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Symbol report for CCL21

HGNC data for CCL21

Approved symbol
CCL21
Approved name

C-C motif chemokine ligand 21

Locus type
gene with protein product
HGNC ID
HGNC:10620
Symbol status
Approved
Previous symbols
SCYA21
Previous names
small inducible cytokine subfamily A (Cys-Cys), member 21
chemokine (C-C motif) ligand 21
Alias symbols
SLC
exodus-2
TCA4
CKb9
6Ckine
ECL
Alias names
beta chemokine exodus-2
secondary lymphoid tissue chemokine
Efficient Chemoattractant for Lymphocytes
Chromosomal location
9p13.3
Gene groups
Bos taurus
CCL21 VGNC:26948 VGNC
Felis catus
CCL21 VGNC:60543 VGNC
Macaca mulatta
CCL21 VGNC:104885 VGNC
Mus musculus
Ccl21a MGI:1349183 Curated
Ccl21b MGI:1349182 Curated
Ccl21d MGI:5434896 Curated
Ccl21e MGI:3711256 Curated
Ccl21f MGI:3710514 Curated
Pan troglodytes
CCL21 VGNC:4651 VGNC
Rattus norvegicus
Ccl21 RGD:1311996
Sus scrofa
CCL21 VGNC:95485 VGNC
IUPHAR/BPS Guide to PHARMACOLOGY
811
Molecular cloning of a novel human CC chemokine secondary lymphoid-tissue chemokine that is a potent chemoattractant for lymphocytes and mapped to chromosome 9p13.
Nagira M et al. J Biol Chem 1997 Aug;272(31)19518-19524
Nagira M, Imai T, Hieshima K, Kusuda J, Ridanpää M, Takagi S, Nishimura M, Kakizaki M, Nomiyama H, Yoshie O.
J Biol Chem 1997 Aug;272(31)19518-19524
Abstract: By searching the Expressed Sequence Tag (EST) data base, we identified partial cDNA sequences potentially encoding a novel human CC chemokine. We determined the entire cDNA sequence which encodes a highly basic polypeptide of 134 amino acids total with a putative signal peptide of 23 amino acids. The predicted mature protein of 111 amino acids has the four canonical cysteine residues and shows 21-33% identity to other human CC chemokines, but has a unique carboxyl-terminal extension of about 30 amino acids which contains two extra cysteine residues. The mRNA was expressed strongly in tissues such as the lymph nodes, Appendix, and spleen. The recombinant protein, which was produced by the baculovirus system and purified to homogeneity, was a highly efficient chemoattractant for certain human T cell lines and a highly potent one for freshly isolated peripheral blood lymphocytes and cultured normal T cells expanded by phytohemagglutinin and interleukin 2. Unlike most other CC chemokines, however, this novel chemokine was not chemotactic for monocytes or neutrophils, suggesting that it is specific for lymphocytes. From these results, we designated this novel CC chemokine as SLC from secondary lymphoid-tissue chemokine. SLC fused with the secreted form of alkaline phosphatase (SLC-SEAP) was used to characterize the SLC receptor. Binding of SLC-SEAP to freshly isolated lymphocytes was blocked by SLC (IC50, 0.12 nM) but not by any other CC chemokine so far tested, suggesting that resting lymphocytes express a class of receptors highly specific for SLC. By using somatic cell hybrids, radiation hybrids, and selected yeast and bacterial artificial chromosome clones, we mapped the SLC gene (SCYA21) at chromosome 9p13 and between chromosomal markers, D9S1978(WI-8765) and AFM326vd1, where the gene for another novel CC chemokine termed ELC from EBI1-ligand chemokine (SCYA19) also exists. Collectively, SLC is a novel CC chemokine specific for lymphocytes and, together with ELC, constitutes a new group of chemokines localized at chromosome 9p13.