Relation Results

Summary

Name AM/b2 integrin
Primary ID SIGNOR-C170
Links CPX-1826
Type complex
Formed by ITGAM, ITGB2
Relations 9

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Type: Score: Layout: SPV 
0.7440.460.70.3010.5670.3180.70.4150.744ITGAMAM/b2 integrinPTK2Cell_adhesionDOK1TLN1ITGB1BP1ECMKindlinITGB2

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Relations
Regulator
Mechanism
target
score ℹ
+ ITGAMform complex img/form-complex.png binding AM/b2 integrin 0.744
Identifier Residue Sequence Organism Cell Line
SIGNOR-253191
pmid sentence
Integrins are one of the major families of cell adhesion receptors (Humphries, 2000; Hynes, 2002). All integrins are non-covalently-linked, heterodimeric molecules containing an α and a β subunit. Both subunits are type I transmembrane proteins, containing large extracellular domains and mostly short cytoplasmic domains (Springer and Wang, 2004; Arnaout et al., 2005). Mammalian genomes contain 18 α subunit and 8 β subunit genes, and to date 24 different α,β combinations have been identified at the protein level. Although some subunits only appear in a single heterodimer, twelve integrins contain the β1 subunit, and five contain αV.
Publications: 1
+ AM/b2 integrinup-regulates activity img/indirect-activation.png PTK2 0.46
Identifier Residue Sequence Organism Cell Line
SIGNOR-257713 Homo sapiens
pmid sentence
Focal adhesion kinase (FAK) is activated by growth factors and integrins during migration, and functions as a receptor-proximal regulator of cell motility. At contacts between cells and the extracellular matrix, FAK functions as an adaptor protein to recruit other focal contact proteins or their regulators, which affects the assembly or disassembly of focal contacts. Whereas it was first hypothesized that FAK might bind directly to the cytoplasmic tails of integrins, accumulated evidence supports an indirect association of FAK with integrins through binding to integrin-associated proteins such as paxillin and talin.
Publications: 1 Organism: Homo Sapiens
+ AM/b2 integrinup-regulates img/indirect-activation.png Cell_adhesion 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-269019 Homo sapiens
pmid sentence
Integrin-mediated cell adhesion is important for development, immune responses, hemostasis and wound healing.
Publications: 1 Organism: Homo Sapiens
+ DOK1down-regulates activity img/direct_inhibition.png binding AM/b2 integrin 0.301
Identifier Residue Sequence Organism Cell Line
SIGNOR-257682 Homo sapiens
pmid sentence
Integrins also bind to many PTBdomain-containing proteins (Calderwood et al., 2003) – including Dok1 and integrincytoplasmic-domain-associated protein 1 (ICAP1) – and these can compete with talin for binding to integrin and so can impair activation
Publications: 1 Organism: Homo Sapiens
+ TLN1up-regulates activity img/direct-activation.png binding AM/b2 integrin 0.567
Identifier Residue Sequence Organism Cell Line
SIGNOR-257620 Mus musculus Blood Platelet
pmid sentence
Over the past 10 years, the binding of talin to the cytoplasmic tail of integrin-β subunits has been established to have a key role in integrin activation. Binding of the phosphotyrosinebinding (PTB)-domain-like subdomain of the protein 4.1, ezrin, radixin, moesin (FERM) domain of talin to the conserved WxxxNP(I/L)Y motif of the β-integrin tail permits additional weaker interactions between talin and the membrane-proximal region of the tail that trigger integrin activation, probably through the disruption of inhibitory interactions between α- and β-subunit cytoplasmic tails.
Publications: 1 Organism: Mus Musculus
+ ITGB1BP1down-regulates activity img/direct_inhibition.png binding AM/b2 integrin 0.318
Identifier Residue Sequence Organism Cell Line
SIGNOR-257651 Homo sapiens
pmid sentence
Integrins also bind to many PTBdomain-containing proteins (Calderwood et al., 2003) – including Dok1 and integrincytoplasmic-domain-associated protein 1 (ICAP1) – and these can compete with talin for binding to integrin and so can impair activation
Publications: 1 Organism: Homo Sapiens
+ ECMup-regulates img/direct-activation.png AM/b2 integrin 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-259052 Homo sapiens
pmid sentence
Upon binding to the extracellular matrix (ECM), the integrins organize the cytoskeleton and activate intracellular signaling, regulating complex cellular behaviors, including survival, proliferation, migration, and various cell fate transitions
Publications: 1 Organism: Homo Sapiens
+ Kindlinup-regulates activity img/direct-activation.png binding AM/b2 integrin 0.415
Identifier Residue Sequence Organism Cell Line
SIGNOR-259025 Homo sapiens
pmid sentence
Kindlins bind with β-integrin cytoplasmic tails and execute broad biological functions including directed cell migration, proliferation, differentiation and survival.
Publications: 1 Organism: Homo Sapiens
+ ITGB2form complex img/form-complex.png binding AM/b2 integrin 0.744
Identifier Residue Sequence Organism Cell Line
SIGNOR-253192
pmid sentence
Integrins are one of the major families of cell adhesion receptors (Humphries, 2000; Hynes, 2002). All integrins are non-covalently-linked, heterodimeric molecules containing an α and a β subunit. Both subunits are type I transmembrane proteins, containing large extracellular domains and mostly short cytoplasmic domains (Springer and Wang, 2004; Arnaout et al., 2005). Mammalian genomes contain 18 α subunit and 8 β subunit genes, and to date 24 different α,β combinations have been identified at the protein level. Although some subunits only appear in a single heterodimer, twelve integrins contain the β1 subunit, and five contain αV.
Publications: 1
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