Relation Results

Summary

Name AL/b2 integrin
Primary ID SIGNOR-C169
Links CPX-1825
Type complex
Formed by ITGAL, ITGB2
Relations 13

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Type: Score: Layout: SPV 
0.9120.4490.9120.4440.4250.3170.70.5920.530.70.4640.8310.3ITGALAL/b2 integrinPTK2ITGB2KindlinRAP1BITGB1BP1Cell_adhesionTLN1CD226ECMRAP1AICAM1DOK1

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Relations
Regulator
Mechanism
target
score ℹ
+ ITGALform complex img/form-complex.png binding AL/b2 integrin 0.912
Identifier Residue Sequence Organism Cell Line
SIGNOR-253189
pmid sentence
Integrins are one of the major families of cell adhesion receptors (Humphries, 2000; Hynes, 2002). All integrins are non-covalently-linked, heterodimeric molecules containing an α and a β subunit. Both subunits are type I transmembrane proteins, containing large extracellular domains and mostly short cytoplasmic domains (Springer and Wang, 2004; Arnaout et al., 2005). Mammalian genomes contain 18 α subunit and 8 β subunit genes, and to date 24 different α,β combinations have been identified at the protein level. Although some subunits only appear in a single heterodimer, twelve integrins contain the β1 subunit, and five contain αV.
Publications: 1
+ AL/b2 integrinup-regulates activity img/indirect-activation.png PTK2 0.449
Identifier Residue Sequence Organism Cell Line
SIGNOR-257712 Homo sapiens
pmid sentence
Focal adhesion kinase (FAK) is activated by growth factors and integrins during migration, and functions as a receptor-proximal regulator of cell motility. At contacts between cells and the extracellular matrix, FAK functions as an adaptor protein to recruit other focal contact proteins or their regulators, which affects the assembly or disassembly of focal contacts. Whereas it was first hypothesized that FAK might bind directly to the cytoplasmic tails of integrins, accumulated evidence supports an indirect association of FAK with integrins through binding to integrin-associated proteins such as paxillin and talin.
Publications: 1 Organism: Homo Sapiens
+ ITGB2form complex img/form-complex.png binding AL/b2 integrin 0.912
Identifier Residue Sequence Organism Cell Line
SIGNOR-253190
pmid sentence
Integrins are one of the major families of cell adhesion receptors (Humphries, 2000; Hynes, 2002). All integrins are non-covalently-linked, heterodimeric molecules containing an α and a β subunit. Both subunits are type I transmembrane proteins, containing large extracellular domains and mostly short cytoplasmic domains (Springer and Wang, 2004; Arnaout et al., 2005). Mammalian genomes contain 18 α subunit and 8 β subunit genes, and to date 24 different α,β combinations have been identified at the protein level. Although some subunits only appear in a single heterodimer, twelve integrins contain the β1 subunit, and five contain αV.
Publications: 1
+ Kindlinup-regulates activity img/direct-activation.png binding AL/b2 integrin 0.444
Identifier Residue Sequence Organism Cell Line
SIGNOR-259024 Homo sapiens
pmid sentence
Kindlins bind with β-integrin cytoplasmic tails and execute broad biological functions including directed cell migration, proliferation, differentiation and survival.
Publications: 1 Organism: Homo Sapiens
+ RAP1Bup-regulates activity img/direct-activation.png binding AL/b2 integrin 0.425
Identifier Residue Sequence Organism Cell Line
SIGNOR-253363 Mus musculus Pro-B-lymphocyte
pmid sentence
The critical cytoplasmic regions of the alphaL/beta2 integrin in Rap1-induced adhesion and migration|Rap1 is a potent inside-out signal that increases LFA-1 adhesive activity.
Publications: 1 Organism: Mus Musculus
+ ITGB1BP1down-regulates activity img/direct_inhibition.png binding AL/b2 integrin 0.317
Identifier Residue Sequence Organism Cell Line
SIGNOR-257650 Homo sapiens
pmid sentence
Integrins also bind to many PTBdomain-containing proteins (Calderwood et al., 2003) – including Dok1 and integrincytoplasmic-domain-associated protein 1 (ICAP1) – and these can compete with talin for binding to integrin and so can impair activation
Publications: 1 Organism: Homo Sapiens
+ AL/b2 integrinup-regulates img/indirect-activation.png Cell_adhesion 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-269018 Homo sapiens
pmid sentence
Integrin-mediated cell adhesion is important for development, immune responses, hemostasis and wound healing.
Publications: 1 Organism: Homo Sapiens
+ TLN1up-regulates activity img/direct-activation.png binding AL/b2 integrin 0.592
Identifier Residue Sequence Organism Cell Line
SIGNOR-257619 Mus musculus Blood Platelet
pmid sentence
Over the past 10 years, the binding of talin to the cytoplasmic tail of integrin-β subunits has been established to have a key role in integrin activation. Binding of the phosphotyrosinebinding (PTB)-domain-like subdomain of the protein 4.1, ezrin, radixin, moesin (FERM) domain of talin to the conserved WxxxNP(I/L)Y motif of the β-integrin tail permits additional weaker interactions between talin and the membrane-proximal region of the tail that trigger integrin activation, probably through the disruption of inhibitory interactions between α- and β-subunit cytoplasmic tails.
Publications: 1 Organism: Mus Musculus
+ CD226up-regulates img/indirect-activation.png AL/b2 integrin 0.53
Identifier Residue Sequence Organism Cell Line
SIGNOR-261427 Homo sapiens Natural Killer Cell
pmid sentence
CD226 and LFA-1 cooperate in cytotoxicity and cytokine secretion mediated by T and NK cells|These results were consistent with our observation that cross-linking CD226 with anti- CD226 mAb did not induce re-directed cytotoxicity against P815 by LFA-1-deficient LAD NK clones (Fig. 4D), suggesting a requirement for LFA-1 for CD226-mediated cytotoxicity.
Publications: 1 Organism: Homo Sapiens
+ ECMup-regulates img/direct-activation.png AL/b2 integrin 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-259051 Homo sapiens
pmid sentence
Upon binding to the extracellular matrix (ECM), the integrins organize the cytoskeleton and activate intracellular signaling, regulating complex cellular behaviors, including survival, proliferation, migration, and various cell fate transitions
Publications: 1 Organism: Homo Sapiens
+ RAP1Aup-regulates activity img/direct-activation.png binding AL/b2 integrin 0.464
Identifier Residue Sequence Organism Cell Line
SIGNOR-253362 Mus musculus Pro-B-lymphocyte
pmid sentence
The critical cytoplasmic regions of the alphaL/beta2 integrin in Rap1-induced adhesion and migration|Rap1 is a potent inside-out signal that increases LFA-1 adhesive activity.
Publications: 1 Organism: Mus Musculus
+ AL/b2 integrinup-regulates activity img/direct-activation.png binding ICAM1 0.831
Identifier Residue Sequence Organism Cell Line
SIGNOR-253364 Mus musculus Pro-B-lymphocyte
pmid sentence
The critical cytoplasmic regions of the alphaL/beta2 integrin in Rap1-induced adhesion and migration|Rap1 is a potent inside-out signal that increases LFA-1 adhesive activity.
Publications: 1 Organism: Mus Musculus
+ DOK1down-regulates activity img/direct_inhibition.png binding AL/b2 integrin 0.3
Identifier Residue Sequence Organism Cell Line
SIGNOR-257681 Homo sapiens
pmid sentence
Integrins also bind to many PTBdomain-containing proteins (Calderwood et al., 2003) – including Dok1 and integrincytoplasmic-domain-associated protein 1 (ICAP1) – and these can compete with talin for binding to integrin and so can impair activation
Publications: 1 Organism: Homo Sapiens
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