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Symbol report for KCNJ6

HGNC data for KCNJ6

Approved symbol
KCNJ6
Approved name

potassium inwardly rectifying channel subfamily J member 6

Locus type
gene with protein product
HGNC ID
HGNC:6267
Symbol status
Approved
Previous symbols
KCNJ7
Previous names
potassium inwardly-rectifying channel, subfamily J, member 6
Alias symbols
Kir3.2
GIRK2
KATP2
BIR1
hiGIRK2
Alias names
G protein-activated inward rectifier potassium channel 2
Chromosomal location
21q22.13
Gene groups
Gene resources for KCNJ6
Ensembl
ENSG00000157542 Curated
Ensembl region in detailEnsembl gene sequence
NCBI Gene
3763 Curated
UCSC
uc002ywn.2
Alliance of Genome Resources
HGNC:6267
Nucleotide resources for KCNJ6
MANE Select
NM_002240.5
ENST00000609713.2
INSDC
U24660 Curated
ENAGenBankDDBJ
RefSeq
NM_002240 Curated
NCBI sequence viewer
CCDS
CCDS42927 Curated
Protein resources for KCNJ6
UniProt/Swiss-Prot
P48051
InterProPDBeReactome
AlphaFold
AF-P48051-F1
Orthologs from selected species for KCNJ6
Bos taurus
KCNJ6 VGNC:53585 VGNC
Canis familiaris
KCNJ6 VGNC:42267 VGNC
Equus caballus
KCNJ6 VGNC:58181 VGNC
Felis catus
KCNJ6 VGNC:67916 VGNC
Macaca mulatta
KCNJ6 VGNC:73991 VGNC
Mus musculus
Kcnj6 MGI:104781 Curated
Pan troglodytes
KCNJ6 VGNC:7466 VGNC
Rattus norvegicus
Kcnj6 RGD:2959
Sus scrofa
KCNJ6 VGNC:89360 VGNC
Specialist resources for KCNJ6
IUPHAR/BPS Guide to PHARMACOLOGY
435
Clinical resources for KCNJ6
OMIM
600877
GenCC
HGNC:6267
MedlinePlus
Search via KCNJ6
DECIPHER
Search via KCNJ6
ClinGen
Search via HGNC:6267
Genetic Testing Registry
Search via NCBI Gene ID 3763
ClinVar
Search via NCBI Gene ID 3763
dbVar
Search via NCBI Gene ID 3763
Orphanet
444179
Other resources for KCNJ6
AmiGO
Search via P48051
QuickGO
Search via P48051
BioGPS
Search via NCBI Gene ID 3763
GeneCards
Search via HGNC:6267
Monarch
Search via HGNC:6267
WikiGenes
Search via NCBI Gene ID 3763
References for KCNJ6
International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels.
Kubo Y et al. Pharmacol Rev 2005 Dec;57(4)509-526
Kubo Y, Adelman JP, Clapham DE, Jan LY, Karschin A, Kurachi Y, Lazdunski M, Nichols CG, Seino S, Vandenberg CA.
Pharmacol Rev 2005 Dec;57(4)509-526
PMID: 16382105 Europe PMC, Pubmed
Characterization and variation of a human inwardly-rectifying-K-channel gene (KCNJ6): a putative ATP-sensitive K-channel subunit.
Sakura H et al. FEBS Lett 1995 Jun;367(2)193-197
Sakura H, Bond C, Warren-Perry M, Horsley S, Kearney L, Tucker S, Adelman J, Turner R, Ashcroft FM.
FEBS Lett 1995 Jun;367(2)193-197
Abstract: The ATP-sensitive K-channel plays a central role in insulin release from pancreatic beta-cells. We report here the cloning of the gene (KCNJ6) encoding a putative subunit of a human ATP-sensitive K-channel expressed in brain and beta-cells, and characterisation of its exon-intron structure. Screening of a somatic cell mapping panel and fluorescent in situ hybridization place the gene on chromosome 21 (21q22.1-22.2). Analysis of single-stranded conformational polymorphisms revealed the presence of two silent polymorphisms (Pro-149: CCG-CCA and Asp-328: GAC-GAT) with similar frequencies in normal and non-insulin-dependent diabetic patients.
PMID: 7796919 Europe PMC, Pubmed