Gpx2 (glutathione peroxidase 2) - Rat Genome Database

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Gene: Gpx2 (glutathione peroxidase 2) Rattus norvegicus
Analyze
Symbol: Gpx2
Name: glutathione peroxidase 2
RGD ID: 727780
Description: Enables glutathione peroxidase activity. Involved in response to salicylic acid and response to selenium ion. Predicted to be located in cytosol; intercellular bridge; and mitotic spindle. Orthologous to human GPX2 (glutathione peroxidase 2); PARTICIPATES IN arachidonic acid metabolic pathway; glutathione metabolic pathway; INTERACTS WITH (+)-schisandrin B; (R)-lipoic acid; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: glutathione peroxidase-gastrointestinal; GPx-2; GPX-GI; GSHPx-2; GSHPx-GI; phospholipid hydroperoxide glutathione peroxidase GPX2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Gpx2-ps1   Gpx2-ps2  
Candidate Gene For: Schws4
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86101,226,745 - 101,230,033 (-)NCBIGRCr8
mRatBN7.2695,493,589 - 95,496,877 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl695,493,589 - 95,496,877 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx695,882,234 - 95,885,509 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0696,180,771 - 96,184,046 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0695,609,574 - 95,612,849 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0699,839,960 - 99,843,245 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl699,839,960 - 99,843,245 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06109,236,420 - 109,239,718 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4699,372,418 - 99,376,230 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1699,375,879 - 99,379,686 (-)NCBI
Celera693,912,759 - 93,916,226 (-)NCBICelera
Cytogenetic Map6q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gpx2RatCarbon Tetrachloride Poisoning treatmentIEP 401827907 RGD 
Gpx2Ratcolon cancer treatmentISOGpx2 (Mus musculus)152995480associated with InflammationRGD 
Gpx2Ratcolorectal adenoma  ISOGPX2 (Homo sapiens)151665806mRNA:increased expression:colorectum (human)RGD 
Gpx2Ratcolorectal cancer disease_progressionISOGPX2 (Homo sapiens)152998902protein:increased expression:large intestine (human)RGD 
Gpx2Ratcolorectal carcinoma  ISOGPX2 (Homo sapiens)151665806mRNA:increased expression:colorectum (human)RGD 
Gpx2Ratulcerative colitis disease_progressionISOGPX2 (Homo sapiens)152998902protein:increased expression:large intestine (human)RGD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gpx2Ratautism spectrum disorder  ISOGPX2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:35663546
Gpx2RatBreast Neoplasms  ISOGPX2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18056462
Gpx2RatLiver Neoplasms  ISOGPX2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:28108177
Gpx2RatNeoplasm Metastasis  ISOGPX2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23867582

1 to 20 of 385 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gpx2Rat(+)-schisandrin B multiple interactionsEXP 6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of GPX2 mRNA]CTDPMID:31150632
Gpx2Rat(1->4)-beta-D-glucan multiple interactionsISOGpx2 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of GPX2 mRNACTDPMID:36331819
Gpx2Rat(R)-lipoic acid multiple interactionsEXP 6480464[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of GPX2 mRNACTDPMID:23830814
Gpx2Rat(S)-naringenin multiple interactionsISOGPX2 (Homo sapiens)6480464[Paraquat co-treated with naringenin] results in increased expression of GPX2 mRNACTDPMID:24561720
Gpx2Rat(S)-naringenin increases expressionISOGPX2 (Homo sapiens)6480464naringenin results in increased expression of GPX2 mRNACTDPMID:24561720
Gpx2Rat1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane affects expressionEXP 6480464o and p'-DDT affects the expression of GPX2 mRNACTDPMID:17984292
Gpx2Rat1,2-dimethylhydrazine increases expressionEXP 64804641 and 2-Dimethylhydrazine results in increased expression of GPX2 mRNACTDPMID:32387197
Gpx2Rat1,2-dimethylhydrazine decreases expressionEXP 64804641 and 2-Dimethylhydrazine results in decreased expression of GPX2 mRNACTDPMID:32028820
Gpx2Rat1,2-dimethylhydrazine multiple interactionsEXP 6480464[1 and 2-Dimethylhydrazine co-treated with morin] results in increased expression of GPX2 mRNACTDPMID:32028820
Gpx2Rat1,2-dimethylhydrazine increases expressionISOGpx2 (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of GPX2 mRNACTDPMID:22206623
Gpx2Rat1,2-dimethylhydrazine multiple interactionsISOGpx2 (Mus musculus)6480464Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in increased expression of GPX2 mRNA]CTDPMID:22206623
Gpx2Rat1-chloro-2,4-dinitrobenzene affects expressionISOGpx2 (Mus musculus)6480464Dinitrochlorobenzene affects the expression of GPX2 mRNACTDPMID:28219650
Gpx2Rat1-chloro-2,4-dinitrobenzene multiple interactionsISOGpx2 (Mus musculus)6480464NFE2L2 protein promotes the reaction [Dinitrochlorobenzene results in increased expression of GPX2 mRNA]CTDPMID:28219650
Gpx2Rat1-naphthyl isothiocyanate multiple interactionsISOGpx2 (Mus musculus)6480464[1-Naphthylisothiocyanate co-treated with Allopurinol] results in increased expression of GPX2 mRNA more ...CTDPMID:30517764 and PMID:33749747
Gpx2Rat1-naphthyl isothiocyanate increases expressionEXP 64804641-Naphthylisothiocyanate results in increased expression of GPX2 mRNACTDPMID:30723492
Gpx2Rat1-naphthyl isothiocyanate increases expressionISOGpx2 (Mus musculus)64804641-Naphthylisothiocyanate results in increased expression of GPX2 mRNACTDPMID:30517764 and PMID:33749747
Gpx2Rat17alpha-ethynylestradiol multiple interactionsISOGpx2 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GPX2 mRNACTDPMID:17942748
Gpx2Rat17alpha-ethynylestradiol increases expressionEXP 6480464Ethinyl Estradiol results in increased expression of GPX2 mRNACTDPMID:15576828 more ...
Gpx2Rat17beta-estradiol multiple interactionsISOGPX2 (Homo sapiens)6480464[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of GPX2 mRNA more ...CTDPMID:17404688 more ...
Gpx2Rat17beta-estradiol multiple interactionsEXP 6480464[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of GPX2 mRNACTDPMID:32741896

1 to 20 of 385 rows

Biological Process
1 to 10 of 10 rows

  
1 to 10 of 10 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gpx2Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Gpx2Ratcytosol located_inISOGPX2 (Homo sapiens)1624291 PMID:8428933RGDGO_REF:0000052 and PMID:8428933
Gpx2Ratcytosol located_inIEAUniProtKB:P18283 and ensembl:ENSP000003742651600115GO_REF:0000107EnsemblGO_REF:0000107
Gpx2Ratcytosol located_inIEAUniProtKB-SubCell:SL-00911600115GO_REF:0000044UniProtGO_REF:0000044
Gpx2Ratintercellular bridge located_inISOGPX2 (Homo sapiens)1624291 RGDGO_REF:0000052
Gpx2Ratintercellular bridge located_inIEAUniProtKB:P18283 and ensembl:ENSP000003742651600115GO_REF:0000107EnsemblGO_REF:0000107
Gpx2Ratmitotic spindle located_inISOGPX2 (Homo sapiens)1624291 RGDGO_REF:0000052
Gpx2Ratmitotic spindle located_inIEAUniProtKB:P18283 and ensembl:ENSP000003742651600115GO_REF:0000107EnsemblGO_REF:0000107

Molecular Function
1 to 13 of 13 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gpx2Ratglutathione peroxidase activity  IDA 1299548 RGD 
Gpx2Ratglutathione peroxidase activity enablesIEAEC:1.11.1.91600115GO_REF:0000003UniProtGO_REF:0000003
Gpx2Ratglutathione peroxidase activity enablesISOGpx2 (Mus musculus)1624291MGI:1888703 PMID:11518697 and PMID:12751789RGDPMID:11518697 and PMID:12751789
Gpx2Ratglutathione peroxidase activity enablesIBAMGI:104887 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Gpx2Ratglutathione peroxidase activity enablesIEARHEA:168331600115GO_REF:0000116RHEAGO_REF:0000116
Gpx2Ratglutathione peroxidase activity enablesIEAUniProtKB:P18283 and ensembl:ENSP000003742651600115GO_REF:0000107EnsemblGO_REF:0000107
Gpx2Ratglutathione peroxidase activity enablesISOGPX2 (Homo sapiens)1624291 PMID:36608588 and PMID:8428933RGDPMID:36608588 and PMID:8428933
Gpx2Ratoxidoreductase activity enablesIEAUniProtKB-KW:KW-05601600115GO_REF:0000043UniProtGO_REF:0000043
Gpx2Ratperoxidase activity enablesIEAInterPro:IPR0008891600115GO_REF:0000002InterProGO_REF:0000002
Gpx2Ratperoxidase activity enablesIEAUniProtKB-KW:KW-05751600115GO_REF:0000043UniProtGO_REF:0000043
Gpx2Ratphospholipid-hydroperoxide glutathione peroxidase activity enablesIEAUniProtKB:P18283 and ensembl:ENSP000003742651600115GO_REF:0000107EnsemblGO_REF:0000107
Gpx2Ratphospholipid-hydroperoxide glutathione peroxidase activity enablesIEARHEA:190571600115GO_REF:0000116RHEAGO_REF:0000116
Gpx2Ratphospholipid-hydroperoxide glutathione peroxidase activity enablesISOGPX2 (Homo sapiens)1624291 PMID:36608588RGDPMID:36608588
1 to 13 of 13 rows

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gpx2Ratarachidonic acid metabolic pathway  IEA 6907045 KEGGrno:00590
Gpx2Ratglutathione metabolic pathway  IEA 6907045 KEGGrno:00480

1 to 16 of 16 rows
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Reference Title
Reference Citation
1. GPx2 counteracts PGE2 production by dampening COX-2 and mPGES-1 expression in human colon cancer cells. Banning A, etal., Antioxid Redox Signal. 2008 Sep;10(9):1491-500. doi: 10.1089/ars.2008.2047.
2. Feeding of selenium alone or in combination with glucoraphanin differentially affects intestinal and hepatic antioxidant and phase II enzymes in growing rats. Blum NM, etal., Biol Trace Elem Res. 2013 Mar;151(3):384-99. doi: 10.1007/s12011-012-9567-6. Epub 2012 Dec 29.
3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, etal., Genome Res 1996 Sep;6(9):791-806.
4. Salicylic acid modulates oxidative stress and glutathione peroxidase activity in the rat colon. Drew JE, etal., Biochem Pharmacol. 2005 Sep 15;70(6):888-93. doi: 10.1016/j.bcp.2005.06.011.
5. Selenium-dependent glutathione peroxidase-GI is a major glutathione peroxidase activity in the mucosal epithelium of rodent intestine. Esworthy RS, etal., Biochim Biophys Acta 1998 Jul 23;1381(2):213-26.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Protective Effects of Ammannia baccifera Against CCl4-Induced Oxidative Stress in Rats. Goodla L, etal., Int J Environ Res Public Health. 2019 Apr 23;16(8):1440. doi: 10.3390/ijerph16081440.
8. Expression of Selenoprotein Genes and Association with Selenium Status in Colorectal Adenoma and Colorectal Cancer. Hughes DJ, etal., Nutrients. 2018 Nov 21;10(11). pii: nu10111812. doi: 10.3390/nu10111812.
9. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. NCBI rat LocusLink and RefSeq merged data October 15, 2003 NCBI rat LocusLink and RefSeq merged data October 15, 2003
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. GOA pipeline RGD automated data pipeline
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Dietary selenium protects adiponectin knockout mice against chronic inflammation induced colon cancer. Saxena A, etal., Cancer Biol Ther. 2017 Apr 3;18(4):257-267. doi: 10.1080/15384047.2016.1276130. Epub 2017 Jan 3.
16. Identification of gene expression profile of dorsal root ganglion in the rat peripheral axotomy model of neuropathic pain. Xiao HS, etal., Proc Natl Acad Sci U S A 2002 Jun 11;99(12):8360-5.
1 to 16 of 16 rows
PMID:11518697   PMID:12751789   PMID:16229841   PMID:17993721   PMID:18056462   PMID:23376485   PMID:23867582   PMID:24962481   PMID:26192016   PMID:37761814  



Gpx2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86101,226,745 - 101,230,033 (-)NCBIGRCr8
mRatBN7.2695,493,589 - 95,496,877 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl695,493,589 - 95,496,877 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx695,882,234 - 95,885,509 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0696,180,771 - 96,184,046 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0695,609,574 - 95,612,849 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0699,839,960 - 99,843,245 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl699,839,960 - 99,843,245 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06109,236,420 - 109,239,718 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4699,372,418 - 99,376,230 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1699,375,879 - 99,379,686 (-)NCBI
Celera693,912,759 - 93,916,226 (-)NCBICelera
Cytogenetic Map6q24NCBI
GPX2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381464,939,158 - 64,942,745 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1464,939,152 - 64,942,746 (-)EnsemblGRCh38hg38GRCh38
GRCh371465,405,876 - 65,409,463 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361464,475,625 - 64,479,284 (-)NCBINCBI36Build 36hg18NCBI36
Build 341464,475,624 - 64,479,284NCBI
Celera1445,460,457 - 45,464,116 (-)NCBICelera
Cytogenetic Map14q23.3NCBI
HuRef1445,575,494 - 45,579,247 (-)NCBIHuRef
CHM1_11465,344,036 - 65,347,793 (-)NCBICHM1_1
T2T-CHM13v2.01459,144,027 - 59,147,614 (-)NCBIT2T-CHM13v2.0
Gpx2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391276,839,109 - 76,842,328 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1276,839,107 - 76,842,273 (-)EnsemblGRCm39 Ensembl
GRCm381276,792,335 - 76,795,554 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1276,792,333 - 76,795,554 (-)EnsemblGRCm38mm10GRCm38
MGSCv371277,893,322 - 77,896,541 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361277,711,177 - 77,714,346 (-)NCBIMGSCv36mm8
Celera1277,874,684 - 77,877,908 (-)NCBICelera
Cytogenetic Map12C3NCBI
cM Map1233.73NCBI
Gpx2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554664,984,631 - 4,987,457 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554664,983,532 - 4,987,780 (+)NCBIChiLan1.0ChiLan1.0
GPX2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21566,048,329 - 66,056,792 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11465,264,842 - 65,273,236 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01445,522,558 - 45,526,678 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11464,401,921 - 64,405,720 (-)NCBIpanpan1.1PanPan1.1panPan2
GPX2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1839,322,040 - 39,325,833 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl839,322,034 - 39,325,817 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha839,014,111 - 39,017,902 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0839,544,781 - 39,548,609 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl839,544,775 - 39,548,593 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1839,166,063 - 39,169,883 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0839,238,883 - 39,242,643 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0839,597,955 - 39,601,701 (-)NCBIUU_Cfam_GSD_1.0
Gpx2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864065,598,245 - 65,601,474 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364958,590,556 - 8,593,367 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364958,590,225 - 8,593,511 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPX2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl789,007,375 - 89,011,620 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1789,007,636 - 89,011,620 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2795,388,550 - 95,392,539 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GPX2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12442,151,205 - 42,155,335 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605330,321,541 - 30,325,285 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gpx2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473436,086,902 - 36,089,855 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473436,086,831 - 36,090,180 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Gpx2
16 total Variants

1 to 10 of 32 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
634330Pia16Pristane induced arthritis QTL 163.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)645790088104200226Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)672202632115200186Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)693701310128713626Rat
1331722Thshl1Thyroid stimulating hormone level QTL 111.70.0001blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)689762877106752806Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)658632962103632962Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)685140138130140138Rat

1 to 10 of 32 rows
RH130461  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2695,493,588 - 95,493,777 (+)MAPPERmRatBN7.2
Rnor_6.0699,839,960 - 99,840,148NCBIRnor6.0
Rnor_5.06109,236,420 - 109,236,608UniSTSRnor5.0
RGSC_v3.4699,372,418 - 99,372,606UniSTSRGSC3.4
Celera693,912,759 - 93,912,947UniSTS
RH 3.4 Map6677.1UniSTS
Cytogenetic Map6q24UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 10 41 111 91 90 59 25 59 6 207 86 91 45 59 31



Ensembl Acc Id: ENSRNOT00000080270   ⟹   ENSRNOP00000072136
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl695,493,589 - 95,496,877 (-)Ensembl
Rnor_6.0 Ensembl699,839,960 - 99,843,245 (-)Ensembl
RefSeq Acc Id: NM_183403   ⟹   NP_899653
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86101,226,745 - 101,230,033 (-)NCBI
mRatBN7.2695,493,589 - 95,496,877 (-)NCBI
Rnor_6.0699,839,960 - 99,843,245 (-)NCBI
Rnor_5.06109,236,420 - 109,239,718 (-)NCBI
RGSC_v3.4699,372,418 - 99,376,230 (-)RGD
Celera693,912,759 - 93,916,226 (-)RGD
Sequence:
Protein RefSeqs NP_899653 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000072136
GenBank Protein P83645 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_899653   ⟸   NM_183403
- UniProtKB: P83645 (UniProtKB/Swiss-Prot),   A0A0G2K278 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072136   ⟸   ENSRNOT00000080270


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13694680
Promoter ID:EPDNEW_R5205
Type:multiple initiation site
Name:Gpx2_1
Description:glutathione peroxidase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0699,843,141 - 99,843,201EPDNEW


1 to 26 of 26 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-37047 BioCyc
BioCyc Pathway DETOX1-PWY-1 [reactive oxygen species degradation] BioCyc
  PWY-4081 [glutathione-peroxide redox reactions] BioCyc
BioCyc Pathway Image DETOX1-PWY-1 BioCyc
  PWY-4081 BioCyc
Ensembl Genes ENSRNOG00000055672 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000080270 ENTREZGENE
Gene3D-CATH Glutaredoxin UniProtKB/Swiss-Prot
InterPro Glutathione_peroxidase UniProtKB/Swiss-Prot
  GPX_AS UniProtKB/Swiss-Prot
  GPX_CS UniProtKB/Swiss-Prot
  Thioredoxin-like_sf UniProtKB/Swiss-Prot
NCBI Gene 29326 ENTREZGENE
PANTHER Glut_peroxidase UniProtKB/Swiss-Prot
  GLUTATHIONE PEROXIDASE 2 UniProtKB/Swiss-Prot
Pfam GSHPx UniProtKB/Swiss-Prot
PhenoGen Gpx2 PhenoGen
PIRSF Glutathion_perox UniProtKB/Swiss-Prot
PRINTS GLUTPROXDASE UniProtKB/Swiss-Prot
PROSITE GLUTATHIONE_PEROXID_1 UniProtKB/Swiss-Prot
  GLUTATHIONE_PEROXID_2 UniProtKB/Swiss-Prot
  GLUTATHIONE_PEROXID_3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000055672 RatGTEx
Superfamily-SCOP Thiordxn-like_fd UniProtKB/Swiss-Prot
UniProt A0A0G2K278 ENTREZGENE, UniProtKB/TrEMBL
  GPX2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 26 of 26 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-12-14 Gpx2  glutathione peroxidase 2      Symbol and Name status set to approved 1299863 APPROVED