gilteritinib (Q27077802)

Gilteritinib (English)

3 October 2016

chemical formula

C₂₉H₄₄N₈O₃

1 reference

Gilteritinib (English)

3 October 2016

canonical SMILES

CCC1=NC(=C(N=C1NC2CCOCC2)NC3=CC(=C(C=C3)N4CCC(CC4)N5CCN(CC5)C)OC)C(=O)N

1 reference

Gilteritinib (English)

physically interacts with

3 October 2016

fms related receptor tyrosine kinase 3

subject has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL3301622

AXL receptor tyrosine kinase

subject has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL3301622

legal status (medicine)

boxed warning

1 reference

https://nctr-crs.fda.gov/fdalabel/ui/spl-summaries/criteria/343802

LiverTox likelihood score

FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links. (English)

LiverTox toxicity likelihood category E*

1 reference

8 April 2021

https://www.ncbi.nlm.nih.gov/books/n/livertox/Gilteritinib

last update

20 January 2019

Commons category

Gilteritinib

0 references

Identifiers

InChI

InChI=1S/C29H44N8O3/c1-4-23-28(31-20-9-17-40-18-10-20)34-29(26(33-23)27(30)38)32-21-5-6-24(25(19-21)39-3)37-11-7-22(8-12-37)36-15-13-35(2)14-16-36/h5-6,19-20,22H,4,7-18H2,1-3H3,(H2,30,38)(H2,31,32,34)

1 reference

Gilteritinib (English)

3 October 2016

1 reference

Global Substance Registration System

Gilteritinib (English)

3 October 2016

2 references

UNII

66D92MGC8M

GILTERITINIB (English)

3 October 2016

https://commonchemistry.cas.org/detail?cas_rn=1254053-43-4

9 April 2021

1 reference

Gilteritinib (English)

3 October 2016

2 references

Gilteritinib (English)

3 October 2016

ChEBI ID

145372

mapping relation type

exact match

3 references

RCSB PDB - C6F Ligand Summary Page (English)

RCSB protein data bank

22 February 2021

https://www.rcsb.org/ligand/C6F

ChEBI release 2021-03-01

International Chemical Identifier

InChI

InChI=1S/C29H44N8O3/c1-4-23-28(31-20-9-17-40-18-10-20)34-29(26(33-23)27(30)38)32-21-5-6-24(25(19-21)39-3)37-11-7-22(8-12-37)36-15-13-35(2)14-16-36/h5-6,19-20,22H,4,7-18H2,1-3H3,(H2,30,38)(H2,31,32,34)

1 reference

GILTERITINIB (English)

3 October 2016

2 references

inferred from InChIKey

1 reference

1 reference

Guide to Pharmacology Ligand ID

LiverTox ID

Gilteritinib

0 references

8708

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

8708

gilteritinib (English)

3 October 2016

0 references

1 reference

Human Metabolome Database ID

HMDB0252717

2 references

based on heuristic

inferred from InChIKey

UNII

66D92MGC8M

2 references

Global Substance Registration System

UNII

66D92MGC8M

GILTERITINIB (English)

3 October 2016