Usp48 (ubiquitin specific peptidase 48) - Rat Genome Database

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Gene: Usp48 (ubiquitin specific peptidase 48) Rattus norvegicus
Analyze
Symbol: Usp48
Name: ubiquitin specific peptidase 48
RGD ID: 735213
Description: Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in regulation of protein stability. Located in postsynaptic membrane. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 85. Orthologous to human USP48 (ubiquitin specific peptidase 48); INTERACTS WITH 1,3-dinitrobenzene; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: deubiquitinating enzyme 48; LOC100911993; synaptic ubiquitin-specific protease; synUSP; ubiquitin carboxyl-terminal hydrolase 48; ubiquitin carboxyl-terminal hydrolase 48-like; ubiquitin specific protease 31; ubiquitin specific protease 48; ubiquitin thioesterase 48; ubiquitin thiolesterase 48; ubiquitin-specific-processing protease 48; Usp31
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85155,083,520 - 155,151,208 (+)NCBIGRCr8
mRatBN7.25149,800,189 - 149,867,838 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5149,800,179 - 149,867,719 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5152,496,642 - 152,563,755 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05154,270,935 - 154,338,044 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05154,252,948 - 154,320,051 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05155,935,102 - 156,002,722 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5155,934,490 - 156,002,721 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05159,690,824 - 159,758,706 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45156,351,117 - 156,418,283 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15156,361,155 - 156,428,321 (+)NCBI
Celera5148,196,521 - 148,263,977 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Usp48Rat3-hydroxy-3-methylglutaryl-CoA lyase deficiency  ISOUSP48 (Homo sapiens)8554872ClinVar Annotator: match by term: Deficiency of hydroxymethylglutaryl-CoA lyaseClinVarPMID:28492532
Usp48Ratautosomal dominant nonsyndromic deafness 85  ISOUSP48 (Homo sapiens)8554872ClinVar Annotator: match by term: Deafness and autosomal dominant 85ClinVarPMID:25741868 and PMID:34059922
Usp48Ratcongenital disorder of glycosylation Ir  ISOUSP48 (Homo sapiens)8554872ClinVar Annotator: match by term: Congenital disorder of glycosylation type IrClinVarPMID:28492532
Usp48Rathyperprolinemia type 2  ISOUSP48 (Homo sapiens)8554872ClinVar Annotator: match by term: Hyperprolinemia type 2ClinVarPMID:28492532
Usp48RatParkinson's disease 6  ISOUSP48 (Homo sapiens)8554872ClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6ClinVarPMID:28492532
Usp48Ratprostate cancer  ISOUSP48 (Homo sapiens)8554872ClinVar Annotator: match by term: Malignant tumor of prostateClinVarPMID:23265383
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Usp48Ratamphetamine abuse  ISOUSP48 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18316681
Usp48Rattype 2 diabetes mellitus  ISOUSP48 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:30718926
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Usp48Ratautosomal dominant nonsyndromic deafness 85  ISOUSP48 (Homo sapiens)7240710 OMIM 

1 to 20 of 57 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Usp48Rat1,2-dimethylhydrazine decreases expressionISOUsp48 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of USP48 mRNACTDPMID:22206623
Usp48Rat1,3-dinitrobenzene increases expressionEXP 64804643-dinitrobenzene results in increased expression of USP48 mRNACTDPMID:24140754
Usp48Rat17alpha-ethynylestradiol increases expressionISOUsp48 (Mus musculus)6480464Ethinyl Estradiol results in increased expression of USP48 mRNACTDPMID:17942748
Usp48Rat17alpha-ethynylestradiol multiple interactionsISOUsp48 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of USP48 mRNACTDPMID:17942748
Usp48Rat2,3',4,4',5-Pentachlorobiphenyl increases expressionISOUsp48 (Mus musculus)64804642 more ...CTDPMID:31388691
Usp48Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOUsp48 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of USP48 mRNACTDPMID:17942748
Usp48Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of USP48 mRNACTDPMID:33387578
Usp48Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of USP48 mRNACTDPMID:34747641
Usp48Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOUsp48 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of USP48 mRNACTDPMID:21570461
Usp48Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOUsp48 (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of USP48 mRNACTDPMID:19770486
Usp48Rat2,6-dinitrotoluene affects expressionEXP 64804642 and 6-dinitrotoluene affects the expression of USP48 mRNACTDPMID:21346803
Usp48Rat3,4-methylenedioxymethamphetamine decreases expressionISOUsp48 (Mus musculus)6480464N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of USP48 mRNACTDPMID:26251327
Usp48Rat6-propyl-2-thiouracil decreases expressionEXP 6480464Propylthiouracil results in decreased expression of USP48 mRNACTDPMID:24780913
Usp48Ratacetamide decreases expressionEXP 6480464acetamide results in decreased expression of USP48 mRNACTDPMID:31881176
Usp48Ratacrylamide increases expressionEXP 6480464Acrylamide results in increased expression of USP48 mRNACTDPMID:28959563
Usp48Rataflatoxin B1 increases expressionISOUsp48 (Mus musculus)6480464Aflatoxin B1 results in increased expression of USP48 mRNACTDPMID:19770486
Usp48Ratall-trans-retinoic acid decreases expressionISOUSP48 (Homo sapiens)6480464Tretinoin results in decreased expression of USP48 mRNACTDPMID:33167477
Usp48Ratantirheumatic drug increases expressionISOUSP48 (Homo sapiens)6480464Antirheumatic Agents results in increased expression of USP48 mRNACTDPMID:24449571
Usp48Ratapigenin increases expressionISOUsp48 (Mus musculus)6480464Apigenin results in increased expression of USP48 mRNACTDPMID:22359648
Usp48Rataristolochic acid A decreases expressionISOUSP48 (Homo sapiens)6480464aristolochic acid I results in decreased expression of USP48 mRNACTDPMID:33212167

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Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Usp48Ratprotein deubiquitination involved_inIEAInterPro:IPR001394 and InterPro:IPR0447431600115GO_REF:0000002InterProGO_REF:0000002
Usp48Ratproteolysis involved_inIEAUniProtKB-KW:KW-06451600115GO_REF:0000043UniProtGO_REF:0000043
Usp48Ratregulation of protein stability involved_inIBAFB:FBgn0016756 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033

Cellular Component
1 to 15 of 15 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Usp48Ratcell projection located_inIEAUniProtKB-KW:KW-09661600115GO_REF:0000043UniProtGO_REF:0000043
Usp48Ratcilium located_inIEAUniProtKB-SubCell:SL-00661600115GO_REF:0000044UniProtGO_REF:0000044
Usp48Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Usp48Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Usp48Ratcytosol located_inISOUSP48 (Homo sapiens) more ...1624291 RGDGO_REF:0000052
Usp48Ratcytosol is_active_inIBAFB:FBgn0016756 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Usp48Ratcytosol located_inIEAUniProtKB:Q86UV5 and ensembl:ENSP000003092621600115GO_REF:0000107EnsemblGO_REF:0000107
Usp48Ratmitochondrion located_inISOUSP48 (Homo sapiens) more ...1624291 RGDGO_REF:0000052
Usp48Ratmitochondrion located_inIEAUniProtKB:Q86UV5 and ensembl:ENSP000003092621600115GO_REF:0000107EnsemblGO_REF:0000107
Usp48Ratnucleoplasm located_inIEAUniProtKB:Q86UV5 and ensembl:ENSP000003092621600115GO_REF:0000107EnsemblGO_REF:0000107
Usp48Ratnucleoplasm located_inISOUSP48 (Homo sapiens) more ...1624291 RGDGO_REF:0000052
Usp48Ratnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
Usp48Ratnucleus is_active_inIBAFB:FBgn0016756 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Usp48Ratnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
Usp48Ratpostsynaptic membrane  IDA 1299652 RGD 
1 to 15 of 15 rows

Molecular Function
1 to 10 of 10 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Usp48Ratcysteine-type deubiquitinase activity enablesIEAInterPro:IPR001394 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Usp48Ratcysteine-type deubiquitinase activity enablesIBAFB:FBgn0005632 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Usp48Ratcysteine-type deubiquitinase activity enablesIEAEC:3.4.19.121600115GO_REF:0000003UniProtGO_REF:0000003
Usp48Ratcysteine-type endopeptidase activity enablesIEAInterPro:IPR0447431600115GO_REF:0000002InterProGO_REF:0000002
Usp48Ratcysteine-type peptidase activity enablesIEAUniProtKB-KW:KW-07881600115GO_REF:0000043UniProtGO_REF:0000043
Usp48Ratdeubiquitinase activity enablesISOUSP48 (Homo sapiens)1624291 PMID:34059922RGDPMID:34059922
Usp48Ratdeubiquitinase activity enablesIEAUniProtKB:Q86UV5 and ensembl:ENSP000003092621600115GO_REF:0000107EnsemblGO_REF:0000107
Usp48Rathydrolase activity enablesIEAUniProtKB-KW:KW-03781600115GO_REF:0000043UniProtGO_REF:0000043
Usp48Ratpeptidase activity enablesIEAUniProtKB-KW:KW-06451600115GO_REF:0000043UniProtGO_REF:0000043
Usp48Ratprotein binding enablesISOUSP48 (Homo sapiens)1624291UniProtKB:Q13148 and PMID:32814053RGDPMID:32814053
1 to 10 of 10 rows


#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. A novel ubiquitin-specific protease, synUSP, is localized at the post-synaptic density and post-synaptic lipid raft. Tian QB, etal., J Neurochem 2003 Nov;87(3):665-75.


Usp48
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85155,083,520 - 155,151,208 (+)NCBIGRCr8
mRatBN7.25149,800,189 - 149,867,838 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5149,800,179 - 149,867,719 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5152,496,642 - 152,563,755 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05154,270,935 - 154,338,044 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05154,252,948 - 154,320,051 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05155,935,102 - 156,002,722 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5155,934,490 - 156,002,721 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05159,690,824 - 159,758,706 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45156,351,117 - 156,418,283 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15156,361,155 - 156,428,321 (+)NCBI
Celera5148,196,521 - 148,263,977 (+)NCBICelera
Cytogenetic Map5q36NCBI
USP48
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38121,678,298 - 21,783,149 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl121,678,298 - 21,783,606 (-)EnsemblGRCh38hg38GRCh38
GRCh37122,004,791 - 22,109,642 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36121,877,378 - 21,982,275 (-)NCBINCBI36Build 36hg18NCBI36
Build 34121,750,393 - 21,854,960NCBI
Celera120,327,493 - 20,432,623 (-)NCBICelera
Cytogenetic Map1p36.12NCBI
HuRef120,248,246 - 20,353,123 (-)NCBIHuRef
CHM1_1122,116,743 - 22,222,156 (-)NCBICHM1_1
T2T-CHM13v2.0121,502,254 - 21,607,091 (-)NCBIT2T-CHM13v2.0
Usp48
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394137,321,079 - 137,385,842 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4137,321,066 - 137,385,848 (+)EnsemblGRCm39 Ensembl
GRCm384137,594,120 - 137,658,537 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4137,593,755 - 137,658,537 (+)EnsemblGRCm38mm10GRCm38
MGSCv374137,150,104 - 137,214,452 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364135,261,884 - 135,263,495 (+)NCBIMGSCv36mm8
MGSCv364136,929,110 - 136,930,605 (+)NCBIMGSCv36mm8
Celera4135,805,168 - 135,866,736 (+)NCBICelera
Cytogenetic Map4D3NCBI
cM Map470.0NCBI
Usp48
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554521,959,396 - 2,031,829 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554521,959,396 - 2,031,829 (-)NCBIChiLan1.0ChiLan1.0
USP48
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21205,156,524 - 205,262,860 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11204,268,387 - 204,374,735 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0120,870,023 - 20,974,251 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1121,834,330 - 21,939,250 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl121,834,638 - 21,939,250 (-)Ensemblpanpan1.1panPan2
USP48
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1277,401,101 - 77,484,139 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl277,379,440 - 77,484,089 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha273,903,899 - 73,988,493 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0277,959,166 - 78,043,360 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl277,933,330 - 78,043,356 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1274,778,845 - 74,862,587 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0275,788,846 - 75,873,345 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0276,791,995 - 76,876,474 (+)NCBIUU_Cfam_GSD_1.0
Usp48
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505841,483,213 - 41,551,300 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364747,307,439 - 7,376,074 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364747,307,475 - 7,376,086 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
USP48
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl679,744,932 - 79,810,220 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1679,744,928 - 79,810,241 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
USP48
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120110,854,966 - 110,958,140 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20110,854,758 - 110,960,529 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660335,331,713 - 5,436,227 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Usp48
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247646,528,084 - 6,610,926 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Usp48
385 total Variants

Predicted Target Of
Summary Value
Count of predictions:556
Count of miRNA genes:255
Interacting mature miRNAs:334
Transcripts:ENSRNOT00000031855
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 38 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
2302369Scl60Serum cholesterol level QTL 603.13blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)5143608201161165651Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5144358090157869054Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5129132447151006154Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat

1 to 10 of 38 rows
D5Got89  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25149,802,648 - 149,802,819 (+)MAPPERmRatBN7.2
Rnor_6.05155,937,541 - 155,937,711NCBIRnor6.0
Rnor_5.05159,693,508 - 159,693,678UniSTSRnor5.0
RGSC_v3.45156,353,104 - 156,353,274UniSTSRGSC3.4
RGSC_v3.45156,353,103 - 156,353,274RGDRGSC3.4
RGSC_v3.45156,311,849 - 156,312,022RGDRGSC3.4
RGSC_v3.45156,311,850 - 156,312,022UniSTSRGSC3.4
RGSC_v3.15156,363,142 - 156,363,313RGD
Celera5148,198,502 - 148,198,672UniSTS
RH 3.4 Map51013.2UniSTS
RH 3.4 Map51013.2RGD
Cytogenetic Map5q36UniSTS
D5Kyo1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25149,859,140 - 149,859,339 (-)MAPPERmRatBN7.2
Rnor_6.01873,418,416 - 73,418,614NCBIRnor6.0
Rnor_6.05155,994,039 - 155,994,223NCBIRnor6.0
Rnor_5.05159,750,008 - 159,750,206UniSTSRnor5.0
Rnor_5.01873,094,373 - 73,094,571UniSTSRnor5.0
RGSC_v3.45156,409,585 - 156,409,783UniSTSRGSC3.4
Celera5148,255,284 - 148,255,468UniSTS
Cytogenetic Map5q36UniSTS
RH128097  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25149,867,608 - 149,867,824 (-)MAPPERmRatBN7.2
mRatBN7.25149,867,608 - 149,867,824 (+)MAPPERmRatBN7.2
Rnor_6.05156,002,493 - 156,002,708NCBIRnor6.0
Rnor_6.01873,409,930 - 73,410,145NCBIRnor6.0
Rnor_5.05159,758,477 - 159,758,692UniSTSRnor5.0
Rnor_5.01873,085,887 - 73,086,102UniSTSRnor5.0
RGSC_v3.45156,418,054 - 156,418,269UniSTSRGSC3.4
Celera5148,263,748 - 148,263,963UniSTS
RH 3.4 Map51009.7UniSTS
Cytogenetic Map5q36UniSTS
AW533548  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25149,865,636 - 149,865,843 (+)MAPPERmRatBN7.2
mRatBN7.25149,865,636 - 149,865,843 (-)MAPPERmRatBN7.2
Rnor_6.01873,411,911 - 73,412,117NCBIRnor6.0
Rnor_6.05156,000,521 - 156,000,727NCBIRnor6.0
Rnor_5.05159,756,505 - 159,756,711UniSTSRnor5.0
Rnor_5.01873,087,868 - 73,088,074UniSTSRnor5.0
RGSC_v3.45156,416,082 - 156,416,288UniSTSRGSC3.4
Celera5148,261,776 - 148,261,982UniSTS
RH 3.4 Map51010.8UniSTS
Cytogenetic Map5q36UniSTS
rs66001705  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25149,810,483 - 149,810,483RGDmRatBN7.2
Rnor_6.05155,945,375 - 155,945,375RGDRnor6.0




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000031855   ⟹   ENSRNOP00000030008
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5149,800,657 - 149,867,719 (+)Ensembl
Rnor_6.0 Ensembl5155,935,554 - 156,002,721 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000077933   ⟹   ENSRNOP00000069188
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5149,800,179 - 149,867,454 (+)Ensembl
Rnor_6.0 Ensembl5155,934,490 - 156,000,528 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000112285   ⟹   ENSRNOP00000095844
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5149,800,657 - 149,867,719 (+)Ensembl
RefSeq Acc Id: NM_198785   ⟹   NP_942080
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85155,084,038 - 155,151,208 (+)NCBI
mRatBN7.25149,800,662 - 149,867,838 (+)NCBI
Rnor_6.05155,935,554 - 156,002,722 (+)NCBI
Rnor_5.05159,690,824 - 159,758,706 (+)NCBI
RGSC_v3.45156,351,117 - 156,418,283 (+)RGD
Celera5148,196,521 - 148,263,977 (+)RGD
Sequence:
RefSeq Acc Id: XM_006239234   ⟹   XP_006239296
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85155,083,520 - 155,151,208 (+)NCBI
mRatBN7.25149,800,189 - 149,867,838 (+)NCBI
Rnor_6.05155,935,103 - 156,002,722 (+)NCBI
Rnor_5.05159,690,824 - 159,758,706 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006239235   ⟹   XP_006239297
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85155,083,520 - 155,151,208 (+)NCBI
mRatBN7.25149,800,189 - 149,867,838 (+)NCBI
Rnor_6.05155,935,103 - 156,002,722 (+)NCBI
Rnor_5.05159,690,824 - 159,758,706 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006239236   ⟹   XP_006239298
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85155,083,520 - 155,151,208 (+)NCBI
mRatBN7.25149,800,189 - 149,867,838 (+)NCBI
Rnor_6.05155,935,103 - 156,002,722 (+)NCBI
Rnor_5.05159,690,824 - 159,758,706 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006239237   ⟹   XP_006239299
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85155,083,520 - 155,151,208 (+)NCBI
mRatBN7.25149,800,189 - 149,867,838 (+)NCBI
Rnor_6.05155,935,103 - 156,002,722 (+)NCBI
Rnor_5.05159,690,824 - 159,758,706 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039110421   ⟹   XP_038966349
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85155,083,520 - 155,113,275 (+)NCBI
mRatBN7.25149,800,189 - 149,829,903 (+)NCBI
RefSeq Acc Id: XR_592739
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85155,083,520 - 155,129,724 (+)NCBI
mRatBN7.25149,800,189 - 149,853,702 (+)NCBI
Rnor_6.05155,935,102 - 155,988,600 (+)NCBI
Sequence:
1 to 10 of 10 rows
Protein RefSeqs NP_942080 (Get FASTA)   NCBI Sequence Viewer  
  XP_006239296 (Get FASTA)   NCBI Sequence Viewer  
  XP_006239297 (Get FASTA)   NCBI Sequence Viewer  
  XP_006239298 (Get FASTA)   NCBI Sequence Viewer  
  XP_006239299 (Get FASTA)   NCBI Sequence Viewer  
  XP_038966349 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAD00009 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000030008
  ENSRNOP00000069188
GenBank Protein Q76LT8 (Get FASTA)   NCBI Sequence Viewer  
1 to 10 of 10 rows
RefSeq Acc Id: NP_942080   ⟸   NM_198785
- UniProtKB: Q76LT8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006239298   ⟸   XM_006239236
- Peptide Label: isoform X3
- UniProtKB: Q76LT8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006239299   ⟸   XM_006239237
- Peptide Label: isoform X4
- UniProtKB: Q76LT8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006239296   ⟸   XM_006239234
- Peptide Label: isoform X1
- UniProtKB: Q76LT8 (UniProtKB/Swiss-Prot),   A0A0G2JUQ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006239297   ⟸   XM_006239235
- Peptide Label: isoform X2
- UniProtKB: Q76LT8 (UniProtKB/Swiss-Prot)
- Sequence:
DUSP   Ubiquitin-like   USP

Name Modeler Protein Id AA Range Protein Structure
AF-Q76LT8-F1-model_v2 AlphaFold Q76LT8 1-1036 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13694181
Promoter ID:EPDNEW_R4706
Type:initiation region
Name:Usp48_1
Description:ubiquitin specific peptidase 48
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05155,935,534 - 155,935,594EPDNEW


1 to 36 of 36 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-39473 BioCyc
Ensembl Genes ENSRNOG00000013602 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000031855 ENTREZGENE
  ENSRNOT00000077933 ENTREZGENE
Gene3D-CATH Cysteine proteinases UniProtKB/Swiss-Prot
  Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1 UniProtKB/Swiss-Prot
InterPro DUSP-like_sf UniProtKB/Swiss-Prot
  Papain-like_cys_pep_sf UniProtKB/Swiss-Prot
  Pept_C19_DUSP UniProtKB/Swiss-Prot
  Peptidase_C19 UniProtKB/Swiss-Prot
  Peptidase_C19_UCH UniProtKB/Swiss-Prot
  Ubiquitin-like_domsf UniProtKB/Swiss-Prot
  Ubiquitin_dom UniProtKB/Swiss-Prot
  Ubl_USP48 UniProtKB/Swiss-Prot
  USP48 UniProtKB/Swiss-Prot
  USP_CS UniProtKB/Swiss-Prot
  USP_dom UniProtKB/Swiss-Prot
KEGG Report rno:362636 UniProtKB/Swiss-Prot
NCBI Gene 362636 ENTREZGENE
PANTHER UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UniProtKB/Swiss-Prot
  UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 48 UniProtKB/Swiss-Prot
Pfam DUSP UniProtKB/Swiss-Prot
  UCH UniProtKB/Swiss-Prot
PhenoGen Usp48 PhenoGen
PROSITE DUSP UniProtKB/Swiss-Prot
  UBIQUITIN_2 UniProtKB/Swiss-Prot
  USP_2 UniProtKB/Swiss-Prot
  USP_3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000013602 RatGTEx
Superfamily-SCOP SSF143791 UniProtKB/Swiss-Prot
  SSF54001 UniProtKB/Swiss-Prot
  SSF54236 UniProtKB/Swiss-Prot
UniProt A0A0G2JUQ8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6B3E6_RAT UniProtKB/TrEMBL
  F1M9B3_RAT UniProtKB/TrEMBL
  Q76LT8 ENTREZGENE, UniProtKB/Swiss-Prot
1 to 36 of 36 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Usp48  ubiquitin specific peptidase 48  LOC100911993  ubiquitin carboxyl-terminal hydrolase 48-like  Data merged from RGD:6489246 737654 PROVISIONAL
2012-07-05 LOC100911993  ubiquitin carboxyl-terminal hydrolase 48-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2010-05-07 Usp48  ubiquitin specific peptidase 48  Usp48  ubiquitin specific protease 48  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Usp48  ubiquitin specific protease 48  Usp31  ubiquitin specific protease 31  Symbol and Name updated 1299863 APPROVED