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Symbol report for EPHB2

Stable symbol

HGNC data for EPHB2

Approved symbol
EPHB2
Approved name

EPH receptor B2

Locus type
gene with protein product
HGNC ID
HGNC:3393
Symbol status
Approved
Previous symbols
DRT
ERK
EPHT3
Previous names
EphB2
Alias symbols
Hek5
Tyro5
Chromosomal location
1p36.12
UCSC
Alliance of Genome Resources
INSDC
AF025304 Curated
CCDS
CCDS229 Curated
CCDS230 Curated
CCDS81279 Curated
Bos taurus
EPHB2 VGNC:54424 VGNC
Canis familiaris
EPHB2 VGNC:40411 VGNC
Equus caballus
EPHB2 VGNC:58626 VGNC
Felis catus
EPHB2 VGNC:80196 VGNC
Macaca mulatta
EPHB2 VGNC:99906 VGNC
Mus musculus
Ephb2 MGI:99611 Curated
Pan troglodytes
EPHB2 VGNC:10612 VGNC
Rattus norvegicus
Ephb2 RGD:1564232
Sus scrofa
EPHB2 VGNC:87737 VGNC
IUPHAR/BPS Guide to PHARMACOLOGY
eek and erk, new members of the eph subclass of receptor protein-tyrosine kinases.
Chan J et al. Oncogene 1991 Jun;6(6)1057-1061
Chan J, Watt VM.
Oncogene 1991 Jun;6(6)1057-1061
Abstract: We have identified human and rat DNAs encoding two novel members of the eph subclass of putative receptor protein-tyrosine kinases. Rat cDNA clones encoding eek (eph- and elk-related kinase) were isolated from a brain cDNA library probed with DNA encoding the kinase region of the insulin receptor-related receptor. The predicted eek protein contains all the amino acid residues conserved in the catalytic domains of protein-tyrosine kinases and is most similar to two putative receptor protein-tyrosine kinases of the eph subclass, elk (69%) and eph (57%). Human genomic DNAs encoding part of eek (EEK) as well as another putative protein-tyrosine kinase most similar to elk (90%), ERK (elk-related kinase), were isolated and partially characterized. The novel identity of these two eph-family genes was further supported by Southern blot analyses and localization to human chromosome 1. In Northern blot analysis of rat RNA, DNAs encoding rat eek and human ERK hybridized to transcripts most abundant in brain and lung, respectively. These two new members of the eph subclass of receptor protein-tyrosine kinases, eek and erk, may therefore have tissue-specific functions distinct from those of other eph family members.