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Symbol report for ROBO3

Stable symbol

HGNC data for ROBO3

Approved symbol
ROBO3
Approved name

roundabout guidance receptor 3

Locus type
gene with protein product
HGNC ID
HGNC:13433
Symbol status
Approved
Previous symbols
HGPPS
Previous names
roundabout (axon guidance receptor, Drosophila) homolog 3
horizontal gaze palsy with progressive scoliosis
roundabout, axon guidance receptor, homolog 3 (Drosophila)
Alias symbols
RBIG1
FLJ21044
HGPS
Chromosomal location
11q24.2
Bos taurus
ROBO3 VGNC:34080 VGNC
Canis familiaris
ROBO3 VGNC:45686 VGNC
Equus caballus
ROBO3 VGNC:22494 VGNC
Felis catus
ROBO3 VGNC:64714 VGNC
Macaca mulatta
ROBO3 VGNC:101392 VGNC
Mus musculus
Robo3 MGI:1343102 Curated
Pan troglodytes
ROBO3 VGNC:1013 VGNC
Rattus norvegicus
Robo3 RGD:1311018
Sus scrofa
ROBO3 VGNC:108613 VGNC
Mutations in a human ROBO gene disrupt hindbrain axon pathway crossing and morphogenesis.
Jen JC et al. Science 2004 Jun;304(5676)1509-1513
Jen JC, Chan WM, Bosley TM, Wan J, Carr JR, Rüb U, Shattuck D, Salamon G, Kudo LC, Ou J, Lin DD, Salih MA, Kansu T, Al Dhalaan H, Al Zayed Z, MacDonald DB, Stigsby B, Plaitakis A, Dretakis EK, Gottlob I, Pieh C, Traboulsi EI, Wang Q, Wang L, Andrews C, Yamada K, Demer JL, Karim S, Alger JR, Geschwind DH, Deller T, Sicotte NL, Nelson SF, Baloh RW, Engle EC.
Science 2004 Jun;304(5676)1509-1513
Abstract: The mechanisms controlling axon guidance are of fundamental importance in understanding brain development. Growing corticospinal and somatosensory axons cross the midline in the medulla to reach their targets and thus form the basis of contralateral motor control and sensory input. The motor and sensory projections appeared uncrossed in patients with horizontal gaze palsy with progressive scoliosis (HGPPS). In patients affected with HGPPS, we identified mutations in the ROBO3 gene, which shares homology with roundabout genes important in axon guidance in developing Drosophila, zebrafish, and mouse. Like its murine homolog Rig1/Robo3, but unlike other Robo proteins, ROBO3 is required for hindbrain axon midline crossing.