| + |
Membrane attack complex | up-regulates 
|
Membrane_disruption |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263456 |
|
|
in vitro |
|
| pmid |
sentence |
| 30552328 |
CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers |
|
| Publications: |
1 |
Organism: |
In Vitro |
| Pathways: | Complement Signaling |
| + |
Membrane attack complex | up-regulates
|
Cell_killing |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263454 |
|
|
in vitro |
|
| pmid |
sentence |
| 30552328 |
Our work provides a structural basis for understanding how β-pore forming proteins breach the membrane and reveals a mechanism for how MAC kills pathogens and regulates cell functions. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| Pathways: | Complement Signaling |
| + |
C8B | form complex 
binding
|
Membrane attack complex |
0.571 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263444 |
|
|
in vitro |
|
| pmid |
sentence |
| 30552328 |
The human MAC pore was formed on liposomes from individual complement proteins. |The maps were further subdivided into three components: an asymmetric region (C5b, C6, C7, and C8), a hinge region (C7, C8, and two C9 molecules), and a C9 oligomer |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
C8G | form complex
binding
|
Membrane attack complex |
0.585 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263446 |
|
|
in vitro |
|
| pmid |
sentence |
| 30552328 |
The human MAC pore was formed on liposomes from individual complement proteins. |The maps were further subdivided into three components: an asymmetric region (C5b, C6, C7, and C8), a hinge region (C7, C8, and two C9 molecules), and a C9 oligomer |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
C8A | form complex
binding
|
Membrane attack complex |
0.576 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263445 |
|
|
in vitro |
|
| pmid |
sentence |
| 30552328 |
The human MAC pore was formed on liposomes from individual complement proteins. |The maps were further subdivided into three components: an asymmetric region (C5b, C6, C7, and C8), a hinge region (C7, C8, and two C9 molecules), and a C9 oligomer |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
Opsonization | up-regulates
|
Membrane attack complex |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263455 |
|
|
in vitro |
|
| pmid |
sentence |
| 30552328 |
CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
C6 | form complex
binding
|
Membrane attack complex |
0.476 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263442 |
|
|
in vitro |
|
| pmid |
sentence |
| 30552328 |
The human MAC pore was formed on liposomes from individual complement proteins. |The maps were further subdivided into three components: an asymmetric region (C5b, C6, C7, and C8), a hinge region (C7, C8, and two C9 molecules), and a C9 oligomer |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
C9 | form complex
binding
|
Membrane attack complex |
0.464 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263441 |
|
|
in vitro |
|
| pmid |
sentence |
| 30552328 |
The human MAC pore was formed on liposomes from individual complement proteins. |The maps were further subdivided into three components: an asymmetric region (C5b, C6, C7, and C8), a hinge region (C7, C8, and two C9 molecules), and a C9 oligomer |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
C5 | form complex
binding
|
Membrane attack complex |
0.604 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263440 |
|
|
in vitro |
|
| pmid |
sentence |
| 30552328 |
The human MAC pore was formed on liposomes from individual complement proteins. |The maps were further subdivided into three components: an asymmetric region (C5b, C6, C7, and C8), a hinge region (C7, C8, and two C9 molecules), and a C9 oligomer |
|
| Publications: |
1 |
Organism: |
In Vitro |
| Pathways: | Complement Signaling |
| + |
C7 | form complex
binding
|
Membrane attack complex |
0.443 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263443 |
|
|
in vitro |
|
| pmid |
sentence |
| 30552328 |
The human MAC pore was formed on liposomes from individual complement proteins. |The maps were further subdivided into three components: an asymmetric region (C5b, C6, C7, and C8), a hinge region (C7, C8, and two C9 molecules), and a C9 oligomer |
|
| Publications: |
1 |
Organism: |
In Vitro |
3.0
Membrane attack complex
CPX-6159