Relation Results

Summary

Name Cohesin complex
Primary ID SIGNOR-C304
Links CPX-5989
Type complex
Formed by STAG, RAD21, SMC1A, SMC3, STAG1
Relations 11

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Type: Score: Layout: SPV 
0.8430.70.20.9090.20.20.9140.8790.9160.20.966NIPBLCohesin complexChromosome_segregationWAPLSMC3SGO1TERB2STAG1SMC1ASTAGTTM complexRAD21

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Relations
Regulator
Mechanism
target
score ℹ
+ NIPBLup-regulates activity img/direct-activation.png binding Cohesin complex 0.843
Identifier Residue Sequence Organism Cell Line
SIGNOR-264522 Homo sapiens
pmid sentence
Scc2 (Nipbl) stimulates cohesin’s ABC-like ATPase and is essential for loading cohesin onto chromosomes. However, it is possible that the stimulation of cohesin’s ATPase by Scc2 also has a post-loading function, for example driving loop extrusion. Using fluorescence recovery after photobleaching (FRAP) and single-molecule tracking in human cells, we show that Scc2 binds dynamically to chromatin, principally through an association with cohesin.
Publications: 1 Organism: Homo Sapiens
+ Cohesin complexup-regulates img/indirect-activation.png Chromosome_segregation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-264523 Homo sapiens
pmid sentence
Cohesin, one of structural maintenance of chromosomes (SMC) complexes, forms a ring-shaped protein complex, and mediates sister chromatid cohesion for accurate chromosome segregation and precise genome inheritance.
Publications: 1 Organism: Homo Sapiens
+ WAPLdown-regulates activity img/direct_inhibition.png Cohesin complex 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-265265 Homo sapiens HeLa Cell
pmid sentence
We show that human Wapl interacts with cohesin throughout the cell cycle via cohesin's Scc1 and SA1/SA2 subunits and that Wapl forms a subcomplex with Pds5A|These results indicate that Wapl is required for the release of cohesin from both interphase chromatin and mitotic chromosomes, perhaps by facilitating opening of the cohesin ring or by modulating direct interactions between cohesin and DNA.
Publications: 1 Organism: Homo Sapiens
+ SMC3form complex img/form-complex.png binding Cohesin complex 0.909
Identifier Residue Sequence Organism Cell Line
SIGNOR-263312
pmid sentence
Cohesin is an evolutionarily conserved complex composed of four core proteins (SMC1A, SMC3, RAD21 and either STAG2 or STAG1) that form a ring-shaped structure able to encircle chromatin
Publications: 1
+ SGO1up-regulates quantity by stabilization img/direct-activation.png binding Cohesin complex 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-265264 Homo sapiens HeLa Cell
pmid sentence
The complex between shugoshin and protein phosphatase 2A (Sgo1-PP2A) localizes to centromeres in mitosis, binds to cohesin in a reaction requiring Cdk-dependent phosphorylation of Sgo1, dephosphorylates cohesin-bound sororin, and protects a centromeric pool of cohesin from mitotic kinases and the cohesin inhibitor Wapl.
Publications: 1 Organism: Homo Sapiens
+ TERB2up-regulates activity img/direct-activation.png relocalization Cohesin complex 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-263306
pmid sentence
Terb1 and Sun1 are two key proteins linking the meiotic telomeres to the NE. Terb1 participates in telomere fortification by recruiting cohesins to the site
Publications: 1
+ STAG1form complex img/form-complex.png binding Cohesin complex 0.914
Identifier Residue Sequence Organism Cell Line
SIGNOR-267729 Drosophila melanogaster
pmid sentence
Integrator is a metazoan-specific multisubunit, multifunctional protein complex composed of 14 subunits named Int1–Int14 (Integrator subunits) 
Publications: 1 Organism: Drosophila Melanogaster
+ SMC1Aform complex img/form-complex.png binding Cohesin complex 0.879
Identifier Residue Sequence Organism Cell Line
SIGNOR-263313
pmid sentence
Cohesin is an evolutionarily conserved complex composed of four core proteins (SMC1A, SMC3, RAD21 and either STAG2 or STAG1) that form a ring-shaped structure able to encircle chromatin
Publications: 1
+ STAGform complex img/form-complex.png binding Cohesin complex 0.916
Identifier Residue Sequence Organism Cell Line
SIGNOR-263314
pmid sentence
Cohesin is an evolutionarily conserved complex composed of four core proteins (SMC1A, SMC3, RAD21 and either STAG2 or STAG1) that form a ring-shaped structure able to encircle chromatin
Publications: 1
+ TTM complexup-regulates activity img/direct-activation.png relocalization Cohesin complex 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-263307
pmid sentence
Terb1 and Sun1 are two key proteins linking the meiotic telomeres to the NE. Terb1 participates in telomere fortification by recruiting cohesins to the site
Publications: 1
+ RAD21form complex img/form-complex.png binding Cohesin complex 0.966
Identifier Residue Sequence Organism Cell Line
SIGNOR-263311
pmid sentence
Cohesin is an evolutionarily conserved complex composed of four core proteins (SMC1A, SMC3, RAD21 and either STAG2 or STAG1) that form a ring-shaped structure able to encircle chromatin
Publications: 1
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