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Symbol report for SIAH2

HGNC data for SIAH2

Approved symbol
SIAH2
Approved name

siah E3 ubiquitin protein ligase 2

Locus type
gene with protein product
HGNC ID
HGNC:10858
Symbol status
Approved
Previous names
seven in absentia (Drosophila) homolog 2
seven in absentia homolog 2 (Drosophila)
Chromosomal location
3q25.1
Gene groups
Bos taurus
SIAH2 VGNC:34614 VGNC
Equus caballus
SIAH2 VGNC:22973 VGNC
Felis catus
SIAH2 VGNC:102843 VGNC
Macaca mulatta
SIAH2 VGNC:77215 VGNC
Mus musculus
Siah2 MGI:108062 Curated
Pan troglodytes
SIAH2 VGNC:2564 VGNC
Rattus norvegicus
Siah2 RGD:620778
Sus scrofa
SIAH2 VGNC:92866 VGNC
Mammalian homologs of seven in absentia regulate DCC via the ubiquitin-proteasome pathway.
Hu G et al. Genes Dev 1997 Oct;11(20)2701-2714
Hu G, Zhang S, Vidal M, Baer JL, Xu T, Fearon ER.
Genes Dev 1997 Oct;11(20)2701-2714
Abstract: DCC (deleted in colorectal cancer) is postulated to function as transmembrane receptor for the axon and cell guidance factor netrin-1. We report here that the DCC cytoplasmic domain binds to proteins encoded by mammalian homologs of the Drosophila seven in absentia (sina) gene, as well as Drosophila Sina. Sina has a critical role in R7 photoreceptor development and shows upward of 85% amino acid identity with its mammalian homologs (termed Siahs), but the function of the Sina/Siah proteins has not been defined. We sought, therefore, to characterize further their interaction with DCC. Immunofluorescence studies suggested the Sina/Siah proteins localized predominantly in the cytoplasm and in association with DCC. DCC was found to be ubiquitinated and the Sina/Siah proteins regulated its expression. Proteasome inhibitors blocked the effects of Sina/Siah on DCC, and the Sina/Siah proteins interacted with ubiquitin-conjugating enzymes (Ubcs). A mutant Siah protein lacking the amino-terminal Ubc-binding sequences complexed with DCC, but did not degrade it. The in vivo interaction between Sina/Siah and DCC was confirmed through studies of transgenic Drosophila lines in which DCC and Sina were ectopically expressed in the eye. Taken together, the data imply that the Sina/Siah proteins regulate DCC and perhaps other proteins via the ubiquitin-proteasome pathway.