node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cnr1 | Fos | ENSRNOP00000010850 | ENSRNOP00000010712 | Cannabinoid receptor 1 ; Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current | Proto-oncogene c-Fos ; Nuclear phosphoprotein which forms a tight but non- covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta- mediated signaling (By similarity). Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 a [...] | 0.738 |
Cnr1 | Oprd1 | ENSRNOP00000010850 | ENSRNOP00000014084 | Cannabinoid receptor 1 ; Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current | Delta-type opioid receptor ; Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Highly stereoselective. receptor for enkephalins | 0.913 |
Cnr1 | Oprk1 | ENSRNOP00000010850 | ENSRNOP00000010255 | Cannabinoid receptor 1 ; Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current | Kappa-type opioid receptor ; Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Receptor for dynorphins. May play a role in arousal and regulation of autonomic and neuroendocrine functions | 0.908 |
Cnr1 | Oprl1 | ENSRNOP00000010850 | ENSRNOP00000047053 | Cannabinoid receptor 1 ; Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current | Nociceptin receptor ; Receptor for the neuropeptide nociceptin/orphanin FQ. Has a potential role in modulating a number of brain functions, including instinctive behaviors and emotions. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase | 0.909 |
Cnr1 | Oprm1 | ENSRNOP00000010850 | ENSRNOP00000051290 | Cannabinoid receptor 1 ; Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current | Mu-type opioid receptor | 0.918 |
Cnr1 | Pdyn | ENSRNOP00000010850 | ENSRNOP00000038921 | Cannabinoid receptor 1 ; Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current | proenkephalin-B preproprotein ; Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity) | 0.916 |
Cnr1 | Pomc | ENSRNOP00000010850 | ENSRNOP00000016976 | Cannabinoid receptor 1 ; Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current | pro-opiomelanocortin precursor ; ACTH stimulates the adrenal glands to release cortisol | 0.924 |
Cnr1 | morphine | ENSRNOP00000010850 | 4253 | Cannabinoid receptor 1 ; Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current | The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle. [PubChem] | 0.990 |
Fos | Cnr1 | ENSRNOP00000010712 | ENSRNOP00000010850 | Proto-oncogene c-Fos ; Nuclear phosphoprotein which forms a tight but non- covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta- mediated signaling (By similarity). Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 a [...] | Cannabinoid receptor 1 ; Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current | 0.738 |
Fos | Pdyn | ENSRNOP00000010712 | ENSRNOP00000038921 | Proto-oncogene c-Fos ; Nuclear phosphoprotein which forms a tight but non- covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta- mediated signaling (By similarity). Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 a [...] | proenkephalin-B preproprotein ; Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity) | 0.522 |
Fos | Pomc | ENSRNOP00000010712 | ENSRNOP00000016976 | Proto-oncogene c-Fos ; Nuclear phosphoprotein which forms a tight but non- covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta- mediated signaling (By similarity). Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 a [...] | pro-opiomelanocortin precursor ; ACTH stimulates the adrenal glands to release cortisol | 0.957 |
Fos | Prkcg | ENSRNOP00000010712 | ENSRNOP00000019825 | Proto-oncogene c-Fos ; Nuclear phosphoprotein which forms a tight but non- covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta- mediated signaling (By similarity). Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 a [...] | Protein kinase C gamma type ; Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing p [...] | 0.888 |
Fos | Th | ENSRNOP00000010712 | ENSRNOP00000027682 | Proto-oncogene c-Fos ; Nuclear phosphoprotein which forms a tight but non- covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta- mediated signaling (By similarity). Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 a [...] | Tyrosine 3-monooxygenase ; Plays an important role in the physiology of adrenergic neurons | 0.769 |
Fos | morphine | ENSRNOP00000010712 | 4253 | Proto-oncogene c-Fos ; Nuclear phosphoprotein which forms a tight but non- covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta- mediated signaling (By similarity). Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 a [...] | The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle. [PubChem] | 0.992 |
Oprd1 | Cnr1 | ENSRNOP00000014084 | ENSRNOP00000010850 | Delta-type opioid receptor ; Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Highly stereoselective. receptor for enkephalins | Cannabinoid receptor 1 ; Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current | 0.913 |
Oprd1 | Oprk1 | ENSRNOP00000014084 | ENSRNOP00000010255 | Delta-type opioid receptor ; Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Highly stereoselective. receptor for enkephalins | Kappa-type opioid receptor ; Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Receptor for dynorphins. May play a role in arousal and regulation of autonomic and neuroendocrine functions | 0.915 |
Oprd1 | Oprl1 | ENSRNOP00000014084 | ENSRNOP00000047053 | Delta-type opioid receptor ; Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Highly stereoselective. receptor for enkephalins | Nociceptin receptor ; Receptor for the neuropeptide nociceptin/orphanin FQ. Has a potential role in modulating a number of brain functions, including instinctive behaviors and emotions. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase | 0.902 |
Oprd1 | Oprm1 | ENSRNOP00000014084 | ENSRNOP00000051290 | Delta-type opioid receptor ; Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Highly stereoselective. receptor for enkephalins | Mu-type opioid receptor | 0.949 |
Oprd1 | Pdyn | ENSRNOP00000014084 | ENSRNOP00000038921 | Delta-type opioid receptor ; Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Highly stereoselective. receptor for enkephalins | proenkephalin-B preproprotein ; Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity) | 0.918 |
Oprd1 | Pomc | ENSRNOP00000014084 | ENSRNOP00000016976 | Delta-type opioid receptor ; Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Highly stereoselective. receptor for enkephalins | pro-opiomelanocortin precursor ; ACTH stimulates the adrenal glands to release cortisol | 0.912 |