Relation Results

Summary

Name Membrane attack complex
Primary ID SIGNOR-C313
Links CPX-6159
Type complex
Formed by C5, C7, C8G, C9, C6, C8B, C8A
Relations 10
Pathways Complement Signaling

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Type: Score: Layout: SPV 
0.70.5760.4810.70.6060.5880.70.4480.4690.58Membrane attack complexMembrane_disruptionC8BC6OpsonizationC5C8GCell_killingC7C9C8A

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Relations
Regulator
Mechanism
target
score ℹ
+ Membrane attack complexup-regulates img/indirect-activation.png Membrane_disruption 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-263456 in vitro
pmid sentence
CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers
Publications: 1 Organism: In Vitro
Pathways:Complement Signaling
+ C8Bform complex img/form-complex.png binding Membrane attack complex 0.576
Identifier Residue Sequence Organism Cell Line
SIGNOR-263444 in vitro
pmid sentence
The human MAC pore was formed on liposomes from individual complement proteins. |The maps were further subdivided into three components: an asymmetric region (C5b, C6, C7, and C8), a hinge region (C7, C8, and two C9 molecules), and a C9 oligomer
Publications: 1 Organism: In Vitro
+ C6form complex img/form-complex.png binding Membrane attack complex 0.481
Identifier Residue Sequence Organism Cell Line
SIGNOR-263442 in vitro
pmid sentence
The human MAC pore was formed on liposomes from individual complement proteins. |The maps were further subdivided into three components: an asymmetric region (C5b, C6, C7, and C8), a hinge region (C7, C8, and two C9 molecules), and a C9 oligomer
Publications: 1 Organism: In Vitro
+ Opsonizationup-regulates img/indirect-activation.png Membrane attack complex 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-263455 in vitro
pmid sentence
CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers
Publications: 1 Organism: In Vitro
+ C5form complex img/form-complex.png binding Membrane attack complex 0.606
Identifier Residue Sequence Organism Cell Line
SIGNOR-263440 in vitro
pmid sentence
The human MAC pore was formed on liposomes from individual complement proteins. |The maps were further subdivided into three components: an asymmetric region (C5b, C6, C7, and C8), a hinge region (C7, C8, and two C9 molecules), and a C9 oligomer
Publications: 1 Organism: In Vitro
Pathways:Complement Signaling
+ C8Gform complex img/form-complex.png binding Membrane attack complex 0.588
Identifier Residue Sequence Organism Cell Line
SIGNOR-263446 in vitro
pmid sentence
The human MAC pore was formed on liposomes from individual complement proteins. |The maps were further subdivided into three components: an asymmetric region (C5b, C6, C7, and C8), a hinge region (C7, C8, and two C9 molecules), and a C9 oligomer
Publications: 1 Organism: In Vitro
+ Membrane attack complexup-regulates img/indirect-activation.png Cell_killing 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-263454 in vitro
pmid sentence
Our work provides a structural basis for understanding how β-pore forming proteins breach the membrane and reveals a mechanism for how MAC kills pathogens and regulates cell functions.
Publications: 1 Organism: In Vitro
Pathways:Complement Signaling
+ C7form complex img/form-complex.png binding Membrane attack complex 0.448
Identifier Residue Sequence Organism Cell Line
SIGNOR-263443 in vitro
pmid sentence
The human MAC pore was formed on liposomes from individual complement proteins. |The maps were further subdivided into three components: an asymmetric region (C5b, C6, C7, and C8), a hinge region (C7, C8, and two C9 molecules), and a C9 oligomer
Publications: 1 Organism: In Vitro
+ C9form complex img/form-complex.png binding Membrane attack complex 0.469
Identifier Residue Sequence Organism Cell Line
SIGNOR-263441 in vitro
pmid sentence
The human MAC pore was formed on liposomes from individual complement proteins. |The maps were further subdivided into three components: an asymmetric region (C5b, C6, C7, and C8), a hinge region (C7, C8, and two C9 molecules), and a C9 oligomer
Publications: 1 Organism: In Vitro
+ C8Aform complex img/form-complex.png binding Membrane attack complex 0.58
Identifier Residue Sequence Organism Cell Line
SIGNOR-263445 in vitro
pmid sentence
The human MAC pore was formed on liposomes from individual complement proteins. |The maps were further subdivided into three components: an asymmetric region (C5b, C6, C7, and C8), a hinge region (C7, C8, and two C9 molecules), and a C9 oligomer
Publications: 1 Organism: In Vitro
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