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Symbol report for MRPL46

HGNC data for MRPL46

Approved symbol
MRPL46
Approved name

mitochondrial ribosomal protein L46

Locus type
gene with protein product
HGNC ID
HGNC:1192
Symbol status
Approved
Previous symbols
C15orf4
Previous names
chromosome 15 open reading frame 4
Alias symbols
LIECG2
P2ECSL
mL46
Chromosomal location
15q25.3
Bos taurus
MRPL46 VGNC:31641 VGNC
Canis familiaris
MRPL46 VGNC:43400 VGNC
Equus caballus
MRPL46 VGNC:20344 VGNC
Felis catus
MRPL46 VGNC:63607 VGNC
Macaca mulatta
MRPL46 VGNC:74728 VGNC
Mus musculus
Mrpl46 MGI:1914558 Curated
Pan troglodytes
MRPL46 VGNC:1912 VGNC
Rattus norvegicus
Mrpl46 RGD:1309123
Sus scrofa
MRPL46 VGNC:90370 VGNC
The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present.
Koc EC et al. J Biol Chem 2001 Nov;276(47)43958-43969
Koc EC, Burkhart W, Blackburn K, Moyer MB, Schlatzer DM, Moseley A, Spremulli LL.
J Biol Chem 2001 Nov;276(47)43958-43969
Abstract: Identification of all the protein components of the large subunit (39 S) of the mammalian mitochondrial ribosome has been achieved by carrying out proteolytic digestions of whole 39 S subunits followed by analysis of the resultant peptides by liquid chromatography and mass spectrometry. Peptide sequence information was used to search the human EST data bases and complete coding sequences were assembled. The human mitochondrial 39 S subunit has 48 distinct proteins. Twenty eight of these are homologs of the Escherichia coli 50 S ribosomal proteins L1, L2, L3, L4, L7/L12, L9, L10, L11, L13, L14, L15, L16, L17, L18, L19, L20, L21, L22, L23, L24, L27, L28, L30, L32, L33, L34, L35, and L36. Almost all of these proteins have homologs in Drosophila melanogaster, Caenorhabditis elegans, and Saccharomyces cerevisiae mitochondrial ribosomes. No mitochondrial homologs to prokaryotic ribosomal proteins L5, L6, L25, L29, and L31 could be found either in the peptides obtained or by analysis of the available data bases. The remaining 20 proteins present in the 39 S subunits are specific to mitochondrial ribosomes. Proteins in this group have no apparent homologs in bacterial, chloroplast, archaebacterial, or cytosolic ribosomes. All but two of the proteins has a clear homolog in D. melanogaster while all can be found in the genome of C. elegans. Ten of the 20 mitochondrial specific 39 S proteins have homologs in S. cerevisiae. Homologs of 2 of these new classes of ribosomal proteins could be identified in the Arabidopsis thaliana genome.
Cloning, mapping and expression analysis of C15orf4, a novel human gene with homology to the yeast mitochondrial ribosomal protein Ym130 gene.
Carim-Todd L et al. DNA Seq 2001 ;12(2)91-96
Carim-Todd L, Sumoy L, Andreu N, Estivill X, Escarceller M.
DNA Seq 2001 ;12(2)91-96
Abstract: We have identified C15orf4, a novel human gene showing homology to the yeast mitochondrial ribosomal protein YmL30. C15orf4 encodes a transcript of 1,006 nt with an ORF of 279 amino acids and a predicted protein size of 31.7 kDa. Expression of C15orf4 is enriched in testis. C15orf4 was positioned to chromosome 15q24 by radiation hybrid mapping. We have identified the C15orf4 mouse orthologue as well as homologues in other species.