everolimus (Q421052)

imported from Wikimedia project

17 November 2015

Everolimus.svg
512 × 400; 16 KB

1 reference

German Wikipedia

mass

957.581 dalton

1 reference

Everolimus (English)

18 November 2016

1 reference

C₅₃H₈₃NO₁₄

1 reference

Everolimus (English)

18 November 2016

CC1CCC2CC(C(=CC=CC=CC(CC(C(=O)C(C(C(=CC(C(=O)CC(OC(=O)C3CCCCN3C(=O)C(=O)C1(O2)O)C(C)CC4CCC(C(C4)OC)OCCO)C)C)O)OC)C)C)C)OC

1 reference

Everolimus (English)

18 November 2016

C[C@@H]1CC[C@H]2C[C@@H](/C(=C/C=C/C=C/[C@H](C[C@H](C(=O)[C@@H]([C@@H](/C(=C/[C@H](C(=O)C[C@H](OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@@]1(O2)O)[C@H](C)C[C@@H]4CC[C@H]([C@@H](C4)OC)OCCO)C)/C)O)OC)C)C)/C)OC

1 reference

Everolimus (English)

18 November 2016

1.5 milligram

route of administration

oral administration

1 reference

https://www.whocc.no/atc_ddd_index/?code=L04AA18

1 reference

14 February 2018

1 reference

European Medicines Agency product number

EMEA/H/C/002311

http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/002311/human_med_001484.jsp

22 March 2017

1 reference

14 February 2018

World Health Organisation international non-proprietary name

everolimus (English)

2 references

medical condition treated

everolimus (English)

4 October 2016

Recommended INN: List 44

publication date

2000

benign neoplasm of brain

1 reference

2 October 2018

neuroendocrine carcinoma

1 reference

2 October 2018

kidney angiomyolipoma

1 reference

renal clear cell carcinoma

2 October 2018

1 reference

2 October 2018

carcinoid syndrome

1 reference

2 October 2018

renal cell carcinoma

1 reference

2 October 2018

carcinoid tumor

1 reference

2 October 2018

acute myeloid leukemia

1 reference

2 October 2018

low-grade astrocytoma

1 reference

2 October 2018

islet cell carcinoma

1 reference

2 October 2018

tuberous sclerosis 1

1 reference

2 October 2018

angiomyolipoma

1 reference

2 October 2018

kidney cancer

1 reference

2 October 2018

lymphoma

1 reference

diffuse large B-cell lymphoma

2 October 2018

1 reference

small intestine carcinoma

2 October 2018

1 reference

Food and Drug Administration

2 October 2018

29 March 2009

1 reference

Inxight: Drugs Database

2 November 2018

https://drugs.ncats.io/drug/9HW64Q8G6G

http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/022334s036lbl.pdf

renal cell carcinoma

start time

29 March 2009

approved by

Food and Drug Administration

1 reference

Inxight: Drugs Database

2 November 2018

https://drugs.ncats.io/drug/9HW64Q8G6G

http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/022334s036lbl.pdf

significant drug interaction

idelalisib

side effect

bone marrow failure

1 reference

sourcing circumstances

hypothetically

A reference set of clinically relevant adverse drug-drug interactions

physically interacts with

mechanistic target of rapamycin kinase

subject has role

enzyme inhibitor

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

5889

17 August 2016

legal status (medicine)

boxed warning

1 reference

https://nctr-crs.fda.gov/fdalabel/ui/spl-summaries/criteria/343802

imported from Wikimedia project

FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links. (English)

pregnancy category

US pregnancy category D

1 reference

English Wikipedia

LiverTox likelihood score

LiverTox toxicity likelihood category E*

1 reference

8 April 2021

https://www.ncbi.nlm.nih.gov/books/n/livertox/Everolimus

last update

26 February 2018

subject has role

protein kinase inhibitors

1 reference

5 March 2018

xenobiotic-transporting ATPase inhibitor

1 reference

5 March 2018

1 reference

Medical Subject Headings

MeSH descriptor ID

D000068338

15 March 2018

immunosuppressive drug

1 reference

InChI=1S/C53H83NO14/c1-32-16-12-11-13-17-33(2)44(63-8)30-40-21-19-38(7)53(62,68-40)50(59)51(60)54-23-15-14-18-41(54)52(61)67-45(35(4)28-39-20-22-43(66-25-24-55)46(29-39)64-9)31-42(56)34(3)27-37(6)48(58)49(65-10)47(57)36(5)26-32/h11-13,16-17,27,32,34-36,38-41,43-46,48-49,55,58,62H,14-15,18-26,28-31H2,1-10H3/b13-11+,16-12+,33-17+,37-27+/t32-,34-,35-,36-,38-,39+,40+,41+,43-,44+,45+,46-,48-,49+,53-/m1/s1

Medical Subject Headings

15 March 2018

0 references

Everolimus

0 references

Identifiers

InChI

1 reference

Everolimus (English)

18 November 2016

2 references

Everolimus (English)

18 November 2016

ChEBI release 2020-09-01

CAS Registry Number

159351-69-6

2 references

Global Substance Registration System

UNII

9HW64Q8G6G

everolimus (English)

18 November 2016

https://commonchemistry.cas.org/detail?cas_rn=159351-69-6

10 April 2021

1 reference

everolimus (English)

18 November 2016

2 references

Everolimus (English)

18 November 2016

InChIKey

ChEBI ID

68478

mapping relation type

2 references

EVEROLIMUS (English)

18 November 2016

International Chemical Identifier

InChI

InChI=1S/C53H83NO14/c1-32-16-12-11-13-17-33(2)44(63-8)30-40-21-19-38(7)53(62,68-40)50(59)51(60)54-23-15-14-18-41(54)52(61)67-45(35(4)28-39-20-22-43(66-25-24-55)46(29-39)64-9)31-42(56)34(3)27-37(6)48(58)49(65-10)47(57)36(5)26-32/h11-13,16-17,27,32,34-36,38-41,43-46,48-49,55,58,62H,14-15,18-26,28-31H2,1-10H3/b13-11+,16-12+,33-17+,37-27+/t32-,34-,35-,36-,38-,39+,40+,41+,43-,44+,45+,46-,48-,49+,53-/m1/s1

1 reference

EVEROLIMUS (English)

18 November 2016

2 references

inferred from InChIKey

InChIKey

Hazardous Substances Data Bank

1 reference

1 reference

28 October 2019

EVEROLIMUS (English)

10 May 2021

2 references

Mapping file of InChIStrings, InChIKeys and DTXSIDs for the EPA CompTox Dashboard

InChIKey

DSSTOX compound identifier

0 references

0 references

1 reference

ECHA Substance Infocard database

ECHA Substance Infocard ID

100.149.896

27 December 2018

ECHA Substance Infocard ID

(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-Dihydroxy-12-((1R)-2-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)-1-methylethyl)-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo(30.3.1.0(sup 4,9))hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentaone (English)

quotation

CAS no.: 159351-69-6 (English)

100.149.896

1 reference

ECHA Substance Infocard database

ECHA Substance Infocard ID

100.149.896

27 December 2018

(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-Dihydroxy-12-((1R)-2-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)-1-methylethyl)-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo(30.3.1.0(sup 4,9))hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentaone (English)

quotation

CAS no.: 159351-69-6 (English)

1 reference