All download files including the archive files are now in a publicly accessible Google Storage Bucket. Downloads page links have been updated.

Not found

Our G-nome assistant hasn't been able to find this symbol report. Please check the URL or use our search to find what you are looking for.

Symbol report for CYP51A1

Stable symbol

HGNC data for CYP51A1

Approved symbol
CYP51A1
Approved name

cytochrome P450 family 51 subfamily A member 1

Locus type
gene with protein product
HGNC ID
HGNC:2649
Symbol status
Approved
Previous symbols
CYP51
Previous names
cytochrome P450, 51 (lanosterol 14-alpha-demethylase)
cytochrome P450, family 51, subfamily A, polypeptide 1
Alias symbols
CP51
CYPL1
P450L1
LDM
P450-14DM
Chromosomal location
7q21.2
Bos taurus
CYP51A1 VGNC:110275 VGNC
Canis familiaris
CYP51A1 VGNC:50376 VGNC
Equus caballus
CYP51A1 VGNC:103425 VGNC
Felis catus
CYP51A1 VGNC:103342 VGNC
Macaca mulatta
CYP51A1 VGNC:103628 VGNC
Mus musculus
Cyp51 MGI:106040 Curated
Pan troglodytes
CYP51A1 VGNC:7373 VGNC
Rattus norvegicus
Cyp51 RGD:2481
Sus scrofa
CYP51A1 VGNC:103377 VGNC
IUPHAR/BPS Guide to PHARMACOLOGY
Structure and mapping of the human lanosterol 14alpha-demethylase gene (CYP51) encoding the cytochrome P450 involved in cholesterol biosynthesis; comparison of exon/intron organization with other mammalian and fungal CYP genes.
Rozman D et al. Genomics 1996 Dec;38(3)371-381
Rozman D, Strömstedt M, Tsui LC, Scherer SW, Waterman MR.
Genomics 1996 Dec;38(3)371-381
Abstract: Sterol 14alpha-demethylase (P45014DM) encoded by CYP51 is a member of the cytochrome P450 (CYP) gene superfamily involved in sterol biosynthesis in fungi, plants, and animals. Constraints imposed by the specific function of CYP51 have severely limited sequence divergence in this family. Consequently, CYP51 is the only P450 family recognizable across all eukaryotic phyla. We have determined the structure of the functional human CYP51 gene, which spans 22 kb, is divided into 10 exons, and maps to 7q21.2-q21.3. The 5' portion of intron 1 is GC-rich and contains potential binding sites for several transcription factors. Primer extension studies reveal predominant transcription initiation sites in liver, kidney, lung, and placenta 250 and 249 bp upstream from the translation start site and a second major site at -100 bp. Ubiquitous expression of human CYP51 (Strömstedt et al., Arch. Biochem. Biophys. 329: 73-81, 1996), the absence of TATA and CAAT patterns, a GC-rich sequence in the promoter region, and initiation of CYP51 transcription at more than one site indicate that CYP51 is a housekeeping gene. The 5'-flanking region, exon 1, and a portion of intron 1 show the characteristics of a CpG island, with the observed/expected CpG ratio of 0.79. Sterol responsive element-like motifs were present in this region, suggesting regulation by oxysterols via a mechanism similar to that associated with other genes involved in cholesterol homeostasis. Comparison of the human CYP51 gene structure with structures of other mammalian and fungal CYP gene families shows that 7 of the 9 CYP51 introns are located at unique positions. More than 80 intron locations exist in mammalian and fungal CYP gene families, and it seems very unlikely that all these introns could have been present in the primordial CYP gene.