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Symbol report for COL24A1

Stable symbol

HGNC data for COL24A1

Approved symbol
COL24A1
Approved name

collagen type XXIV alpha 1 chain

Locus type
gene with protein product
HGNC ID
HGNC:20821
Symbol status
Approved
Previous names
collagen, type XXIV, alpha 1
Chromosomal location
1p22.3
Gene groups
Canis familiaris
COL24A1 VGNC:39469 VGNC
Equus caballus
COL24A1 VGNC:16735 VGNC
Felis catus
COL24A1 VGNC:107514 VGNC
Macaca mulatta
COL24A1 VGNC:106343 VGNC
Mus musculus
Col24a1 MGI:1918605 Curated
Pan troglodytes
COL24A1 VGNC:57569 VGNC
Rattus norvegicus
Col24a1 RGD:1565539
CREB-AP1 protein complexes regulate transcription of the collagen XXIV gene (Col24a1) in osteoblasts.
Matsuo N et al. J Biol Chem 2006 Mar;281(9)5445-5452
Matsuo N, Tanaka S, Gordon MK, Koch M, Yoshioka H, Ramirez F.
J Biol Chem 2006 Mar;281(9)5445-5452
Abstract: Collagen XXIV is a newly discovered and poorly characterized member of the fibril-forming family of collagen molecules, which displays unique structural features of invertebrate fibrillar collagens and is expressed predominantly in bone tissue. Here we report the characterization of the proximal promoter of the mouse gene (Col24a1) and its regulation in osteoblastic cells. Using well characterized murine models of osteoblast differentiation, we found that the Col24a1 gene is activated sometime before onset of the late differentiation marker osteocalcin. Additional analyses revealed that Col24a1 produces equal amounts of two alternatively spliced products with different 5'-untranslated sequences that originate from distinct transcriptional start sites. Cell transfection experiments in combination with DNA binding assays demonstrated that Col24a1 promoter activity in ROS17/2.8 osteosarcoma cells is under the control of an upstream cis-acting element, which is shared by both transcripts and is recognized by specific combinations of c-Jun, CREB1, ATF1, and ATF2 dimers. Consistent with these results, overexpression of c-Jun, ATF1, ATF2, or CREB1 in transiently transfected osteoblastic cells stimulated transcription from reporter gene constructs driven by the Col24a1 promoter to different degrees. Moreover, chromatin immunoprecipitation experiments showed that these nuclear factors bind the same upstream sequence of the endogenous Col24a1 gene. Collectively these data provide new information about transcriptional control of collagen fibrillogenesis, in addition to implicating for the first time CREB-AP1 protein complexes in the regulation of collagen gene expression in osteoblasts.