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Symbol report for IL23A

HGNC data for IL23A

Approved symbol
IL23A
Approved name

interleukin 23 subunit alpha

Locus type
gene with protein product
HGNC ID
HGNC:15488
Symbol status
Approved
Previous names
interleukin 23, alpha subunit p19
Alias symbols
SGRF
IL23P19
IL-23
IL-23A
P19
Alias names
interleukin-six, G-CSF related factor
Chromosomal location
12q13.3
Gene groups
Bos taurus
IL23A VGNC:30146 VGNC
Canis familiaris
IL23A VGNC:41972 VGNC
Equus caballus
IL23A VGNC:19021 VGNC
Felis catus
IL23A VGNC:62907 VGNC
Macaca mulatta
IL23A VGNC:73601 VGNC
Mus musculus
Il23a MGI:1932410 Curated
Pan troglodytes
IL23A VGNC:8422 VGNC
Rattus norvegicus
Il23a RGD:620873
Sus scrofa
IL23A VGNC:89099 VGNC
IUPHAR/BPS Guide to PHARMACOLOGY
Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12.
Oppmann B et al. Immunity 2000 Nov;13(5)715-725
Oppmann B, Lesley R, Blom B, Timans JC, Xu Y, Hunte B, Vega F, Yu N, Wang J, Singh K, Zonin F, Vaisberg E, Churakova T, Liu M, Gorman D, Wagner J, Zurawski S, Liu Y, Abrams JS, Moore KW, Rennick D, de Waal-Malefyt R, Hannum C, Bazan JF, Kastelein RA.
Immunity 2000 Nov;13(5)715-725
Abstract: A novel sequence discovered in a computational screen appears distantly related to the p35 subunit of IL-12. This factor, which we term p19, shows no biological activity by itself; instead, it combines with the p40 subunit of IL-12 to form a novel, biologically active, composite cytokine, which we term IL-23. Activated dendritic cells secrete detectable levels of this complex. IL-23 binds to IL-12R beta 1 but fails to engage IL-12R beta 2; nonetheless, IL-23 activates Stat4 in PHA blast T cells. IL-23 induces strong proliferation of mouse memory (CD4(+)CD45Rb(low)) T cells, a unique activity of IL-23 as IL-12 has no effect on this cell population. Similar to IL-12, human IL-23 stimulates IFN-gamma production and proliferation in PHA blast T cells, as well as in CD45RO (memory) T cells.