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Symbol report for ITGAE

HGNC data for ITGAE

Approved symbol
ITGAE
Approved name

integrin subunit alpha E

Locus type
gene with protein product
HGNC ID
HGNC:6147
Symbol status
Approved
Previous names
integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
Alias symbols
CD103
HUMINAE
Alias names
antigen CD103
human mucosal lymphocyte antigen 1, alpha polypeptide
Chromosomal location
17p13.2
UCSC
Alliance of Genome Resources
Bos taurus
ITGAE VGNC:30321 VGNC
Canis familiaris
ITGAE VGNC:42131 VGNC
Equus caballus
ITGAE VGNC:19171 VGNC
Felis catus
ITGAE VGNC:67847 VGNC
Mus musculus
Itgae MGI:1298377 Curated
Pan troglodytes
ITGAE VGNC:9338 VGNC
Rattus norvegicus
Itgae RGD:621644
Sus scrofa
ITGAE VGNC:89239 VGNC
HCDM
CD103 Curated
IUPHAR/BPS Guide to PHARMACOLOGY
Molecular cloning of the human mucosal lymphocyte integrin alpha E subunit. Unusual structure and restricted RNA distribution.
Shaw SK et al. J Biol Chem 1994 Feb;269(8)6016-6025
Shaw SK, Cepek KL, Murphy EA, Russell GJ, Brenner MB, Parker CM.
J Biol Chem 1994 Feb;269(8)6016-6025
Abstract: The human mucosal lymphocyte-1 (HML-1) antigen is expressed on a subclass of T-lymphocytes known as intra-epithelial lymphocytes which are located between mucosal epithelial cells. The HML-1 complex is known to mediate adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers in vitro. We and others have shown that the HML-1 antigen is an integrin composed of the beta 7 subunit in association with a novel alpha subunit, alpha E. Here we report the cloning of the alpha E cDNA and its primary amino acid sequence. alpha E contained an inserted or I domain and was more homologous to the other I domain containing integrins than to the cleaved group of integrin alpha subunits. However, alpha E contained a unique extra domain of 55 amino acids located just NH2-terminal to the I domain without counterpart in other integrins. This extra domain contained a stretch of 18 consecutive charged residues and included a proteolytic cleavage site. Thus alpha E is the only I domain containing integrin alpha subunit that is also cleaved, and the cleavage site is distinct from that of members of the cleaved group of integrin alpha subunits. These structural features mark alpha E as an unusual member of the integrin family. High levels of alpha E and beta 7 mRNA were restricted to mucosal lymphocytes supporting the hypothesis that alpha E beta 7 plays a role in the localization or site-specific functions of intra-epithelial T-lymphocytes.