Relation Results

Summary

Name A5/b1 integrin
Primary ID SIGNOR-C163
Links CPX-1794
Type complex
Formed by ITGA5, ITGB1
Relations 21
Pathways myCAF signaling in PDAC

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Type: Score: Layout: SPV 
0.5950.3240.3210.5390.270.9130.360.3730.70.70.7470.20.20.2520.7440.70.7560.310.9130.20.738A5/b1 integrinPTK2ACANDOK1COL18A1DLL1ITGB1TGFBIKindlinECMActivated PSCa7/b1 integrinBCL2CCN2HOXD3TLN1Cell_adhesionITGB1BP1JAG1ITGA5NEU1FN1

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Relations
Regulator
Mechanism
target
score ℹ
+ A5/b1 integrinup-regulates activity img/indirect-activation.png PTK2 0.595
Identifier Residue Sequence Organism Cell Line
SIGNOR-257705 Homo sapiens
pmid sentence
Focal adhesion kinase (FAK) is activated by growth factors and integrins during migration, and functions as a receptor-proximal regulator of cell motility. At contacts between cells and the extracellular matrix, FAK functions as an adaptor protein to recruit other focal contact proteins or their regulators, which affects the assembly or disassembly of focal contacts. Whereas it was first hypothesized that FAK might bind directly to the cytoplasmic tails of integrins, accumulated evidence supports an indirect association of FAK with integrins through binding to integrin-associated proteins such as paxillin and talin.
Publications: 1 Organism: Homo Sapiens
+ ACANup-regulates activity img/direct-activation.png binding A5/b1 integrin 0.324
Identifier Residue Sequence Organism Cell Line
SIGNOR-266988 Homo sapiens Chondrocyte Cell Line
pmid sentence
Cartilage Oligomeric Matrix Protein/Thrombospondin 5 Supports Chondrocyte Attachment through Interaction with Integrins|We show that COMP/TSP5 can support chondrocyte attachment and that the RGD sequence in COMP/TSP5 and the integrin receptors alpha5beta1 and alphaVbeta3 on the chondrocytes are involved in mediating this attachment. The interactions of COMP/TSP5 with the integrins are dependent on COMP/TSP5 conformation.
Publications: 1 Organism: Homo Sapiens
+ DOK1down-regulates activity img/direct_inhibition.png binding A5/b1 integrin 0.321
Identifier Residue Sequence Organism Cell Line
SIGNOR-257674 Homo sapiens
pmid sentence
Integrins also bind to many PTBdomain-containing proteins (Calderwood et al., 2003) – including Dok1 and integrincytoplasmic-domain-associated protein 1 (ICAP1) – and these can compete with talin for binding to integrin and so can impair activation
Publications: 1 Organism: Homo Sapiens
+ COL18A1up-regulates img/direct-activation.png binding A5/b1 integrin 0.539
Identifier Residue Sequence Organism Cell Line
SIGNOR-99871 Homo sapiens
pmid sentence
The activity of human endostatin is mediated by alpha 5 beta 1 integrin.
Publications: 1 Organism: Homo Sapiens
+ A5/b1 integrinup-regulates quantity by expression img/indirect-activation.png DLL1 0.27
Identifier Residue Sequence Organism Cell Line
SIGNOR-253286 Mus musculus
pmid sentence
First, EPCs incorporated into the neovascular region recognize the TGFBIp secreted by cells in the environment via binding to integrins a4 and a5. Second, binding of TGFBIp to integrins in EPCs induces phosphorylation of intracellular signaling molecules in a pathway necessary for TGFBIp-mediated angiogenic activity of EPCs. In addition, binding of TGFBIp to integrins activates the NF-kappaB signaling pathway that induces expression of DLL1 and JAG1 in EPCs.
Publications: 1 Organism: Mus Musculus
+ ITGB1form complex img/form-complex.png binding A5/b1 integrin 0.913
Identifier Residue Sequence Organism Cell Line
SIGNOR-253178
pmid sentence
Integrins are one of the major families of cell adhesion receptors (Humphries, 2000; Hynes, 2002). All integrins are non-covalently-linked, heterodimeric molecules containing an α and a β subunit. Both subunits are type I transmembrane proteins, containing large extracellular domains and mostly short cytoplasmic domains (Springer and Wang, 2004; Arnaout et al., 2005). Mammalian genomes contain 18 α subunit and 8 β subunit genes, and to date 24 different α,β combinations have been identified at the protein level. Although some subunits only appear in a single heterodimer, twelve integrins contain the β1 subunit, and five contain αV.
Publications: 1
+ TGFBIup-regulates activity img/direct-activation.png A5/b1 integrin 0.36
Identifier Residue Sequence Organism Cell Line
SIGNOR-253284 Mus musculus Endothelial Progenitor Cell
pmid sentence
First, EPCs incorporated into the neovascular region recognize the TGFBIp secreted by cells in the environment via binding to integrins a4 and a5. Second, binding of TGFBIp to integrins in EPCs induces phosphorylation of intracellular signaling molecules in a pathway necessary for TGFBIp-mediated angiogenic activity of EPCs. In addition, binding of TGFBIp to integrins activates the NF-kappaB signaling pathway that induces expression of DLL1 and JAG1 in EPCs.
Publications: 1 Organism: Mus Musculus
+ Kindlinup-regulates activity img/direct-activation.png binding A5/b1 integrin 0.373
Identifier Residue Sequence Organism Cell Line
SIGNOR-259017 Homo sapiens
pmid sentence
Kindlins bind with β-integrin cytoplasmic tails and execute broad biological functions including directed cell migration, proliferation, differentiation and survival.
Publications: 1 Organism: Homo Sapiens
+ ECMup-regulates img/direct-activation.png A5/b1 integrin 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-259046 Homo sapiens
pmid sentence
Upon binding to the extracellular matrix (ECM), the integrins organize the cytoskeleton and activate intracellular signaling, regulating complex cellular behaviors, including survival, proliferation, migration, and various cell fate transitions
Publications: 1 Organism: Homo Sapiens
+ A5/b1 integrinup-regulates img/direct-activation.png Activated PSC 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-277688 Homo sapiens
pmid sentence
CTGF is highly expressed in PDAC tissues, especially in tumor stroma (as shown by immunohistochemistry, CTGF: brown stain). The tumor cell-secreted CTGF promotes pancreatic stellate cell (PSC) proliferation, adhesion, and migration via integrin α5β1, leading to extracellular matrix (ECM) deposition.Pancreatic cancer cells secrete high levels of CTGF that binds to integrin α5β1, promoting PSC proliferation, adhesion, and migration
Publications: 1 Organism: Homo Sapiens
+ a7/b1 integrindown-regulates activity img/indirect_inhibition.png A5/b1 integrin 0.747
Identifier Residue Sequence Organism Cell Line
SIGNOR-253251
pmid sentence
These data indicate that alpha7 expression leads to the functional down regulation of alpha5beta1 integrin by decreasing ligand binding affinity and surface expression. In conclusion, the data reported establish the existence of a negative cooperativity between alpha7 and alpha5 integrins that may be important in determining functional regulation of integrins during myogenic differentiation.
Publications: 1
+ A5/b1 integrinup-regulates quantity img/indirect-activation.png BCL2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-253310
pmid sentence
Previous reports indicated that the prosurvival signal mediated through α5β1-fibronectin interactions was due to increased Bcl-2 levels
Publications: 1
+ CCN2up-regulates activity img/direct-activation.png binding A5/b1 integrin 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-277687 Homo sapiens
pmid sentence
CTGF is highly expressed in PDAC tissues, especially in tumor stroma (as shown by immunohistochemistry, CTGF: brown stain). The tumor cell-secreted CTGF promotes pancreatic stellate cell (PSC) proliferation, adhesion, and migration via integrin α5β1, leading to extracellular matrix (ECM) deposition.Pancreatic cancer cells secrete high levels of CTGF that binds to integrin α5β1, promoting PSC proliferation, adhesion, and migration
Publications: 1 Organism: Homo Sapiens
+ HOXD3up-regulates quantity by expression img/direct-activation.png transcriptional regulation A5/b1 integrin 0.252
Identifier Residue Sequence Organism Cell Line
SIGNOR-261650 Homo sapiens HMEC-1 Cell
pmid sentence
The homeobox transcription factor Hox D3 promotes integrin alpha5beta1 expression and function during angiogenesis.
Publications: 1 Organism: Homo Sapiens
+ TLN1up-regulates activity img/direct-activation.png binding A5/b1 integrin 0.744
Identifier Residue Sequence Organism Cell Line
SIGNOR-257612 Mus musculus Blood Platelet
pmid sentence
Over the past 10 years, the binding of talin to the cytoplasmic tail of integrin-β subunits has been established to have a key role in integrin activation. Binding of the phosphotyrosinebinding (PTB)-domain-like subdomain of the protein 4.1, ezrin, radixin, moesin (FERM) domain of talin to the conserved WxxxNP(I/L)Y motif of the β-integrin tail permits additional weaker interactions between talin and the membrane-proximal region of the tail that trigger integrin activation, probably through the disruption of inhibitory interactions between α- and β-subunit cytoplasmic tails.
Publications: 1 Organism: Mus Musculus
+ A5/b1 integrinup-regulates img/indirect-activation.png Cell_adhesion 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-269012 Homo sapiens
pmid sentence
Integrin-mediated cell adhesion is important for development, immune responses, hemostasis and wound healing.
Publications: 1 Organism: Homo Sapiens
+ ITGB1BP1down-regulates activity img/direct_inhibition.png binding A5/b1 integrin 0.756
Identifier Residue Sequence Organism Cell Line
SIGNOR-257643 Homo sapiens
pmid sentence
Integrins also bind to many PTBdomain-containing proteins (Calderwood et al., 2003) – including Dok1 and integrincytoplasmic-domain-associated protein 1 (ICAP1) – and these can compete with talin for binding to integrin and so can impair activation
Publications: 1 Organism: Homo Sapiens
+ A5/b1 integrinup-regulates quantity by expression img/indirect-activation.png JAG1 0.31
Identifier Residue Sequence Organism Cell Line
SIGNOR-253288 Mus musculus
pmid sentence
First, EPCs incorporated into the neovascular region recognize the TGFBIp secreted by cells in the environment via binding to integrins a4 and a5. Second, binding of TGFBIp to integrins in EPCs induces phosphorylation of intracellular signaling molecules in a pathway necessary for TGFBIp-mediated angiogenic activity of EPCs. In addition, binding of TGFBIp to integrins activates the NF-kappaB signaling pathway that induces expression of DLL1 and JAG1 in EPCs.
Publications: 1 Organism: Mus Musculus
+ ITGA5form complex img/form-complex.png binding A5/b1 integrin 0.913
Identifier Residue Sequence Organism Cell Line
SIGNOR-253177
pmid sentence
Integrins are one of the major families of cell adhesion receptors (Humphries, 2000; Hynes, 2002). All integrins are non-covalently-linked, heterodimeric molecules containing an α and a β subunit. Both subunits are type I transmembrane proteins, containing large extracellular domains and mostly short cytoplasmic domains (Springer and Wang, 2004; Arnaout et al., 2005). Mammalian genomes contain 18 α subunit and 8 β subunit genes, and to date 24 different α,β combinations have been identified at the protein level. Although some subunits only appear in a single heterodimer, twelve integrins contain the β1 subunit, and five contain αV.
Publications: 1
+ NEU1down-regulates activity img/direct_inhibition.png binding A5/b1 integrin 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-260658 Homo sapiens YTS-1 Cell
pmid sentence
NEU1 disrupts FN/ α5β1 interaction. taken together, strongly indicate that overexpressed NEU1 inhibits the Akt pathway by disrupting FN-integrin α5β1 interaction.
Publications: 1 Organism: Homo Sapiens
+ FN1up-regulates activity img/direct-activation.png binding A5/b1 integrin 0.738
Identifier Residue Sequence Organism Cell Line
SIGNOR-253250 Homo sapiens K-562 Cell
pmid sentence
We have developed a cell-free assay for binding of solubilized beta1 integrins to their physiologically relevant ligands using an electrochemiluminescent detection method|Binding was clearly optimal for the presumed physiological ligands, i.e., collagen IV for a1b1, collagen I for a2b1, VCAM-Ig for a4b1, fibronectin (the 120-kDa cell attachment fragment was used) for a5b1, and laminin for a6b1.
Publications: 1 Organism: Homo Sapiens
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