Relation Results

Summary

Name mTORC1
Primary ID SIGNOR-C3
Type complex
Formed by AKT1S1, DEPTOR, MLST8, RPTOR, MTOR
Relations 118
Pathways AMPK Signaling, Autophagy, EGFR Signaling, Glioblastoma Multiforme, Insulin Signaling, Luminal Breast Cancer, Macropinocytosis , Myofiber: BMP, mTOR in cancer, Myofiber: IGF1R, Pancreatic ductal adenocarcinoma (PDA), PI3K/AKT Signaling, Satellite: IGF1R, Thyroid Hormone Metabolism, WNT/FLT3
Inhibitors sirolimus

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Type: Score: Layout: SPV 
0.20.20.370.2870.6080.4690.7540.3480.7510.4750.2440.80.70.6790.3860.8320.4730.720.8590.8830.5640.70.3920.7220.4720.3360.70.70.6160.3340.2650.80.7970.5640.70.4320.7930.5150.80.2920.5880.70.20.80.4530.7220.3110.3490.70.8980.6040.5720.30.6260.3430.3650.80.2610.5330.320.70.6390.3680.20.20.2740.690.470.2540.20.40.290.3060.8mTORC1NRBF2ISCUTFEBPIP4K2CSGK1MAF1EIF4EBP1EEF2KRPS6KB1RPS6KJMJD1CglutamineProliferationRAGACMAPK1SLC38A9DEPTORRPTORMLST8ULK1/Atg13/Fip200AutophagyMAPK3AKT1MAPK11GFsCell_growthTSCGABARAPCIB2L-arginineAKT1S1GlutaminolysisPPARGRHEB14-3-3leucineDYRK3RPS6KB2AdipogenesisLNPKL-glutamine zwitterionAMPKAKTMTMR3MYCSkeletal_muscle_differentiationMTORTTI1AKT2GOLPH3ULK1PIH1D1GRB10arginineATP6V1ATELO2RAB1ALysosome fusionRRAGDHIF1ACILK1SMAD1/5/8/SMAD4APOBRRAGCRPS6KA1TBCKGbetaERK1/2BTRCLARP1sirolimus

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ mTORC1up-regulates activity img/direct-activation.png phosphorylation NRBF2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-265876 Ser113 AEDAEGQsPLSQKYS Homo sapiens
pmid sentence
Human NRBF2 is phosphorylated by MTORC1 at S113 and S120. Upon nutrient starvation or MTORC1 inhibition, NRBF2 phosphorylation is diminished. Phosphorylated NRBF2 preferentially interacts with PIK3C3/PIK3R4. Suppression of NRBF2 phosphorylation by MTORC1 inhibition alters its binding preference from PIK3C3/PIK3R4 to ATG14/BECN1, leading to increased autophagic PtdIns3K complex assembly, as well as enhancement of ULK1 protein complex association.
Identifier Residue Sequence Organism Cell Line
SIGNOR-265877 Ser120 SPLSQKYsPSTEKCL Homo sapiens
pmid sentence
Human NRBF2 is phosphorylated by MTORC1 at S113 and S120. Upon nutrient starvation or MTORC1 inhibition, NRBF2 phosphorylation is diminished. Phosphorylated NRBF2 preferentially interacts with PIK3C3/PIK3R4. Suppression of NRBF2 phosphorylation by MTORC1 inhibition alters its binding preference from PIK3C3/PIK3R4 to ATG14/BECN1, leading to increased autophagic PtdIns3K complex assembly, as well as enhancement of ULK1 protein complex association.
Publications: 2 Organism: Homo Sapiens
+ mTORC1up-regulates img/direct-activation.png phosphorylation ISCU 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-217082 Ser14 FRLRRAAsALLLRSP Homo sapiens
pmid sentence
Here, we demonstrate that mtorc1 associates with iscu and phosphorylates iscu at serine 14. This phosphorylation stabilized iscu protein.
Publications: 1 Organism: Homo Sapiens
+ mTORC1down-regulates activity img/direct_inhibition.png phosphorylation TFEB 0.37
Identifier Residue Sequence Organism Cell Line
SIGNOR-255309 Ser142 AGNSAPNsPMAMLHI Homo sapiens HEK-293 Cell
pmid sentence
Here, we have used an mTORC1 in-vitro kinase assay and a phosphoantibody to demonstrate that serine S142, which we previously found to be phosphorylated by ERK2, is also phosphorylated by mTOR and that this phosphorylation has a crucial role in controlling TFEB subcellular localization and activity.
Identifier Residue Sequence Organism Cell Line
SIGNOR-248274 Ser211 LVGVTSSsCPADLTQ Homo sapiens HeLa Cell
pmid sentence
Our data points to the lysosome as the site where mTORC1-dependent phosphorylation of TFEB occurs. [...]Our study has revealed a specific role for phosphorylation of TFEB S211 in the negative regulation of the nuclear abundance of TFEB. This occurs through the promotion of 14-3-3 binding and the masking of the nearby NLS on TFEB.
Publications: 2 Organism: Homo Sapiens
+ mTORC1up-regulates quantity img/direct-activation.png phosphorylation PIP4K2C 0.287
Identifier Residue Sequence Organism Cell Line
SIGNOR-273680 Ser324 GPPALVGsYGTSPEG Homo sapiens HeLa Cell
pmid sentence
 PIP4kγ was phosphorylated by mTORC1 and associated with the complex. Phosphorylated PIP4kγ was enriched in light microsomal vesicles, whereas the unphosphorylated form was enriched in heavy microsomal vesicles associated with the Golgi. 
Identifier Residue Sequence Organism Cell Line
SIGNOR-273681 Ser328 LVGSYGTsPEGIGGY Homo sapiens HeLa Cell
pmid sentence
 PIP4kγ was phosphorylated by mTORC1 and associated with the complex. Phosphorylated PIP4kγ was enriched in light microsomal vesicles, whereas the unphosphorylated form was enriched in heavy microsomal vesicles associated with the Golgi. 
Publications: 2 Organism: Homo Sapiens
+ mTORC1up-regulates activity img/direct-activation.png phosphorylation SGK1 0.608
Identifier Residue Sequence Organism Cell Line
SIGNOR-217078 Ser422 AEAFLGFsYAPPTDS in vitro
pmid sentence
Mtor phosphorylated sgk1, but not sgk1-s422a, in vitro. Sgk1 phosphorylated p27 in vitro. These data implicate sgk1 as an mtorc1 (mtor-raptor) substrate. mtor may promote g1 progression in part through sgk1 activation
Publications: 1 Organism: In Vitro
Pathways:Insulin Signaling
+ mTORC1down-regulates img/direct_inhibition.png phosphorylation MAF1 0.469
Identifier Residue Sequence Organism Cell Line
SIGNOR-217149 Ser60 PHVLEALsPPQTSGL Homo sapiens
pmid sentence
The protein is phosphorylated mainly on residues s60, s68, and s75, and this inhibits its pol iii repression function. The responsible kinase is mtorc1, which phosphorylates maf1 directly.
Identifier Residue Sequence Organism Cell Line
SIGNOR-217145 Ser68 PPQTSGLsPSRLSKS Homo sapiens
pmid sentence
The protein is phosphorylated mainly on residues s60, s68, and s75, and this inhibits its pol iii repression function. The responsible kinase is mtorc1, which phosphorylates maf1 directly.
Identifier Residue Sequence Organism Cell Line
SIGNOR-217153 Ser75 SPSRLSKsQGGEEEG Homo sapiens
pmid sentence
The protein is phosphorylated mainly on residues s60, s68, and s75, and this inhibits its pol iii repression function. The responsible kinase is mtorc1, which phosphorylates maf1 directly.
Publications: 3 Organism: Homo Sapiens
+ mTORC1down-regulates activity img/direct_inhibition.png phosphorylation EIF4EBP1 0.754
Identifier Residue Sequence Organism Cell Line
SIGNOR-236690 Ser65 FLMECRNsPVTKTPP Homo sapiens HEK-293 Cell
pmid sentence
Phosphorylated on serine and threonine residues in response to insulin, egf and pdgf. Phosphorylation at thr-37, thr-46, ser-65 and thr-70, corresponding to the hyperphosphorylated form, is regulated by mtorc1 and abolishes binding to eif4e.
Identifier Residue Sequence Organism Cell Line
SIGNOR-217137 Ser65 FLMECRNsPVTKTPP Homo sapiens
pmid sentence
These results indicate that arg, leu, and gln act coordinately to stimulate proliferation of ptr cells through activation of the mtor-rps6k-rps6-eif4ebp1 signal transduction pathway. Specifically as part of mtorc1, mtor directly phosphorylates the ribosomal protein s6 kinases (s6k1 and s6k2) and the eukaryotic initiation factor 4e (eif4e)-binding proteins (4e-bp1 and 4e-bp2), both of which control specific steps in the initiation of cap-dependent translation
Identifier Residue Sequence Organism Cell Line
SIGNOR-217086 Thr36 LPPGDYStTPGGTLF Homo sapiens
pmid sentence
Mtorc1 promotes protein synthesis by phosphorylating the eukaryotic initiation factor 4e (eif4e)- binding protein 1 (4e-bp1) and the p70 ribosomal s6 kinase 1 (s6k1). Raft1 phosphorylation of 4e-bp1 on thr-36 and thr-45 blocks its association with the cap-binding protein, eif-4e,in vitro. in response to insulin and nutrients, mtorc1, consisting of mtor, raptor (regulatory-associated protein of mtor), and mlst8, is activated and phosphorylates eukaryotic initiation factor 4e-binding protein (4ebp) and p70 s6 kinase to promote protein synthesis and cell size.
Identifier Residue Sequence Organism Cell Line
SIGNOR-236694 Thr37 PPGDYSTtPGGTLFS Homo sapiens
pmid sentence
Phosphorylated on serine and threonine residues in response to insulin, egf and pdgf. Phosphorylation at thr-37, thr-46, ser-65 and thr-70, corresponding to the hyperphosphorylated form, is regulated by mtorc1 and abolishes binding to eif4e.
Identifier Residue Sequence Organism Cell Line
SIGNOR-217110 Thr37 PPGDYSTtPGGTLFS Homo sapiens
pmid sentence
These results indicate that arg, leu, and gln act coordinately to stimulate proliferation of ptr cells through activation of the mtor-rps6k-rps6-eif4ebp1 signal transduction pathway. Specifically as part of mtorc1, mtor directly phosphorylates the ribosomal protein s6 kinases (s6k1 and s6k2) and the eukaryotic initiation factor 4e (eif4e)-binding proteins (4e-bp1 and 4e-bp2), both of which control specific steps in the initiation of cap-dependent translation
Identifier Residue Sequence Organism Cell Line
SIGNOR-217090 Thr45 PGGTLFStTPGGTRI Homo sapiens
pmid sentence
Mtorc1 promotes protein synthesis by phosphorylating the eukaryotic initiation factor 4e (eif4e)- binding protein 1 (4e-bp1) and the p70 ribosomal s6 kinase 1 (s6k1). Raft1 phosphorylation of 4e-bp1 on thr-36 and thr-45 blocks its association with the cap-binding protein, eif-4e,in vitro. in response to insulin and nutrients, mtorc1, consisting of mtor, raptor (regulatory-associated protein of mtor), and mlst8, is activated and phosphorylates eukaryotic initiation factor 4e-binding protein (4ebp) and p70 s6 kinase to promote protein synthesis and cell size.
Identifier Residue Sequence Organism Cell Line
SIGNOR-217114 Thr46 GGTLFSTtPGGTRII Homo sapiens
pmid sentence
These results indicate that arg, leu, and gln act coordinately to stimulate proliferation of ptr cells through activation of the mtor-rps6k-rps6-eif4ebp1 signal transduction pathway. Specifically as part of mtorc1, mtor directly phosphorylates the ribosomal protein s6 kinases (s6k1 and s6k2) and the eukaryotic initiation factor 4e (eif4e)-binding proteins (4e-bp1 and 4e-bp2), both of which control specific steps in the initiation of cap-dependent translation
Identifier Residue Sequence Organism Cell Line
SIGNOR-236698 Thr46 GGTLFSTtPGGTRII Homo sapiens
pmid sentence
Phosphorylated on serine and threonine residues in response to insulin, egf and pdgf. Phosphorylation at thr-37, thr-46, ser-65 and thr-70, corresponding to the hyperphosphorylated form, is regulated by mtorc1 and abolishes binding to eif4e.
Identifier Residue Sequence Organism Cell Line
SIGNOR-236702 Thr70 RNSPVTKtPPRDLPT Homo sapiens HEK-293 Cell
pmid sentence
Mammalian target of rapamycin-dependent phosphorylation of phas-i in four (s/t)p sites detected by phospho-specific antibodies.
Identifier Residue Sequence Organism Cell Line
SIGNOR-217141 Thr70 RNSPVTKtPPRDLPT Homo sapiens
pmid sentence
These results indicate that arg, leu, and gln act coordinately to stimulate proliferation of ptr cells through activation of the mtor-rps6k-rps6-eif4ebp1 signal transduction pathway. Specifically as part of mtorc1, mtor directly phosphorylates the ribosomal protein s6 kinases (s6k1 and s6k2) and the eukaryotic initiation factor 4e (eif4e)-binding proteins (4e-bp1 and 4e-bp2), both of which control specific steps in the initiation of cap-dependent translation
Identifier Residue Sequence Organism Cell Line
SIGNOR-235964 Thr70 RNSPVTKtPPRDLPT Homo sapiens
pmid sentence
Phosphorylated on serine and threonine residues in response to insulin, egf and pdgf. Phosphorylation at thr-37, thr-46, ser-65 and thr-70, corresponding to the hyperphosphorylated form, is regulated by mtorc1 and abolishes binding to eif4e.
Identifier Residue Sequence Organism Cell Line
SIGNOR-236678 Homo sapiens HEK-293 Cell
pmid sentence
Our data demonstrate that the TOS motif functions as a docking site for the mTOR/raptor complex, which is required for multisite phosphorylation of 4E-BP1, eIF4E release from 4E-BP1, and cell growth.
Identifier Residue Sequence Organism Cell Line
SIGNOR-235745 Mus musculus MEF Cell
pmid sentence
Specifically as part of mTORC1, mTOR directly phosphorylates the ribosomal protein S6 kinases (S6K1 and S6K2) and the eukaryotic initiation factor 4E (eIF4E)-binding proteins (4E-BP1 and 4E-BP2)phosphorylation of the 4E-BPs leads to their inhibition and release from eIF4E at the 5_ cap of mRNAs
Identifier Residue Sequence Organism Cell Line
SIGNOR-235748 Cricetulus griseus
pmid sentence
In response to insulin and nutrients, mTORC1, consisting of mTOR, raptor (regulatory-associated protein of mTOR), and mLST8, is activated and phosphorylates eukaryotic initiation factor 4E-binding protein (4EBP) and p70 S6 kinase to promote protein synthesis and cell size.
Publications: 14 Organism: Homo Sapiens, Mus Musculus, Cricetulus Griseus
Pathways:AMPK Signaling, Insulin Signaling, PI3K/AKT Signaling
+ mTORC1down-regulates activity img/direct_inhibition.png phosphorylation EEF2K 0.348
Identifier Residue Sequence Organism Cell Line
SIGNOR-277908 Ser70 LTKSERYsSSGSPAN Homo sapiens MCF-7 Cell
pmid sentence
Our phosphoproteomics analysis add to this body of knowledge as it indicates that mTORC1 modulates additional phosphorylation sites in eEF2K, such as Y69, S70, S72, and S74, which is consistent with our previous findings
Identifier Residue Sequence Organism Cell Line
SIGNOR-277906 Ser72 KSERYSSsGSPANSF Homo sapiens MCF-7 Cell
pmid sentence
Our phosphoproteomics analysis add to this body of knowledge as it indicates that mTORC1 modulates additional phosphorylation sites in eEF2K, such as Y69, S70, S72, and S74, which is consistent with our previous findings
Identifier Residue Sequence Organism Cell Line
SIGNOR-277907 Ser74 ERYSSSGsPANSFHF Homo sapiens MCF-7 Cell
pmid sentence
Our phosphoproteomics analysis add to this body of knowledge as it indicates that mTORC1 modulates additional phosphorylation sites in eEF2K, such as Y69, S70, S72, and S74, which is consistent with our previous findings
Identifier Residue Sequence Organism Cell Line
SIGNOR-277909 Tyr69 NLTKSERySSSGSPA Homo sapiens MCF-7 Cell
pmid sentence
Our phosphoproteomics analysis add to this body of knowledge as it indicates that mTORC1 modulates additional phosphorylation sites in eEF2K, such as Y69, S70, S72, and S74, which is consistent with our previous findings
Publications: 4 Organism: Homo Sapiens
+ mTORC1up-regulates activity img/direct-activation.png phosphorylation RPS6KB1 0.751
Identifier Residue Sequence Organism Cell Line
SIGNOR-255840 Thr390 DSKFTRQtPVDSPDD Homo sapiens
pmid sentence
Thr229 phosphorylation requires prior phosphorylation of the Ser/Thr-Pro sites in the autoinhibitory domain and Thr389 in the linker domain,[…] Moreover, in vitro mTOR directly phosphorylates Ser371, and this event modulates Thr389phosphorylation by mTOR, compatible with earlier in vivo findings.
Identifier Residue Sequence Organism Cell Line
SIGNOR-273843 Homo sapiens HEK-293 Cell
pmid sentence
Here we report that ribosomal protein S6 kinase beta 1 (S6K1), a member of AGC kinases and downstream target of mechanistic target of rapamycin complex 1 (mTORC1), directly phosphorylates PDK1 at its pleckstrin homology (PH) domain, and impairs PDK1 interaction with and activation of AKT.
Publications: 2 Organism: Homo Sapiens
Pathways:Insulin Signaling
+ mTORC1up-regulates activity img/direct-activation.png phosphorylation RPS6K 0.475
Identifier Residue Sequence Organism Cell Line
SIGNOR-255842 Thr390 DSKFTRQtPVDSPDD Homo sapiens
pmid sentence
Thr229 phosphorylation requires prior phosphorylation of the Ser/Thr-Pro sites in the autoinhibitory domain and Thr389 in the linker domain [..]. Moreover, in vitro mTOR directly phosphorylates Ser371, and this event modulates Thr389phosphorylation by mTOR, compatible with earlier in vivo findings.
Publications: 1 Organism: Homo Sapiens
Pathways:PI3K/AKT Signaling
+ mTORC1up-regulates img/direct-activation.png phosphorylation RPS6KB1 0.751
Identifier Residue Sequence Organism Cell Line
SIGNOR-217067 Thr412 NQVFLGFtYVAPSVL Homo sapiens
pmid sentence
Mtorc1 promotes protein synthesis by phosphorylating the eukaryotic initiation factor 4e (eif4e)- binding protein 1 (4e-bp1) and the p70 ribosomal s6 kinase 1 (s6k1). In vitro activation of p70alfa by mtor-catalyzed phosphorylation involving p70alfa thr-412. Mtor-catalyzed p70alfa phosphorylation in vitro is accompanied by a substantial restoration in p70alfa kinase activity toward its physiologic substrate, the 40 s ribosomal protein s6. In response to insulin and nutrients, mtorc1, consisting of mtor, raptor (regulatory-associated protein of mtor), and mlst8, is activated and phosphorylates eukaryotic initiation factor 4e-binding protein (4ebp) and p70 s6 kinase to promote protein synthesis and cell size.
Identifier Residue Sequence Organism Cell Line
SIGNOR-217056 Thr412 NQVFLGFtYVAPSVL Homo sapiens
pmid sentence
Mtorc1 promotes protein synthesis by phosphorylating the eukaryotic initiation factor 4e (eif4e)- binding protein 1 (4e-bp1) and the p70 ribosomal s6 kinase 1 (s6k1). In vitro activation of p70alfa by mtor-catalyzed phosphorylation involving p70alfa thr-412. Mtor-catalyzed p70alfa phosphorylation in vitro is accompanied by a substantial restoration in p70alfa kinase activity toward its physiologic substrate, the 40 s ribosomal protein s6. In response to insulin and nutrients, mtorc1, consisting of mtor, raptor (regulatory-associated protein of mtor), and mlst8, is activated and phosphorylates eukaryotic initiation factor 4e-binding protein (4ebp) and p70 s6 kinase to promote protein synthesis and cell size.
Identifier Residue Sequence Organism Cell Line
SIGNOR-217071 Thr412 NQVFLGFtYVAPSVL Homo sapiens
pmid sentence
Mtorc1 promotes protein synthesis by phosphorylating the eukaryotic initiation factor 4e (eif4e)- binding protein 1 (4e-bp1) and the p70 ribosomal s6 kinase 1 (s6k1). In vitro activation of p70alfa by mtor-catalyzed phosphorylation involving p70alfa thr-412. Mtor-catalyzed p70alfa phosphorylation in vitro is accompanied by a substantial restoration in p70alfa kinase activity toward its physiologic substrate, the 40 s ribosomal protein s6. in response to insulin and nutrients, mtorc1, consisting of mtor, raptor (regulatory-associated protein of mtor), and mlst8, is activated and phosphorylates eukaryotic initiation factor 4e-binding protein (4ebp) and p70 s6 kinase to promote protein synthesis and cell size.
Identifier Residue Sequence Organism Cell Line
SIGNOR-217060 Thr412 NQVFLGFtYVAPSVL Homo sapiens
pmid sentence
Mtorc1 promotes protein synthesis by phosphorylating the eukaryotic initiation factor 4e (eif4e)- binding protein 1 (4e-bp1) and the p70 ribosomal s6 kinase 1 (s6k1). In vitro activation of p70alfa by mtor-catalyzed phosphorylation involving p70alfa thr-412. Mtor-catalyzed p70alfa phosphorylation in vitro is accompanied by a substantial restoration in p70alfa kinase activity toward its physiologic substrate, the 40 s ribosomal protein s6. In response toinsulinand nutrients, mtorc1, consisting of mtor, raptor (regulatory-associated protein of mtor), and mlst8, is activated and phosphorylates eukaryotic initiation factor 4e-binding protein (4ebp) and p70 s6 kinase to promote protein synthesis and cell size.
Publications: 4 Organism: Homo Sapiens
Pathways:Insulin Signaling
+ mTORC1up-regulates activity img/direct-activation.png phosphorylation JMJD1C 0.244
Identifier Residue Sequence Organism Cell Line
SIGNOR-265168 Thr505 KFVSRPPtPKCVIDI Homo sapiens HEK-293 Cell
pmid sentence
We show that, by direct interaction with USF-1, JMJD1C is recruited to lipogenic promoters. We also show that JMJD1C is phosphorylated at T505 by mammalian target of rapamyci (mTOR) to be recruited to lipogenic genes in response to insulin/feeding. we detected phosphorylation of WT JMJD1C but not T505A mutant when we co-transfected JMJD1C constructs along with the mTORC1 in 293FT cells
Publications: 1 Organism: Homo Sapiens
+ glutamineup-regulates activity img/indirect-activation.png mTORC1 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-268008 Homo sapiens HeLa Cell
pmid sentence
Leucine and Glutamine Activate Glutaminolysis and mTORC1
Identifier Residue Sequence Organism Cell Line
SIGNOR-268012 Homo sapiens HeLa Cell
pmid sentence
 Importantly, asparagine/glutamine pre-load only results in mTOR activation following amino acid stimulation (Fig. 5a), indicating that it is their exchange factor roles that elicit mTORC1 activation.
Publications: 2 Organism: Homo Sapiens
+ mTORC1up-regulates img/indirect-activation.png Proliferation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-256064 Homo sapiens
pmid sentence
Phosphorylation of mTOR by Akt leads to mTOR activation (40, 52) and the subsequent activation of p70S6K (47). This latter event has great potential importance for the promotion of muscle growth by the IGF-I/Akt/mTOR pathway, because p70S6k is a potent stimulator of protein synthesis that can be activated by increases in muscle contraction
Identifier Residue Sequence Organism Cell Line
SIGNOR-256063 Homo sapiens
pmid sentence
The mammalian target of rapamycin complex 1 (mTORC1) integrates mitogen and nutrient signals to control cell proliferation and cell size.
Publications: 2 Organism: Homo Sapiens
Tissue: Skeletal Muscle, HEK-293 Cell
Pathways:AMPK Signaling, EGFR Signaling, Glioblastoma Multiforme, Insulin Signaling, Luminal Breast Cancer, mTOR in cancer, Pancreatic ductal adenocarcinoma (PDA), PI3K/AKT Signaling, WNT/FLT3
+ RAGACup-regulates activity img/direct-activation.png relocalization mTORC1 0.679
Identifier Residue Sequence Organism Cell Line
SIGNOR-228158 Homo sapiens
pmid sentence
The Rag GTPases interact with mTORC1 and are proposed to activate it in response to amino acids by promoting mTORC1 translocation to a membrane-bound compartment that contains the mTORC1 activator, Rheb
Publications: 1 Organism: Homo Sapiens
Pathways:mTOR in cancer
+ MAPK1 img/unknown.png phosphorylation mTORC1 0.386
Identifier Residue Sequence Organism Cell Line
SIGNOR-217574 Homo sapiens
pmid sentence
We found three proline-directed residues within raptor, ser(8), ser(696), and ser(863), which are directly phosphorylated by erk1/2. Expression of phosphorylation-deficient alleles of raptor revealed that phosphorylation of these sites by erk1/2 normally promotes mtorc1 activity and signaling to downstream substrates, such as 4e-bp1.
Publications: 1 Organism: Homo Sapiens
+ mTORC1up-regulates activity img/direct-activation.png phosphorylation mTORC1 0.832
Identifier Residue Sequence Organism Cell Line
SIGNOR-235518 Mus musculus NIH-3T3 Cell
pmid sentence
We propose that after mtorc1 kinase activation by upstream regulators, pras40 is phosphorylated directly by mtor, thus contributing to the relief of pras40-mediated substrate competition. We also find that mutation of ser-221 to ala increases the inhibitory activity of pras40 toward mtorc1.
Publications: 1 Organism: Mus Musculus
Pathways:AMPK Signaling, Autophagy, EGFR Signaling, Glioblastoma Multiforme, Insulin Signaling, Luminal Breast Cancer, mTOR in cancer, Pancreatic ductal adenocarcinoma (PDA), PI3K/AKT Signaling, Thyroid Hormone Metabolism, WNT/FLT3
+ SLC38A9up-regulates activity img/indirect-activation.png mTORC1 0.473
Identifier Residue Sequence Organism Cell Line
SIGNOR-255311 Homo sapiens HEK-293 Cell
pmid sentence
Activation of mTORC1 by arginine requires SLC38A9, a poorly understood lysosomal membrane protein with homology to amino acid transporters.
Identifier Residue Sequence Organism Cell Line
SIGNOR-268014 Homo sapiens
pmid sentence
SLC38A9 is a Lysosomal Membrane Protein Required for mTORC1 Activation
Publications: 2 Organism: Homo Sapiens
+ DEPTORform complex img/form-complex.png binding mTORC1 0.72
Identifier Residue Sequence Organism Cell Line
SIGNOR-205600 Homo sapiens
pmid sentence
Depending on their binding partners and sensitivities to rapamycin, mtor resides in at least two distinct complexes, termed mtor complex 1 (mtorc1, containing raptor, fkbp12, pras40 and mlst8) and mtor complex 2 (mtorc2, containing rictor, sin1, protor and mlst8)
Publications: 1 Organism: Homo Sapiens
+ RPTORform complex img/form-complex.png binding mTORC1 0.859
Identifier Residue Sequence Organism Cell Line
SIGNOR-205627 Homo sapiens
pmid sentence
Depending on their binding partners and sensitivities to rapamycin, mtor resides in at least two distinct complexes, termed mtor complex 1 (mtorc1, containing raptor, fkbp12, pras40 and mlst8) and mtor complex 2 (mtorc2, containing rictor, sin1, protor and mlst8)
Publications: 1 Organism: Homo Sapiens
+ MLST8form complex img/form-complex.png binding mTORC1 0.883
Identifier Residue Sequence Organism Cell Line
SIGNOR-205609 Homo sapiens
pmid sentence
Depending on their binding partners and sensitivities to rapamycin, mtor resides in at least two distinct complexes, termed mtor complex 1 (mtorc1, containing raptor, fkbp12, pras40 and mlst8) and mtor complex 2 (mtorc2, containing rictor, sin1, protor and mlst8)
Publications: 1 Organism: Homo Sapiens
+ ULK1/Atg13/Fip200down-regulates activity img/direct_inhibition.png phosphorylation mTORC1 0.564
Identifier Residue Sequence Organism Cell Line
SIGNOR-209910 Homo sapiens
pmid sentence
Raptor phosphorylation by ULK1 was sufficient to completely block Rheb-induced mTORC1 activity in cells as well as mTORC1 kinase activity invitro
Publications: 1 Organism: Homo Sapiens
Pathways:AMPK Signaling, Autophagy
+ mTORC1down-regulates img/indirect_inhibition.png Autophagy 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-209922 Homo sapiens
pmid sentence
Historically, it was known that autophagy was switched off when mTORC1 was active and that inhibition of mTORC1 was a potent autophagy inducer.
Publications: 1 Organism: Homo Sapiens
Pathways:AMPK Signaling, Autophagy
+ MAPK3up-regulates img/direct-activation.png phosphorylation mTORC1 0.392
Identifier Residue Sequence Organism Cell Line
SIGNOR-217544 Homo sapiens
pmid sentence
The phosphorylation of Raptor on these sites enhances mTORC1 activity, and contributes largely to arsenite-induced mTORC1 activation.
Identifier Residue Sequence Organism Cell Line
SIGNOR-217559 Homo sapiens
pmid sentence
Here we focus primarily although not exclusively on raptor Ser(863) phosphorylation. We report that insulin promotes mTORC1-associated phosphorylation of raptor Ser(863) via the canonical PI3K/TSC/Rheb pathway in a rapamycin-sensitive manner. mTORC1 activation by other stimuli (e.g. amino acids, epidermal growth factor/MAPK signaling, and cellular energy) also promote raptor Ser(863) phosphorylation.
Identifier Residue Sequence Organism Cell Line
SIGNOR-217556 Homo sapiens
pmid sentence
The phosphorylation of raptor is stimulated by insulin and inhibited by rapamycin. Importantly, the site-directed mutation of raptor at one phosphorylation site, Ser(863), reduced mTORC1 activity both in vitro and in vivo.
Publications: 3 Organism: Homo Sapiens
+ MAPK3up-regulates activity img/direct-activation.png phosphorylation mTORC1 0.392
Identifier Residue Sequence Organism Cell Line
SIGNOR-209859 Homo sapiens
pmid sentence
Activation of mTORC1 in two steps: Rheb-GTP activation of catalytic function and increased binding of substrates to raptor.
Publications: 1 Organism: Homo Sapiens
+ AKT1up-regulates img/direct-activation.png phosphorylation mTORC1 0.722
Identifier Residue Sequence Organism Cell Line
SIGNOR-255844 Homo sapiens
pmid sentence
Once phosphorylated, Akt can act on a broad spectrum of substrates that can influence cell survival and proliferation and protein synthesis (65). Phosphorylation of mTOR by Akt leads to mTOR activation (40, 52) and the subsequent activation of p70S6K
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
Pathways:Glioblastoma Multiforme
+ RPS6Kup-regulates img/direct-activation.png phosphorylation mTORC1 0.472
Identifier Residue Sequence Organism Cell Line
SIGNOR-252794 Homo sapiens
pmid sentence
Ser719, ser721, and ser722 are the predominant rsk-dependent phosphorylation sites in raptor raptor phosphorylation regulates mtorc1 activity
Publications: 1 Organism: Homo Sapiens
Pathways:PI3K/AKT Signaling
+ MAPK11 img/unknown.png phosphorylation mTORC1 0.336
Identifier Residue Sequence Organism Cell Line
SIGNOR-217580 Homo sapiens
pmid sentence
Arsenite treatment of cells activates p38_ and induces interaction between p38_ and raptor, a regulatory component of mtorc1, resulting in phosphorylation of raptor on ser(863) and ser(771). The phosphorylation of raptor on these sites enhances mtorc1 activity, and contributes largely to arsenite-induced mtorc1 activation.
Publications: 1 Organism: Homo Sapiens
+ GFsup-regulates img/indirect-activation.png mTORC1 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-219382 Homo sapiens
pmid sentence
Growth factors and nutrients regulate the mTORC1 [mammalian (or mechanistic) target of rapamycin complex 1] by different mechanisms. The players that link growth factors and mTORC1 activation have been known for several years and mouse models have validated its relevance for human physiology and disease.
Publications: 1 Organism: Homo Sapiens
Pathways:Autophagy
+ mTORC1up-regulates img/indirect-activation.png Cell_growth 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-209919 Homo sapiens
pmid sentence
Cellular energy and nutrient status will dictate whether mTORC1 takes over and drives cell growth or conversely whether AMPK becomes active once again to drive consecutive waves of autophagy thorough ULK1.
Publications: 1 Organism: Homo Sapiens
Pathways:AMPK Signaling, EGFR Signaling, Glioblastoma Multiforme, Insulin Signaling, Luminal Breast Cancer
+ TSCdown-regulates activity img/indirect_inhibition.png mTORC1 0.616
Identifier Residue Sequence Organism Cell Line
SIGNOR-251527 Homo sapiens HEK-293 Cell, U2-OS Cell
pmid sentence
These findings strongly implicate the tuberin-hamartin tumor suppressor complex as an inhibitor of mtor
Publications: 1 Organism: Homo Sapiens
Pathways:AMPK Signaling, Insulin Signaling, Luminal Breast Cancer, mTOR in cancer
+ GABARAPup-regulates activity img/direct-activation.png binding mTORC1 0.334
Identifier Residue Sequence Organism Cell Line
SIGNOR-219391 Homo sapiens
pmid sentence
N-terminal proline/serine rich (ps) domain of ulk1 (amino acid 287-416) is required for ulk1-gate-16 and ulk1-gabarap protein interactions
Publications: 1 Organism: Homo Sapiens
Pathways:Autophagy
+ CIB2down-regulates activity img/direct_inhibition.png binding mTORC1 0.265
Identifier Residue Sequence Organism Cell Line
SIGNOR-269663 Mus musculus
pmid sentence
Mechanistically, CIB2 negatively regulates mTORC1 by preferentially binding to 'nucleotide empty' or inactive GDP-loaded Rheb. 
Publications: 1 Organism: Mus Musculus
+ L-arginineup-regulates activity img/indirect-activation.png mTORC1 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-268018 Homo sapiens HeLa Cell
pmid sentence
 Importantly, asparagine/glutamine pre-load only results in mTOR activation following amino acid stimulation (Fig. 5a), indicating that it is their exchange factor roles that elicit mTORC1 activation.
Publications: 1 Organism: Homo Sapiens
+ AKT1S1form complex img/form-complex.png binding mTORC1 0.797
Identifier Residue Sequence Organism Cell Line
SIGNOR-205597 Homo sapiens
pmid sentence
Depending on their binding partners and sensitivities to rapamycin, mtor resides in at least two distinct complexes, termed mtor complex 1 (mtorc1, containing raptor, fkbp12, pras40 and mlst8) and mtor complex 2 (mtorc2, containing rictor, sin1, protor and mlst8)
Publications: 1 Organism: Homo Sapiens
+ mTORC1down-regulates activity img/direct_inhibition.png phosphorylation ULK1/Atg13/Fip200 0.564
Identifier Residue Sequence Organism Cell Line
SIGNOR-209904 Homo sapiens
pmid sentence
Several studies published simultaneously illustrated that the equivalent mammalian ULK1Atg13FIP200 complex was also negatively regulated by mTORC1 in an analogous manner [17,18,24]. In mammalian cells, amino acid starvation or rapamycin treatment causes dephosphorylation of both Atg13 and ULK1, indicating that an mTORC1 input regulates the ULK1Atg13FIP200 complex mTORC1 modulates the kinase activity of ULK1 directly, with rapamycin treatment of cells leading to enhanced ULK1 kinase activity, whereas Rheb overexpression causes a decrease in ULK1 kinase activity
Publications: 1 Organism: Homo Sapiens
Pathways:AMPK Signaling, Autophagy
+ Glutaminolysisup-regulates activity img/indirect-activation.png mTORC1 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-268007 Homo sapiens HeLa Cell
pmid sentence
Glutaminolysis Is Required for the Activation of mTORC1 by Leucine and Glutamine
Publications: 1 Organism: Homo Sapiens
+ mTORC1up-regulates quantity by expression img/indirect-activation.png PPARG 0.432
Identifier Residue Sequence Organism Cell Line
SIGNOR-235343 Mus musculus
pmid sentence
Activation of mTORC1 causes a robust increase in the mRNA and protein expression of peroxisome proliferator-activated receptor gamma (PPARgamma), which is the master transcriptional regulator of adipocyte differentiation.
Publications: 1 Organism: Mus Musculus
+ RHEBup-regulates activity img/direct-activation.png mTORC1 0.793
Identifier Residue Sequence Organism Cell Line
SIGNOR-235355 Mus musculus 3T3-L1 Cell
pmid sentence
These results suggest that Rheb induces alteration in the binding of 4E-BP1 with mTORC1 to regulate mTORC1 activation.
Identifier Residue Sequence Organism Cell Line
SIGNOR-232208 Homo sapiens
pmid sentence
Recent studies document that Rheb activates mTORC1 via direct, GTP-dependent interaction with the peptidyl-prolyl-cis/trans-isomerase FKBP38, which is proposed to act as an inhibitor of mTORC1.
Publications: 2 Organism: Mus Musculus, Homo Sapiens
Pathways:AMPK Signaling, Insulin Signaling, Luminal Breast Cancer, mTOR in cancer
+ 14-3-3down-regulates img/direct_inhibition.png binding mTORC1 0.515
Identifier Residue Sequence Organism Cell Line
SIGNOR-217565 Homo sapiens
pmid sentence
Akt can phosphorylate pras40, a raptor binding protein that also acts as an inhibitor of torc1. Akt-mediated phosphorylation of pras40 again promotes 14-3-3 binding, in this case leading to relief from pras40-mediated inhibition.
Publications: 1 Organism: Homo Sapiens
+ leucineup-regulates activity img/indirect-activation.png mTORC1 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-268010 Homo sapiens
pmid sentence
Leucine and Glutamine Activate Glutaminolysis and mTORC1
Publications: 1 Organism: Homo Sapiens
+ DYRK3down-regulates img/direct_inhibition.png phosphorylation mTORC1 0.292
Identifier Residue Sequence Organism Cell Line
SIGNOR-217571 Homo sapiens
pmid sentence
When dyrk3 is active, it allows stress granule dissolution, releasing mtorc1 for signaling and promoting its activity by directly phosphorylating the mtorc1 inhibitor pras40
Publications: 1 Organism: Homo Sapiens
+ mTORC1up-regulates img/direct-activation.png phosphorylation RPS6KB2 0.588
Identifier Residue Sequence Organism Cell Line
SIGNOR-217074 Homo sapiens
pmid sentence
In response to insulin and nutrients, mtorc1, consisting of mtor, raptor (regulatory-associated protein of mtor), and mlst8, is activated and phosphorylates eukaryotic initiation factor 4e-binding protein (4ebp) and p70 s6 kinase to promote protein synthesis and cell size.
Publications: 1 Organism: Homo Sapiens
+ mTORC1up-regulates img/indirect-activation.png Adipogenesis 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-235349 Mus musculus
pmid sentence
Activation of mTORC1 causes a robust increase in the mRNA and protein expression of peroxisome proliferator-activated receptor gamma (PPARgamma), which is the master transcriptional regulator of adipocyte differentiation.
Publications: 1 Organism: Mus Musculus
Pathways:Thyroid Hormone Metabolism
+ LNPKup-regulates activity img/direct-activation.png binding mTORC1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-272200 Homo sapiens HEK-293 Cell
pmid sentence
We demonstrate that Lunapark interacts with mechanistic target of rapamycin complex-1 (mTORC1), a central cellular regulator that coordinates growth and metabolism with environmental conditions. We show that mTORC1 binds Lunapark specifically at three-way junctions, and lysosomes, where mTORC1 is activated, make contact with three-way junctions where Lunapark resides.
Publications: 1 Organism: Homo Sapiens
+ L-glutamine zwitterionup-regulates activity img/indirect-activation.png mTORC1 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-268017 Homo sapiens HeLa Cell
pmid sentence
 Importantly, asparagine/glutamine pre-load only results in mTOR activation following amino acid stimulation (Fig. 5a), indicating that it is their exchange factor roles that elicit mTORC1 activation.
Identifier Residue Sequence Organism Cell Line
SIGNOR-268015 Homo sapiens HeLa Cell
pmid sentence
Leucine and Glutamine Activate Glutaminolysis and mTORC1
Publications: 2 Organism: Homo Sapiens
+ AMPKdown-regulates activity img/direct_inhibition.png phosphorylation mTORC1 0.453
Identifier Residue Sequence Organism Cell Line
SIGNOR-216430 Homo sapiens HEK-293 Cell
pmid sentence
The phosphorylation of raptor by ampk is required for the inhibition of mtorc1 and cell-cycle arrest induced by energy stress.
Identifier Residue Sequence Organism Cell Line
SIGNOR-216422 Homo sapiens
pmid sentence
A recent study revealed that ampk can inhibit mtorc1 independently of tsc2 by phosphorylating raptor at ser863.
Identifier Residue Sequence Organism Cell Line
SIGNOR-209862 Homo sapiens
pmid sentence
AMPK inhibits mTORC1 through two means: first, through phosphorylation of TSC2 to activate its GAP (GTPase-activating protein) activity that converts Rheb into an inactive GDP-bound state, thus switching off mitogenic stimulation of mTORC1 [31], and, secondly, through phosphorylation of raptor at Ser722 and Ser792, which leads to 14-3-3 protein binding and mTORC1 inhibition
Identifier Residue Sequence Organism Cell Line
SIGNOR-216418 Mus musculus MEF Cell
pmid sentence
AMP-activated protein kinase (AMPK), which is activated by LKB1/Strad/Mo25 upon high AMP levels, stimulates autophagy by inhibiting mTORC1.
Publications: 4 Organism: Homo Sapiens, Mus Musculus
Pathways:AMPK Signaling, Autophagy
+ AKTup-regulates activity img/direct-activation.png phosphorylation mTORC1 0.722
Identifier Residue Sequence Organism Cell Line
SIGNOR-217586 Homo sapiens
pmid sentence
Pras40 is an insulin-regulated inhibitor of the mtorc1 protein kinase. Insulin stimulates akt/pkb-mediated phosphorylation of pras40, which prevents its inhibition of mtorc1 in cells and in vitro. Phosphorylation of pras40 on thr246 by pkb/akt facilitates efficient phosphorylation of ser183 by mtorc1.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252817 Mus musculus 3T3-L1 Cell
pmid sentence
In examining the requirements for different Akt-mediated phosphorylation sites on TSC2, we find that only TSC2 mutants lacking all five previously identified Akt sites fully block insulin-stimulated mTORC1 signaling in reconstituted Tsc2 null cells, and this mutant also inhibits adipogenesis
Publications: 2 Organism: Homo Sapiens, Mus Musculus
Tissue: Muscle, Skeletal Muscle, Myotube
Pathways:AMPK Signaling, EGFR Signaling, Glioblastoma Multiforme, Insulin Signaling, Luminal Breast Cancer, mTOR in cancer, Pancreatic ductal adenocarcinoma (PDA), PI3K/AKT Signaling, Thyroid Hormone Metabolism, WNT/FLT3
+ MTMR3down-regulates activity img/direct_inhibition.png mTORC1 0.311
Identifier Residue Sequence Organism Cell Line
SIGNOR-245108 Homo sapiens HEK-293 Cell
pmid sentence
The PtdIns3-phosphatase MTMR3 interacts with mTORC1 and suppresses its activity.
Publications: 1 Organism: Homo Sapiens
Pathways:Autophagy
+ mTORC1up-regulates img/indirect-activation.png MYC 0.349
Identifier Residue Sequence Organism Cell Line
SIGNOR-256172 Homo sapiens
pmid sentence
MTORC1 and mTORC2 converge on c-Myc to control metabolic reprogramming in cancer. mTORC1 and mTORC2 conspire to link growth factor receptor–PI3K signaling with c-Myc-dependent metabolic reprogramming by controlling both c-Myc levels and activity
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR Signaling, mTOR in cancer, WNT/FLT3
+ mTORC1up-regulates activity img/indirect-activation.png Skeletal_muscle_differentiation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-256273 Mus musculus Satellite Cell
pmid sentence
Knockdown (KD) of either mTORC or its subunit Raptor delayed SC activation without influencing the differentiation program.
Publications: 1 Organism: Mus Musculus
Pathways:Thyroid Hormone Metabolism
+ MTORform complex img/form-complex.png binding mTORC1 0.898
Identifier Residue Sequence Organism Cell Line
SIGNOR-205615 Homo sapiens
pmid sentence
Depending on their binding partners and sensitivities to rapamycin, mtor resides in at least two distinct complexes, termed mtor complex 1 (mtorc1, containing raptor, fkbp12, pras40 and mlst8) and mtor complex 2 (mtorc2, containing rictor, sin1, protor and mlst8)
Publications: 1 Organism: Homo Sapiens
Pathways:Glioblastoma Multiforme, Pancreatic ductal adenocarcinoma (PDA)
+ TTI1up-regulates quantity by stabilization img/direct-activation.png binding mTORC1 0.604
Identifier Residue Sequence Organism Cell Line
SIGNOR-272002 Homo sapiens HEK-293 Cell
pmid sentence
MTOR exists in two distinct complexes, mTORC1 and mTORC2, that differ in their subunit composition. In this study, we identified KIAA0406 as a novel mTOR-interacting protein. Because it has sequence homology with Schizosaccharomyces pombe Tti1, we named it mammalian Tti1. Tti1 constitutively interacts with mTOR in both mTORC1 and mTORC2. Knockdown of Tti1 suppresses phosphorylation of both mTORC1 substrates (S6K1 and 4E-BP1) and an mTORC2 substrate (Akt) and also induces autophagy. Furthermore, using immunoprecipitation and size-exclusion chromatography analyses, we found that knockdown of either Tti1 or Tel2 causes disassembly of mTORC1 and mTORC2.
Publications: 1 Organism: Homo Sapiens
+ AKT2up-regulates activity img/direct-activation.png phosphorylation mTORC1 0.572
Identifier Residue Sequence Organism Cell Line
SIGNOR-236705 Homo sapiens HEK-293 Cell
pmid sentence
Insulin-stimulated phosphorylation of pras40 by akt/pkb suppresses its mtorc1 inhibitory activity.
Identifier Residue Sequence Organism Cell Line
SIGNOR-235967 Homo sapiens
pmid sentence
Furthermore, pras40 phosphorylation by akt and association with 14-3-3, a cytosolic anchor protein, are crucial for insulin to stimulate mtor. These findings identify pras40 as an important regulator of insulin sensitivity of the akt-mtor pathway and a potential target for the treatment of cancers, insulin resistance and hamartoma syndromes.
Publications: 2 Organism: Homo Sapiens
+ GOLPH3up-regulates activity img/indirect-activation.png mTORC1 0.3
Identifier Residue Sequence Organism Cell Line
SIGNOR-253555 Homo sapiens
pmid sentence
Mechanistically, GOLPH3 regulates cell size, enhances growth factor-induced mTOR signaling in human cancer cells and alters response to mTOR inhibitor in vivo.
Publications: 1 Organism: Homo Sapiens
+ mTORC1down-regulates img/direct_inhibition.png phosphorylation ULK1 0.626
Identifier Residue Sequence Organism Cell Line
SIGNOR-217133 Homo sapiens
pmid sentence
The complementary inhibitory mechanism in which mtorc1 phosphorylates the autophagy regulatory complex containing unc-51-like kinase 1 (ulk1), the mammalian atg13 protein, and focal adhesion kinase interacting protein of 200 kd (fip200) has also been elucidated.
Publications: 1 Organism: Homo Sapiens
+ PIH1D1up-regulates quantity by stabilization img/direct-activation.png binding mTORC1 0.343
Identifier Residue Sequence Organism Cell Line
SIGNOR-265897 Homo sapiens MCF-7 Cell
pmid sentence
PIH1D1 interacts with mTOR complex 1 and enhances ribosome RNA transcription.PIH1D1 is important for mTORC1 assembly
Publications: 1 Organism: Homo Sapiens
+ RPS6Kup-regulates activity img/direct-activation.png phosphorylation mTORC1 0.472
Identifier Residue Sequence Organism Cell Line
SIGNOR-252796 Homo sapiens HEK-293 Cell
pmid sentence
The mitogen-activated protein kinase (mapk)-activated kinase, p90 ribosomal s6 kinase (rsk) 1, was found to interact with and phosphorylate tuberin at a regulatory site, ser-1798, located at the evolutionarily conserved c terminus of tuberin. Rsk1 phosphorylation of ser-1798 inhibits the tumor suppressor function of the tuberin/hamartin complex, resulting in increased mtor signaling to s6k1
Publications: 1 Organism: Homo Sapiens
Pathways:PI3K/AKT Signaling
+ mTORC1up-regulates img/direct-activation.png phosphorylation GRB10 0.365
Identifier Residue Sequence Organism Cell Line
SIGNOR-217063 Homo sapiens
pmid sentence
The adaptor protein grb10 was identified as an mtorc1 substrate that mediates the phosphoinositide 3-kinase.
Publications: 1 Organism: Homo Sapiens
+ DEPTORdown-regulates activity img/direct_inhibition.png binding mTORC1 0.72
Identifier Residue Sequence Organism Cell Line
SIGNOR-251658 Homo sapiens HEK-293 Cell
pmid sentence
DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival
Publications: 1 Organism: Homo Sapiens
+ arginineup-regulates activity img/indirect-activation.png mTORC1 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-268013 Homo sapiens HeLa Cell
pmid sentence
 Importantly, asparagine/glutamine pre-load only results in mTOR activation following amino acid stimulation (Fig. 5a), indicating that it is their exchange factor roles that elicit mTORC1 activation.
Publications: 1 Organism: Homo Sapiens
+ mTORC1up-regulates quantity by expression img/indirect-activation.png ATP6V1A 0.261
Identifier Residue Sequence Organism Cell Line
SIGNOR-260636 Mus musculus
pmid sentence
These data suggested that V-ATPase mRNA levels were upregulated by mTORC1 through a transcriptional mechanism. Tfeb is required for mTORC1-induced V-ATPase expression.
Publications: 1 Organism: Mus Musculus
+ TELO2up-regulates quantity by stabilization img/direct-activation.png binding mTORC1 0.533
Identifier Residue Sequence Organism Cell Line
SIGNOR-272001 Homo sapiens HEK-293 Cell
pmid sentence
MTOR exists in two distinct complexes, mTORC1 and mTORC2, that differ in their subunit composition. In this study, we identified KIAA0406 as a novel mTOR-interacting protein. Because it has sequence homology with Schizosaccharomyces pombe Tti1, we named it mammalian Tti1. Tti1 constitutively interacts with mTOR in both mTORC1 and mTORC2. Knockdown of Tti1 suppresses phosphorylation of both mTORC1 substrates (S6K1 and 4E-BP1) and an mTORC2 substrate (Akt) and also induces autophagy. Furthermore, using immunoprecipitation and size-exclusion chromatography analyses, we found that knockdown of either Tti1 or Tel2 causes disassembly of mTORC1 and mTORC2.
Publications: 1 Organism: Homo Sapiens
+ RAB1Aup-regulates activity img/direct-activation.png binding mTORC1 0.32
Identifier Residue Sequence Organism Cell Line
SIGNOR-261286 Homo sapiens HEK-293 Cell
pmid sentence
Hemagglutinin (HA)-Rab1A is associated with mTOR and Raptor, not Rictor (Figure S2A), and is bound more with Myc-Raptor than Myc-mTOR (Figures S2B and S2C).|Rab1A Is an mTORC1 Activator and a Colorectal Oncogene
Publications: 1 Organism: Homo Sapiens
+ mTORC1down-regulates activity img/indirect_inhibition.png Lysosome fusion 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-277786 Homo sapiens
pmid sentence
The fusion of matured macropinosomes with lysosomes is promoted by TRPML1, and degradation of macropinosomes is inhibited by mTORC1.
Publications: 1 Organism: Homo Sapiens
+ RRAGDup-regulates img/direct-activation.png binding mTORC1 0.639
Identifier Residue Sequence Organism Cell Line
SIGNOR-217550 Homo sapiens
pmid sentence
Active rag and gtr heterodimers are able to bind and activate torc1, through direct interactions with raptor
Publications: 1 Organism: Homo Sapiens
+ mTORC1up-regulates img/indirect-activation.png HIF1A 0.368
Identifier Residue Sequence Organism Cell Line
SIGNOR-167187 Homo sapiens
pmid sentence
Hif1alfa is the transcription factor downstream of mtorc1 in the control of glycolytic genes.
Publications: 1 Organism: Homo Sapiens
+ CILK1up-regulates img/direct-activation.png phosphorylation mTORC1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-217562 Homo sapiens
pmid sentence
Our findings demonstrate an important role for ick in modulating the activity of mtorc1 through phosphorylation of raptor thr-908 and thus implicate a potential signaling mechanism by which ick regulates cell proliferation and division.
Publications: 1 Organism: Homo Sapiens
+ AKT1up-regulates activity img/direct-activation.png phosphorylation mTORC1 0.722
Identifier Residue Sequence Organism Cell Line
SIGNOR-252539 Homo sapiens
pmid sentence
Pras40 is an insulin-regulated inhibitor of the mtorc1 protein kinase. Insulin stimulates akt/pkb-mediated phosphorylation of pras40, which prevents its inhibition of mtorc1 in cells and in vitro. Phosphorylation of pras40 on thr246 by pkb/akt facilitates efficient phosphorylation of ser183 by mtorc1.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252540 Homo sapiens
pmid sentence
Phosphorylation of pras40-thr246 by pkb/akt, and pras40-ser183 and pras40-ser221 by mtorc1 results in dissociation from mtorc1, and its binding to 14-3-3 proteins.
Publications: 2 Organism: Homo Sapiens
Pathways:Glioblastoma Multiforme
+ SMAD1/5/8/SMAD4up-regulates activity img/indirect-activation.png mTORC1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-256487 Mus musculus
pmid sentence
The BMP pathway is a positive regulator of muscle mass. Increasing the expression of BMP7 or the activity of BMP receptors in muscles induced hypertrophy that was dependent on Smad1/5-mediated activation of mTOR signaling
Publications: 1 Organism: Mus Musculus
Tissue: Muscle
+ mTORC1down-regulates quantity by repression img/indirect_inhibition.png translation regulation APOB 0.274
Identifier Residue Sequence Organism Cell Line
SIGNOR-252117 Homo sapiens
pmid sentence
Activation of mTORC1 also has dual effects on ApoB synthesis: it inhibits ApoB secretion by decreasing ApoB translation, but promotes ApoB secretion by inhibiting sortilin.
Publications: 1 Organism: Homo Sapiens
+ RRAGCup-regulates img/direct-activation.png binding mTORC1 0.69
Identifier Residue Sequence Organism Cell Line
SIGNOR-217547 Homo sapiens
pmid sentence
Active rag and gtr heterodimers are able to bind and activate torc1, through direct interactions with raptor.
Publications: 1 Organism: Homo Sapiens
+ RPS6KA1up-regulates img/direct-activation.png phosphorylation mTORC1 0.47
Identifier Residue Sequence Organism Cell Line
SIGNOR-217553 Homo sapiens
pmid sentence
Ser719, ser721, and ser722 are the predominant rsk-dependent phosphorylation sites in raptor raptor phosphorylation regulates mtorc1 activity
Publications: 1 Organism: Homo Sapiens
Pathways:AMPK Signaling
+ TBCKup-regulates activity img/indirect-activation.png mTORC1 0.254
Identifier Residue Sequence Organism Cell Line
SIGNOR-266699 Homo sapiens Brain
pmid sentence
TBCK included two types of alternatively spliced isoforms (long TBCK and short TBCK). Although there is a long way to go to fully understand the function of TBCK, recent research indicates that TBCK plays an important role in brain development. BCK deficiency would disturb activation of the mTOR complex 1 (mTORC1), thus, affecting the autophagy process and further leading to autophagosomal-lysosomal dysfunction
Publications: 1 Organism: Homo Sapiens
+ Gbeta img/unknown.png phosphorylation mTORC1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270027 Homo sapiens
pmid sentence
We found three proline-directed residues within raptor, ser(8), ser(696), and ser(863), which are directly phosphorylated by erk1/2. Expression of phosphorylation-deficient alleles of raptor revealed that phosphorylation of these sites by erk1/2 normally promotes mtorc1 activity and signaling to downstream substrates, such as 4e-bp1.
Publications: 1 Organism: Homo Sapiens
+ MAPK3 img/unknown.png phosphorylation mTORC1 0.392
Identifier Residue Sequence Organism Cell Line
SIGNOR-217577 Homo sapiens
pmid sentence
We found three proline-directed residues within raptor, ser(8), ser(696), and ser(863), which are directly phosphorylated by erk1/2. Expression of phosphorylation-deficient alleles of raptor revealed that phosphorylation of these sites by erk1/2 normally promotes mtorc1 activity and signaling to downstream substrates, such as 4e-bp1.
Publications: 1 Organism: Homo Sapiens
+ ERK1/2 img/unknown.png phosphorylation mTORC1 0.4
Identifier Residue Sequence Organism Cell Line
SIGNOR-270150 Homo sapiens
pmid sentence
We found three proline-directed residues within raptor, ser(8), ser(696), and ser(863), which are directly phosphorylated by erk1/2. Expression of phosphorylation-deficient alleles of raptor revealed that phosphorylation of these sites by erk1/2 normally promotes mtorc1 activity and signaling to downstream substrates, such as 4e-bp1.
Publications: 1 Organism: Homo Sapiens
Pathways:AMPK Signaling, EGFR Signaling, Glioblastoma Multiforme, Insulin Signaling, Luminal Breast Cancer, Pancreatic ductal adenocarcinoma (PDA), PI3K/AKT Signaling, WNT/FLT3
+ mTORC1up-regulates activity img/direct-activation.png phosphorylation BTRC 0.29
Identifier Residue Sequence Organism Cell Line
SIGNOR-267829 Mus musculus MEF Cell
pmid sentence
mTORC1 regulates the stability of CREB2. Our data suggest that mTORC1 promotes the binding of the E3 ligase, βTrCP, to CREB2 (Figure 4D), promoting CREB2 degradation by the proteasome (Figure 4E). Here, we show that mTORC1 promotes glutamine anaplerosis by activating glutamate dehydrogenase (GDH). This regulation requires transcriptional repression of SIRT4, the mitochondrial-localized sirtuin that inhibits GDH. Mechanistically, mTORC1 represses SIRT4 by promoting the proteasome-mediated destabilization of cAMP-responsive element binding 2 (CREB2).
Publications: 1 Organism: Mus Musculus
+ LARP1up-regulates activity img/direct-activation.png binding mTORC1 0.306
Identifier Residue Sequence Organism Cell Line
SIGNOR-260993 Homo sapiens HEK-293T Cell
pmid sentence
LARP1-mTORC1 interaction occurs through direct protein-protein contacts. phosphorylated LARP1 facilitates mTORC1-dependent phosphorylation of S6K1 and 4EBP1 on the LARP1-containing mRNPs by scaffolding mTORC1.
Publications: 1 Organism: Homo Sapiens
+ sirolimusdown-regulates img/direct_inhibition.png chemical inhibition mTORC1 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-219385 in vitro
pmid sentence
Rapamycin is an immunosuppressive drug that binds simultaneously to the 12-kDa FK506- and rapamycin-binding protein (FKBP12, or FKBP) and the FKBP-rapamycin binding (FRB) domain of the mammalian target of rapamycin (mTOR) kinase. The resulting ternary complex has been used to conditionally perturb protein function, and one such method involves perturbation of a protein of interest through its mislocalization.
Publications: 1 Organism: In Vitro
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