Relation Results

Summary

Name Fibrin
Primary ID SIGNOR-C317
Links CPX-6225
Type complex
Formed by Fibrinogen
Relations 4

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Type: Score: Layout: SPV 
0.70.20.20.7FibrinFibrin_clot_formationFibrinogenPLATFibrinolysis

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Regulator
Mechanism
target
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+ Fibrinup-regulates img/direct-activation.png binding Fibrin_clot_formation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-263531 Homo sapiens
pmid sentence
A fibrin clot is the final product of the blood clotting cascade. Thrombin catalyzes release of fibrinopeptide A from fibrinogen to create fibrin monomers, which then aggregate to protofibrils. Proteolytic release of fibrinopeptide B by thrombin permits lateral protofibril aggregation, resulting in a three-dimensional fibrin gel.|Fibrin clots were formed as described for turbidity experiments, in which the fibrinogen, calcium, and polyP (when included) were preincubated for 15 minutes before adding thrombin.
Publications: 1 Organism: Homo Sapiens
Tissue: Blood Plasma
+ Fibrinogenform complex img/form-complex.png cleavage Fibrin 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-263551 Homo sapiens
pmid sentence
A fibrin clot is the final product of the blood clotting cascade. Thrombin catalyzes release of fibrinopeptide A from fibrinogen to create fibrin monomers, which then aggregate to protofibrils. Proteolytic release of fibrinopeptide B by thrombin permits lateral protofibril aggregation, resulting in a three-dimensional fibrin gel.|Fibrin clots were formed as described for turbidity experiments, in which the fibrinogen, calcium, and polyP (when included) were preincubated for 15 minutes before adding thrombin.
Publications: 1 Organism: Homo Sapiens
Tissue: Blood Plasma
+ Fibrinup-regulates img/indirect-activation.png PLAT 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-263536 Homo sapiens
pmid sentence
The presence of fibrin greatly accelerates the activation of plasminogen by tPA and hence can exert a regulatory influence over plasminogen activation
Publications: 1 Organism: Homo Sapiens
Tissue: Blood Plasma
+ Fibrinolysisdown-regulates img/indirect_inhibition.png Fibrin 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-263532 Homo sapiens
pmid sentence
The fibrinolytic system is sequentially composed of plasminogen activation and fibrin degradation [1, 2]. Three distinct inhibitors of the fibrinolytic system that differently regulate these two steps are plasminogen activator inhibitor type-1 (PAI-1), α2-antiplasmin (α2AP) and thrombin activatable fibrinolysis inhibitor (TAFI) [3]. PAI-1 limits the amount of free tissue-type plasminogen activator (tPA) both in plasma and on vascular endothelial cells (VECs), and regulates plasminogen activation potential to dissolve fibrin
Publications: 1 Organism: Homo Sapiens
Tissue: Blood Plasma
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