| + |
NFYA | form complex 
binding
|
NFY |
0.962 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-63013 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9885213 |
Nf-y is one of the best characterized ccaat binding proteins, and its unique structure and evolutionary conservation suggest that it plays a crucial role in transcription of eukaryotic genes.It Is a ubiquitous heteromeric transcription factor, composed of three subunits, nf-ya, nf-yb, and nf-yc, all necessary for dna binding. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NFYC | form complex
binding
|
NFY |
0.966 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-63019 |
|
|
Homo sapiens |
Macrophage, Monocyte |
| pmid |
sentence |
| 9885213 |
Nf-y is one of the best characterized ccaat binding proteins, and its unique structure and evolutionary conservation suggest that it plays a crucial role in transcription of eukaryotic genes.It Is a ubiquitous heteromeric transcription factor, composed of three subunits, nf-ya, nf-yb, and nf-yc, all necessary for dna binding. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NFY | up-regulates quantity by expression 
transcriptional regulation
|
ZDHHC5 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261151 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28775165 |
Mechanistic investigations revealed that mutant p53 transcriptionally upregulated ZDHHC5 along with the nuclear transcription factor NF-Y |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PML-RARalpha | up-regulates activity
binding
|
NFY |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255747 |
|
|
Homo sapiens |
HEP-3B Cell |
| pmid |
sentence |
| 18025157 |
We show that the ID1 and ID2 promoters are activated by PML-RARalpha but, unexpectedly, not by wild-type RARalpha/RXR. Our data support a model in which the PML-RARalpha fusion protein regulates a novel class of target genes by interaction with the Sp1 and NF-Y transcription factors, without directly binding to the DNA, defining a gain-of-function for the oncoprotein. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, FLT3 in AML |
| + |
NFY | up-regulates quantity by expression 
transcriptional regulation
|
CCNB2 |
0.371 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-65638 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10086339 |
In this study, we analysed the mechanisms leading to activation of the cyclin b2 ccaat boxes: a combination of (i) genomic footprinting, (ii) transfections with single, double and triple mutants, (iii) emsas with nuclear extracts, antibodies and nf-y recombinant proteins and (iv) transfections with an nf-ya dominant negative mutant established the positive role of the three ccaat sequences and proved that nf-y plays a crucial role in their activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NFY | up-regulates quantity by expression
transcriptional regulation
|
ID1 |
0.274 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255746 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18025157 |
We show that the ID1 and ID2 promoters are activated by PML-RARalpha but, unexpectedly, not by wild-type RARalpha/RXR. Our data support a model in which the PML-RARalpha fusion protein regulates a novel class of target genes by interaction with the Sp1 and NF-Y transcription factors, without directly binding to the DNA, defining a gain-of-function for the oncoprotein. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, FLT3 in AML |
| + |
NFYB | form complex
binding
|
NFY |
0.963 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-63016 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9885213 |
Nf-y is one of the best characterized ccaat binding proteins, and its unique structure and evolutionary conservation suggest that it plays a crucial role in transcription of eukaryotic genes.It Is a ubiquitous heteromeric transcription factor, composed of three subunits, nf-ya, nf-yb, and nf-yc, all necessary for dna binding. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NFY | up-regulates quantity by expression
transcriptional regulation
|
CCNB1 |
0.366 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235834 |
|
|
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 10362252 |
In conclusion, our data demonstrate that nf-y is required for cyclin b1 promoter activity. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Muscle, Skeletal Muscle |
| + |
NFY | up-regulates quantity by expression
transcriptional regulation
|
TOP2A |
0.276 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242526 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25328138 |
The expression of human TOP2A is controlled by its promoter region that contains two GC boxes and five CCAAT boxes. NF-Y recognizes and binds to the ICBs. This binding of NF-Y to the TOP2A promoter can be promoted by HMGB1/2 and inhibited by pRb. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
NFY
CPX-1956