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Symbol report for MCM3

HGNC data for MCM3

Approved symbol
MCM3
Approved name

minichromosome maintenance complex component 3

Locus type
gene with protein product
HGNC ID
HGNC:6945
Symbol status
Approved
Previous names
minichromosome maintenance deficient (S. cerevisiae) 3
MCM3 minichromosome maintenance deficient 3 (S. cerevisiae)
Chromosomal location
6p12.2
UCSC
Alliance of Genome Resources
Bos taurus
MCM3 VGNC:31309 VGNC
Canis familiaris
MCM3 VGNC:43082 VGNC
Equus caballus
MCM3 VGNC:20034 VGNC
Felis catus
MCM3 VGNC:68213 VGNC
Macaca mulatta
MCM3 VGNC:74681 VGNC
Mus musculus
Mcm3 MGI:101845 Curated
Pan troglodytes
MCM3 VGNC:3458 VGNC
Rattus norvegicus
Sus scrofa
MCM3 VGNC:90074 VGNC
Properties of the nuclear P1 protein, a mammalian homologue of the yeast Mcm3 replication protein.
Thömmes P et al. Nucleic Acids Res 1992 Mar;20(5)1069-1074
Thömmes P, Fett R, Schray B, Burkhart R, Barnes M, Kennedy C, Brown NC, Knippers R.
Nucleic Acids Res 1992 Mar;20(5)1069-1074
Abstract: Polyclonal antibodies were raised against a multiprotein 'holoenzyme' form of calf thymus DNA polymerase alpha-primase and used to probe a human cDNA-protein expression library constructed in the lambda gt11 vector. The probe identified a series of cDNA clones derived from a 3.2 kb mRNA which encodes a novel 105 kDa polypeptide, the P1 protein. In intact cells, the P1 protein was specifically associated with the nucleus, and in cell extracts, it was associated with complex forms of DNA polymerase alpha-primase. The synthesis of human P1-specific mRNA was stimulated upon addition of fresh serum to growth-arrested cells, and RNA blot analyses with the human P1-cDNA probe indicated that P1 is encoded by a strictly conserved mammalian gene. The amino acid sequence deduced from a 240-codon open reading frame resident in the largest human P1-cDNA (0.84 kb) displayed greater than 96% identity with that deduced from the equivalent segment of a 795-codon open reading frame of a larger mouse P1-cDNA (2.8 kb). Throughout its length, the primary structure of mammalian P1 displayed strong homology with that of Mcm3, a 125 kDa yeast protein thought to be involved in the initiation of DNA replication (Gibson et al. 1990. Mol. Cell. Biol. 10: 5707-5720). The P1-Mcm3 homology, the strong conservation of P1 among mammals, its nuclear localization, and its association with the replication-specific DNA polymerase alpha strongly suggest an important role of the P1 protein in the replication of mammalian DNA.