Relation Results

Summary

Name IKK-complex
Primary ID SIGNOR-C14
Links CPX-3269
Type complex
Formed by CHUK, IKBKB, IKBKG
Relations 42
Pathways B-cell activation, COVID-19 Causal Network, EBV infection, FLT3-ITD signaling, Innate Immune Response, IL1 Signaling , Inflammosome Activation, Inhibition of Apoptosis, Macrophage polarization, Macrophage: IL1 beta, Macrophage: Polarization and myogenesis, Macrophage: TNF alpha, Mitochondrial dynamics in T cell exhaustion, Multiple sclerosis, NF-KB Canonical, NF-KB Non Canonical, Pancreatic ductal adenocarcinoma (PDA), Satellite: IL1 , SARS-CoV INFLAMMATORY RESPONSE, SARS-CoV INNATE RESPONSE TO dsRNA, Satellite: TNFA, TNF-alpha Signaling, T cell activation, Toll like receptors, Tnfa_Notch_crosstalk

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Type: Score: Layout: SPV 
0.4160.2650.8860.9290.6190.20.5370.5350.2580.7190.5980.3830.6640.6460.8090.9290.8140.20.7760.20.6460.20.20.4420.8380.40.20.714IKK-complexNCOR2BADNFKBIAIKBKGCYLDMTURNFOXOFOXO3PRKAA2MAP3K7ERC1SRCRIPK1AKT1IKBKBNfKb-p65/p50CHUKRUNX1AKTEBNA1MAKT2AKT3HES1MAP3K14

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ IKK-complexdown-regulates img/direct_inhibition.png phosphorylation NCOR2 0.416
Identifier Residue Sequence Organism Cell Line
SIGNOR-216393 Ser2407 AKVSGRPsSRKAKSP Homo sapiens
pmid sentence
Nf-kappab transcription requires ikkalpha to phosphorylate smrt on chromatin, stimulating the exchange of corepressor for coactivator complexes. Ikk directly phosphorylates smrt to stimulate nuclear export. Ikkalpha orchestrates smrt derepression, a prerequisite for nf-kappab transcription and survival.
Publications: 1 Organism: Homo Sapiens
+ IKK-complexdown-regulates activity img/direct_inhibition.png phosphorylation BAD 0.265
Identifier Residue Sequence Organism Cell Line
SIGNOR-209776 Ser25 AERGLGPsPAGDGPS Mus musculus MEF Cell
pmid sentence
Ikk phosphorylates bad at serine-26 (ser26) and primes it for inactivation.
Publications: 1 Organism: Mus Musculus
Pathways:COVID-19 Causal Network, FLT3-ITD signaling, Inhibition of Apoptosis
+ IKK-complexdown-regulates img/direct_inhibition.png phosphorylation NFKBIA 0.886
Identifier Residue Sequence Organism Cell Line
SIGNOR-216385 Ser32 LLDDRHDsGLDSMKD Homo sapiens
pmid sentence
We described the purification of a 900 kda protein kinase complex, the ikb kinase (ikk), that phosphorylates ikbalfa and ikbbeta at the sites that mediate their ubiquitination and degradation
Identifier Residue Sequence Organism Cell Line
SIGNOR-216389 Ser36 RHDSGLDsMKDEEYE Homo sapiens
pmid sentence
We described the purification of a 900 kda protein kinase complex, the ikb kinase (ikk), that phosphorylates ikbalfa and ikbbeta at the sites that mediate their ubiquitination and degradation
Identifier Residue Sequence Organism Cell Line
SIGNOR-216396 Homo sapiens
pmid sentence
Tak1 become activated and then phosphorilates and activates ikk2 which in turn now phosphorylates ikba, marking it for k48-ubiquitination and proteasomal degradation
Publications: 3 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, EBV infection, FLT3-ITD signaling, IL1 Signaling , Inhibition of Apoptosis, Multiple sclerosis, NF-KB Canonical, Pancreatic ductal adenocarcinoma (PDA), TNF-alpha Signaling, T cell activation, Toll like receptors
+ IKK-complexdown-regulates quantity by destabilization img/direct_inhibition.png phosphorylation NFKBIA 0.886
Identifier Residue Sequence Organism Cell Line
SIGNOR-209773 Ser36 RHDSGLDsMKDEEYE Homo sapiens HeLa Cell
pmid sentence
We described the purification of a 900 kda protein kinase complex, the ikb kinase (ikk), that phosphorylates ikbalfa and ikbbeta at the sites that mediate their ubiquitination and degradation
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, EBV infection, FLT3-ITD signaling, IL1 Signaling , Inhibition of Apoptosis, Multiple sclerosis, NF-KB Canonical, Pancreatic ductal adenocarcinoma (PDA), TNF-alpha Signaling, T cell activation, Toll like receptors
+ IKK-complex img/unknown.png phosphorylation IKBKG 0.929
Identifier Residue Sequence Organism Cell Line
SIGNOR-209792 Ser376 PPAPAYLsSPLALPS Homo sapiens
pmid sentence
Phosphopeptide-mapping experiments with metabolically radiolabeled cells indicate that ikkbeta phosphorylates human ikkgamma at ser-31, ser-43, and ser-376
Identifier Residue Sequence Organism Cell Line
SIGNOR-216403 Ser43 PAMLHLPsEQGAPET Homo sapiens
pmid sentence
In this study we analyze the ikkbeta-mediated phosphorylation of the ikk-binding domain of nemo. In vitro, ikkbeta phosphorylates three serine residues in the domain of nemo at positions 43, 68, and 85. However, mutational analysis revealed that only the phosphorylation of serine 68 in the center of the ikk-binding domain plays an essential role for the formation and the function of the ikk complex. Thus, ser(68) phosphorylation attenuates the amino-terminal dimerization of nemo as well as the ikkbeta-nemo interaction. I
Publications: 2 Organism: Homo Sapiens
Pathways:EBV infection, IL1 Signaling , Inhibition of Apoptosis, NF-KB Canonical, Toll like receptors
+ IKK-complexdown-regulates activity img/direct_inhibition.png phosphorylation CYLD 0.619
Identifier Residue Sequence Organism Cell Line
SIGNOR-266435 Ser418 TTENRFHsLPFSLTK Homo sapiens JURKAT Cell
pmid sentence
In response to cellular stimuli, CYLD undergoes rapid and transient phosphorylation, which is required for signal-induced TRAF2 ubiquitination and activation of downstream signaling events. Interestingly, the CYLD phosphorylation requires IkappaB kinase gamma (IKKgamma) and can be induced by IKK catalytic subunits.
Publications: 1 Organism: Homo Sapiens
Pathways:NF-KB Canonical
+ IKK-complexdown-regulates activity img/direct_inhibition.png phosphorylation MTURN 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-273641 Ser58 GDNFHVWsESEDCLP Mus musculus MEF Cell
pmid sentence
Here we report that viral infection induced upregulation of INKIT, an inhibitor for NF-κB and IRF3 that restricted innate antiviral responses by blocking phosphorylation of p65 and IRF3. Viral infection induced IKK-mediated phosphorylation of INKIT at Ser58, resulting in its dissociation from the IKKs. INKIT is associated with IKKα/β and TBK1/IKKɛ and inhibits the recruitment and phosphorylation of p65 and IRF3, respectively. IKKα and TBK1 phosphorylate INKIT at Ser58, which results in disassociation of INKIT from IKKα or TBK1 and thereby allows for the subsequent recruitment and phosphorylation of p65 and IRF3
Publications: 1 Organism: Mus Musculus
+ IKK-complexdown-regulates quantity by destabilization img/direct_inhibition.png phosphorylation FOXO 0.537
Identifier Residue Sequence Organism Cell Line
SIGNOR-252951 Ser644 GLDFNFDsLISTQNV Homo sapiens
pmid sentence
Ikkbeta phosphorylates foxo3a at ser644. Ikappab kinase (ikk) physically interacts with, phosphorylates, and inhibits foxo3a independent of akt and causes proteolysis of foxo3a via the ub-dependent proteasome pathway
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling
+ IKK-complexdown-regulates img/direct_inhibition.png phosphorylation FOXO3 0.535
Identifier Residue Sequence Organism Cell Line
SIGNOR-216407 Ser644 GLDFNFDsLISTQNV Homo sapiens
pmid sentence
Ikappab kinase promotes tumorigenesis through inhibition of forkhead foxo3a. The tnf treatment of ht-29 cells increased ikk-dependent foxo3 ser644 phosphorylation.
Publications: 1 Organism: Homo Sapiens
Pathways:Inhibition of Apoptosis
+ IKK-complexdown-regulates img/direct_inhibition.png phosphorylation FOXO 0.537
Identifier Residue Sequence Organism Cell Line
SIGNOR-252950 Ser644 GLDFNFDsLISTQNV Homo sapiens Breast Cancer Cell
pmid sentence
Ikappab kinase promotes tumorigenesis through inhibition of forkhead foxo3a. The tnf treatment of ht-29 cells increased ikk-dependent foxo3 ser644 phosphorylation.
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling
+ IKK-complexdown-regulates quantity by destabilization img/direct_inhibition.png phosphorylation FOXO3 0.535
Identifier Residue Sequence Organism Cell Line
SIGNOR-209769 Ser644 GLDFNFDsLISTQNV Homo sapiens
pmid sentence
Ikkbeta phosphorylates foxo3a at ser644. Ikappab kinase (ikk) physically interacts with, phosphorylates, and inhibits foxo3a independent of akt and causes proteolysis of foxo3a via the ub-dependent proteasome pathway
Publications: 1 Organism: Homo Sapiens
Pathways:Inhibition of Apoptosis
+ IKK-complexdown-regulates activity img/direct_inhibition.png phosphorylation IKBKG 0.929
Identifier Residue Sequence Organism Cell Line
SIGNOR-209788 Ser68 LRDAIRQsNQILRER Homo sapiens
pmid sentence
In this study we analyze the ikkbeta-mediated phosphorylation of the ikk-binding domain of nemo. In vitro, ikkbeta phosphorylates three serine residues in the domain of nemo at positions 43, 68, and 85. However, mutational analysis revealed that only the phosphorylation of serine 68 in the center of the ikk-binding domain plays an essential role for the formation and the function of the ikk complex. Thus, ser(68) phosphorylation attenuates the amino-terminal dimerization of nemo as well as the ikkbeta-nemo interaction. I
Identifier Residue Sequence Organism Cell Line
SIGNOR-209784 Ser85 ELLHFQAsQREEKEF Homo sapiens
pmid sentence
In this study we analyze the ikkbeta-mediated phosphorylation of the ikk-binding domain of nemo. In vitro, ikkbeta phosphorylates three serine residues in the domain of nemo at positions 43, 68, and 85. However, mutational analysis revealed that only the phosphorylation of serine 68 in the center of the ikk-binding domain plays an essential role for the formation and the function of the ikk complex. Thus, ser(68) phosphorylation attenuates the amino-terminal dimerization of nemo as well as the ikkbeta-nemo interaction. I
Publications: 2 Organism: Homo Sapiens
Pathways:EBV infection, IL1 Signaling , Inhibition of Apoptosis, NF-KB Canonical, Toll like receptors
+ PRKAA2up-regulates img/direct-activation.png phosphorylation IKK-complex 0.258
Identifier Residue Sequence Organism Cell Line
SIGNOR-217457 Homo sapiens Monocyte
pmid sentence
These results demonstrate that the ikk is a direct substrate of ampk_2 and that its phosphorylation on ser177 and ser181no initiates the activation of the ampk_2 in endothelial cells which in turn phosphorylates and activates the _-subunit of the ikk. The latter also induces a higher rate of ikk auto-inactivation and thus attenuates the activation of nf_b and the expression of inflammatory genes
Publications: 1 Organism: Homo Sapiens
+ MAP3K7up-regulates img/direct-activation.png phosphorylation IKK-complex 0.719
Identifier Residue Sequence Organism Cell Line
SIGNOR-217445 Homo sapiens
pmid sentence
Tak1 kinase complex phosphorylates and activates ikk in a manner that depends on traf6 and ubc13-uev1a
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, EBV infection, IL1 Signaling , Inflammosome Activation, Inhibition of Apoptosis, NF-KB Canonical, SARS-CoV INFLAMMATORY RESPONSE, Toll like receptors
+ MAP3K7up-regulates activity img/direct-activation.png phosphorylation IKK-complex 0.719
Identifier Residue Sequence Organism Cell Line
SIGNOR-256024 Homo sapiens
pmid sentence
RIP-1 recruitment of MEKK-3 and transforming growth factor-beta (TGFbeta)-activated kinase (TAK1) subsequently activates the IKK (inhibitor of κB kinase) complex
Identifier Residue Sequence Organism Cell Line
SIGNOR-209759 Homo sapiens
pmid sentence
Tak1 become activated and then phosphorilates and activates ikk2 whic in turn now phosphorylates ikba, marking it for k48-ubiquitination and proteasomal degradation.
Publications: 2 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, EBV infection, IL1 Signaling , Inflammosome Activation, Inhibition of Apoptosis, NF-KB Canonical, SARS-CoV INFLAMMATORY RESPONSE, Toll like receptors
+ ERC1up-regulates img/direct-activation.png binding IKK-complex 0.598
Identifier Residue Sequence Organism Cell Line
SIGNOR-217448 Homo sapiens
pmid sentence
Elks likely functions by recruiting ikappabalpha to the ikk complex and thus serves a regulatory function for ikk activation.
Publications: 1 Organism: Homo Sapiens
+ SRCup-regulates img/direct-activation.png phosphorylation IKK-complex 0.383
Identifier Residue Sequence Organism Cell Line
SIGNOR-217439 Homo sapiens
pmid sentence
These results indicate that c-src can associate with ikkbeta and phosphorylate its tyrosine residues after tnf-alfa or tpa stimulation.
Identifier Residue Sequence Organism Cell Line
SIGNOR-217442 Homo sapiens
pmid sentence
These results indicate that c-src can associate with ikkbeta and phosphorylate its tyrosine residues after tnf-alfa or tpa stimulation.
Publications: 2 Organism: Homo Sapiens
+ RIPK1up-regulates activity img/direct-activation.png binding IKK-complex 0.664
Identifier Residue Sequence Organism Cell Line
SIGNOR-245026 Mus musculus Fibroblast
pmid sentence
We found that TNF-R1-mediated IKK activation requires both RIP and TRAF2 proteins. Although TRAF2 or RIP can be independently recruited to the TNF-R1 complex, neither one of them alone is capable of transducing the TNF signal that leads to IKK activation
Publications: 1 Organism: Mus Musculus
Pathways:COVID-19 Causal Network, Innate Immune Response, Inflammosome Activation, Macrophage polarization, Multiple sclerosis, NF-KB Canonical, SARS-CoV INFLAMMATORY RESPONSE, SARS-CoV INNATE RESPONSE TO dsRNA, TNF-alpha Signaling
+ AKT1up-regulates img/direct-activation.png phosphorylation IKK-complex 0.646
Identifier Residue Sequence Organism Cell Line
SIGNOR-217460 Homo sapiens Thymoma Cell
pmid sentence
Although there are likely to be multiple levels of crosstalk between the pi3k-akt and nf-kb pathways, one mechanism has been attributed to direct phosphorylation of the amino acid residue t23 on ikb kinase alfa (ikkalfa) by akt, thereby leading to activation of this kinase upstream of nf-kb akt mediates ikkalpha phosphorylation at threonine 23 akt transiently associates in vivo with ikk and induces ikk activation. Akt mediates ikkalfa phosphorylation at threonine 23.Akt phosphorylates ikkalpha on t23, and this phosphorylation event is a prerequisite for the phosphorylation of p65 at s534 by ikkalpha and beta
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling
+ IKBKBform complex img/form-complex.png binding IKK-complex 0.809
Identifier Residue Sequence Organism Cell Line
SIGNOR-164509 Homo sapiens
pmid sentence
The kinase(s) responsible for the phosphorylation of the ikb inhibitors remained elusive for many years, until the biochemical purification of a cytoplasmic high-molecular weight complex migrating around 700900 kda and containing two related catalytic subunits, ikkalfa and ikkbeta.
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling
+ IKBKGform complex img/form-complex.png binding IKK-complex 0.929
Identifier Residue Sequence Organism Cell Line
SIGNOR-217436 Homo sapiens
pmid sentence
The n-terminal domain of ikkgamma is required both for the binding of ikkalfa and ikkbeta and their assembly into a high-molecular-weight complex essential for activation
Identifier Residue Sequence Organism Cell Line
SIGNOR-209762 Mus musculus
pmid sentence
Proinflammatory NF-kappaB activation requires the IkappaB (inhibitor of NF-kappaB) kinase (IKK) complex that contains two catalytic subunits named IKKalpha and IKKbeta and a regulatory subunit named NF-kappaB essential modulator (NEMO).
Publications: 2 Organism: Homo Sapiens, Mus Musculus
Pathways:EBV infection, IL1 Signaling , Inhibition of Apoptosis, NF-KB Canonical, Toll like receptors
+ IKK-complexup-regulates img/direct-activation.png phosphorylation NfKb-p65/p50 0.814
Identifier Residue Sequence Organism Cell Line
SIGNOR-216341 Homo sapiens
pmid sentence
Chromatographic fractionation of cell extracts allowed the identification of two distinct enzymatic activities phosphorylating ser-536. Peak 1 represents an unknown kinase, whereas peak 2 contained ikkalpha, ikkbeta, ikkepsilon, and tbk1. collectively, our results provide evidence for at least five kinases that converge on ser-536 of p65 and a novel function for this phosphorylation site in the recruitment of components of the basal transcriptional machinery to the interleukin-8 promoter.
Identifier Residue Sequence Organism Cell Line
SIGNOR-216365 Homo sapiens HEK-293 Cell
pmid sentence
Our data suggest that the stimulation of nfkb by akt is dependent on the phosphorylation of p65 at s534, mediated by ikk (ikb kinase) alfa and beta.
Publications: 2 Organism: Homo Sapiens
Pathways:B-cell activation, COVID-19 Causal Network, EBV infection, FLT3-ITD signaling, Innate Immune Response, IL1 Signaling , Inflammosome Activation, Inhibition of Apoptosis, Macrophage polarization, Multiple sclerosis, NF-KB Canonical, Pancreatic ductal adenocarcinoma (PDA), SARS-CoV INFLAMMATORY RESPONSE, SARS-CoV INNATE RESPONSE TO dsRNA, TNF-alpha Signaling, T cell activation, Toll like receptors
+ MTURNdown-regulates activity img/direct_inhibition.png binding IKK-complex 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-273663 Mus musculus MEF Cell
pmid sentence
Here we report that viral infection induced upregulation of INKIT, an inhibitor for NF-κB and IRF3 that restricted innate antiviral responses by blocking phosphorylation of p65 and IRF3. Viral infection induced IKK-mediated phosphorylation of INKIT at Ser58, resulting in its dissociation from the IKKs. INKIT is associated with IKKα/β and TBK1/IKKɛ and inhibits the recruitment and phosphorylation of p65 and IRF3, respectively. IKKα and TBK1 phosphorylate INKIT at Ser58, which results in disassociation of INKIT from IKKα or TBK1 and thereby allows for the subsequent recruitment and phosphorylation of p65 and IRF3
Publications: 1 Organism: Mus Musculus
+ CHUKform complex img/form-complex.png binding IKK-complex 0.776
Identifier Residue Sequence Organism Cell Line
SIGNOR-164506 Homo sapiens
pmid sentence
The kinase(s) responsible for the phosphorylation of the ikb inhibitors remained elusive for many years, until the biochemical purification of a cytoplasmic high-molecular weight complex migrating around 700900 kda and containing two related catalytic subunits, ikkalfa and ikkbeta.
Publications: 1 Organism: Homo Sapiens
Pathways:NF-KB Non Canonical
+ RUNX1down-regulates activity img/direct_inhibition.png binding IKK-complex 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-255690 Homo sapiens
pmid sentence
We found that AML1 inhibits NF-κB signaling through interaction with IκB kinase complex in the cytoplasm. Remarkably, AML1 mutants found in myeloid tumors lack the ability to inhibit NF-κB signaling, and human cases with AML1-related leukemia exhibits distinctly activated NF-κB signaling
Publications: 1 Organism: Homo Sapiens
+ AKTup-regulates img/direct-activation.png phosphorylation IKK-complex 0.646
Identifier Residue Sequence Organism Cell Line
SIGNOR-244281 Homo sapiens Thymoma Cell
pmid sentence
Although there are likely to be multiple levels of crosstalk between the pi3k-akt and nf-kb pathways, one mechanism has been attributed to direct phosphorylation of the amino acid residue t23 on ikb kinase alfa (ikkalfa) by akt, thereby leading to activation of this kinase upstream of nf-kb akt mediates ikkalpha phosphorylation at threonine 23 akt transiently associates in vivo with ikk and induces ikk activation. Akt mediates ikkalfa phosphorylation at threonine 23.Akt phosphorylates ikkalpha on t23, and this phosphorylation event is a prerequisite for the phosphorylation of p65 at s534 by ikkalpha and beta
Publications: 1 Organism: Homo Sapiens
Pathways:B-cell activation, COVID-19 Causal Network, EBV infection, FLT3-ITD signaling, Inflammosome Activation, Inhibition of Apoptosis, Pancreatic ductal adenocarcinoma (PDA), SARS-CoV INFLAMMATORY RESPONSE, T cell activation
+ EBNA1down-regulates activity img/indirect_inhibition.png IKK-complex 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-266802 Homo sapiens
pmid sentence
EBNA1 has been reported to block p65 activation by inhibiting IKKα/β through an unknown mechanism, we suggest that, in NPC, NF-κB signaling and EBNA1 may form a regulatory loop which supports EBV latent gene expression, while also limiting NF-κB activity
Publications: 1 Organism: Homo Sapiens
Pathways:EBV infection
+ Mdown-regulates activity img/direct_inhibition.png binding IKK-complex 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-260261 Chlorocebus aethiops
pmid sentence
Together, these results indicate that SARS-CoV M suppresses NF-kappaB activity probably through a direct interaction with IKKbeta, resulting in lower Cox-2 expression.
Publications: 1 Organism: Chlorocebus Aethiops
Pathways:COVID-19 Causal Network, SARS-CoV INFLAMMATORY RESPONSE
+ AKT2up-regulates img/direct-activation.png phosphorylation IKK-complex 0.442
Identifier Residue Sequence Organism Cell Line
SIGNOR-217463 Homo sapiens Thymoma Cell
pmid sentence
Although there are likely to be multiple levels of crosstalk between the pi3k-akt and nf-kb pathways, one mechanism has been attributed to direct phosphorylation of the amino acid residue t23 on ikb kinase alfa (ikkalfa) by akt, thereby leading to activation of this kinase upstream of nf-kb akt mediates ikkalpha phosphorylation at threonine 23 akt transiently associates in vivo with ikk and induces ikk activation. Akt mediates ikkalfa phosphorylation at threonine 23.Akt phosphorylates ikkalpha on t23, and this phosphorylation event is a prerequisite for the phosphorylation of p65 at s534 by ikkalpha and beta
Publications: 1 Organism: Homo Sapiens
+ IKK-complexdown-regulates img/direct_inhibition.png phosphorylation IKK-complex 0.838
Identifier Residue Sequence Organism Cell Line
SIGNOR-216373 Homo sapiens
pmid sentence
Once activated, ikkbeta autophosphorylated at a carboxyl-terminal serine cluster. Such phosphorylation decreased ikk activity and may prevent prolonged activation of the inflammatory response
Publications: 1 Organism: Homo Sapiens
Pathways:B-cell activation, COVID-19 Causal Network, EBV infection, FLT3-ITD signaling, Innate Immune Response, IL1 Signaling , Inflammosome Activation, Inhibition of Apoptosis, Macrophage polarization, Multiple sclerosis, NF-KB Canonical, NF-KB Non Canonical, Pancreatic ductal adenocarcinoma (PDA), SARS-CoV INFLAMMATORY RESPONSE, SARS-CoV INNATE RESPONSE TO dsRNA, TNF-alpha Signaling, T cell activation, Toll like receptors
+ AKT3up-regulates img/direct-activation.png phosphorylation IKK-complex 0.4
Identifier Residue Sequence Organism Cell Line
SIGNOR-217466 Homo sapiens Thymoma Cell
pmid sentence
Although there are likely to be multiple levels of crosstalk between the pi3k-akt and nf-kb pathways, one mechanism has been attributed to direct phosphorylation of the amino acid residue t23 on ikb kinase alfa (ikkalfa) by akt, thereby leading to activation of this kinase upstream of nf-kb akt mediates ikkalpha phosphorylation at threonine 23 akt transiently associates in vivo with ikk and induces ikk activation. Akt mediates ikkalfa phosphorylation at threonine 23.Akt phosphorylates ikkalpha on t23, and this phosphorylation event is a prerequisite for the phosphorylation of p65 at s534 by ikkalpha and beta
Publications: 1 Organism: Homo Sapiens
+ IKK-complexup-regulates quantity by expression img/indirect-activation.png HES1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-253586 Homo sapiens
pmid sentence
Tnf-α enhanced the transcriptional activity of a classical Notch target gene via Ikk2 by inducing histone H3 phosphorylation
Publications: 1 Organism: Homo Sapiens
+ IKK-complexdown-regulates img/direct_inhibition.png phosphorylation BAD 0.265
Identifier Residue Sequence Organism Cell Line
SIGNOR-216399 Homo sapiens
pmid sentence
Ikk phosphorylates bad at serine-26 (ser26) and primes it for inactivation.
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, FLT3-ITD signaling, Inhibition of Apoptosis
+ MAP3K14up-regulates img/direct-activation.png phosphorylation IKK-complex 0.714
Identifier Residue Sequence Organism Cell Line
SIGNOR-217433 Homo sapiens
pmid sentence
Nf-kappab-inducing kinase activates ikk-alpha by phosphorylation of ser-176.Nik preferentially phosphorylates ikk-alpha over ikk-beta, leading to the activation of ikk-alpha kinase activity; the accumulated nik phosphorylates ikkalfa.
Publications: 1 Organism: Homo Sapiens
Pathways:Innate Immune Response, NF-KB Non Canonical
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