor-promoting phorbol esters, such as phorbol 12-myristate 13-acetate (pma). here we identify six sites in mapkap-k1a that become phosphorylated in transfected cos-1 cells. The inactive form of mapkap-k1a in unstimulated cells is partially phosphorylated at ser222 and ser733. Stimulation with phorbol 12-myristate 13-acetate induces the phosphorylation of thr360, ser364, thr574, and ser381 and increases the phosphorylation of ser222 and ser733.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252746 Ser380 HQLFRGFsFVATGLM Chlorocebus aethiops COS Cell
pmid sentence
Several lines of evidence indicate that the mapkap-k1 isoforms are also activated by mapks in vivo via the ras-dependent protein kinase cascade that is triggered by growth factors or tumor-promoting phorbol esters, such as phorbol 12-myristate 13-acetate (pma). here we identify six sites in mapkap-k1a that become phosphorylated in transfected cos-1 cells. The inactive form of mapkap-k1a in unstimulated cells is partially phosphorylated at ser222 and ser733. Stimulation with phorbol 12-myristate 13-acetate induces the phosphorylation of thr360, ser364, thr574, and ser381 and increases the phosphorylation of ser222 and ser733.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252744 Ser732 RRVRKLPsTTL Chlorocebus aethiops COS Cell
pmid sentence
Several lines of evidence indicate that the mapkap-k1 isoforms are also activated by mapks in vivo via the ras-dependent protein kinase cascade that is triggered by growth factors or tumor-promoting phorbol esters, such as phorbol 12-myristate 13-acetate (pma). here we identify six sites in mapkap-k1a that become phosphorylated in transfected cos-1 cells. The inactive form of mapkap-k1a in unstimulated cells is partially phosphorylated at ser222 and ser733. Stimulation with phorbol 12-myristate 13-acetate induces the phosphorylation of thr360, ser364, thr574, and ser381 and increases the phosphorylation of ser222 and ser733.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252745 Thr359 DTEFTSRtPKDSPGI Chlorocebus aethiops COS Cell
pmid sentence
Several lines of evidence indicate that the mapkap-k1 isoforms are also activated by mapks in vivo via the ras-dependent protein kinase cascade that is triggered by growth factors or tumor-promoting phorbol esters, such as phorbol 12-myristate 13-acetate (pma). here we identify six sites in mapkap-k1a that become phosphorylated in transfected cos-1 cells. The inactive form of mapkap-k1a in unstimulated cells is partially phosphorylated at ser222 and ser733. Stimulation with phorbol 12-myristate 13-acetate induces the phosphorylation of thr360, ser364, thr574, and ser381 and increases the phosphorylation of ser222 and ser733.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252743 Thr573 AENGLLMtPCYTANF Chlorocebus aethiops COS Cell
pmid sentence
Several lines of evidence indicate that the mapkap-k1 isoforms are also activated by mapks in vivo via the ras-dependent protein kinase cascade that is triggered by growth factors or tumor-promoting phorbol esters, such as phorbol 12-myristate 13-acetate (pma). here we identify six sites in mapkap-k1a that become phosphorylated in transfected cos-1 cells. The inactive form of mapkap-k1a in unstimulated cells is partially phosphorylated at ser222 and ser733. Stimulation with phorbol 12-myristate 13-acetate induces the phosphorylation of thr360, ser364, thr574, and ser381 and increases the phosphorylation of ser222 and ser733.
Publications: 6 Organism: Chlorocebus Aethiops
Pathways:FLT3-ITD signaling, Leptin Signaling, PI3K/AKT Signaling
+ ERK1/2up-regulates activity img/direct-activation.png phosphorylation RPS6KA1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-250553 Ser221 DHEKKAYsFCGTVEY Chlorocebus aethiops COS Cell
pmid sentence
Several lines of evidence indicate that the mapkap-k1 isoforms are also activated by mapks in vivo via the ras-dependent protein kinase cascade that is triggered by growth factors or tumor-promoting phorbol esters, such as phorbol 12-myristate 13-acetate (pma). here we identify six sites in mapkap-k1a that become phosphorylated in transfected cos-1 cells. The inactive form of mapkap-k1a in unstimulated cells is partially phosphorylated at ser222 and ser733. Stimulation with phorbol 12-myristate 13-acetate induces the phosphorylation of thr360, ser364, thr574, and ser381 and increases the phosphorylation of ser222 and ser733.
Identifier Residue Sequence Organism Cell Line
SIGNOR-250554 Ser363 TSRTPKDsPGIPPSA Chlorocebus aethiops COS Cell
pmid sentence
Several lines of evidence indicate that the mapkap-k1 isoforms are also activated by mapks in vivo via the ras-dependent protein kinase cascade that is triggered by growth factors or tumor-promoting phorbol esters, such as phorbol 12-myristate 13-acetate (pma). here we identify six sites in mapkap-k1a that become phosphorylated in transfected cos-1 cells. The inactive form of mapkap-k1a in unstimulated cells is partially phosphorylated at ser222 and ser733. Stimulation with phorbol 12-myristate 13-acetate induces the phosphorylation of thr360, ser364, thr574, and ser381 and increases the phosphorylation of ser222 and ser733.
Identifier Residue Sequence Organism Cell Line
SIGNOR-250555 Ser380 HQLFRGFsFVATGLM Chlorocebus aethiops COS Cell
pmid sentence
Several lines of evidence indicate that the mapkap-k1 isoforms are also activated by mapks in vivo via the ras-dependent protein kinase cascade that is triggered by growth factors or tumor-promoting phorbol esters, such as phorbol 12-myristate 13-acetate (pma). here we identify six sites in mapkap-k1a that become phosphorylated in transfected cos-1 cells. The inactive form of mapkap-k1a in unstimulated cells is partially phosphorylated at ser222 and ser733. Stimulation with phorbol 12-myristate 13-acetate induces the phosphorylation of thr360, ser364, thr574, and ser381 and increases the phosphorylation of ser222 and ser733.
Identifier Residue Sequence Organism Cell Line
SIGNOR-250556 Ser732 RRVRKLPsTTL Chlorocebus aethiops COS Cell
pmid sentence
Several lines of evidence indicate that the mapkap-k1 isoforms are also activated by mapks in vivo via the ras-dependent protein kinase cascade that is triggered by growth factors or tumor-promoting phorbol esters, such as phorbol 12-myristate 13-acetate (pma). here we identify six sites in mapkap-k1a that become phosphorylated in transfected cos-1 cells. The inactive form of mapkap-k1a in unstimulated cells is partially phosphorylated at ser222 and ser733. Stimulation with phorbol 12-myristate 13-acetate induces the phosphorylation of thr360, ser364, thr574, and ser381 and increases the phosphorylation of ser222 and ser733.
Identifier Residue Sequence Organism Cell Line
SIGNOR-250557 Thr359 DTEFTSRtPKDSPGI Chlorocebus aethiops COS Cell
pmid sentence
Several lines of evidence indicate that the mapkap-k1 isoforms are also activated by mapks in vivo via the ras-dependent protein kinase cascade that is triggered by growth factors or tumor-promoting phorbol esters, such as phorbol 12-myristate 13-acetate (pma). here we identify six sites in mapkap-k1a that become phosphorylated in transfected cos-1 cells. The inactive form of mapkap-k1a in unstimulated cells is partially phosphorylated at ser222 and ser733. Stimulation with phorbol 12-myristate 13-acetate induces the phosphorylation of thr360, ser364, thr574, and ser381 and increases the phosphorylation of ser222 and ser733.
Identifier Residue Sequence Organism Cell Line
SIGNOR-250558 Thr573 AENGLLMtPCYTANF Chlorocebus aethiops COS Cell
pmid sentence
Several lines of evidence indicate that the mapkap-k1 isoforms are also activated by mapks in vivo via the ras-dependent protein kinase cascade that is triggered by growth factors or tumor-promoting phorbol esters, such as phorbol 12-myristate 13-acetate (pma). here we identify six sites in mapkap-k1a that become phosphorylated in transfected cos-1 cells. The inactive form of mapkap-k1a in unstimulated cells is partially phosphorylated at ser222 and ser733. Stimulation with phorbol 12-myristate 13-acetate induces the phosphorylation of thr360, ser364, thr574, and ser381 and increases the phosphorylation of ser222 and ser733.
Publications: 6 Organism: Chlorocebus Aethiops
Pathways:AMPK Signaling, FLT3-ITD signaling, Inhibition of Apoptosis, MTOR Signaling
+ ERK1/2up-regulates img/direct-activation.png phosphorylation SPHK1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-118542 Ser225 VGSKTPAsPVVVQQG Homo sapiens
pmid sentence
Activation of sphingosine kinase 1 by erk1/2-mediated phosphorylation.
Publications: 1 Organism: Homo Sapiens
+ ERK1/2down-regulates img/direct_inhibition.png phosphorylation NR3C1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-93554 Ser226 IDENCLLsPLAGEDD in vitro
pmid sentence
Cyclin-dependent kinase (CDK) and mitogen-activated protein kinase (MAPK) phosphorylate the rat glucocorticoid receptor in vitro at distinct sites that together correspond to the major phosphorylated receptor residues observed in vivo; MAPK phosphorylates receptor residues threonine 171 and serine 246, whereas multiple CDK complexes modify serines 224 and 232.|MAPKs and CDKs exert opposite effects on receptor transcriptional enhancement. From our results, we speculate that activators of the MAPK pathway, such as growth factors, insulin, and certain oncoproteins, or inhibitors of CDK function, such as tumor growth factor beta (TGF_), p21, and p27, might attenuate receptor-induced transcrip- tional responses. In contrast, negative regulators of MAPK, such as pKA, as well as activators of CDK, such as the cyclins or CAKs, should potentiate receptor action.
Publications: 1 Organism: In Vitro
Pathways:Adipogenesis
+ ERK1/2up-regulates img/direct-activation.png phosphorylation RPS6KA3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-244692 Ser227 DHEKKAYsFCGTVEY Homo sapiens
pmid sentence
We have generated two monoclonal antibodies that recognize two phosphorylated sites, p-ser227 and p-thr577, in the n- and c-terminal kinase domains of rsk2, respectively. phosphorylation and activation of rsk2 by uv light involves the erk pathway
Identifier Residue Sequence Organism Cell Line
SIGNOR-244696 Thr577 AENGLLMtPCYTANF Homo sapiens
pmid sentence
We have generated two monoclonal antibodies that recognize two phosphorylated sites, p-ser227 and p-thr577, in the n- and c-terminal kinase domains of rsk2, respectively. phosphorylation and activation of rsk2 by uv light involves the erk pathway
Identifier Residue Sequence Organism Cell Line
SIGNOR-244699 Homo sapiens
pmid sentence
Erk-activates the rsk family of serine/threonine kinases,rsk1, rsk2, and rsk3.
Publications: 3 Organism: Homo Sapiens
+ ERK1/2up-regulates img/direct-activation.png phosphorylation EP300 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-244533 Ser2279 PVQPNPMsPQQHMLP Homo sapiens
pmid sentence
Serine residues (ser-2279, ser-2315, and ser-2366) on the c terminus of p300 were the major signaling targets of egf. Furthermore, the c-terminal serine phosphorylation of p300 stimulated its histone acetyltransferase activity these results also constituted the first report identifying the unique p300 phosphorylation sites induced by erk2 in vivo.
Identifier Residue Sequence Organism Cell Line
SIGNOR-244634 Ser2315 RSPQPVPsPRPQSQP Homo sapiens
pmid sentence
Erk2-mediated c-terminal serine phosphorylation of p300 (ser-2279, ser-2315, and ser-2366) is vital to the regulation of epidermal growth factor-induced keratin 16 gene expression.
Identifier Residue Sequence Organism Cell Line
SIGNOR-244537 Ser2366 MEQGHFAsPDQNSML Homo sapiens
pmid sentence
Serine residues (ser-2279, ser-2315, and ser-2366) on the c terminus of p300 were the major signaling targets of egf. Furthermore, the c-terminal serine phosphorylation of p300 stimulated its histone acetyltransferase activity these results also constituted the first report identifying the unique p300 phosphorylation sites induced by erk2 in vivo.
Publications: 3 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3 in AML, COVID-19 Causal Network
+ ERK1/2up-regulates activity img/direct-activation.png phosphorylation DHPS 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-277815 Ser233 KNHIPVFsPALTDGS Homo sapiens HEK-293A Cell
pmid sentence
The Ser-233 phosphorylation of DHPS by ERK1/2 is important for its function in cell proliferation.
Identifier Residue Sequence Organism Cell Line
SIGNOR-266376 Ser233 KNHIPVFsPALTDGS Homo sapiens HEK-293 Cell
pmid sentence
The Ser-233 phosphorylation of DHPS by ERK1/2 is important for its function in cell proliferation.
Identifier Residue Sequence Organism Cell Line
SIGNOR-277822 Ser233 KNHIPVFsPALTDGS Homo sapiens HEK-293A Cell
pmid sentence
 The Ser-233 phosphorylation of DHPS by ERK1/2 is important for its function in cell proliferation.
Identifier Residue Sequence Organism Cell Line
SIGNOR-277801 Ser233 KNHIPVFsPALTDGS Homo sapiens HEK-293A Cell
pmid sentence
The Ser-233 phosphorylation of DHPS by ERK1/2 is important for its function in cell proliferation.
Publications: 4 Organism: Homo Sapiens
+ ERK1/2up-regulates img/direct-activation.png phosphorylation SMAD2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-244719 Ser245 NQSMDTGsPAELSPT Homo sapiens
pmid sentence
These results suggest that oncogenic ras, acting through mek1 and erk kinases, induces the phosphorylation of smad2 and smad3 .we show that phosphorylation of smad2, a mediator of the activin/transforming growth factor-beta signal, by activated extracellular signal-regulated kinase 1 (erk1) increases the amount of smad2 protein and leads to enhanced transcriptional activity
Identifier Residue Sequence Organism Cell Line
SIGNOR-244723 Ser250 TGSPAELsPTTLSPV Homo sapiens
pmid sentence
These results suggest that oncogenic ras, acting through mek1 and erk kinases, induces the phosphorylation of smad2 and smad3 .we show that phosphorylation of smad2, a mediator of the activin/transforming growth factor-beta signal, by activated extracellular signal-regulated kinase 1 (erk1) increases the amount of smad2 protein and leads to enhanced transcriptional activity
Identifier Residue Sequence Organism Cell Line
SIGNOR-244727 Ser255 ELSPTTLsPVNHSLD Homo sapiens
pmid sentence
These results suggest that oncogenic ras, acting through mek1 and erk kinases, induces the phosphorylation of smad2 and smad3 .we show that phosphorylation of smad2, a mediator of the activin/transforming growth factor-beta signal, by activated extracellular signal-regulated kinase 1 (erk1) increases the amount of smad2 protein and leads to enhanced transcriptional activity
Identifier Residue Sequence Organism Cell Line
SIGNOR-255020 Ser255 ELSPTTLsPVNHSLD Homo sapiens
pmid sentence
Taken together, ERK-mediated Smad2 linker phosphorylation is responsible for TH17 differentiation
Identifier Residue Sequence Organism Cell Line
SIGNOR-244731 Thr220 QSNYIPEtPPPGYIS Homo sapiens
pmid sentence
Phosphorylation of smad2 by erk increases its transcriptional activity /thr220 and ser245, ser250, and ser255 were possible phosphorylation sites. The phosphorylation of peak a peptide by erk1 is consistent with that prediction.
Identifier Residue Sequence Organism Cell Line
SIGNOR-244735 Thr8 MSSILPFtPPVVKRL Homo sapiens
pmid sentence
These results suggest that oncogenic ras, acting through mek1 and erk kinases, induces the phosphorylation of smad2 and smad3 .we show that phosphorylation of smad2, a mediator of the activin/transforming growth factor-beta signal, by activated extracellular signal-regulated kinase 1 (erk1) increases the amount of smad2 protein and leads to enhanced transcriptional activity
Publications: 6 Organism: Homo Sapiens
Tissue: Lung, Breast, Lung
Pathways:Hepatocellular Tumor, Pancreatic ductal adenocarcinoma (PDA)
+ ERK1/2up-regulates img/direct-activation.png phosphorylation RUNX1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-244703 Ser249 DTRQIQPsPPWSYDQ Homo sapiens HEK-293T Cell
pmid sentence
We have identified four phosphorylation sites on aml1c that are necessary for transcriptional activity of aml1c in k562 and 293t cells (27).4 mutation of these four sites (serine 276, serine 293, serine 303, and threonine 300) to alanine abolishes transcriptional activation, whereas mutation of these sites to aspartic acid (which mimics phosphorylation) results in a hyperactive protein.
Identifier Residue Sequence Organism Cell Line
SIGNOR-244707 Ser266 QYLGSIAsPSVHPAT Homo sapiens HEK-293T Cell
pmid sentence
We have identified four phosphorylation sites on aml1c that are necessary for transcriptional activity of aml1c in k562 and 293t cells (27).4 mutation of these four sites (serine 276, serine 293, serine 303, and threonine 300) to alanine abolishes transcriptional activation, whereas mutation of these sites to aspartic acid (which mimics phosphorylation) results in a hyperactive protein.
Identifier Residue Sequence Organism Cell Line
SIGNOR-244715 Thr273 SPSVHPAtPISPGRA Homo sapiens HEK-293T Cell
pmid sentence
We have identified four phosphorylation sites on aml1c that are necessary for transcriptional activity of aml1c in k562 and 293t cells (27).4 mutation of these four sites (serine 276, serine 293, serine 303, and threonine 300) to alanine abolishes transcriptional activation, whereas mutation of these sites to aspartic acid (which mimics phosphorylation) results in a hyperactive protein.
Publications: 3 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3 in AML, KIT in AML, NPM1_new
+ ERK1/2down-regulates activity img/direct_inhibition.png phosphorylation RXRA 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-244573 Ser260 NMGLNPSsPNDPVTN Homo sapiens
pmid sentence
In colon cancer cells, the Ras/mitogen‐activated protein kinase (MAPK) pathway phosphorylates RXRalpha, which impairs its function as a heterodimeric partner for PPARgamma|A point‐mutated RXRalpha T82A/S260A, which mimics the unphosphorylated form of RXRalpha, can form a heterodimer with PPARgamma and thereby activate target gene expression by binding to the PPRE
Identifier Residue Sequence Organism Cell Line
SIGNOR-262960 Thr82 HSMSVPTtPTLGFST Homo sapiens
pmid sentence
In colon cancer cells, the Ras/mitogen‐activated protein kinase (MAPK) pathway phosphorylates RXRalpha, which impairs its function as a heterodimeric partner for PPARgamma|A point‐mutated RXRalpha T82A/S260A, which mimics the unphosphorylated form of RXRalpha, can form a heterodimer with PPARgamma and thereby activate target gene expression by binding to the PPRE
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ ERK1/2down-regulates img/direct_inhibition.png phosphorylation GPHN 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-200953 Ser268 ASLSTTPsESPRAQA Homo sapiens
pmid sentence
Erk phosphorylates gephyrin at ser-268 to regulate size of gephyrin postsynaptic scaffold and strength of gabaergic transmission./ Ser-268 phosphorylation restricts gephyrin cluster size via calpain 1 proteolysis
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ ERK1/2up-regulates activity img/direct-activation.png phosphorylation ALOX5 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-264443 Ser272 CSLERQLsLEQEVQQ Homo sapiens HeLa Cell
pmid sentence
Intriguingly, a significant difference in the potency of nonredox-type inhibitors (but not of BWA4C) was determined between wild-type 5-LO and the mutant S271A/S663A-5-LO (lacking phosphorylation sites for ERK1/2 and MAPKAPK-2) in HeLa cells. Collectively, our data suggest that compared with Ca2+-mediated 5-LO product formation, enzyme activation involving 5-LO phosphorylation events specifically and strongly alters the susceptibility of 5-LO toward nonredox-type inhibitors in intact cells.
Identifier Residue Sequence Organism Cell Line
SIGNOR-264442 Ser664 QLPYYYLsPDRIPNS Homo sapiens HeLa Cell
pmid sentence
Intriguingly, a significant difference in the potency of nonredox-type inhibitors (but not of BWA4C) was determined between wild-type 5-LO and the mutant S271A/S663A-5-LO (lacking phosphorylation sites for ERK1/2 and MAPKAPK-2) in HeLa cells. Collectively, our data suggest that compared with Ca2+-mediated 5-LO product formation, enzyme activation involving 5-LO phosphorylation events specifically and strongly alters the susceptibility of 5-LO toward nonredox-type inhibitors in intact cells.
Publications: 2 Organism: Homo Sapiens
+ ERK1/2down-regulates activity img/direct_inhibition.png phosphorylation GORASP1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-260605 Ser274 DPLPGPGsPSHSAPD Rattus norvegicus
pmid sentence
Supporting the conclusion that phosphorylation of GRASP65 at Ser277 by ERK is critical for Golgi polarization. We have demonstrated a closely integrated mechanism in which Golgi remodeling by phosphorylation of GRASP65 acts as a negative regulator of Golgi and, surprisingly, centrosome orientation. Our data indicate that ERK phosphorylates GRASP65 in interphase cells, resulting in the loss of GRASP65 oligomerization and causing subsequent Golgi cisternal unstacking.
Publications: 1 Organism: Rattus Norvegicus
+ ERK1/2up-regulates activity img/direct-activation.png phosphorylation RUNX1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-244711 Ser276 VHPATPIsPGRASGM Homo sapiens
pmid sentence
We have identified four phosphorylation sites on aml1c that are necessary for transcriptional activity of aml1c in k562 and 293t cells (27).4 mutation of these four sites (serine 276, serine 293, serine 303, and threonine 300) to alanine abolishes transcriptional activation, whereas mutation of these sites to aspartic acid (which mimics phosphorylation) results in a hyperactive protein.
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3 in AML, KIT in AML, NPM1_new
+ ERK1/2up-regulates activity img/direct-activation.png phosphorylation BAG3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-274070 Ser289 RSSTPLHsPSPIRVH Homo sapiens A-172 Cell
pmid sentence
ERK-dependent phosphorylation of BIS following H2O2 treatment.
Identifier Residue Sequence Organism Cell Line
SIGNOR-274071 Thr285 GSPARSStPLHSPSP Homo sapiens A-172 Cell
pmid sentence
ERK-dependent phosphorylation of BIS following H2O2 treatment.
Publications: 2 Organism: Homo Sapiens
+ ERK1/2down-regulates activity img/direct_inhibition.png phosphorylation RAF1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-244677 Ser289 RSHSESAsPSALSSS Mus musculus
pmid sentence
Here, we identify six residues of Raf-1 (S29, S43, S289, S296, S301, and S642) that become hyperphosphorylated in a manner coincident with Raf-1 inactivation. | Five of the identified sites are proline-directed targets of activated ERK, and phosphorylation of all six sites requires MEK signaling, indicating a negative feedback mechanism. Hyperphosphorylation of these six sites inhibits the Ras/Raf-1 interaction and desensitizes Raf-1 to additional stimuli.|FLAG-Raf-1 phosphorylated by activated ERK2
Identifier Residue Sequence Organism Cell Line
SIGNOR-244681 Ser296 SPSALSSsPNNLSPT Mus musculus
pmid sentence
Here, we identify six residues of Raf-1 (S29, S43, S289, S296, S301, and S642) that become hyperphosphorylated in a manner coincident with Raf-1 inactivation. | Five of the identified sites are proline-directed targets of activated ERK, and phosphorylation of all six sites requires MEK signaling, indicating a negative feedback mechanism. Hyperphosphorylation of these six sites inhibits the Ras/Raf-1 interaction and desensitizes Raf-1 to additional stimuli.|FLAG-Raf-1 phosphorylated by activated ERK2
Publications: 2 Organism: Mus Musculus
Pathways:Adipogenesis, COVID-19 Causal Network, Insulin Signaling, Integrin Signaling, Noonan syndrome, Oxytocin signaling, SARS-CoV MAPK PERTURBATION
+ ERK1/2down-regulates activity img/direct_inhibition.png phosphorylation H3-3A 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-263068 Ser29 ATKAARKsAPSTGGV Homo sapiens
pmid sentence
In the present study, ERK1, ERK2, or p38 kinase strongly phosphorylated H3 at serine 28 in vitro. JNK1 or JNK2 was able also to phosphorylate H3 at serine 28 in vitro but to a lesser degree. Histone H3 phosphorylation is related closely to chromatin remodeling and chromosome condensation. H3 phosphorylation at serine 28 is coupled with mitotic chromosome condensation in diverse mammalian cell lines.
Publications: 1 Organism: Homo Sapiens
+ ERK1/2down-regulates img/direct_inhibition.png phosphorylation RAF1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-244685 Ser301 SSSPNNLsPTGWSQP Homo sapiens
pmid sentence
Using mass spectrometry, we identified raf-1 phosphorylation on three sp motif sites: s289/s296/s301. These sites were phosphorylated by extracellular signal-regulated kinase (erk)-1 in vitro, and their phosphorylation in vivo was dependent on endogenous erk activity. Functionally, erk-1 expression sustains raf-1 activation in a manner dependent on raf-1 phosphorylation on the identified sites, and s289/296/301a substitution markedly decreases the in vivo activity of raf-1 s259a.
Identifier Residue Sequence Organism Cell Line
SIGNOR-244688 Homo sapiens
pmid sentence
Mapkerk1/2 is also able to phopshorylate the egf receptor, the ras exchange factor sos, mkkkraf1, and mkkmek1. The phosphorylation of each of these proteins by mapkerk1/2 is believed to reduce their catalytic activity
Publications: 2 Organism: Homo Sapiens
Pathways:Adipogenesis, COVID-19 Causal Network, Insulin Signaling, Integrin Signaling, Noonan syndrome, Oxytocin signaling, SARS-CoV MAPK PERTURBATION
+ ERK1/2up-regulates img/direct-activation.png phosphorylation ELK1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-252085 Ser324 RDLELPLsPSLLGGP Homo sapiens
pmid sentence
Erki phosphorylates five c-terminal sites in elk-i (s324, t336, s383, s389 and s422) with varying degrees of efficiency.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252083 Ser383 IHFWSTLsPIAPRSP Homo sapiens
pmid sentence
Erki phosphorylates five c-terminal sites in elk-i (s324, t336, s383, s389 and s422) with varying degrees of efficiency.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252086 Ser389 LSPIAPRsPAKLSFQ Homo sapiens
pmid sentence
Erki phosphorylates five c-terminal sites in elk-i (s324, t336, s383, s389 and s422) with varying degrees of efficiency.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252084 Ser422 LSTPVVLsPGPQKP Homo sapiens
pmid sentence
Erki phosphorylates five c-terminal sites in elk-i (s324, t336, s383, s389 and s422) with varying degrees of efficiency.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252082 Thr336 GGPGPERtPGSGSGS Homo sapiens
pmid sentence
Erki phosphorylates five c-terminal sites in elk-i (s324, t336, s383, s389 and s422) with varying degrees of efficiency.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252081 Homo sapiens
pmid sentence
The tcf protein elk-1 is phosphorylated by the jnk and erk groups of mitogen-activated protein (map) kinases causing increased dna binding, ternary complex formation, and transcriptional activation
Publications: 6 Organism: Homo Sapiens
Pathways:EGFR Signaling, Glioblastoma Multiforme, IL6 Signaling, Integrin Signaling, Noonan syndrome
+ ERK1/2up-regulates img/direct-activation.png phosphorylation HNRNPK 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-105754 Ser353 DSAIDTWsPSEWQMA Homo sapiens
pmid sentence
When subjected to phosphorylation by erk, the most efficient decrease in erk phosphorylation was observed with the s353a mutantamong the mechanisms underlying k protein ability to confer increased transcriptional output are interconversion of duplex and single-stranded dna (59) and association with the c/ebp_ (60), each of which could be better affected by the phosphorylated form of the k protein, which may increase affinity to associated proteins or dna.
Publications: 1 Organism: Homo Sapiens
+ ERK1/2down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation RAMAC 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-277819 Ser36 YLKRPPEsPPIVEEW Homo sapiens Embryonic Stem Cell Line
pmid sentence
ERK1/2 phosphorylates RAM serine-36, targeting it for ubiquitination and proteasomal degradation, ultimately resulting in changes in gene expression associated with loss of pluripotency.
Identifier Residue Sequence Organism Cell Line
SIGNOR-277267 Ser36 YLKRPPEsPPIVEEW Homo sapiens
pmid sentence
During differentiation, ERK1/2 phosphorylates RAM serine-36, targeting it for ubiquitination and proteasomal degradation, ultimately resulting in changes in gene expression associated with loss of pluripotency.
Publications: 2 Organism: Homo Sapiens
+ ERK1/2up-regulates img/direct-activation.png phosphorylation RPS6KA5 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-249572 Ser360 TEMDPTYsPAALPQS Homo sapiens
pmid sentence
Together, our in vivo and in vitro studies indicate that the pkc/c-raf/mek/erk pathway plays a major role in the s6k1 activation in hypertrophic cardiac growth.
Identifier Residue Sequence Organism Cell Line
SIGNOR-249573 Thr581 PDNQPLKtPCFTLHY Homo sapiens
pmid sentence
Together, our in vivo and in vitro studies indicate that the pkc/c-raf/mek/erk pathway plays a major role in the s6k1 activation in hypertrophic cardiac growth.
Publications: 2 Organism: Homo Sapiens
Pathways:Adipogenesis, Malignant Melanoma
+ ERK1/2down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation LIMA1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-263062 Ser362 PVHPKPLsPDSRASS Homo sapiens Prostate Cancer Cell Line
pmid sentence
Mechanistic study revealed that EGF could activate the phosphorylation, ubiquitination, and degradation of EPLIN through an extracellular signal-regulated kinase 1/2 (ERK1/2)-dependent signaling cascade. Pharmacological inhibition of the ERK1/2 pathway effectively antagonized EGF-induced EPLIN degradation. Two serine residues, i.e. serine 362 and serine 604, were identified as putative ERK1/2 phosphorylation sites in human EPLIN, whose point mutation rendered resistance to EGF-induced protein turnover.
Identifier Residue Sequence Organism Cell Line
SIGNOR-263063 Ser604 FQSTSVKsPKTVSPP Homo sapiens Prostate Cancer Cell Line
pmid sentence
Mechanistic study revealed that EGF could activate the phosphorylation, ubiquitination, and degradation of EPLIN through an extracellular signal-regulated kinase 1/2 (ERK1/2)-dependent signaling cascade. Pharmacological inhibition of the ERK1/2 pathway effectively antagonized EGF-induced EPLIN degradation. Two serine residues, i.e. serine 362 and serine 604, were identified as putative ERK1/2 phosphorylation sites in human EPLIN, whose point mutation rendered resistance to EGF-induced protein turnover.
Publications: 2 Organism: Homo Sapiens
+ ERK1/2up-regulates activity img/direct-activation.png phosphorylation FOS 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-262995 Ser362 AAAHRKGsSSNEPSS
pmid sentence
Serine 374 and serine 362 are the primary sites targeted by Erk1/2 and the mitogen-activated protein kinase-activated kinases Rsk1/2 (12, 13, 37, 38, 41), respectively. Their phosphorylation leads to protein stabilization (3, 13, 20, 41). Threonine 325 and threonine 331 are secondary targets of Erk1/2; their modification occurs only when serines 362 and 374 are phosphorylated and Erk1/2 activation is sufficiently sustained (37, 38). This enhances the transcriptional activity of c-Fos
Identifier Residue Sequence Organism Cell Line
SIGNOR-251524 Ser374 PSSDSLSsPTLLAL Homo sapiens
pmid sentence
In a previous study we have observed that exposure of nih 3t3 cells to pdgf or serum leads to c-fos phosphorylation by erk on specific residues, thr232, thr325, thr331, and ser374, within the cooh-terminal c-fos tad we have recently shown that erk phosphorylates multiple residues within the carboxylterminal transactivation domain (tad) of c-fos, thus resulting in its increased transcriptional activity.
Identifier Residue Sequence Organism Cell Line
SIGNOR-263010 Thr325 TELEPLCtPVVTCTP
pmid sentence
Serine 374 and serine 362 are the primary sites targeted by Erk1/2 and the mitogen-activated protein kinase-activated kinases Rsk1/2 (12, 13, 37, 38, 41), respectively. Their phosphorylation leads to protein stabilization (3, 13, 20, 41). Threonine 325 and threonine 331 are secondary targets of Erk1/2; their modification occurs only when serines 362 and 374 are phosphorylated and Erk1/2 activation is sufficiently sustained (37, 38). This enhances the transcriptional activity of c-Fos
Identifier Residue Sequence Organism Cell Line
SIGNOR-251522 Thr325 TELEPLCtPVVTCTP Homo sapiens
pmid sentence
In a previous study we have observed that exposure of nih 3t3 cells to pdgf or serum leads to c-fos phosphorylation by erk on specific residues, thr232, thr325, thr331, and ser374, within the cooh-terminal c-fos tad we have recently shown that erk phosphorylates multiple residues within the carboxylterminal transactivation domain (tad) of c-fos, thus resulting in its increased transcriptional activity.
Identifier Residue Sequence Organism Cell Line
SIGNOR-251523 Thr331 CTPVVTCtPSCTAYT Homo sapiens
pmid sentence
In a previous study we have observed that exposure of nih 3t3 cells to pdgf or serum leads to c-fos phosphorylation by erk on specific residues, thr232, thr325, thr331, and ser374, within the cooh-terminal c-fos tad we have recently shown that erk phosphorylates multiple residues within the carboxylterminal transactivation domain (tad) of c-fos, thus resulting in its increased transcriptional activity.
Identifier Residue Sequence Organism Cell Line
SIGNOR-263009 Thr331 CTPVVTCtPSCTAYT
pmid sentence
Serine 374 and serine 362 are the primary sites targeted by Erk1/2 and the mitogen-activated protein kinase-activated kinases Rsk1/2 (12, 13, 37, 38, 41), respectively. Their phosphorylation leads to protein stabilization (3, 13, 20, 41). Threonine 325 and threonine 331 are secondary targets of Erk1/2; their modification occurs only when serines 362 and 374 are phosphorylated and Erk1/2 activation is sufficiently sustained (37, 38). This enhances the transcriptional activity of c-Fos
Publications: 6 Organism: , Homo Sapiens
Pathways:Acute Myeloid Leukemia, EGFR Signaling, Leptin Signaling, T cell activation
+ ERK1/2up-regulates img/direct-activation.png phosphorylation CSNK2A1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-244521 Ser362 ISSVPTPsPLGPLAG Homo sapiens Glioblastoma Cell
pmid sentence
Erk2, which is activated by egfr signaling, directly binds to ck2alpha via the erk2 docking groove and phosphorylates ck2alpha primarily at t360/s362, subsequently enhancing ck2alpha activity
Identifier Residue Sequence Organism Cell Line
SIGNOR-244525 Thr360 SGISSVPtPSPLGPL Homo sapiens Glioblastoma Cell
pmid sentence
Erk2, which is activated by egfr signaling, directly binds to ck2alpha via the erk2 docking groove and phosphorylates ck2alpha primarily at t360/s362, subsequently enhancing ck2alpha activity
Publications: 2 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network
+ ERK1/2up-regulates activity img/direct-activation.png phosphorylation ASB2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-272239 Ser371 RIRRSGVsPLHLAAE
pmid sentence
Indeed, using mass spectrometry, we showed for the first time that ASB2a is phosphorylated and that phosphorylation of serine-323 (Ser-323) of ASB2a is crucial for the targeting of the actin-binding protein filamin A (FLNa) to degradation. |Moreover, inhibition of the extracellular signal-regulated kinases 1 and 2 (Erk1/2) activity reduced ASB2a-mediated FLNa degradation.
Publications: 1
+ ERK1/2up-regulates img/direct-activation.png phosphorylation PARP1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-244669 Ser372 VAATPPPsTASAPAA Homo sapiens Neuron
pmid sentence
Parp1 phosphorylation by erk1/2 is required for maximal parp-1 activation after dna damage. S372a and t373a mutations impaired parp-1 activation.
Identifier Residue Sequence Organism Cell Line
SIGNOR-244673 Thr373 AATPPPStASAPAAV Homo sapiens Neuron
pmid sentence
Parp1 phosphorylation by erk1/2 is required for maximal parp-1 activation after dna damage. S372a and t373a mutations impaired parp-1 activation.
Publications: 2 Organism: Homo Sapiens
Tissue: Brain
Pathways:Acute Myeloid Leukemia, COVID-19 Causal Network, FLT3-ITD in AML, FLT3-ITD signaling, Inhibition of Apoptosis
+ ERK1/2up-regulates img/direct-activation.png phosphorylation AP1 0.783
Identifier Residue Sequence Organism Cell Line
SIGNOR-252358 Ser374 PSSDSLSsPTLLAL Homo sapiens
pmid sentence
In a previous study we have observed that exposure of nih 3t3 cells to pdgf or serum leads to c-fos phosphorylation by erk on specific residues, thr232, thr325, thr331, and ser374, within the cooh-terminal c-fos tad we have recently shown that erk phosphorylates multiple residues within the carboxylterminal transactivation domain (tad) of c-fos, thus resulting in its increased transcriptional activity.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252359 Thr232 GGLPEVAtPESEEAF Homo sapiens
pmid sentence
Phosphorylation of the c-fos and c-jun hob1 motif stimulates its activation capacity here we show that the hob1-containing activation domain of c-fos is stimulated by ha-ras in vivo and phosphorylated by a map kinase family member in vitro and that mutating t232 to ala abolishes both functions.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252357 Thr325 TELEPLCtPVVTCTP Homo sapiens
pmid sentence
In a previous study we have observed that exposure of nih 3t3 cells to pdgf or serum leads to c-fos phosphorylation by erk on specific residues, thr232, thr325, thr331, and ser374, within the cooh-terminal c-fos tad we have recently shown that erk phosphorylates multiple residues within the carboxylterminal transactivation domain (tad) of c-fos, thus resulting in its increased transcriptional activity.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252353 Thr331 CTPVVTCtPSCTAYT Homo sapiens
pmid sentence
In a previous study we have observed that exposure of nih 3t3 cells to pdgf or serum leads to c-fos phosphorylation by erk on specific residues, thr232, thr325, thr331, and ser374, within the cooh-terminal c-fos tad we have recently shown that erk phosphorylates multiple residues within the carboxylterminal transactivation domain (tad) of c-fos, thus resulting in its increased transcriptional activity.
Publications: 4 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3 in AML, B-cell activation, COVID-19 Causal Network, FLT3-ITD signaling, Hepatocellular Tumor, Luminal Breast Cancer, Leptin Signaling, Pancreatic ductal adenocarcinoma (PDA), SARS-CoV MAPK PERTURBATION, T cell activation, Toll like receptors
+ ERK1/2up-regulates activity img/direct-activation.png phosphorylation RPS6KA5 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-249574 Ser376 EKLFQGYsFVAPSIL Homo sapiens
pmid sentence
In the present study, we show that, in addition to being phosphorylated on Thr-581 and Ser-360 by ERK1/2 or p38, MSK1 can autophosphorylate on at least six sites: Ser-212, Ser-376, Ser-381, Ser-750, Ser-752 and Ser-758. Of these sites, the N-terminal T-loop residue Ser-212 and the 'hydrophobic motif' Ser-376 are phosphorylated by the C-terminal kinase domain of MSK1, and their phosphorylation is essential for the catalytic activity of the N-terminal kinase domain of MSK1
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis, Malignant Melanoma
+ ERK1/2down-regulates img/direct_inhibition.png phosphorylation CASP8 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-244509 Ser387 YLEMDLSsPQTRYIP Homo sapiens
pmid sentence
We demonstrate that perk 1/2 can phosphorylate pro-caspase-8 at s387 by knocking-down the endogenous pro-caspase-8 using rnai and replacing it with its non-phosphorylatable counterpart (s387a), a significant increase in caspase-8 activity
Publications: 1 Organism: Homo Sapiens
Tissue: Breast
Pathways:COVID-19 Causal Network
+ ERK1/2down-regulates activity img/direct_inhibition.png phosphorylation XPO5 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-262980 Ser416 GFPSKTDsPSCEYSR Homo sapiens HEK-293 Cell
pmid sentence
Here we show that ERK suppresses pre-miRNA export from the nucleus through phosphorylation of exportin-5 (XPO5) at T345/S416/S497. After phosphorylation by ERK, conformation of XPO5 is altered by prolyl isomerase Pin1, resulting in reduction of pre-miRNA loading. 
Identifier Residue Sequence Organism Cell Line
SIGNOR-262983 Ser497 GSLCSVFsPSFVQWE Homo sapiens HEK-293 Cell
pmid sentence
Here we show that ERK suppresses pre-miRNA export from the nucleus through phosphorylation of exportin-5 (XPO5) at T345/S416/S497. After phosphorylation by ERK, conformation of XPO5 is altered by prolyl isomerase Pin1, resulting in reduction of pre-miRNA loading. 
Identifier Residue Sequence Organism Cell Line
SIGNOR-262986 Thr345 GADSDVEtPSNFGKY Homo sapiens HEK-293 Cell
pmid sentence
Here we show that ERK suppresses pre-miRNA export from the nucleus through phosphorylation of exportin-5 (XPO5) at T345/S416/S497. After phosphorylation by ERK, conformation of XPO5 is altered by prolyl isomerase Pin1, resulting in reduction of pre-miRNA loading. 
Publications: 3 Organism: Homo Sapiens
+ ERK1/2down-regulates activity img/direct_inhibition.png phosphorylation STK11 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-244595 Ser428 SSKIRRLsACKQQ Homo sapiens
pmid sentence
Directly and/or through the activation of p90RSK, ERK phosphorylates LKB-1 at Ser325 and Ser428. The phosphorylation of LKB-1 causes the dissociation of LKB-1 from AMPK, resulting in the impaired activation of AMPK.
Publications: 1 Organism: Homo Sapiens
Pathways:AMPK Signaling, FLT3-ITD signaling
+ ERK1/2up-regulates quantity by stabilization img/direct-activation.png phosphorylation METTL3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-265953 Ser43 RNPEAALsPTFRSDS Homo sapiens HEK-293 Cell
pmid sentence
Mass spectrometry analysis showed that ERK phosphorylates METTL3 at three highly conserved residues: S43, S50, and S525 (Figures 2D and 2E). Mutational analysis further confirmed these three sites as main ERK phosphorylation sites (Figure 2F). Phosphorylation of METTL3 increases interaction with USP5, decreasing ubiquitination to stabilize the m6 A methyltransferase complex.
Identifier Residue Sequence Organism Cell Line
SIGNOR-265951 Ser50 SPTFRSDsPVPTAPT Homo sapiens HEK-293 Cell
pmid sentence
Mass spectrometry analysis showed that ERK phosphorylates METTL3 at three highly conserved residues: S43, S50, and S525 (Figures 2D and 2E). Mutational analysis further confirmed these three sites as main ERK phosphorylation sites (Figure 2F). Phosphorylation of METTL3 increases interaction with USP5, decreasing ubiquitination to stabilize the m6 A methyltransferase complex.
Identifier Residue Sequence Organism Cell Line
SIGNOR-265952 Ser525 YGMIERLsPGTRKIE Homo sapiens HEK-293 Cell
pmid sentence
Mass spectrometry analysis showed that ERK phosphorylates METTL3 at three highly conserved residues: S43, S50, and S525 (Figures 2D and 2E). Mutational analysis further confirmed these three sites as main ERK phosphorylation sites (Figure 2F). Phosphorylation of METTL3 increases interaction with USP5, decreasing ubiquitination to stabilize the m6 A methyltransferase complex.
Publications: 3 Organism: Homo Sapiens
+ ERK1/2up-regulates activity img/direct-activation.png phosphorylation CACNA1B 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-262967 Ser446 ADLCAVGsPFARASL Chlorocebus aethiops
pmid sentence
Thus, Ser-447 on Ca(v)2.2 and Ser-161 and Ser-348 of Ca(v)beta1b appear to be both necessary and sufficient for ERK-dependent modulation of these channels. Together, our data strongly suggest that modulation of neuronal N-type VDCCs by ERK involves phosphorylation of Ca(v)2.2alpha1 and to a lesser extent possibly also Ca(v)beta subunits. On the basis of the evidence presented here, it is therefore suggested that ERK-dependent up-regulation of Cav2.2 channels is primarily mediated by phosphorylation of Ser-447 on the I–II loop of Cav2.2 and possibly also the two SP sites conserved on Cavβs.
Publications: 1 Organism: Chlorocebus Aethiops
+ ERK1/2up-regulates activity img/direct-activation.png phosphorylation GAB1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-129188 Ser454 YVPMNPNsPPRQHSS Homo sapiens
pmid sentence
Erk phosphorylation enhances hgf-dependent gab1/pi3k but inhibits egf-dependent gab1/pi3k association and activation implicates that mapk activation provides another specific regulatory mechanism which can result in divergent effects for distinct rtks.we identified four serine and two threonine residues that are phosphorylated by erk in vitro. Five of these phosphorylation sites (t312, s454, t476, s581, s597)
Identifier Residue Sequence Organism Cell Line
SIGNOR-129192 Ser597 VPMNPNLsSEDPNLF Homo sapiens
pmid sentence
Erk phosphorylation enhances hgf-dependent gab1/pi3k but inhibits egf-dependent gab1/pi3k association and activation implicates that mapk activation provides another specific regulatory mechanism which can result in divergent effects for distinct rtks.we identified four serine and two threonine residues that are phosphorylated by erk in vitro. Five of these phosphorylation sites (t312, s454, t476, s581, s597)
Identifier Residue Sequence Organism Cell Line
SIGNOR-129196 Thr312 ISYDIPPtPGNTYQI Homo sapiens
pmid sentence
Erk phosphorylation enhances hgf-dependent gab1/pi3k but inhibits egf-dependent gab1/pi3k association and activation implicates that mapk activation provides another specific regulatory mechanism which can result in divergent effects for distinct rtks.we identified four serine and two threonine residues that are phosphorylated by erk in vitro. Five of these phosphorylation sites (t312, s454, t476, s581, s597)
Identifier Residue Sequence Organism Cell Line
SIGNOR-129200 Thr476 EANYVPMtPGTFDFS Homo sapiens
pmid sentence
Erk phosphorylation enhances hgf-dependent gab1/pi3k but inhibits egf-dependent gab1/pi3k association and activation implicates that mapk activation provides another specific regulatory mechanism which can result in divergent effects for distinct rtks.we identified four serine and two threonine residues that are phosphorylated by erk in vitro. Five of these phosphorylation sites (t312, s454, t476, s581, s597)
Publications: 4 Organism: Homo Sapiens
Pathways:EGFR Signaling, Hepatocellular Tumor, Noonan syndrome, PI3K/AKT Signaling, Rhabdomyosarcoma
+ ERK1/2down-regulates img/direct_inhibition.png phosphorylation AR 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-244606 Ser516 VSRVPYPsPTCVKSE Homo sapiens Prostate Gland Cancer Cell
pmid sentence
Map kinase-dependent phosphorylation at ar ser-515 was supported by the decrease in intensity of the slower migrating 23-kda band after treatment with both egf and increasing concentrations of the map kinase inhibitor, u0126
Publications: 1 Organism: Homo Sapiens
+ ERK1/2down-regulates img/direct_inhibition.png phosphorylation JAK2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-244553 Ser523 GVSDVPTsPTLQRPT Chlorocebus aethiops COS Cell
pmid sentence
We hypothesize that phosphorylation of ser523 in jak2 by erks 1 and/or 2 or other as-yet-unidentified kinases acts in a negative feedback manner
Publications: 1 Organism: Chlorocebus Aethiops
Pathways:Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, KIT in AML, EGFR Signaling, Leptin Signaling
+ ERK1/2down-regulates img/direct_inhibition.png phosphorylation MYB 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-244569 Ser532 KIKQEVEsPTDKSGN Homo sapiens JURKAT Cell
pmid sentence
Functional analysis of phosphorylation at serine 532 of human c-myb by map kinase. expression of a polypeptide containing the c-myb c-terminal domain stimulated c-myb activity. This effect is reduced upon mapk-dependent phosphorylation of serine 532. Our data suggest that the mapk-dependent state of phosphorylation modifies the cellular function of c-myb by modulating its interaction with a putative inhibitory factor
Publications: 1 Organism: Homo Sapiens
+ ERK1/2up-regulates activity img/direct-activation.png phosphorylation PAPOLA 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-268341 Ser537 DNSMSVPsPTSATKT Mus musculus Oocyte
pmid sentence
Once an oocyte resumes meiosis, activated CDK1 and ERK1/2 cooperatively mediate the phosphorylation of three serine residues of PAPalpha, 537, 545 and 558, thereby leading to increased activity.
Identifier Residue Sequence Organism Cell Line
SIGNOR-268342 Ser545 PTSATKTsPLNSSGS Mus musculus Oocyte
pmid sentence
Once an oocyte resumes meiosis, activated CDK1 and ERK1/2 cooperatively mediate the phosphorylation of three serine residues of PAPalpha, 537, 545 and 558, thereby leading to increased activity.
Identifier Residue Sequence Organism Cell Line
SIGNOR-268343 Ser558 GSSQGRNsPAPAVTA Mus musculus Oocyte
pmid sentence
Once an oocyte resumes meiosis, activated CDK1 and ERK1/2 cooperatively mediate the phosphorylation of three serine residues of PAPalpha, 537, 545 and 558, thereby leading to increased activity.
Publications: 3 Organism: Mus Musculus
+ ERK1/2down-regulates activity img/direct_inhibition.png phosphorylation TSC2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-249455 Ser540 KVMARSLsPPPELEE Mus musculus NIH-3T3 Cell
pmid sentence
Here, we show that Erk may play a critical role in TSC progression through posttranslational inactivation of TSC2. Erk-dependent phosphorylation leads to TSC1-TSC2 dissociation and markedly impairs TSC2 ability to inhibit mTOR signaling, cell proliferation, and oncogenic transformation. |Serine to alanine substitution at S664 or double S664A/S540A mutagenesis resulted in a marked reduction in TSC2 phosphorylation to a similar extent. In contrast, S540A substitution only moderately impaired TSC2 phosphorylation (Figure 3D), corroborating the notion that in vivo S664 is the most relevant residue for Erk-mediated phosphorylation.
Identifier Residue Sequence Organism Cell Line
SIGNOR-244602 Homo sapiens Breast Cancer Cell, Prostate Gland Cancer Cell, Leukemia Cell, Glioblastoma Cell
pmid sentence
Phosphorylation of tsc2 (by akt and erk;refs. 28, 29) and tsc1(by ikkbeta;ref. 30) results in the disruption of the tsc1/2 complex, and thereby activates the oncogenic mtor signaling contributing to tumor progression
Publications: 2 Organism: Mus Musculus, Homo Sapiens
+ ERK1/2up-regulates activity img/direct-activation.png phosphorylation DNM1L 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-275407 Ser616 PIPIMPAsPQKGHAV Homo sapiens HEK-293 Cell
pmid sentence
Here, we show that expression of oncogenic Ras or direct activation of the MAPK pathway leads to increased mitochondrial fragmentation and that blocking this phenotype, through knockdown of the mitochondrial fission-mediating GTPase Drp1, inhibits tumor growth. This fission is driven by Erk2-mediated phosphorylation of Drp1 on Serine 616, and both this phosphorylation and mitochondrial fragmentation are increased in human pancreatic cancer.
Publications: 1 Organism: Homo Sapiens
+ ERK1/2up-regulates quantity by stabilization img/direct-activation.png phosphorylation MYC 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-252079 Ser62 LLPTPPLsPSRRSGL Rattus norvegicus Embryonic Fibroblast
pmid sentence
Phosphorylation of Ser 62 is required for Ras-induced stabilization of Myc, likely mediated through the action of ERK.
Publications: 1 Organism: Rattus Norvegicus
Pathways:Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, KIT in AML, AML_TRIPLETS, Colorectal Carcinoma, EGFR Signaling, FLT3-ITD in AML, FLT3-ITD signaling, Hepatocellular Tumor, Nucleotide Biosynthesis, Triple mutant AML, NPM1_new, Rhabdomyosarcoma, Thyroid cancer, WNT/FLT3
+ ERK1/2down-regulates img/direct_inhibition.png phosphorylation TSC2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-244765 Ser664 KKTSGPLsPPTGPPG Homo sapiens
pmid sentence
Here, we show that erk may play a critical role in tsc progression through posttranslational inactivation of tsc2. s664 is the primary erk phosphorylation site on tsc2 in vitro and in vivo
Publications: 1 Organism: Homo Sapiens
+ ERK1/2up-regulates quantity by stabilization img/direct-activation.png phosphorylation BCL2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-244501 Ser70 RDPVARTsPLQTPAA Chlorocebus aethiops COS Cell
pmid sentence
Erk1 and erk2 directly phosphorylate bcl2 exclusively at ser-70.
Identifier Residue Sequence Organism Cell Line
SIGNOR-244505 Ser87 AAAGPALsPVPPVVH Homo sapiens HeLa Cell
pmid sentence
The results of this study reveal the following novel findings: destruction of the three putative MAP kinase sites at positions 56, 74, and 87 results in ubiquitination and subsequent degradation of the protein. Progressive inactivation of these MAP kinase sites revealed that Bcl-2 stability is mainly regulated by phosphorylation at Thr74 and Ser87, with Ser87 phosphorylation playing a predominant role. TNF-α or the MAP kinase-specific inhibitor PD98059 diminishes Ser87 phosphorylation of Bcl-2 in vivo, while activated ERK2 induces phosphorylation of Bcl-2 in vivo and in vitro.
Identifier Residue Sequence Organism Cell Line
SIGNOR-244610 Thr56 FSSQPGHtPHPAASR Homo sapiens
pmid sentence
The results of this study reveal the following novel findings: destruction of the three putative MAP kinase sites at positions 56, 74, and 87 results in ubiquitination and subsequent degradation of the protein. Progressive inactivation of these MAP kinase sites revealed that Bcl-2 stability is mainly regulated by phosphorylation at Thr74 and Ser87.
Identifier Residue Sequence Organism Cell Line
SIGNOR-244494 Thr74 ARTSPLQtPAAPGAA Homo sapiens HeLa Cell
pmid sentence
The results of this study reveal the following novel findings: destruction of the three putative MAP kinase sites at positions 56, 74, and 87 results in ubiquitination and subsequent degradation of the protein. Progressive inactivation of these MAP kinase sites revealed that Bcl-2 stability is mainly regulated by phosphorylation at Thr74 and Ser87, with Ser87 phosphorylation playing a predominant role. TNF-α or the MAP kinase-specific inhibitor PD98059 diminishes Ser87 phosphorylation of Bcl-2 in vivo, while activated ERK2 induces phosphorylation of Bcl-2 in vivo and in vitro.
Publications: 4 Organism: Chlorocebus Aethiops, Homo Sapiens
Pathways:Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, KIT in AML, AML_TRIPLETS, COVID-19 Causal Network, Colorectal Carcinoma, FLT3-ITD signaling, Inhibition of Apoptosis, Malignant Melanoma, Triple mutant AML, NPM1_new, Non-small-cell lung cancer (NSCLC), SARS-CoV MAPK PERTURBATION
+ ERK1/2up-regulates activity img/direct-activation.png phosphorylation GRIP1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-263056 Ser734 SLKGKPLsEAIHLLQ in vitro
pmid sentence
Here we show that epidermal growth factor regulates the activities of the p160 GRIP1 through the extracellular signal-regulated kinase (ERK) family of mitogen-activated protein kinases. ERKs phosphorylate GRIP1 at a specific site, Ser-736, the integrity of which is required for full growth factor induction of GRIP1 transcriptional activation and coactivator function.
Publications: 1 Organism: In Vitro
+ ERK1/2down-regulates img/direct_inhibition.png phosphorylation FGFR1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-244541 Ser777 SMPLDQYsPSFPDTR Homo sapiens
pmid sentence
Erk-mediated phosphorylation of fibroblast growth factor receptor 1 on ser777 inhibits signaling
Publications: 1 Organism: Homo Sapiens
Pathways:Luminal Breast Cancer
+ ERK1/2up-regulates activity img/direct-activation.png phosphorylation RPTOR 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-174878 Ser863 LTQSAPAsPTNKGVH Homo sapiens
pmid sentence
We found three proline-directed residues within raptor, ser(8), ser(696), and ser(863), which are directly phosphorylated by erk1/2. Expression of phosphorylation-deficient alleles of raptor revealed that phosphorylation of these sites by erk1/2 normally promotes mtorc1 activity and signaling to downstream substrates, such as 4e-bp1.
Publications: 1 Organism: Homo Sapiens
Pathways:MTOR Signaling
+ ERK1/2down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation GABBR1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-277853 Ser868 ITRGEWQsEAQDTMK Homo sapiens HEK-293 Cell
pmid sentence
We found that, in addition to CaMKIIβ, also ERK1/2 is involved in the degradation pathway of GABAB receptors under physiological and ischemic conditions. In contrast to our previous view, CaMKIIβ does not appear to directly phosphorylate S867. Instead, the data support a mechanism in which CaMKIIβ activates ERK1/2, which then phosphorylates S867 and T872 in GABAB1.
Identifier Residue Sequence Organism Cell Line
SIGNOR-277852 Thr873 WQSEAQDtMKTGSST Homo sapiens HEK-293 Cell
pmid sentence
We found that, in addition to CaMKIIβ, also ERK1/2 is involved in the degradation pathway of GABAB receptors under physiological and ischemic conditions. In contrast to our previous view, CaMKIIβ does not appear to directly phosphorylate S867. Instead, the data support a mechanism in which CaMKIIβ activates ERK1/2, which then phosphorylates S867 and T872 in GABAB1.
Publications: 2 Organism: Homo Sapiens
+ ERK1/2up-regulates activity img/direct-activation.png phosphorylation RHOA 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-277202 Ser88 LMCFSIDsPDSLENI Chlorocebus aethiops COS-7 Cell
pmid sentence
We have recently reported that Rac1 is phosphorylated on threonine 108 (108T) by extracellular signal-regulated kinases (ERK) in response to epidermal growth factor (EGF) stimulation. Here, we provide evidence that RhoA is phosphorylated by ERK on 88S and 100T in response to EGF stimulation.
Identifier Residue Sequence Organism Cell Line
SIGNOR-277203 Thr100 ENIPEKWtPEVKHFC Chlorocebus aethiops COS-7 Cell
pmid sentence
We have recently reported that Rac1 is phosphorylated on threonine 108 (108T) by extracellular signal-regulated kinases (ERK) in response to epidermal growth factor (EGF) stimulation. Here, we provide evidence that RhoA is phosphorylated by ERK on 88S and 100T in response to EGF stimulation.
Publications: 2 Organism: Chlorocebus Aethiops
Pathways:WNT/FLT3
+ ERK1/2down-regulates activity img/direct_inhibition.png phosphorylation GSK3B 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-262522 Ser9 SGRPRTTsFAESCKP Mus musculus MEF Cell
pmid sentence
We demonstrate that insulin-mediated activation of ERK1/2 results in phosphorylation of GSK3β at S9 independently of Akt/mTORC1 activity in Tsc2 null mouse embryonic fibroblasts. In addition, we show that inhibition of ERK1/2 rescues GSK3β activity and restores protein synthesis in Tsc2 −/− MEFs to normal levels
Publications: 1 Organism: Mus Musculus
Pathways:Adipogenesis, Acute Myeloid Leukemia, AML_TRIPLETS, FLT3-ITD signaling, Insulin Signaling, MTOR Signaling, Triple mutant AML, PI3K/AKT Signaling, WNT/FLT3
+ ERK1/2up-regulates activity img/direct-activation.png phosphorylation HECTD3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-272330 Thr157 ARLVPIDtPNHLQRQ Homo sapiens KYSE-30 Cell
pmid sentence
HECTD3 binds and ubiquitinates caspase-9.Phosphorylation of HECTD3 by ERK is required for the association of HECTD3 and caspase-9. HECTD3 suppressing caspase-9 activation is dependent on T157 phosphorylation by ERK.
Publications: 1 Organism: Homo Sapiens
+ ERK1/2down-regulates activity img/direct_inhibition.png phosphorylation SHC4 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-273669 Thr159 GHRATALtPDSCPLP in vitro
pmid sentence
The luminescence obtained in the kinase assay with FLAG-ShcD as substrate was significantly different to that with FLAG peptide suggesting that ShcD is a direct substrate of ERK (Fig. 2C).Furthermore, Thr159 was mutated to either alanine (A) or glutamic acid (E) to study whether the threonine phosphorylation state influences the ShcD/ERK interaction. Introducing the T159E mutation obliterated the ShcD/ERK interaction.
Publications: 1 Organism: In Vitro
+ ERK1/2up-regulates img/direct-activation.png phosphorylation CDK2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-244614 Thr160 GVPVRTYtHEVVTLW Homo sapiens
pmid sentence
In addition to its role in stimulating cyclin d1 expression and nuclear translocation of cdk2, erk regulates thr-160 phosphorylation of cdk2-cyclin e.
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis
+ ERK1/2up-regulates activity img/direct-activation.png phosphorylation MAPK3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-244565 Thr207 FLTEYVAtRWYRAPE Homo sapiens
pmid sentence
Here we show that autophosphorylation of erk1/2 on thr188 directs erk1/2 to phosphorylate nuclear targets known to cause cardiac hypertrophy.
Publications: 1 Organism: Homo Sapiens
Tissue: Heart
+ ERK1/2up-regulates img/direct-activation.png phosphorylation FOS 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-251525 Thr232 GGLPEVAtPESEEAF Homo sapiens
pmid sentence
Phosphorylation of the c-fos and c-jun hob1 motif stimulates its activation capacity here we show that the hob1-containing activation domain of c-fos is stimulated by ha-ras in vivo and phosphorylated by a map kinase family member in vitro and that mutating t232 to ala abolishes both functions.
Identifier Residue Sequence Organism Cell Line
SIGNOR-260762 Homo sapiens HuH-7 Cell
pmid sentence
3b Augments c-Fos Levels by Activating the ERK Pathway. | Higher c-Fos levels were observed in 3b-expressing cells than in GFP-expressing control cells
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, EGFR Signaling, Leptin Signaling, T cell activation
+ ERK1/2up-regulates activity img/direct-activation.png phosphorylation CEBPB 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-238303 Thr235 SSSSPPGtPSPADAK Homo sapiens Lung Cancer Cell
pmid sentence
Phosphorylation of cebpb at thr(235) peaked at 16 hours in il-1beta-stimulated cells. The mek inhibitor u0126 inhibited this phosphorylation and reduced mmp-1 gene induction.
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis, Acute Myeloid Leukemia, FLT3-ITD signaling
+ ERK1/2down-regulates activity img/direct_inhibition.png phosphorylation SOX10 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-277821 Thr240 GQSHGPPtPPTTPKT Homo sapiens A-375 Cell
pmid sentence
Phosphorylation of SOX10 by ERK inhibits its transcription activity toward multiple target genes by interfering with the sumoylation of SOX10 at K55, which is essential for its transcription activity.ERK2 directly phosphorylates SOX10 at T240 and T244.
Identifier Residue Sequence Organism Cell Line
SIGNOR-277820 Thr244 GPPTPPTtPKTELQS Homo sapiens A-375 Cell
pmid sentence
Phosphorylation of SOX10 by ERK inhibits its transcription activity toward multiple target genes by interfering with the sumoylation of SOX10 at K55, which is essential for its transcription activity.ERK2 directly phosphorylates SOX10 at T240 and T244.
Publications: 2 Organism: Homo Sapiens
+ ERK1/2up-regulates activity img/direct-activation.png phosphorylation MKNK1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-253014 Thr250 NSCTPITtPELTTPC Homo sapiens MCF-7 Cell
pmid sentence
We generated a phosphospecific antibody to Thr(P)-214 in the T-loop of MNKs and found that phosphorylations of both Thr-209 and Thr-214 in human MNK1 are required for activation
Identifier Residue Sequence Organism Cell Line
SIGNOR-253015 Thr255 ITTPELTtPCGSAEY Homo sapiens MCF-7 Cell
pmid sentence
We generated a phosphospecific antibody to Thr(P)-214 in the T-loop of MNKs and found that phosphorylations of both Thr-209 and Thr-214 in human MNK1 are required for activation
Identifier Residue Sequence Organism Cell Line
SIGNOR-253013 in vitro
pmid sentence
These results indicate that MNK1 is a novel class of protein kinase that is activated through both the ERK and p38 MAP kinase signaling pathways
Publications: 3 Organism: Homo Sapiens, In Vitro
Pathways:PI3K/AKT Signaling
+ ERK1/2up-regulates img/direct-activation.png phosphorylation SMAD4 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-244739 Thr277 GSRTAPYtPNLPHHQ Homo sapiens
pmid sentence
Our results suggest that map kinase can phosphorylate thr276 of smad4 and that phosphorylation can lead to enhanced tgf-beta-induced nuclear accumulation and, as a consequence, enhanced transcriptional activity of smad4.
Publications: 1 Organism: Homo Sapiens
Pathways:Colorectal Carcinoma, Hepatocellular Tumor, Pancreatic ductal adenocarcinoma (PDA)
+ ERK1/2down-regulates activity img/direct_inhibition.png phosphorylation MAP2K1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-244557 Thr292 ETPPRPRtPGRPLSS Chlorocebus aethiops COS Cell
pmid sentence
We propose that activation of erk during adhesion creates a feedback system in which erk phosphorylates mek1 on t292, and this in turn blocks additional s298 phosphorylation in response to integrin signaling.
Identifier Residue Sequence Organism Cell Line
SIGNOR-244561 Thr386 IGLNQPStPTHAAGV Homo sapiens HEK-293 Cell
pmid sentence
An ERK2-binding site at the N terminus of MEK1 was reported to mediate their stable association. We examined the importance of this binding site in the feedback phosphorylation of mek1 on thr(292) and thr(386) by erk2
Publications: 2 Organism: Chlorocebus Aethiops, Homo Sapiens
+ ERK1/2down-regulates activity img/direct_inhibition.png phosphorylation BANP 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-266377 Thr337 VKSFSRRtPNSSSYC Homo sapiens HeLa Cell
pmid sentence
ERK-MAPK pathway that regulates alternative splicing facilitates ERK-1/2-mediated phosphorylation of SMAR1 at threonines 345 and 360 and localizes SMAR1 to the cytoplasm, preventing its interaction with Sam68.
Identifier Residue Sequence Organism Cell Line
SIGNOR-266203 Thr337 VKSFSRRtPNSSSYC Homo sapiens HeLa Cell
pmid sentence
ERK-MAPK pathway that regulates alternative splicing facilitates ERK-1/2-mediated phosphorylation of SMAR1 at threonines 345 and 360 and localizes SMAR1 to the cytoplasm, preventing its interaction with Sam68.
Identifier Residue Sequence Organism Cell Line
SIGNOR-266378 Thr352 PSEPMMStPPPASEL Homo sapiens HeLa Cell
pmid sentence
ERK-MAPK pathway that regulates alternative splicing facilitates ERK-1/2-mediated phosphorylation of SMAR1 at threonines 345 and 360 and localizes SMAR1 to the cytoplasm, preventing its interaction with Sam68.
Identifier Residue Sequence Organism Cell Line
SIGNOR-266204 Thr352 PSEPMMStPPPASEL Homo sapiens HeLa Cell
pmid sentence
ERK-MAPK pathway that regulates alternative splicing facilitates ERK-1/2-mediated phosphorylation of SMAR1 at threonines 345 and 360 and localizes SMAR1 to the cytoplasm, preventing its interaction with Sam68.
Publications: 4 Organism: Homo Sapiens
+ ERK1/2down-regulates img/direct_inhibition.png phosphorylation BRAF 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-170339 Thr401 STTGLSAtPPASLPG Homo sapiens
pmid sentence
We show that b-raf is a calcineurin substrate;among calcineurin target residues on b-raf is t401, a site of negative feedback phosphorylation by erk1/2. Blocking calcineurin activity in _ cells prevents dephosphorylation of b-raf t401 and decreases b-raf and erk1/2 activities.
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, KIT in AML, AML_TRIPLETS, Colorectal Carcinoma, EGFR Signaling, ErbB receptors in cancer, FLT3-ITD signaling, Glioblastoma Multiforme, Hepatocellular Tumor, IL6 Signaling, Inhibition of Apoptosis, Luminal Breast Cancer, Malignant Melanoma, NPM1_new, Noonan syndrome, Non-small-cell lung cancer (NSCLC), Pancreatic ductal adenocarcinoma (PDA), PI3K/AKT Signaling, Rett syndrome, Rhabdomyosarcoma, RTKs in cancer, Thyroid cancer, T cell activation, VEGF Signaling
+ ERK1/2up-regulates activity img/direct-activation.png phosphorylation CAD 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-267441 Thr456 KVYFLPItPHYVTQV in vitro
pmid sentence
The multifunctional protein CAD initiates de novo pyrimidine biosynthesis in mammalian cells. CAD is activated by MAP kinase (Erk1/2) just prior to the S phase of the cell cycle, when the demand for pyrimidine nucleotides is greatest, and down-regulated as the cells emerge from S phase by protein kinase A (PKA) phosphorylation. MAP kinase phosphorylates Thr456, while PKA phosphorylates Ser1406 and Ser1859, although only Ser1406 is involved in regulation. 
Publications: 1 Organism: In Vitro
Pathways:Nucleotide Biosynthesis
+ ERK1/2up-regulates activity img/direct-activation.png phosphorylation MFN1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-274134 Thr562 LPRSLASTPTAPTTP Mus musculus MEF Cell
pmid sentence
Finally, in Mfn1 -/- cells re-expressing the MFN1 T562A mutant, phosphorylation was undetectable even in the presence of EGF. Taken together, these data indicate that ERK phosphorylates MFN1 at T562.
Publications: 1 Organism: Mus Musculus
+ ERK1/2up-regulates img/direct-activation.png phosphorylation ATF2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-260755 Thr69 SVIVADQtPTPTRFL Homo sapiens
pmid sentence
Phosphorylation of thr-69 by mapk14 and mapk11, and at thr-71 by mapk1/erk2, mapk3/erk1, mapk11, mapk12 and mapk14 in response to external stimulus like insulin causes increased transcriptional activity.
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV MAPK PERTURBATION
+ ERK1/2down-regulates img/direct_inhibition.png phosphorylation EGFR 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-244529 Thr693 RELVEPLtPSGEAPN Homo sapiens
pmid sentence
It is likely that the map2 and ert kinases account for the phosphorylation of the egf receptor at thr669 (egf receptor (krel veplt669psgeapnqallr)) observed in cultured cells.Phosphorylation at ser-695 is partial and occurs only if thr-693 is phosphorylated. Phosphorylation at thr-678 and thr-693 by prkd1 inhibits egf-induced mapk8/jnk1 activation.
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, COVID-19 Causal Network, EGFR Signaling, FLT3-ITD in AML, Glioblastoma Multiforme, Hepatocellular Tumor, Noonan syndrome, Non-small-cell lung cancer (NSCLC), Pancreatic ductal adenocarcinoma (PDA), PI3K/AKT Signaling, SARS-CoV MAPK PERTURBATION
+ ERK1/2up-regulates img/direct-activation.png phosphorylation ADAM17 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-89614 Thr735 KPFPAPQtPGRLQPA Homo sapiens
pmid sentence
We report that the cytosolic tail of the tumor necrosis factor alpha-converting enzyme (tace) is phosphorylated by erk at threonine 735.These results demonstrate that secretases are able to discriminate between the different stimuli that trigger membrane protein ectodomain cleavage and indicate that phosphorylation by mapks may regulate the proteolytic function of membrane secretases.
Publications: 1 Organism: Homo Sapiens
+ ERK1/2up-regulates quantity by stabilization img/direct-activation.png phosphorylation DIAPH1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-276483 Thr768 PVLPFGLtPKKLYKP Homo sapiens NCI-H295R Cell
pmid sentence
 DIAPH1 is phosphorylated in response to dibutyryl cAMP (Bt2cAMP) at Thr-759 via a pathway that requires extracellular signal-related kinase (ERK).We also show that Bt2cAMP promotes the PKA- and ERK-dependent phosphorylation of DIAPH1 at T759 and that mutation of this site alters the stability of the protein and the rate of cAMP-stimulated mitochondrial movement.
Publications: 1 Organism: Homo Sapiens
+ ERK1/2up-regulates activity img/direct-activation.png phosphorylation ARHGAP31 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-263057 Thr789 PPAPPPPtPLEESTP Chlorocebus aethiops COS-7 Cell
pmid sentence
CdGAP interacts with and is phosphorylated by ERK-1 and RSK-1 in vitro. A putative DEF (docking for ERK FXFP) domain located in the proline-rich region of CdGAP is required for efficient binding and phosphorylation by ERK1/2. We identify Thr776 as an in vivo target site of ERK1/2 and as an important regulatory site of CdGAP activity. Together, these data suggest that CdGAP is a novel substrate of ERK1/2 and mediates cross talk between the Ras/mitogen-activated protein kinase pathway and regulation of Rac1 activity.
Publications: 1 Organism: Chlorocebus Aethiops
+ ERK1/2up-regulates img/direct-activation.png phosphorylation GTF2I 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270169 Homo sapiens
pmid sentence
Tfii-i can be phosphorylated in vitro by erk and mutation of consensus map kinase substrate sites at serines 627 and 633 impairs the phosphorylation of tfii-i by erk and its activity on the c-fos promoter. These results suggest that erk regulates the activity of tfii-i by direct phosphorylation.
Publications: 1 Organism: Homo Sapiens
+ ERK1/2up-regulates img/direct-activation.png phosphorylation NFATC4 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270160 Homo sapiens
pmid sentence
The formation of rsk-nfatc4-dna transcription complex is also apparent upon adipogenesis. Bound rsk phosphorylates ser(676) and potentiates nfatc4 dna binding by escalating nfat-dna association. Ser(676) is also targeted by the erk map kinase, which interacts with nfat at a distinct region than rsk. Thus, integration of the erk/rsk signaling pathway provides a mechanism to modulate nfatc4 transcription activity.
Publications: 1 Organism: Homo Sapiens
+ MAP2K2up-regulates activity img/direct-activation.png phosphorylation ERK1/2 0.737
Identifier Residue Sequence Organism Cell Line
SIGNOR-258995 Mus musculus
pmid sentence
Raf proteins have been shown to phosphorylate and activate MAPKKs (MAP kinase kinases) called MEKs (MAPK or ERK kinases) which in turn phosphorylate and activate MAPKs (MAP kinases) called ERKs
Publications: 1 Organism: Mus Musculus
+ ERK1/2down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation SCNN1B 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270163 in vitro
pmid sentence
Using a number of different approaches it was demonstrated that the protein kinase acting on betaThr-613 and gammaThr-623 is the extracellular regulated kinase (ERK). It is suggested that an ERK-mediated phosphorylation of betaThr-613 and gammaThr-623 down-regulates the channel by facilitating its interaction with Nedd4.
Publications: 1 Organism: In Vitro
+ ERK1/2up-regulates activity img/direct-activation.png phosphorylation RCAN1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270149 Mus musculus C2C12 Cell
pmid sentence
Consensus phosphorylation sites for p42/44 MAPK and GSK-3 are present in the SP repeat of MCIP1 at serine 112 and serine 108, respectively |Several endogenous proteins are capable of inhibiting the catalytic activity of calcineurin. Modulatory calcineurin interacting protein 1 (MCIP1) is unique among these proteins on the basis of its pattern of expression and its function in a negative feedback loop to regulate calcineurin activity. Here we show that MCIP1 can be phosphorylated by MAPK and glycogen synthase kinase-3 and that phosphorylated MCIP1 is a substrate for calcineurin.
Publications: 1 Organism: Mus Musculus
+ ERK1/2up-regulates img/direct-activation.png phosphorylation ARHGEF2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270138 Homo sapiens HeLa Cell
pmid sentence
Activates rhoa and as a result regulates actin assembly.
Publications: 1 Organism: Homo Sapiens
+ ERK1/2up-regulates img/direct-activation.png phosphorylation GRB10 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270178 Homo sapiens
pmid sentence
Phosphorylation of grb10 by mitogen-activated protein kinase: identification of ser150 and ser476 of human grb10zeta as major phosphorylation sitesreplacing ser(150) and ser(476) with alanines reduced the inhibitory effect of human grb10zeta on insulin-stimulated irs1 tyrosine phosphorylation
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3 in AML, FLT3-ITD signaling
+ ERK1/2up-regulates img/direct-activation.png phosphorylation SPHK2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270154 Homo sapiens Breast Cancer Cell
pmid sentence
Sphingosine kinase type 2 activation by erk-mediated phosphorylation. site-directed mutagenesis indicated that hsphk2 is phosphorylated on ser-351 and thr-578 by erk1
Publications: 1 Organism: Homo Sapiens
+ ERK1/2up-regulates img/indirect-activation.png Macrophage_differentiation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-255573 Homo sapiens
pmid sentence
The Erk1/2 pathway has a central role in CSF-1R-regulated myeloid differentiation. CSF-1 induces early (peaking at ∼5 min) and persistent (starting at 1 h) waves of MEK/Erk1/2 phosphorylation
Publications: 1 Organism: Homo Sapiens
+ ERK1/2up-regulates activity img/direct-activation.png phosphorylation SP1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-233523 Homo sapiens
pmid sentence
Erk also undergoes rapid translocation into the nucleus, where it phosphorylates and activates a variety of transcription factor targets, including sp1, e2f, elk-1, and ap1.
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3 in AML
+ ERK1/2up-regulates activity img/direct-activation.png phosphorylation IRX2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270193 in vitro
pmid sentence
To identify the phosphorylated residue, we introduced a serine-to-alanine substitution at residues 294 and 326 and a threonine-to-alanine substitution at residue 331 in Irx2(291–356). Erk1 phosphorylated S294A and T331A, but not S326A (Fig. 4b), indicating that Ser326 is the bona fide MAP kinase target.
Publications: 1 Organism: In Vitro
+ MAP3K8up-regulates activity img/indirect-activation.png ERK1/2 0.362
Identifier Residue Sequence Organism Cell Line
SIGNOR-256078 Mus musculus B-lymphocyte, Macrophage
pmid sentence
Mitogen-activated protein 3 kinase Tpl2, levels of which are markedly reduced in nfkb1(-/-) cells, is required for extracellular signal-regulated kinase (ERK) activation in bone marrow-derived macrophages and B cells stimulated with diverse TLR ligands
Publications: 1 Organism: Mus Musculus
Pathways:Toll like receptors
+ PTPN11up-regulates activity img/indirect-activation.png ERK1/2 0.862
Identifier Residue Sequence Organism Cell Line
SIGNOR-263500 Homo sapiens
pmid sentence
We show here that leptin can activate ERK signaling in thehypothalamus and that this stimulation is likely to occur viatwo pathways, both involving SHP-2.We have shown above that SHP-2 is a positive mediator of ERK activation by ObRb and that this requires both the phosphatase activity and tyrosine phosphorylation of SHP-2. Furthermore,Tyr-985 is required for maximal ERK phosphorylation.
Identifier Residue Sequence Organism Cell Line
SIGNOR-263499 Homo sapiens
pmid sentence
We show here that leptin can activate ERK signaling in thehypothalamus and that this stimulation is likely to occur viatwo pathways, both involving SHP-2.We have shown above that SHP-2 is a positive mediator of ERK activation by ObRb and that this requires both the phosphatase activity and tyrosine phosphorylation of SHP-2. Furthermore,Tyr-985 is required for maximal ERK phosphorylation.
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3 in AML, KIT in AML, AML_TRIPLETS, EGFR Signaling, FLT3-ITD signaling, Leptin Signaling, NPM1_new, Noonan syndrome
+ ERK1/2down-regulates activity img/direct_inhibition.png phosphorylation IRS1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270132 Homo sapiens
pmid sentence
Insulin also activates jnk, erk, pkc and mtor, which induce the phosphorylation of irs1 on serine residues 307, 612 and 632 and inhibit its functions. Our results indicate that the insulin-stimulated degradation of irs-1 via the phosphatidylinositol 3-kinase pathway is in part dependent upon the ser(312) phosphorylation of irs-1.
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis, AMPK Signaling, Insulin Signaling, Luminal Breast Cancer, Leptin Signaling, MTOR Signaling
+ ERK1/2up-regulates img/direct-activation.png phosphorylation IL16 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270168 Homo sapiens T-lymphocyte
pmid sentence
The precursor form of the cytokine il-16 (proil-16) was shown to be phosphorylated on ser144 in antigen receptor-, sdf1alpha- and il-2-activated t cells. Genetic and pharmacological-inhibitor experiments showed that the phosphorylation of proil-16 is dependent on activation of the kinases erk1/2. Il-16 is secreted by mitogen-activated t cells, and the biochemical link between proil-16 and erk1/2, revealed by studies with pap-1, prompted analysis of the role of map kinases in this response.
Publications: 1 Organism: Homo Sapiens
+ selumetinibdown-regulates activity img/direct_inhibition.png chemical inhibition ERK1/2 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-262313 Homo sapiens HuH-7 Cell
pmid sentence
Inhibitors of MEK1/2 (trametinib) and/or ERK1/2 (selumetinib) had the strongest and most conserved inhibitory activities, suggesting that MEK1/2 and ERK1/2 may have unique capabilities as stand-alone or combinatorial therapies for MERS-CoV infections. 
Publications: 1 Organism: Homo Sapiens
Pathways:SARS-CoV MAPK PERTURBATION
+ PEA15down-regulates img/indirect_inhibition.png ERK1/2 0.863
Identifier Residue Sequence Organism Cell Line
SIGNOR-269925 Homo sapiens
pmid sentence
Here, we report that pea-15, a protein variably expressed in multiple cell types, blocks erk-dependent transcription and proliferation by binding erks and preventing their localization in the nucleus._ Pea-15 can redirect the biological outcome of map kinase signaling by regulating the subcellular localization of erk map kinase.
Publications: 1 Organism: Homo Sapiens
+ PPP2CAdown-regulates img/direct_inhibition.png dephosphorylation ERK1/2 0.635
Identifier Residue Sequence Organism Cell Line
SIGNOR-269918 Homo sapiens
pmid sentence
P-erk1/2 proteins were efficiently dephosphorylated in vitro by protein phosphatases 1 and 2a (pp1/2a) and mapk phosphatase 3 (mkp3).
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, PI3K/AKT Signaling
+ ERK1/2down-regulates img/direct_inhibition.png phosphorylation TOB1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270210 Homo sapiens
pmid sentence
Tob is rapidly phosphorylated at Ser 152, Ser 154, and Ser 164 by Erk1 and Erk2 upon growth-factor stimulation.
Publications: 1 Organism: Homo Sapiens
+ ERK1/2up-regulates img/indirect-activation.png Proliferation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-254354 Homo sapiens
pmid sentence
In addition to the JAK2–STAT5 pathway, the Ras GTPase–extracellular signal-regulated kinase (Ras–ERK) pathway has also been implicated in signaling of IL-5 and is important for IL-5-dependent cell survival, proliferation and differentiation of eosinophils.
Identifier Residue Sequence Organism Cell Line
SIGNOR-255120 Mus musculus
pmid sentence
Furthermore, stimulation of myoblasts with CCL2, CCL3, or CCL4 was sufficient to induce phosphorylation and activation of ERK1/2. This outcome may be functionally important because ERK1/2 activation is a component of the pathway through which many mitogenic growth factors can stimulate cell proliferation.
Identifier Residue Sequence Organism Cell Line
SIGNOR-256216 Homo sapiens
pmid sentence
ERK1/2 activation is a component of the pathway through which many mitogenic growth factors can stimulate cell proliferation
Identifier Residue Sequence Organism Cell Line
SIGNOR-255580 Homo sapiens Monocyte
pmid sentence
The GM-CSF promoted cell survival and proliferation correlated with MEK-1 dependent ERK1/2, Elk-1 and CREB phosphorylation and Egr-1, c-Fos expression as well as with increased STAT-5, AP-1, c-Myb and NF-kappaB DNA-binding.
Identifier Residue Sequence Organism Cell Line
SIGNOR-254374 Homo sapiens
pmid sentence
Activation of PDGFRα stimulates proliferation of PDGFRα(+) cells through PI3K-Akt and MEK2-MAPK signaling pathways, and aberrant accumulation of PDGFRα(+) cells was conspicuous in muscles of patients with both genetic and non-genetic muscle diseases.
Publications: 5 Organism: Homo Sapiens, Mus Musculus
Tissue: Skeletal Muscle
Pathways:Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, KIT in AML, AML_TRIPLETS, AMPK Signaling, B-cell activation, COVID-19 Causal Network, Colorectal Carcinoma, EGFR Signaling, ErbB receptors in cancer, FLT3-ITD in AML, FLT3-ITD signaling, Glioblastoma Multiforme, Hepatocellular Tumor, IL6 Signaling, Insulin Signaling, Integrin Signaling, Luminal Breast Cancer, Leptin Signaling, Malignant Melanoma, Triple mutant AML, NPM1_new, Non-small-cell lung cancer (NSCLC), Pancreatic ductal adenocarcinoma (PDA), PI3K/AKT Signaling, Rhabdomyosarcoma, RTKs in cancer, SARS-CoV MAPK PERTURBATION, Thyroid cancer, VEGF Signaling, WNT/FLT3
+ RETup-regulates img/direct-activation.png phosphorylation ERK1/2 0.443
Identifier Residue Sequence Organism Cell Line
SIGNOR-244643 Homo sapiens
pmid sentence
We hypothesized that ret could directly phosphorylate fak and erk. erk 2 could be phosphorylated at y187 (y204 in erk1).
Publications: 1 Organism: Homo Sapiens
Pathways:Thyroid cancer
+ DUSP6down-regulates img/direct_inhibition.png dephosphorylation ERK1/2 0.902
Identifier Residue Sequence Organism Cell Line
SIGNOR-269926 Homo sapiens
pmid sentence
P-erk1/2 proteins were efficiently dephosphorylated in vitro by protein phosphatases 1 and 2a (pp1/2a) and mapk phosphatase 3 (mkp3).
Publications: 1 Organism: Homo Sapiens
+ ERK1/2 img/unknown.png phosphorylation NUP153 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270159 Homo sapiens
pmid sentence
These results indicate that phosphorylation of nup153 and nup214 by erk strongly reduces their affinity for importin-. nup153 depletion caused a strong inhibition of nuclear accumulation of gfp?importin-beta in both erk-inhibited and erk-activated cells (fig. 8b,c), indicating that nup153 is essential for the efficient importin-beta transport.
Publications: 1 Organism: Homo Sapiens
+ ERK1/2 img/unknown.png phosphorylation RPS3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270145 Homo sapiens
pmid sentence
Erk phosphorylates threonine 42 residue of ribosomal protein s3.
Publications: 1 Organism: Homo Sapiens
+ ERK1/2up-regulates activity img/direct-activation.png phosphorylation PLCB1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270200 in vitro
pmid sentence
Plc beta1 could be efficiently phosphorylated by activated mitogen-activated protein kinase but not by pka. The erk phosphorylation site was mapped to serine 982
Publications: 1 Organism: In Vitro
Pathways:Oxytocin signaling
+ ERK1/2up-regulates img/indirect-activation.png Neurogenesis 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-264978 Mus musculus Neuron
pmid sentence
Activation of the Ras-MAPK/Erk signaling cascade is essential for neurotrophin-promoted differentiation of neurons and PC12 cells.
Publications: 1 Organism: Mus Musculus
Pathways:Oxytocin signaling, Rett syndrome
+ ERK1/2down-regulates img/direct_inhibition.png phosphorylation LIFR 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270134 Homo sapiens
pmid sentence
Thus, our results identify the human lifr as a substrate for mapk and suggest a mechanism of heterologous receptor regulation of lifr signaling occurring at ser-1044.
Publications: 1 Organism: Homo Sapiens
Pathways:IL6 Signaling
+ FGF2up-regulates img/indirect-activation.png ERK1/2 0.598
Identifier Residue Sequence Organism Cell Line
SIGNOR-269929 Homo sapiens
pmid sentence
We show that several proline-directed mitogen-activated protein kinases (mapks), such as p38, erk1/2, and jnk1 are sufficient and required for the phosphorylation of ppps/tp motifs of lrp6. External stimuli, which control the activity of mapks, such as phorbol esters and fibroblast growth factor 2 (fgf2) control the choice of the lrp6-ppps/tp kinase and regulate the amplitude of lrp6 phosphorylation and wnt/beta-catenin-dependent transcription.
Publications: 1 Organism: Homo Sapiens
+ PLD2up-regulates img/indirect-activation.png ERK1/2 0.57
Identifier Residue Sequence Organism Cell Line
SIGNOR-254983 Homo sapiens
pmid sentence
Altogether, these data suggest that PLD acting upstream of the MAP kinases ERK1/2 may play a key role in the regulation of IL-2 production by stimulated Jurkat cells.
Publications: 1 Organism: Homo Sapiens
+ ERK1/2up-regulates img/direct-activation.png phosphorylation CTTN 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270164 Homo sapiens Neuron
pmid sentence
Cortactin is regulated by multiple phosphorylation events, including phosphorylation of s405 and s418 by extracellular regulated kinases (erk)1/2. Erk1/2 phosphorylation of cortactin has emerged as an important positive regulatory modification, enabling cortactin to bind and activate the arp2/3 regulator neuronal wiskott-aldrich syndrome protein (n-wasp), promoting actin polymerization and enhancing tumor cell movement.
Publications: 1 Organism: Homo Sapiens
Pathways:T cell activation
+ ERK1/2up-regulates img/direct-activation.png phosphorylation SP3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270165 Homo sapiens
pmid sentence
Here, we show that sp3, which, as sp1, belongs to the gc-rich binding transcription factor family, is also phosphorylated by erk in vitro on serine 73.
Publications: 1 Organism: Homo Sapiens
+ ERK1/2down-regulates activity img/direct_inhibition.png phosphorylation MCRIP1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270188 Homo sapiens HEK-293 Cell
pmid sentence
When phosphorylated by ERK, MCRIP1 dissociates from CtBP, allowing CtBP to interact with ZEB1. In this manner, the CtBP co-repressor complex is recruited to, and silences, the E-cadherin promoter by inducing chromatin modifications.| While substitution of S4 or S18 with Ala did not affect the phosphorylation of MCRIP1 by ERK, substitution of either S21 or T30 significantly reduced MCRIP1 phosphorylation
Publications: 1 Organism: Homo Sapiens
+ ANXA3up-regulates activity img/indirect-activation.png ERK1/2 0.28
Identifier Residue Sequence Organism Cell Line
SIGNOR-262211 Homo sapiens A-549 Cell
pmid sentence
We also investigated the potential regulation of cancer-associated signaling pathways by Anxa3 through screening for the altered expression of some common signaling molecules after Anxa3 downregulation. Decreased phosphorylation of MEK1/2, ERK1/2, Akt, and IκBα was detected after downregulating Anxa3 expression in A549 cells.
Publications: 1 Organism: Homo Sapiens
+ CCR2up-regulates activity img/direct-activation.png phosphorylation ERK1/2 0.336
Identifier Residue Sequence Organism Cell Line
SIGNOR-255117 Mus musculus
pmid sentence
The investigators showed that myoblasts constitutively express receptors for CCL2 (CCR2), CCL3 (CCR1 and CCR5), and CCL4 (CCR5), and that stimulation with either CCL2 or CCL4 was sufficient to promote myoblast proliferation. Furthermore, stimulation of myoblasts with CCL2, CCL3, or CCL4 was sufficient to induce phosphorylation and activation of ERK1/2.
Publications: 1 Organism: Mus Musculus
+ CSF1Rup-regulates img/indirect-activation.png ERK1/2 0.29
Identifier Residue Sequence Organism Cell Line
SIGNOR-255572 Homo sapiens
pmid sentence
The Erk1/2 pathway has a central role in CSF-1R-regulated myeloid differentiation. CSF-1 induces early (peaking at ∼5 min) and persistent (starting at 1 h) waves of MEK/Erk1/2 phosphorylation
Publications: 1 Organism: Homo Sapiens
+ ERK1/2up-regulates img/direct-activation.png phosphorylation RPS6KA2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270144 Homo sapiens
pmid sentence
Several lines of investigation have suggested that rsk is phosphorylated and activated by erk1/2 mapk isoforms
Publications: 1 Organism: Homo Sapiens
+ ERK1/2up-regulates img/direct-activation.png phosphorylation NCF1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270187 Homo sapiens Neutrophil
pmid sentence
Inhibitors of the erk1/2 pathway abrogated gm-csf-induced phosphorylation of ser345, while p38 mapk inhibitor abrogated tnf-alpha-induced phosphorylation of ser345.These results show that the ala-mutated p47phox acts as a dominant-negative inhibitor of endogenous p47phox and clearly indicate that phosphorylation of ser345 is required for the priming of nadph oxidase activity in neutrophil-like cells.
Publications: 1 Organism: Homo Sapiens
+ ERK1/2 img/unknown.png phosphorylation KRT8 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270135
pmid sentence
Also, several probable in vivo K8 kinases have been identified including Erk1/2 for K8 Ser431 (Ku and Omary, 1997), and p38 and Jun kinases for K8 Ser73 (Ku et al., 2002a; He et al., 2002).
Publications: 1
+ ERK1/2up-regulates quantity by expression img/direct-activation.png transcriptional regulation SOX2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-241977 Mus musculus P-19 Cell
pmid sentence
During neural fate specification, nuclear translocation of ERK1/2 is critical for its activation of Sox2 transcription. More-over, melatonin-induced Sox2 expression, through ERK1/ 2 activation, could locate between base pairs2719 and 1708 in the mouse Sox2 gene.
Publications: 1 Organism: Mus Musculus
+ ERK1/2down-regulates img/direct_inhibition.png phosphorylation PAK1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270186 Homo sapiens
pmid sentence
Activated erk can phosphorylate t292 in the prs, and this blocks the ability of pak to phosphorylate s298 and of rac-pak signaling to enhance mek1-erk complex formation.
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR Signaling, T cell activation, Toll like receptors
+ NR3C1down-regulates activity img/indirect_inhibition.png ERK1/2 0.619
Identifier Residue Sequence Organism Cell Line
SIGNOR-269920 Mus musculus NIH-3T3 Cell
pmid sentence
Both induction of MKP-1 expression and inhibition of its degradation are necessary for glucocorticoid-mediated inhibition of Erk-1/2 activation.
Publications: 1 Organism: Mus Musculus
Pathways:Adipogenesis
+ ERK1/2down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation FOXO 0.71
Identifier Residue Sequence Organism Cell Line
SIGNOR-270146 Homo sapiens
pmid sentence
Phosphorylation of foxo3a by erk1/2 at residues ser 294, ser 344 and ser 425 increases foxo3amdm2 interaction and enhances foxo3a degradation via an mdm2-dependent ubiquitin-proteasome pathway
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, FLT3-ITD in AML, FLT3-ITD signaling, NPM1_new, PI3K/AKT Signaling
+ ERK1/2up-regulates img/direct-activation.png phosphorylation PLA2G4A 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270192 Homo sapiens
pmid sentence
Activated map kinase phosphorylates cpla2 at ser-505, causing increased enzymatic activity of cpla2, which is only realized upon translocation of cpla2 to the membrane.
Publications: 1 Organism: Homo Sapiens
+ ERK1/2up-regulates img/direct-activation.png phosphorylation LRP6 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-244662 Homo sapiens
pmid sentence
We show that several proline-directed mitogen-activated protein kinases (mapks), such as p38, erk1/2, and jnk1 are sufficient and required for the phosphorylation of ppps/tp motifs of lrp6.
Publications: 1 Organism: Homo Sapiens
Pathways:WNT/FLT3
+ ERK1/2up-regulates img/direct-activation.png phosphorylation SREBF2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270141 Homo sapiens
pmid sentence
Insulin-activated erk-mitogen-activated protein kinases phosphorylate sterol regulatory element-binding protein-2 at serine residues 432 and 455 in vivo.Further characterization by electrophoretic mobility shift assay and promoter reporter gene analyses revealed that phosphorylation does not influence protein/dna interaction, but enhances trans-activity.
Publications: 1 Organism: Homo Sapiens
+ ERK1/2up-regulates img/indirect-activation.png transcriptional regulation SOX9 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-244750 Homo sapiens
pmid sentence
Soluble pref-1 inhibits adipocyte differentiation through the activation of extracellular signal-regulated kinase/mitogen-activated protein kinase (erk/mapk) and the subsequent upregulation of sox9 expression.
Publications: 1 Organism: Homo Sapiens
+ ERK1/2down-regulates img/direct_inhibition.png phosphorylation PCYT1A 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270151 Homo sapiens
pmid sentence
Oxysterols inhibit phosphatidylcholine synthesis via erk docking and phosphorylation of ctp:phosphocholine cytidylyltransferase. Mutagenesis of ser315 within cctalpha was both required and sufficient to confer significant resistance to 22-hc/9-cis-ra inhibition of ptdcho synthesis.
Publications: 1 Organism: Homo Sapiens
Tissue: Lung
+ ERK1/2 img/unknown.png phosphorylation EWSR1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270172 Homo sapiens
pmid sentence
Here we report that ews and ews-fli1 become phosphorylated at thr79 in the n-terminal domain in response to mitogens or dna damage. Mitogen-induced phosphorylation of ews and ews-fli1 was weak and catalysed by erk1 (extracellular signal-regulated kinase 1) and erk2.
Publications: 1 Organism: Homo Sapiens
+ MEK1/2up-regulates img/direct-activation.png phosphorylation ERK1/2 0.749
Identifier Residue Sequence Organism Cell Line
SIGNOR-244776 Homo sapiens
pmid sentence
Mapk1 is phosphorylated by map2k1/mek1 and map2k2/mek2 on thr-185 and tyr-187 in response to external stimuli like insulin or ngf. Both phosphorylations are required for activity.
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis, Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, KIT in AML, AML_TRIPLETS, B-cell activation, COVID-19 Causal Network, Colorectal Carcinoma, EGFR Signaling, ErbB receptors in cancer, FLT3-ITD signaling, Glioblastoma Multiforme, Hepatocellular Tumor, IL6 Signaling, Insulin Signaling, Inhibition of Apoptosis, Integrin Signaling, Luminal Breast Cancer, Malignant Melanoma, NPM1_new, Noonan syndrome, Non-small-cell lung cancer (NSCLC), Oxytocin signaling, Pancreatic ductal adenocarcinoma (PDA), PI3K/AKT Signaling, Rett syndrome, Rhabdomyosarcoma, RTKs in cancer, SARS-CoV MAPK PERTURBATION, Thyroid cancer, T cell activation, Toll like receptors, VEGF Signaling
+ ERK1/2up-regulates activity img/direct-activation.png phosphorylation JUN 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-253214 Homo sapiens Lung Cancer Cell Line
pmid sentence
Substrates for ERK1/2 include nuclear proteins such as C-JUN, this leads to activation of the AP-1 transcription factor, which is made up of FOS-JUN heterodimers.
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, EGFR Signaling, Glioblastoma Multiforme, Insulin Signaling, Luminal Breast Cancer, WNT/FLT3
+ ERK1/2up-regulates img/direct-activation.png phosphorylation PTTG1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270155 Homo sapiens
pmid sentence
Pttg is phosphorylated in vitro on ser(162) by map kinase and this phosphorylation site plays an essential role in pttg transactivation function.
Publications: 1 Organism: Homo Sapiens
+ PTPRBup-regulates img/direct-activation.png dephosphorylation ERK1/2 0.443
Identifier Residue Sequence Organism Cell Line
SIGNOR-269931 Homo sapiens
pmid sentence
When cells are stimulated with various ligands such as growth factors, hormones, neurotransmitters, or tumor promoters, erk1/2 is activated through dualphosphorylation at the -ptepy-motif. Subsequently, p-erk1/2 translocates into the nucleus and phosphorylates elk-1, thereby acting as a transcription factor for cell proliferationthese data indicate that sa-p-erk1/2 might not only be regulated by mkp such as rvhr, but also by pp1 and ptp as well
Publications: 1 Organism: Homo Sapiens
+ ERK1/2down-regulates img/direct_inhibition.png phosphorylation CIITA 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270173 Homo sapiens
pmid sentence
In this study we show that the extracellular signal-regulated kinases 1 and 2 (erk1/2) interact directly with ciita, targeting serine residues in the amino terminus of the protein, including serine 288. These data suggest a model whereby erk1/2-mediated phosphorylation of ciita down-regulates ciita activity by priming it for nuclear export, thus providing a means for cells to tightly regulate the extent of antigen presentation.
Publications: 1 Organism: Homo Sapiens
+ SCRIBdown-regulates activity img/direct_inhibition.png binding ERK1/2 0.373
Identifier Residue Sequence Organism Cell Line
SIGNOR-263067 Homo sapiens HEK-293 Cell
pmid sentence
These two KIM sites are found at N- and C-terminal locations on hScrib, and both are essential for directing the interaction between ERK and hScrib, but with the C-terminal site having the strongest affinity for ERK. One of the most likely consequences of this interaction is to inhibit ERK translocation to the nucleus.
Publications: 1 Organism: Homo Sapiens
+ ERK1/2down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation TCF3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270139 Mus musculus NIH-3T3 Cell
pmid sentence
Notch-induced degradation requires phosphorylation of E47 by p42/p44 MAP kinases. |Wild_type E47 but not the Mm mutant reacted to the antibodies, suggesting that E47 is at least phosphorylated at the M2 site (Figure 3A)|anti_phospho_M2 peptide (SSPSpTPVGSPQG)
Publications: 1 Organism: Mus Musculus
+ ERK1/2up-regulates quantity img/indirect-activation.png IL10 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-256080 Mus musculus Bone Marrow-derived Macrophage
pmid sentence
The mitogen activated protein kinases ERK1/2 play an important role in response to toll like receptor (TLR) activation and cytokine production, including IL-10 and IL-12.
Publications: 1 Organism: Mus Musculus
+ BZW2up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ERK1/2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-261219 Homo sapiens
pmid sentence
WB showed that BZW2 silence significantly decreased p‐ERK protein level in Colo205 cells, whereas BZW2 overexpression upregulated p‐ERK protein expression in HCT116 cells (Figure 3a,b)
Publications: 1 Organism: Homo Sapiens
+ FLT3up-regulates activity img/indirect-activation.png ERK1/2 0.296
Identifier Residue Sequence Organism Cell Line
SIGNOR-260132 Homo sapiens
pmid sentence
Oncogenic, constitutively active mutants of FLT3 are known to be expressed in acute myeloid leukemia and to correlate with poor prognosis. Activation of the receptor mediates cell survival, cell proliferation and differentiation of cells. Several of the signal transduction pathways downstream of FLT3 have been shown to include various members of the SRC family of kinases (SFKs). They are involved in regulating the activity of RAS/ERK pathways through the scaffolding protein GAB2 and the adaptor protein SHC.
Identifier Residue Sequence Organism Cell Line
SIGNOR-261521 Mus musculus
pmid sentence
These data confirm previous findings that FLT3 receptors with ITD mutations efficiently trigger the activation of ERK, STAT5 and Akt in the absence of FL stimulation.
Publications: 2 Organism: Homo Sapiens, Mus Musculus
Pathways:Acute Myeloid Leukemia, FLT3 in AML, AML_TRIPLETS, FLT3-ITD in AML, FLT3-ITD signaling, Triple mutant AML, NPM1_new, WNT/FLT3
+ KITup-regulates activity img/indirect-activation.png ERK1/2 0.309
Identifier Residue Sequence Organism Cell Line
SIGNOR-254947 Homo sapiens Mast Cell
pmid sentence
A number of studies have demonstrated the ability of SCF to activate the Ras-Erk pathway. The adapter protein Grb2 can directly associate with phosphorylated Y703 and Y936 in c-Kit
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, KIT in AML, Malignant Melanoma
+ MAP2K2up-regulates img/direct-activation.png phosphorylation ERK1/2 0.737
Identifier Residue Sequence Organism Cell Line
SIGNOR-244637 Homo sapiens
pmid sentence
Mapk1 is phosphorylated by map2k1/mek1 and map2k2/mek2 on thr-185 and tyr-187 in response to external stimuli like insulin or ngf. Both phosphorylations are required for activity.
Publications: 1 Organism: Homo Sapiens
+ ERK1/2up-regulates img/direct-activation.png phosphorylation JUND 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270183 Homo sapiens
pmid sentence
Menin binds the jun family transcription factor jund and inhibits its transcriptional activity. The menin-jund interaction blocks jun n-terminal kinase (jnk)-mediated jund phosphorylation and suppresses jund-induced transcription. We found a role for phosphorylation of the ser100 residue of jund;jund phosphorylation were prevented by inhibitors of calcium, calmodulin, or erk1/2 kinase.
Publications: 1 Organism: Homo Sapiens
+ ERK1/2up-regulates activity img/direct-activation.png phosphorylation PTPN7 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270202 in vitro
pmid sentence
First, Erk phosphorylates HePTP at residues Thr45 and Ser72. Second, HePTP dephosphorylates Erk at PTyr185.|
Publications: 1 Organism: In Vitro
+ ERK1/2up-regulates activity img/direct-activation.png phosphorylation PTPRR 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270147
pmid sentence
Specifically, the complex formation between PTP-SL and ERK2 involves an unusual interaction leading to the phosphorylation of PTP-SL by ERK2 at Thr253 and the inactivating dephosphorylation of ERK2 by PTP-SL.
Publications: 1
+ MAP3K1down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination ERK1/2 0.524
Identifier Residue Sequence Organism Cell Line
SIGNOR-272609 Homo sapiens HEK-293 Cell
pmid sentence
ERK1/2 MAP kinases are important regulators in cellular signaling, whose activity is normally reversibly regulated by threonine-tyrosine phosphorylation. In contrast, we have found that stress-induced ERK1/2 activity is downregulated by ubiquitin/proteasome-mediated degradation of ERK1/2. The PHD domain of MEKK1, a RING finger-like structure, exhibited E3 ubiquitin ligase activity toward ERK2 in vitro and in vivo. Therefore, MEKK1 functions not only as an upstream activator of the ERK and JNK through its kinase domain, but also as an E3 ligase through its PHD domain, providing a negative regulatory mechanism for decreasing ERK1/2 activity.
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, EGFR Signaling, SARS-CoV MAPK PERTURBATION, Toll like receptors
+ ERK1/2down-regulates img/direct_inhibition.png phosphorylation ARRB1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270190 Homo sapiens
pmid sentence
Erk1 and erk2 phosphorylate beta-arrestin1 at ser-412 in vitro. . in the resting state, cytosolic arrestin1 proteins are constitutively phosphorylated by extracellular signal-regulated kinase (erk) at ser412, located within their distal c terminus. erk-phosphorylated arrestin1 is unable to associate with clathrin cages, whereas this constraint is removed upon its dephosphorylation
Publications: 1 Organism: Homo Sapiens
+ ERK1/2down-regulates activity img/direct_inhibition.png phosphorylation CASP9 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270184 Homo sapiens
pmid sentence
Inhibition of caspase-9 through phosphorylation at thr 125 by erk mapk
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Inhibition of Apoptosis
+ ERK1/2down-regulates activity img/direct_inhibition.png phosphorylation STMN1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270182 Homo sapiens HEK-293 Cell
pmid sentence
Stress-induced stathmin phosphorylation is not de- pendent on ERK. Stathmin is also known to be phos- phorylated by ERK on Ser-25 and Ser-38 (17). Thus, it is possible that ERK phosphorylates stathmin in 293 cells|In subsequent reports (28, 29) it was shown that phosphorylation of stathmin blocks its ability to destabilize MTs.
Publications: 1 Organism: Homo Sapiens
+ ERK1/2up-regulates img/indirect-activation.png transcriptional regulation CEBPA 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-235322 Mus musculus 3T3-L1 Cell
pmid sentence
We demonstrate that exposure of post-confluent 3T3-L1 preadipocytes to insulin, isobutylmethylxanthine (MIX), dexamethasone (DEX), and fetal bovine serum induces a rapid but transient activation of MEK1 as indicated by extensive phosphorylation of ERK1 and ERK2 during the initial 2 h of adipogenesis. We further show that activation of MEK1 significantly enhances the transactivation of the C/EBPalpha minimal promoter during the early phase of the differentiation process.
Publications: 1 Organism: Mus Musculus
Pathways:Adipogenesis, Acute Myeloid Leukemia, FLT3 in AML, AML_TRIPLETS, FLT3-ITD in AML, Triple mutant AML, NPM1_new
+ ERK1/2down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation FOXO3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270175 Homo sapiens
pmid sentence
Phosphorylation of foxo3a by erk1/2 at residues ser 294, ser 344 and ser 425 increases foxo3amdm2 interaction and enhances foxo3a degradation via an mdm2-dependent ubiquitin-proteasome pathway
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3 in AML, AMPK Signaling, Insulin Signaling, Inhibition of Apoptosis, Integrin Signaling, Thyroid cancer
+ CSF2RA/CSF2RBup-regulates activity img/indirect-activation.png ERK1/2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-255586 Homo sapiens Monocyte
pmid sentence
As a consequence of Jak2 activation and tyrosine phosphorylation of the cytoplasmic tail of beta-c, Src homology 2 and phosphotyrosine binding domain proteins are recruited to the active receptor and initiate the major tyrosine phosphorylation-dependent signaling pathways, including the Jak/signal transducer and activator of transcription, Ras/mitogen-activated protein kinase, and phosphatidylinositol 3 (PI-3) kinase pathways
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
Pathways:Acute Myeloid Leukemia, BCR-ABL in AML
+ ERK1/2down-regulates img/direct_inhibition.png phosphorylation PGR 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270157 Homo sapiens Breast Cancer Cell
pmid sentence
Specifically, down-regulation of mature prs occurs by a mechanism in which ligand binding activates pr phosphorylation by mapks at a unique serine residue, which then targets the receptors for degradation.
Publications: 1 Organism: Homo Sapiens
+ ERK1/2up-regulates img/direct-activation.png phosphorylation PML 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270153 Homo sapiens Leukemia Cell
pmid sentence
Phosphorylation of pml by mitogen-activated protein kinases plays a key role in arsenic trioxide-mediated apoptosis.
Publications: 1 Organism: Homo Sapiens
+ CCR3up-regulates activity img/direct-activation.png ERK1/2 0.3
Identifier Residue Sequence Organism Cell Line
SIGNOR-256093 Homo sapiens Eosinophil
pmid sentence
Activation of ERK2 and p38 by eotaxin is mediated through CCR3.
Publications: 1 Organism: Homo Sapiens
+ ERK1/2down-regulates img/direct_inhibition.png phosphorylation BCL6 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270140 Homo sapiens T-lymphocyte, Lymphoma Cell
pmid sentence
Here we show that antigen receptor activation leads to bcl-6 phosphorylation by mitogen-activated protein kinase (mapk). Phosphorylation, in turn, targets bcl-6 for rapid degradation by the ubiquitin/proteasome pathway.
Publications: 1 Organism: Homo Sapiens
+ ERK1/2 img/unknown.png phosphorylation ARHGAP26 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270170 in vitro
pmid sentence
In vitro, purified mitogen-activated protein (MAP) kinase catalyzed the phosphorylation of Graf on serine 510, suggesting that Graf phosphorylation may be mediated through MAP kinase signaling.
Publications: 1 Organism: In Vitro
+ ERK1/2down-regulates img/direct_inhibition.png phosphorylation PDE4D 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270174 Homo sapiens
pmid sentence
These straddle the target residue, ser(579), for erk2 phosphorylation of pde4d3. Mutation of either or both of these docking sites prevented erk2 from being co-immunoprecipitated with pde4d3, ablated the ability of epidermal growth factor to inhibit pde4d3 through erk2 action in transfected cos cells, and attenuated the ability of erk2 to phosphorylate pde4d3 in vitro.
Publications: 1 Organism: Homo Sapiens
+ ERK1/2up-regulates img/direct-activation.png phosphorylation MCL1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270158 Homo sapiens Breast Cancer Cell
pmid sentence
We then showed that erk could phosphorylate mcl-1 at two consensus residues, thr 92 and 163, which is required for the association of mcl-1 and pin1, resulting in stabilization of mcl-1.
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, COVID-19 Causal Network
+ ERK1/2 img/unknown.png phosphorylation JUN 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-236767 Homo sapiens SW-620 Cell
pmid sentence
The results revealed that PAR2-AP and FVIIa could upregulate c-Jun expression and c-Jun phosphorylation in SW620 cells in a time-dependent manner. The effect of FVIIa was significantly blocked by anti-TF and anti-PAR2 antibodies. Protein kinase C_ (PKC_) inhibitor safingol and extracellular signal-regulated kinase 1 and 2 (ERK1/2) inhibitor U0126 abrogated the activation of c-Jun
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, EGFR Signaling, Glioblastoma Multiforme, Insulin Signaling, Luminal Breast Cancer, WNT/FLT3
+ DUSP5down-regulates img/direct_inhibition.png dephosphorylation ERK1/2 0.773
Identifier Residue Sequence Organism Cell Line
SIGNOR-269932 Homo sapiens
pmid sentence
Extracellular regulated kinases (erk) 1 and erk2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase vhr. A novel role in down-regulating the erk pathway
Publications: 1 Organism: Homo Sapiens
+ ERK1/2down-regulates img/direct_inhibition.png phosphorylation DUSP1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270189 Homo sapiens
pmid sentence
The dual-specificity mapk phosphatase mkp-1/cl100/dusp1 is an inducible nuclear protein controlled by p44/42 mapk (erk1/2) in a negative feedback mechanism to inhibit kinase activity. Here, we report on the molecular basis for a novel positive feedback mechanism to sustain erk activation by triggering mkp-1 proteolysis. Active erk2 docking to the def motif (fxfp, residues 339-342) of n-terminally truncated mkp-1 in vitro initiated phosphorylation at the ser(296)/ser(323) domain
Publications: 1 Organism: Homo Sapiens
+ MAP2K1up-regulates activity img/direct-activation.png phosphorylation ERK1/2 0.743
Identifier Residue Sequence Organism Cell Line
SIGNOR-235352 Mus musculus 3T3-L1 Cell
pmid sentence
MEK1 as indicated by extensive phosphorylation of ERK1 and ERK2 during the initial 2 h of adipogenesis.
Identifier Residue Sequence Organism Cell Line
SIGNOR-258992 Mus musculus
pmid sentence
Raf proteins have been shown to phosphorylate and activate MAPKKs (MAP kinase kinases) called MEKs (MAPK or ERK kinases) which in turn phosphorylate and activate MAPKs (MAP kinases) called ERKs
Publications: 2 Organism: Mus Musculus
+ ERK1/2up-regulates img/direct-activation.png phosphorylation NCOA1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270194 Homo sapiens Prostate Gland Cancer Cell
pmid sentence
Mapk also directly phosphorylates src-1 at thr1179 and ser1185. Phosphorylation of src-1 by mitogen-activated protein kinase (mapk) is required for optimal progesterone receptor-dependent transcription and for functional cooperation with camp response element-binding protein-binding protein
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ ERK1/2down-regulates img/indirect_inhibition.png T-reg_differentiation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-254687 Homo sapiens
pmid sentence
Lowering the extent of costimulation of P2X in T cells diminishes the extent of ERK phosphorylation without affecting TCR-mediated nuclear translocation of NFAT (10). In Tregs, this mechanism would favor the stability of their transcriptional program through the stabilization of nuclear complexes of NFAT and Foxp3 (47).
Identifier Residue Sequence Organism Cell Line
SIGNOR-254686 Homo sapiens
pmid sentence
In the current study, addition of ERK inhibitors suppressed IL-6-induced RORgammat expression and promoted TGF-beta-induced Foxp3 expression.
Publications: 2 Organism: Homo Sapiens
+ ERK1/2 img/unknown.png phosphorylation WWC1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270208 Homo sapiens
pmid sentence
We demonstrated that erk1/2 phosphorylate kibra at ser(548) in cells as well as in vitro.
Publications: 1 Organism: Homo Sapiens
Tissue: Breast
+ DUSP1down-regulates img/direct_inhibition.png dephosphorylation ERK1/2 0.828
Identifier Residue Sequence Organism Cell Line
SIGNOR-269930 Homo sapiens
pmid sentence
The mitogen-activated protein (map) kinase cascade is inactivated at the level of map kinase by members of the map kinase phosphatase (mkp) family, including mkp-1.
Publications: 1 Organism: Homo Sapiens
+ ERK1/2down-regulates activity img/direct_inhibition.png phosphorylation GSK3B/Axin/APC 0.358
Identifier Residue Sequence Organism Cell Line
SIGNOR-262519 Mus musculus MEF Cell
pmid sentence
We demonstrate that insulin-mediated activation of ERK1/2 results in phosphorylation of GSK3β at S9 independently of Akt/mTORC1 activity in Tsc2 null mouse embryonic fibroblasts. In addition, we show that inhibition of ERK1/2 rescues GSK3β activity and restores protein synthesis in Tsc2 −/− MEFs to normal levels
Publications: 1 Organism: Mus Musculus
Pathways:Colorectal Carcinoma, Hepatocellular Tumor
+ PDCD1down-regulates activity img/indirect_inhibition.png ERK1/2 0.265
Identifier Residue Sequence Organism Cell Line
SIGNOR-275411 Homo sapiens T-lymphocyte
pmid sentence
MEK1/2 was phosphorylated and activated upon activation of T cells through TCR-CD3 and CD28, which resulted in phosphorylation of its downstream target ERK1/2, as determined by Western blotting analysis with an antibody specific for ERK1/2 phosphorylated at Thr202 and Tyr204, markers of activation. PD-1 substantially inhibited the activation of MEK1/2 and ERK1/2
Publications: 1 Organism: Homo Sapiens
+ ERK1/2down-regulates img/direct_inhibition.png phosphorylation TSC1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-244761 Homo sapiens
pmid sentence
Here, we show that erk may play a critical role in tsc progression through posttranslational inactivation of tsc2. Erk-dependent phosphorylation leads to tsc1-tsc2 dissociation and markedly impairs tsc2 ability to inhibit mtor signalin.
Publications: 1 Organism: Homo Sapiens
Pathways:Insulin Signaling
+ ERK1/2up-regulates img/direct-activation.png phosphorylation MAPKAPK2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270206 Homo sapiens
pmid sentence
Erk phosphorylates multiple cytoplasmatic and cytoskeletal proteins, including mapk-activated protein kinases and the ribosomal p70-s6 kinase
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling
+ NPC2down-regulates activity img/indirect_inhibition.png ERK1/2 0.359
Identifier Residue Sequence Organism Cell Line
SIGNOR-260660 Homo sapiens
pmid sentence
Here we show that NPC2 deficiency in human fibroblasts confers their activation. The activation phenomenon was not limited to fibroblasts as it was also observed in aortic smooth muscle cells upon silencing NPC2 gene by siRNA. The molecular mechanism responsible for activation of NPC2-null cells was shown to be a sustained phosphorylation of ERK 1/2 mitogen-activated protein kinase (MAPK), which fulfills both the sufficient and necessary fibroblast activation criteria. All of these findings highlight a novel mechanism where NPC2 by negatively regulating ERK 1/2 MAPK phosphorylation may efficiently suppress development of maladaptive tissue remodeling and inflammation.
Publications: 1 Organism: Homo Sapiens
+ SHC1up-regulates activity img/indirect-activation.png ERK1/2 0.709
Identifier Residue Sequence Organism Cell Line
SIGNOR-242628 Mus musculus NIH-3T3 Cell
pmid sentence
We report that upon TGF__ stimulation, the activated TGF__ type I receptor (T_RI) recruits and directly phosphorylates ShcA proteins on tyrosine and serine. This dual phosphorylation results from an intrinsic T_RI tyrosine kinase activity that complements its well_defined serine_threonine kinase function. TGF___induced ShcA phosphorylation induces ShcA association with Grb2 and Sos, thereby initiating the well_characterised pathway linking receptor tyrosine kinases with Erk MAP kinases.
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, EGFR Signaling, FLT3-ITD in AML, IL6 Signaling, Noonan syndrome, Thyroid cancer
+ ERK1/2up-regulates img/direct-activation.png phosphorylation CAPN2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270179 Homo sapiens
pmid sentence
Epidermal growth factor activates m-calpain (calpain ii), at least in part, by extracellular signal-regulated kinase-mediated phosphorylation.We now show that erk directly phosphorylates and activates m-calpain both in vitro and in vivo. We identified serine 50 as required for epidermal growth factor (egf)-induced calpain activation in vitro and in vivo.
Publications: 1 Organism: Homo Sapiens
+ ERK1/2down-regulates img/direct_inhibition.png phosphorylation MBP 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270195 Homo sapiens
pmid sentence
Phosphorylation decreased the ability of mbp to polymerize actin and to bundle actin filaments but had no effect on the dissociation constant of the mbp-actin complex or on the ability of ca2+-calmodulin to dissociate the complex. The most significant effect of phosphorylation on the mbp-actin complex was a dramatic reduction in its ability to bind to negatively charged lipid bilayers. The identification of myelin basic protein (phosphorylation at -pro-arg-thr-pro-) as a substrate for the erk kinases (fig. 1) demonstrates that there are other determinants important for substrate recognition than those present in the originally identified consensus sequence.
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ ANO6up-regulates activity img/indirect-activation.png ERK1/2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-261214 Mus musculus
pmid sentence
Ano6 deficiency significantly reduces ERK/AKT phosphorylation. Our data have also shown that Ano6-KD significantly attenuates ERK phosphorylation, which is implicated in the regulation of cancer cell proliferation by Ano1, suggesting that Ano6 is potentially involved in regulating myoblast proliferation through the ERK signaling pathway.
Publications: 1 Organism: Mus Musculus
+ NEU1down-regulates activity img/indirect_inhibition.png ERK1/2 0.251
Identifier Residue Sequence Organism Cell Line
SIGNOR-260656 Homo sapiens
pmid sentence
One of the major molecular changes by NEU1 was decreased sialylation of integrin beta4, assessed by PNA- and MAL-II-lectin blotting of immunoprecipitates with anti-integrin beta4 antibody. The desialylation was accompanied by decreased phosphorylation of the integrin followed by attenuation of focal adhesion kinase and Erk1/2 pathway.
Publications: 1 Organism: Homo Sapiens
+ IL5RAup-regulates img/indirect-activation.png ERK1/2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-254350 Homo sapiens
pmid sentence
Human blood eosinophils exhibit a hyperactive phenotype in response to chemotactic factors after cell priming with IL-5 family cytokines. Earlier work has identified ERK1/2 as molecular markers for IL-5 priming
Publications: 1 Organism: Homo Sapiens
+ ERK1/2up-regulates img/indirect-activation.png Fibrosis 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-254373 Homo sapiens
pmid sentence
PDGF signaling has been implicated in several fibrotic conditions and is assumed to play a role in driving proliferation of cells with a myofibroblast phenotype.
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network
+ ERK1/2down-regulates img/direct_inhibition.png phosphorylation KLC1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270176 Homo sapiens
pmid sentence
Phosphorylation of kinesin light chain 1 at serine 460 modulates binding and trafficking of calsyntenin-1mutation of klc1ser460 to an alanine residue, to preclude phosphorylation, increased the binding of calsyntenin-1, whereas mutation to an aspartate residueklc1ser460 is a predicted mitogen-activated protein kinase (mapk) target site, and we show that extracellular-signal-regulated kinase (erk) phosphorylates this residue in vitro.
Publications: 1 Organism: Homo Sapiens
+ ERK1/2up-regulates img/indirect-activation.png Survival 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-255579 Homo sapiens Monocyte
pmid sentence
The GM-CSF promoted cell survival and proliferation correlated with MEK-1 dependent ERK1/2, Elk-1 and CREB phosphorylation and Egr-1, c-Fos expression as well as with increased STAT-5, AP-1, c-Myb and NF-kappaB DNA-binding.
Identifier Residue Sequence Organism Cell Line
SIGNOR-254948 Homo sapiens Mast Cell
pmid sentence
Numerous studies have implicated the critical importance of the Ras/Erk pathway in cell division and survival
Publications: 2 Organism: Homo Sapiens
Tissue: Skeletal Muscle
Pathways:Colorectal Carcinoma, ErbB receptors in cancer, Glioblastoma Multiforme, Hepatocellular Tumor, Inhibition of Apoptosis, Luminal Breast Cancer, Malignant Melanoma, Non-small-cell lung cancer (NSCLC), Pancreatic ductal adenocarcinoma (PDA), PI3K/AKT Signaling, Rhabdomyosarcoma, RTKs in cancer, Thyroid cancer
+ ERK1/2up-regulates quantity by expression img/indirect-activation.png transcriptional regulation EGR1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-263507 Homo sapiens
pmid sentence
We also show for the first time that leptin rapidly stimulates the mRNA expression of the zinc finger transcription factor, Egr-1, in the hypothalamus of mice. Our transfection results suggest that this regulation by leptin occurs by activation of theegr-1 promoter via activation of SHP-2 and of the ERK pathway. 
Publications: 1 Organism: Homo Sapiens
Pathways:Leptin Signaling
+ MEK1/2up-regulates activity img/direct-activation.png phosphorylation ERK1/2 0.749
Identifier Residue Sequence Organism Cell Line
SIGNOR-258989 Mus musculus
pmid sentence
Raf proteins have been shown to phosphorylate and activate MAPKKs (MAP kinase kinases) called MEKs (MAPK or ERK kinases) which in turn phosphorylate and activate MAPKs (MAP kinases) called ERKs
Publications: 1 Organism: Mus Musculus
Pathways:Adipogenesis, Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, KIT in AML, AML_TRIPLETS, B-cell activation, COVID-19 Causal Network, Colorectal Carcinoma, EGFR Signaling, ErbB receptors in cancer, FLT3-ITD signaling, Glioblastoma Multiforme, Hepatocellular Tumor, IL6 Signaling, Insulin Signaling, Inhibition of Apoptosis, Integrin Signaling, Luminal Breast Cancer, Malignant Melanoma, NPM1_new, Noonan syndrome, Non-small-cell lung cancer (NSCLC), Oxytocin signaling, Pancreatic ductal adenocarcinoma (PDA), PI3K/AKT Signaling, Rett syndrome, Rhabdomyosarcoma, RTKs in cancer, SARS-CoV MAPK PERTURBATION, Thyroid cancer, T cell activation, Toll like receptors, VEGF Signaling
+ ERK1/2down-regulates img/direct_inhibition.png phosphorylation CALD1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270162 Homo sapiens
pmid sentence
Extracellular signal-regulated kinases (erks) phosphorylate the high molecular mass isoform of the actin-binding protein caldesmon (h-cad) at two sites (ser(759) and ser(789)) during smooth muscle stimulation. Nmr spectroscopy shows that the actin binding properties of the minimal inhibitory region of caldesmon, residues 750-779, alter upon map kinase phosphorylation of ser-759, a residue not involved in actin binding. This phosphorylation leads to markedly diminished actin affinity as a result of the loss of interaction at one of the two sites that bind to f-actin.
Publications: 1 Organism: Homo Sapiens
Tissue: Smooth Muscle
+ ERK1/2down-regulates img/direct_inhibition.png phosphorylation MRTFA 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270131 Homo sapiens
pmid sentence
Serum induces rhoa-dependent translocation of mkl1 from the cytoplasm to the nucleus and also causes a rapid increase in mkl1 phosphorylation. Serum-induced phosphorylation of the serum response factor coactivator mkl1 by the extracellular signal-regulated kinase 1/2 pathway inhibits its nuclear localization.
Publications: 1 Organism: Homo Sapiens
+ CCR3up-regulates img/indirect-activation.png ERK1/2 0.3
Identifier Residue Sequence Organism Cell Line
SIGNOR-254357 Homo sapiens
pmid sentence
We and others have recently found that eotaxin activates extracellular signal-regulated kinase (ERK)-1/2 and p38 mitogen-activated protein (MAP) kinases in eosinophils, and that these kinases are indispensable for eosinophil chemotaxis and degranulation
Publications: 1 Organism: Homo Sapiens
+ ERK1/2up-regulates img/direct-activation.png phosphorylation TH 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270167 Homo sapiens
pmid sentence
In this paper we have studied the phosphorylation and activation of alternatively spliced forms of human th by mapkap kinase-1 , mapkap kinase-2, map kinase, and cam kinase-11
Publications: 1 Organism: Homo Sapiens
+ ERK1/2up-regulates img/direct-activation.png phosphorylation ABI1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270161 Homo sapiens
pmid sentence
We show that erk colocalizes with the wrc at lamellipodial leading edges and directly phosphorylates two wrc components: wave2 and abi1.
Publications: 1 Organism: Homo Sapiens
+ ERK1/2down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation SCNN1G 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270171 in vitro
pmid sentence
Using a number of different approaches it was demonstrated that the protein kinase acting on betaThr-613 and gammaThr-623 is the extracellular regulated kinase (ERK). It is suggested that an ERK-mediated phosphorylation of betaThr-613 and gammaThr-623 down-regulates the channel by facilitating its interaction with Nedd4.
Publications: 1 Organism: In Vitro
+ ERK1/2down-regulates img/direct_inhibition.png phosphorylation AMPH 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270197 Homo sapiens
pmid sentence
Thus, we propose that mapk phosphorylation of amphiphysin1 controls ngf receptor/trka-mediated endocytosis by terminating the amphiphysin1-ap-2 interaction.Our results indicate that phosphorylation of amphiphysin 1 at ser-285 and/or ser-293 affects the function of amphiphysin1.Mapk phosphorylation of ser-285 and ser-293 could modulate the interaction between prd and ap-2, resulting in the dissociation of amphiphysin1 from ap-2.
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ ERK1/2down-regulates img/direct_inhibition.png phosphorylation PPP2R5C 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270196 Homo sapiens
pmid sentence
Iex-1 binds to b56 subunits and perk independently, enhances b56 phosphorylation by erk at a conserved ser/pro site in this complex and triggers dissociation from the catalytic subunit.
Publications: 1 Organism: Homo Sapiens
+ ERK1/2down-regulates img/direct_inhibition.png phosphorylation SMAD2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-244576 Homo sapiens
pmid sentence
These results suggest that oncogenic ras, acting through mek1 and erk kinases, induces the phosphorylation of smad2 and smad3
Publications: 1 Organism: Homo Sapiens
Tissue: Lung, Breast
Pathways:Hepatocellular Tumor, Pancreatic ductal adenocarcinoma (PDA)
+ PPP2R5Cdown-regulates img/direct_inhibition.png binding ERK1/2 0.5
Identifier Residue Sequence Organism Cell Line
SIGNOR-269922 Homo sapiens
pmid sentence
B56-containing pp2a dephosphorylate erk and their activity is controlled by the early gene iex-1 and erk
Publications: 1 Organism: Homo Sapiens
+ ERK1/2up-regulates img/direct-activation.png phosphorylation HIF1A 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270191 Homo sapiens HeLa Cell
pmid sentence
We show that at least two different nuclear protein kinases, one of them identified as p42/p44 mapk, can modify hif-1_. Analysis of in vitro phosphorylated hif-1_ by mass spectroscopy revealed residues ser-641 and ser-643 as possible mapk phosphorylation sites these data suggest that phosphorylation of ser-641/643 by mapk promotes the nuclear accumulation and transcriptional activity of hif-1_
Publications: 1 Organism: Homo Sapiens
+ ERK1/2up-regulates activity img/direct-activation.png phosphorylation PPARA 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270180 Homo sapiens Hep-G2 Cell
pmid sentence
We now demonstrate that amino acids 1-92 of hPPARalpha contain an activation function (AF)-1-like domain, which is further activated by insulin through a pathway involving the mitogen-activated protein kinases p42 and p44. Further analysis of the amino-terminal region of PPARalpha revealed that the insulin-induced trans-activation occurs through the phosphorylation of two mitogen-activated protein kinase sites at positions 12 and 21, both of which are conserved across evolution.
Publications: 1 Organism: Homo Sapiens
+ ERK1/2down-regulates img/direct_inhibition.png phosphorylation UBTF 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270181 Homo sapiens
pmid sentence
Erk1/2 was found to phosphorylate the architectural transcription factor ubf at amino acids 117 and 201 within hmg boxes 1 and 2, preventing their interaction with dna
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ ERK1/2down-regulates img/direct_inhibition.png phosphorylation DUSP6 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270205 Homo sapiens
pmid sentence
Phosphorylation of serines 159 and 197 by erk1/2 enhances proteasomal degradation of mkp-3
Publications: 1 Organism: Homo Sapiens
+ ERK1/2down-regulates activity img/direct_inhibition.png phosphorylation THRB 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270143 Homo sapiens
pmid sentence
We concluded that serine 142 of the tr dbd is the likely site of phosphorylation by t(4)-activated mapk and that the docking site on tr for activated mapk includes residues 128-133 (kgffrr), a basic amino acid-enriched motif novel for mapk substrates. Tr mutations in the proposed mapk docking domain and at residue 142 modulated t(4)-conditioned shedding of co-repressor and recruitment of co-activator proteins by the receptor, and they altered transcriptional activity of tr in a thyroid hormone response element-luciferase reporter assay.
Publications: 1 Organism: Homo Sapiens
+ LCKup-regulates img/direct-activation.png phosphorylation ERK1/2 0.57
Identifier Residue Sequence Organism Cell Line
SIGNOR-269921 Homo sapiens T-lymphocyte
pmid sentence
The sh3 domain of lck modulates t-cell receptor-dependent activation of extracellular signal-regulated kinase through activation of raf-1.
Publications: 1 Organism: Homo Sapiens
Pathways:T cell activation
+ PP1down-regulates img/direct_inhibition.png dephosphorylation ERK1/2 0.505
Identifier Residue Sequence Organism Cell Line
SIGNOR-269923 Homo sapiens
pmid sentence
P-erk1/2 proteins were efficiently dephosphorylated in vitro by protein phosphatases 1 and 2a (pp1/2a) and mapk phosphatase 3 (mkp3). the dual specificity phosphatases that specifically dephosphorylate and inactivate the p-erk1/2 are called mapk phosphatases
Publications: 1 Organism: Homo Sapiens
+ ERK1/2up-regulates quantity by expression img/direct-activation.png phosphorylation PPARG 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-235334 Mus musculus 3T3-L1 Cell
pmid sentence
Our results suggest that activation of the MEK/ERK signaling pathway during the initial 12 h of adipogenesis enhances the activity of factors that regulate both C/EBPalpha and PPARgamma expression.
Publications: 1 Organism: Mus Musculus
Pathways:Adipogenesis, Leptin Signaling, MTOR Signaling, Rett syndrome, Thyroid cancer
+ ERK1/2up-regulates img/direct-activation.png phosphorylation TWIST1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270209 Homo sapiens Breast Cancer Cell
pmid sentence
Phosphorylation of serine 68 of twist1 by mapks stabilizes twist1 protein and promotes breast cancer cell invasiveness. this ser 68 is phosphorylated by p38, c-jun n-terminal kinases (jnk), and extracellular signal-regulated kinases1/2 in vitro
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ ERK1/2up-regulates activity img/direct-activation.png phosphorylation LIPE 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270207 Mus musculus NIH-3T3 Cell
pmid sentence
Thus, activation of the ERK pathway appears to be able to regulate adipocyte lipolysis by phosphorylating HSL on Ser(600) and increasing the activity of HSL.
Publications: 1 Organism: Mus Musculus
+ ERK1/2up-regulates img/direct-activation.png phosphorylation STAT5A 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270136 Homo sapiens
pmid sentence
Serine 780 is the only substrate in full-length stat5a for active erk
Publications: 1 Organism: Homo Sapiens
Tissue: Ovary
Pathways:Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, KIT in AML, AML_TRIPLETS, B-cell activation, FLT3-ITD in AML, FLT3-ITD signaling, Leptin Signaling, Triple mutant AML
+ EML4-ALKup-regulates activity img/direct-activation.png phosphorylation ERK1/2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-259174 Mus musculus NIH-3T3 Cell
pmid sentence
We also found that phosphorylation of both the mitogen-activated proteinkinase (MAPK) ERK and STAT3 was markedly increased inthe cells expressing either variant of EML4-ALK[.]. Oncogenic EML4-ALK tyrosine kinase activates ERKand STAT3 signaling pathways
Publications: 1 Organism: Mus Musculus
+ ERK1/2down-regulates img/direct_inhibition.png phosphorylation NOXA1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270203 Homo sapiens
pmid sentence
Accumulating evidence indicates that protein phosphorylation regulates nox activity. In this report, we show that serine282 residue of nox activator 1 (noxa1) is phosphorylated by erk in response to egf resulting in desensitization of nox1 activity
Publications: 1 Organism: Homo Sapiens
+ VAV1up-regulates img/indirect-activation.png ERK1/2 0.522
Identifier Residue Sequence Organism Cell Line
SIGNOR-244640 Homo sapiens
pmid sentence
Vav may link gp130 activation to downstream mapk activation in hematopoietic cells.
Publications: 1 Organism: Homo Sapiens
+ DUSP3down-regulates activity img/direct_inhibition.png dephosphorylation ERK1/2 0.659
Identifier Residue Sequence Organism Cell Line
SIGNOR-269928 Chlorocebus aethiops COS Cell
pmid sentence
Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway.|Catalysis by VHR requires the native structure of ERK and is specific for tyrosine 185 of ERK2
Publications: 1 Organism: Chlorocebus Aethiops
+ ERK1/2up-regulates img/direct-activation.png phosphorylation GAB2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270133 Homo sapiens
pmid sentence
Phosphorylation of grb2-associated binder 2 on serine 623 by erk mapk regulates its association with the phosphatase shp-2 and decreases stat5 activation.We and others have demonstrated that il-2-induced tyrosine phosphorylation of gab2 and its interaction with its sh2 domain-containing partners, shp-2, p85 pi3k, and crkl (5, 26, 27). we report that pretreatment of kit 225 cells with the mek inhibitor u0126, strongly decreased the characteristic shift of gab2 in response to il-2 and increased gab2/shp-2 association, an effect that could be ascribed to erk phosphorylation of serine 623.
Publications: 1 Organism: Homo Sapiens
+ ERK1/2down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation BCL2L11 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270152 Homo sapiens
pmid sentence
In vitro, bimel was phosphorylated by extracellular signal-regulated kinase on ser(69), which resides in the bimel-specific insert region. Using phosphospecific antibody against this site, we show that this residue is actually phosphorylated in cells. We also show that phosphorylation of ser(69) promotes ubiquitination of bimel. We conclude that mek inhibitors sensitize mda-mb231 and hbc4 cells to anoikis by blocking phosphorylation and hence degradation of bimel
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Inhibition of Apoptosis
+ TLR4up-regulates activity img/direct-activation.png phosphorylation ERK1/2 0.438
Identifier Residue Sequence Organism Cell Line
SIGNOR-261930 Homo sapiens
pmid sentence
Binding of S100A9 to TLR4 stimulates the phosphorylation of JNK, ERK1/2, and p38 MAPK, which leads to the activation of c-Jun, CREB, and NF-κB. Activation of neutrophils by S100A9 also proceeds via p38 MAPK, JNK, and ERK1/2 phosphorylation.
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling
+ ERK1/2down-regulates img/direct_inhibition.png phosphorylation TFCP2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270201 Homo sapiens
pmid sentence
We previously established that phosphorylation of lsf in early g1 at ser-291 and ser-309 inhibits its transcriptional activity and that dephosphorylation later in g1 is required for its reactivation. At the peak activities of erk and cyclin c/cdk2 in early g1, lsf is efficiently phosphorylated on ser-291 and ser-309.
Publications: 1 Organism: Homo Sapiens
+ DUSP9down-regulates img/direct_inhibition.png binding ERK1/2 0.715
Identifier Residue Sequence Organism Cell Line
SIGNOR-269924 Homo sapiens
pmid sentence
Here we demonstrate that inactivation of both erk1/2 and p38_ by dusp9/mkp-4 is mediated by a conserved arginine-rich kinase interaction motif located within the amino-terminal non-catalytic domain of the protein.
Publications: 1 Organism: Homo Sapiens
+ ERK1/2down-regulates activity img/direct_inhibition.png phosphorylation GJA1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270148 Homo sapiens HeLa Cell
pmid sentence
These studies confirm that connexin-43 is a MAP kinase substrate in vivo and that phosphorylation on Ser255, Ser279, and/or Ser282 initiates the down-regulation of gap junctional communication. Studies with connexin-43 mutants suggest that MAP kinase phosphorylation at one or more of the tandem Ser279/Ser282 sites is sufficient to disrupt gap junctional intercellular communication.
Publications: 1 Organism: Homo Sapiens
+ ERK1/2down-regulates img/direct_inhibition.png phosphorylation POLR2A 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270156 Homo sapiens
pmid sentence
Erk1/2 are major ser-5 kinases after h2o2 treatment. These results suggest that subsequent to h2o2 treatment, the ser-5-phosphorylated form, but not the ser-2-phosphorylated form or the unphosphorylated form, is targeted for rapid proteasomal degradation through its ubiquitination.
Publications: 1 Organism: Homo Sapiens
+ CCR5up-regulates activity img/direct-activation.png phosphorylation ERK1/2 0.327
Identifier Residue Sequence Organism Cell Line
SIGNOR-255119 Mus musculus
pmid sentence
The investigators showed that myoblasts constitutively express receptors for CCL2 (CCR2), CCL3 (CCR1 and CCR5), and CCL4 (CCR5), and that stimulation with either CCL2 or CCL4 was sufficient to promote myoblast proliferation. Furthermore, stimulation of myoblasts with CCL2, CCL3, or CCL4 was sufficient to induce phosphorylation and activation of ERK1/2.
Publications: 1 Organism: Mus Musculus
+ ERK1/2down-regulates img/direct_inhibition.png phosphorylation SMAD1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270137 Homo sapiens
pmid sentence
Ras signaling was shown previously to induce the phosphorylation of the bmp mediator smad1 at four erk consensus sites in the linker domain (kretzschmar et al. 1997a). Phosphorylation of these four sites inhibits smad1 accumulation in the nucleus
Publications: 1 Organism: Homo Sapiens
Tissue: Lung, Breast
+ PDGFRAup-regulates img/indirect-activation.png ERK1/2 0.33
Identifier Residue Sequence Organism Cell Line
SIGNOR-254377 Homo sapiens
pmid sentence
To further investigate the signaling pathway through which PDGFRαpromotes the proliferation of PDGFRα+ cells, we used inhibitors of PI3K-Akt and Ras-MAPK pathways, which are known to be downstream signaling pathways of PDGFRα. Thus, both PI3K-Akt and MEK2-MAPK pathways are necessary for PDGFRα-driven proliferation.
Publications: 1 Organism: Homo Sapiens
Pathways:Rhabdomyosarcoma
+ PPP1CAdown-regulates img/direct_inhibition.png dephosphorylation ERK1/2 0.457
Identifier Residue Sequence Organism Cell Line
SIGNOR-269927 Homo sapiens
pmid sentence
P-erk1/2 proteins were efficiently dephosphorylated in vitro by protein phosphatases 1 and 2a (pp1/2a) and mapk phosphatase 3 (mkp3). the dual specificity phosphatases that specifically dephosphorylate and inactivate the p-erk1/2 are called mapk phosphatases
Publications: 1 Organism: Homo Sapiens
Pathways:Noonan syndrome
+ ERK1/2down-regulates activity img/direct_inhibition.png phosphorylation BAD 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-244497 in vitro
pmid sentence
The rapid phosphorylation of bad following il-3 connects a proximal survival signal with the bcl-2 family, modulating this checkpoint for apoptosis.phosphorylatedBAD is bound to 14-3-3 within the cytosol, while only nonphosphorylated BAD is heterodimerized with membrane-bound BCL-XL.
Publications: 1 Organism: In Vitro
Pathways:Acute Myeloid Leukemia, COVID-19 Causal Network, FLT3-ITD in AML, FLT3-ITD signaling, Inhibition of Apoptosis, Malignant Melanoma, VEGF Signaling
+ ERK1/2up-regulates activity img/direct-activation.png phosphorylation RPS6KB1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270198 Homo sapiens
pmid sentence
Erk phosphorylates multiple cytoplasmatic and cytoskeletal proteins, including mapk-activated protein kinases and the ribosomal p70-s6 kinase
Publications: 1 Organism: Homo Sapiens
Tissue: Carcinoma Cell
Pathways:FLT3-ITD signaling, Insulin Signaling, MTOR Signaling, Nucleotide Biosynthesis
+ ERK1/2up-regulates img/indirect-activation.png Differentiation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-254355 Homo sapiens
pmid sentence
In addition to the JAK2–STAT5 pathway, the Ras GTPase–extracellular signal-regulated kinase (Ras–ERK) pathway has also been implicated in signaling of IL-5 and is important for IL-5-dependent cell survival, proliferation and differentiation of eosinophils.
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3 in AML, KIT in AML, AML_TRIPLETS, B-cell activation, FLT3-ITD in AML, Triple mutant AML, NPM1_new
+ ERK1/2down-regulates img/direct_inhibition.png phosphorylation POU5F1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270185 Homo sapiens
pmid sentence
Phosphorylation of this site downregulates nanog, sox2, rex1 and upregulates bmp4, gata6, ddlx5.
Publications: 1 Organism: Homo Sapiens
+ ERK1/2up-regulates img/direct-activation.png phosphorylation MED1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270199 Homo sapiens
pmid sentence
Phosphorylation of transcriptional coactivator peroxisome proliferator-activated receptor (ppar)-binding protein (pbp). Stimulation of transcriptional regulation by mitogen-activated protein kinase
Publications: 1 Organism: Homo Sapiens
+ IL6STup-regulates img/indirect-activation.png ERK1/2 0.281
Identifier Residue Sequence Organism Cell Line
SIGNOR-255022 Homo sapiens
pmid sentence
Upon formation of the IL-6/IL-6Ralpha/gp130 hexameric signaling complex, two distinct signaling pathways are activated: 1) Janus kinase (JAK)/signal transducers and activator of transcription (STAT) and 2) the Src homology 2-containing tyrosine phosphatase (SHP-2)/extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) pathways
Publications: 1 Organism: Homo Sapiens
Pathways:IL6 Signaling
+ BRAFup-regulates activity img/indirect-activation.png ERK1/2 0.647
Identifier Residue Sequence Organism Cell Line
SIGNOR-260082 Homo sapiens
pmid sentence
RAF, a cytoplasmic serine-threonine protein kinase, is a member of the RAS-RAF-MEK-ERK cell-signaling pathway [also known as the MAP kinase (MAPK) pathway], and it plays an essential role in mediating cellular differentiation, proliferation, senescence, and survival in response to extracellular cues. Raf phosphorylates and activates MAP-ERK kinase (MEK), which phosphorylates and activates extracellular signal-regulated kinase (ERK).
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, KIT in AML, AML_TRIPLETS, Colorectal Carcinoma, EGFR Signaling, ErbB receptors in cancer, FLT3-ITD signaling, Glioblastoma Multiforme, Hepatocellular Tumor, IL6 Signaling, Inhibition of Apoptosis, Luminal Breast Cancer, Malignant Melanoma, NPM1_new, Noonan syndrome, Non-small-cell lung cancer (NSCLC), Pancreatic ductal adenocarcinoma (PDA), PI3K/AKT Signaling, Rett syndrome, Rhabdomyosarcoma, RTKs in cancer, Thyroid cancer, T cell activation, VEGF Signaling
+ ERK1/2 img/unknown.png phosphorylation mTORC1 0.4
Identifier Residue Sequence Organism Cell Line
SIGNOR-270150 Homo sapiens
pmid sentence
We found three proline-directed residues within raptor, ser(8), ser(696), and ser(863), which are directly phosphorylated by erk1/2. Expression of phosphorylation-deficient alleles of raptor revealed that phosphorylation of these sites by erk1/2 normally promotes mtorc1 activity and signaling to downstream substrates, such as 4e-bp1.
Publications: 1 Organism: Homo Sapiens
Pathways:AMPK Signaling, EGFR Signaling, Glioblastoma Multiforme, Insulin Signaling, Luminal Breast Cancer, Pancreatic ductal adenocarcinoma (PDA), PI3K/AKT Signaling, WNT/FLT3
+ 3bup-regulates activity img/indirect-activation.png ERK1/2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-260763 Homo sapiens
pmid sentence
3b Augments c-Fos Levels by Activating the ERK Pathway. | An increase of∼2.0-fold inphospho ERK (Thr-202/Tyr-204) levels in 3b-expressing Huh7cells as compared to GFP-transfected control cells (Figure 4a)was observed. This increase in phospho ERK levels was also
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV MAPK PERTURBATION
+ ERK1/2up-regulates activity img/direct-activation.png phosphorylation ELK1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-233520 Homo sapiens
pmid sentence
Erk also undergoes rapid translocation into the nucleus, where it phosphorylates and activates a variety of transcription factor targets, including sp1, e2f, elk-1, and ap1.
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR Signaling, Glioblastoma Multiforme, IL6 Signaling, Integrin Signaling, Noonan syndrome
+ ERK1/2up-regulates img/direct-activation.png phosphorylation MKNK2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270204 Homo sapiens
pmid sentence
Erk and p38 phosphorylate mnk1 and mnk2, which stimulates their in vitro kinase activity.
Publications: 1 Organism: Homo Sapiens
+ ERK1/2down-regulates img/direct_inhibition.png phosphorylation SMAD3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270142 Homo sapiens
pmid sentence
These results suggest that oncogenic ras, acting through mek1 and erk kinases, induces the phosphorylation of smad2 and smad3.
Publications: 1 Organism: Homo Sapiens
Tissue: Lung, Breast
Pathways:Adipogenesis, COVID-19 Causal Network, Colorectal Carcinoma, Hepatocellular Tumor, Pancreatic ductal adenocarcinoma (PDA)
+ PTPRJdown-regulates img/direct_inhibition.png dephosphorylation ERK1/2 0.47
Identifier Residue Sequence Organism Cell Line
SIGNOR-269919 Homo sapiens
pmid sentence
A dominant-negative mutant of high cell densityenhanced ptp 1 (dep-1)//cd148 as well as reduction of its expression by rna interference partially restore vegfr-2 phosphorylation and map kinase activation.
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML
+ ERK1/2down-regulates activity img/direct_inhibition.png phosphorylation MEK1/2 0.749
Identifier Residue Sequence Organism Cell Line
SIGNOR-244858 Homo sapiens HEK-293 Cell
pmid sentence
An ERK2-binding site at the N terminus of MEK1 was reported to mediate their stable association. We examined the importance of this binding site in the feedback phosphorylation of mek1 on thr(292) and thr(386) by erk2
Identifier Residue Sequence Organism Cell Line
SIGNOR-244862 Chlorocebus aethiops COS Cell
pmid sentence
We propose that activation of erk during adhesion creates a feedback system in which erk phosphorylates mek1 on t292, and this in turn blocks additional s298 phosphorylation in response to integrin signaling.
Publications: 2 Organism: Homo Sapiens, Chlorocebus Aethiops
Pathways:Adipogenesis, Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, KIT in AML, AML_TRIPLETS, B-cell activation, COVID-19 Causal Network, Colorectal Carcinoma, EGFR Signaling, ErbB receptors in cancer, FLT3-ITD signaling, Glioblastoma Multiforme, Hepatocellular Tumor, IL6 Signaling, Insulin Signaling, Inhibition of Apoptosis, Integrin Signaling, Luminal Breast Cancer, Malignant Melanoma, NPM1_new, Noonan syndrome, Non-small-cell lung cancer (NSCLC), Oxytocin signaling, Pancreatic ductal adenocarcinoma (PDA), PI3K/AKT Signaling, Rett syndrome, Rhabdomyosarcoma, RTKs in cancer, SARS-CoV MAPK PERTURBATION, Thyroid cancer, T cell activation, Toll like receptors, VEGF Signaling
+ ERK1/2up-regulates activity img/direct-activation.png phosphorylation E2F1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-233526 Homo sapiens
pmid sentence
Erk also undergoes rapid translocation into the nucleus, where it phosphorylates and activates a variety of transcription factor targets, including sp1, e2f, elk-1, and ap1.
Publications: 1 Organism: Homo Sapiens
Pathways:Luminal Breast Cancer, Malignant Melanoma, Pancreatic ductal adenocarcinoma (PDA)
+ ERK1/2down-regulates img/indirect_inhibition.png MAPK14 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-244665 Homo sapiens Macrophage
pmid sentence
In addition, immunoblot and immunostaining analysis revealed that phosphorylation of erk was increased by treatment with sb203580;whereas pd98059 increased the phosphorylation of p38, which implies a seesaw-like balance between erk and p38 phosphorylation.
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling, Toll like receptors
+ ERK1/2up-regulates activity img/direct-activation.png phosphorylation LCK 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270177 Homo sapiens HeLa Cell
pmid sentence
Phosphorylation at Ser-59 (or alternatively, its mutation to Glu) reverses the inhibition and allows interaction of the p56lck SH2 domain with p62.|phosphotyrosine-independent binding of p62 to the p56lck SH2 domain appears to provide an alternative pathway for p56lck signaling that is regulated by Ser-59 phosphorylation.
Publications: 1 Organism: Homo Sapiens
Pathways:T cell activation
+ ERK1/2 img/unknown.png phosphorylation APBB1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270166 Homo sapiens
pmid sentence
Thus, fe65 has at least two apparently disparate functions and may also be involved in the pathogenesis of alzheimer's disease. The mechanisms by which fe65 trafficking and metabolism are regulated to fulfil these different roles are unclear. Our findings reported here, which demonstrate that fe65 is a phosphoprotein that is targeted by erk1/2 and which identify four in vivo phosphorylation sites, provide one possible mechanism whereby functional diversity might be achieved.
Publications: 1 Organism: Homo Sapiens
+ CCR1up-regulates activity img/direct-activation.png phosphorylation ERK1/2 0.316
Identifier Residue Sequence Organism Cell Line
SIGNOR-255118 Mus musculus
pmid sentence
The investigators showed that myoblasts constitutively express receptors for CCL2 (CCR2), CCL3 (CCR1 and CCR5), and CCL4 (CCR5), and that stimulation with either CCL2 or CCL4 was sufficient to promote myoblast proliferation. Furthermore, stimulation of myoblasts with CCL2, CCL3, or CCL4 was sufficient to induce phosphorylation and activation of ERK1/2.
Publications: 1 Organism: Mus Musculus
+ DUSP4down-regulates activity img/direct_inhibition.png dephosphorylation ERK1/2 0.753
Identifier Residue Sequence Organism Cell Line
SIGNOR-269933 Rattus norvegicus
pmid sentence
Dephosphorylation and Inactivation of ERKs|ERK1 phosphorylated on either threonine (ERK1*Y204F) or tyrosine alone (ERK1*T202A) was utilized as a substrate for HVH2. Threonine 202 and tyrosine 204 in ERK1 (53) correspond to threonine 183 and tyrosine 185 in ERK2 which are the activation-phosphorylation sites by MEK(14, 15, 16). ERK1*, a kinase-deficient mutant, was phosphorylated on both threonine and tyrosine by MEK2 (Fig. 3B). ERK1*T202A, having threonine 202 substituted by an alanine, was phosphorylated only on tyrosine while ERK1*Y204F, having tyrosine 204 substituted by a phenylalanine, was phosphorylated only on threonine (Fig. 3B). GST-HVH2 dephosphorylated all three ERK1* mutants (Fig. 3A), suggesting that double phosphorylations of adjacent threonine and tyrosine were not a prerequisite for HVH2 recognition. However, HVH2 dephosphorylated ERK1* and ERK1*T202A more efficiently than ERK1*Y204F (Fig. 3A), indicating that HVH2 preferred phosphotyrosine over phosphothreonine. Interestingly, MEK also phosphorylated tyrosine residues more efficiently than threonine residues of ERK
Publications: 1 Organism: Rattus Norvegicus
+ TGFBR1up-regulates img/indirect-activation.png ERK1/2 0.318
Identifier Residue Sequence Organism Cell Line
SIGNOR-255033 Homo sapiens
pmid sentence
TbRI phosphorylates not only the C-termini of R-Smads but also activates various protein kinases including mitogen-activated protein kinases (MAPKs): extracellular signal regulated kinase (ERK), c-Jun N-terminal kinase (JNK) and p38 MAPK (p38), which then phosphorylate the variable linker regions of R-Smad
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis, COVID-19 Causal Network, Colorectal Carcinoma, Hepatocellular Tumor, Pancreatic ductal adenocarcinoma (PDA), SARS-CoV MAPK PERTURBATION, Thyroid cancer
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