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Symbol report for MYO1A

Stable symbol

HGNC data for MYO1A

Approved symbol
MYO1A
Approved name

myosin IA

Locus type
gene with protein product
HGNC ID
HGNC:7595
Symbol status
Approved
Previous symbols
MYHL
DFNA48
BBMI
Alias names
Unconventional myosin-Ia
Brush border myosin I
Chromosomal location
12q13.3
UCSC
Alliance of Genome Resources
Bos taurus
MYO1A VGNC:31816 VGNC
Canis familiaris
MYO1A VGNC:43560 VGNC
Equus caballus
MYO1A VGNC:20499 VGNC
Felis catus
MYO1A VGNC:68388 VGNC
Macaca mulatta
MYO1A VGNC:75110 VGNC
Mus musculus
Myo1a MGI:107732 Curated
Pan troglodytes
MYO1A VGNC:13427 VGNC
Rattus norvegicus
Myo1a RGD:3135
Sus scrofa
MYO1A VGNC:90525 VGNC
Multiple mutations of MYO1A, a cochlear-expressed gene, in sensorineural hearing loss.
Donaudy F et al. Am J Hum Genet 2003 Jun;72(6)1571-1577
Donaudy F, Ferrara A, Esposito L, Hertzano R, Ben-David O, Bell RE, Melchionda S, Zelante L, Avraham KB, Gasparini P.
Am J Hum Genet 2003 Jun;72(6)1571-1577
Abstract: Myosin I isozymes have been implicated in various motile processes, including organelle translocation, ion-channel gating, and cytoskeleton reorganization. Unconventional myosins were among the first family of proteins found to be associated with hearing loss in both humans and mice. Here, we report the identification of a nonsense mutation, of a trinucleotide insertion leading to an addition of an amino acid, and of six missense mutations in MYO1A cDNA sequence in a group of hearing-impaired patients from Italy. MYO1A, which is located within the DFNA48 locus, is the first myosin I family member found to be involved in causing deafness and may be a major contributor to autosomal dominant-hearing loss.
Mapping of unconventional myosins in mouse and human.
Hasson T et al. Genomics 1996 Sep;36(3)431-439
Hasson T, Skowron JF, Gilbert DJ, Avraham KB, Perry WL, Bement WM, Anderson BL, Sherr EH, Chen ZY, Greene LA, Ward DC, Corey DP, Mooseker MS, Copeland NG, Jenkins NA.
Genomics 1996 Sep;36(3)431-439
Abstract: Myosins are molecular motors that move along filamentous actin. Seven classes of myosin are expressed in vertebrates: conventional myosin, or myosin-II, as well as the 6 unconventional myosin classes-I, -V, -VI, -VII, -IX, and -X. We have mapped in mouse 22 probes encompassing all known unconventional myosins and, as a result, have identified 16 potential unconventional myosin genes. These genes include 7 myosins-I, 2 myosins-V, 1 myosin-VI, 3 myosins-VII, 2 myosins-IX, and 1 myosin-X. The map location of 5 of these genes was identified in human chromosomes by fluorescence in situ hybridization.