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Symbol report for PPP1R11

HGNC data for PPP1R11

Approved symbol
PPP1R11
Approved name

protein phosphatase 1 regulatory inhibitor subunit 11

Locus type
gene with protein product
HGNC ID
HGNC:9285
Symbol status
Approved
Previous symbols
TCTE5
Previous names
protein phosphatase 1, regulatory (inhibitor) subunit 11
Alias symbols
HCGV
Tctex5
HCG-V
CFAP255
Chromosomal location
6p22.1
Bos taurus
PPP1R11 VGNC:33222 VGNC
Canis familiaris
PPP1R11 VGNC:44877 VGNC
Equus caballus
PPP1R11 VGNC:21754 VGNC
Macaca mulatta
PPP1R11 VGNC:82209 VGNC
Mus musculus
Ppp1r11 MGI:1923747 Curated
Pan troglodytes
PPP1R11 VGNC:11182 VGNC
Rattus norvegicus
Ppp1r11 RGD:1303163
Sus scrofa
PPP1R11 VGNC:91718 VGNC
Identification and characterization of the human HCG V gene product as a novel inhibitor of protein phosphatase-1.
Zhang J et al. Biochemistry 1998 Nov;37(47)16728-16734
Zhang J, Zhang L, Zhao S, Lee EY.
Biochemistry 1998 Nov;37(47)16728-16734
Abstract: The catalytic subunit of mammalian protein phosphatase-1 (PP1) is known to bind to a number of regulatory subunits, whose functions include the targeting of the catalytic subunit to the molecular proximity of its substrate proteins. In addition, PP1 is potently inhibited by several inhibitory polypeptides that include inhibitor-1 and inhibitor-2. In this study the yeast two-hybrid system was used to screen a human cDNA library for putative PP1-binding proteins. Ten putative positive clones were identified, one of which was found to be a partial cDNA of the hemochromatosis candidate gene V (HCG V) whose function was previously unknown. The full-length protein of 126 amino acid residues was expressed in Escherichia coli as a glutathione S-transferase fusion protein and also as a nonfusion protein. The recombinant protein inhibited recombinant and rabbit muscle protein phosphatase-1 with IC50s of ca. 1 nM, but did not inhibit PP2A. The term inhibitor-3 is proposed for this novel inhibitor. It is extremely hydrophilic, is heat stable, and behaves anomalously on SDS-PAGE with an apparent molecular mass of 23 kDa and on gel filtration with a relative molecular weight of 55 000, in contrast to its calculated molecular mass of 14 kDa. These characteristics are shared by the previously described protein phosphatase-1 inhibitor-2 and inhibitor-1 proteins.
Cloning of a human homologue of the mouse Tctex-5 gene within the MHC class I region.
Giffon T et al. Immunogenetics 1996 ;44(5)331-339
Giffon T, Lepourcelet M, Pichon L, Jezequel P, Bouric P, Carn G, Pontarotti P, Gall JY, David V.
Immunogenetics 1996 ;44(5)331-339
Abstract: Using a positional cloning strategy to identify the hemochromatosis gene (HFE), we isolated seven cDNAs by cDNA selection from a region of 400 kilobases (kb) located near the HLA-A and HLA-F loci. In this paper, we report the study of one of the corresponding genes, referred to as HCG V (hemochromatosis candidate gene), localized 150 kb centromeric to HLA-A. This gene was found to be expressed ubiquitously in the form of a 1.8 kb transcript, and to be apparently well conserved during evolution. The gene spanned 3.1 kb and is organized in three exons and two introns. The cDNA of 1620 base pairs (bp) showed an open reading frame of 378 bp, encoding for a 126 amino acid polypeptide which displayed a strong identity with the predicted product of a mouse Tctex-5 gene (t complex, testis expressed) localized in the t complex on chromosome 17. The HCG V gene was assessed as a potential candidate for hemochromatosis in regard to its localization in the linkage disequilibrium area between HFE and polymorphic markers. The study of deletions and point mutations in hemochromatosis patients revealed a single bp polymorphism within the coding region; however, no associated disease changes were found. Therefore we conclude that HCG V is unlikely to be involved in the pathogenesis of hemochromatosis.