Abcc3 (ATP binding cassette subfamily C member 3) - Rat Genome Database

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Gene: Abcc3 (ATP binding cassette subfamily C member 3) Rattus norvegicus
Analyze
Symbol: Abcc3
Name: ATP binding cassette subfamily C member 3
RGD ID: 71101
Description: Enables ABC-type bile acid transporter activity. Involved in several processes, including bile acid and bile salt transport; response to estradiol; and response to tetrachloromethane. Acts upstream of or within canalicular bile acid transport. Located in basolateral plasma membrane. Biomarker of bilirubin metabolic disorder (multiple); cholestasis; hyperprolactinemia; kidney disease (multiple); and liver disease (multiple). Orthologous to human ABCC3 (ATP binding cassette subfamily C member 3); PARTICIPATES IN doxorubicin pharmacokinetics pathway; etoposide pharmacodynamics pathway; etoposide pharmacokinetics pathway; INTERACTS WITH (S)-colchicine; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ATP-binding cassette sub-family C member 3; ATP-binding cassette, sub-family C (CFTR/MRP), member 3; ATP-binding cassette, subfamily C (CFTR/MRP), member 3; canalicular multispecific organic anion transporter 2; MLP-2; Mlp2; MRP-like protein 2; Mrp3; multidrug resistance protein 3; multidrug resistance-associated protein 3; organic anion transporter
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81079,793,571 - 79,839,528 (-)NCBIGRCr8
mRatBN7.21079,296,681 - 79,342,749 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1079,296,693 - 79,342,595 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1083,901,889 - 83,947,612 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01083,400,010 - 83,445,731 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01078,914,311 - 78,960,418 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01082,047,308 - 82,116,928 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1082,047,863 - 82,117,109 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01081,879,487 - 81,880,151 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01081,896,621 - 81,938,192 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41082,986,552 - 83,030,799 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1078,085,499 - 78,131,465 (-)NCBICelera
Cytogenetic Map10q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
Abcc3Ratacute myeloid leukemia disease_progressionISOABCC3 (Homo sapiens)11081145 RGD 
Abcc3Ratbilirubin metabolic disorder  IEP 2301069mRNA:increased expression:liverRGD 
Abcc3Ratcholestasis  IEP 11535162protein:increased expression:liverRGD 
Abcc3Ratcholestasis  IEP 2301060protein:increased expression:liverRGD 
Abcc3RatDubin-Johnson syndrome  IEP 1598620 RGD 
Abcc3Ratend stage renal disease  IEP 2301067protein:decreased expression:intestineRGD 
Abcc3RatExperimental Diabetes Mellitus  IEP 11541075mRNA:increased expression:liverRGD 
Abcc3Rathepatocellular carcinoma  IEP 11535155mRNA:increased expression:liverRGD 
Abcc3Rathyperprolactinemia  IEP 11535162protein:increased expression:liverRGD 
Abcc3Ratkidney disease severityIEP 2301062mRNA:increased expression:kidneyRGD 
Abcc3Ratmetabolic dysfunction-associated steatotic liver disease  IEP 11040992protein:increased expression:liverRGD 
Abcc3Ratpancreatic cancer severityISOABCC3 (Homo sapiens)2325200mRNA:increased expression:pancreasRGD 
Abcc3Ratsteatotic liver disease  IEP 2301064mRNA and protein:increased expression:liverRGD 
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Abcc3Rathereditary breast ovarian cancer syndrome  ISOABCC3 (Homo sapiens)8554872ClinVar Annotator: match by term: Breast-ovarian cancer more ...ClinVarPMID:38922859
Abcc3Rattrichodontoosseous syndrome  ISOABCC3 (Homo sapiens)8554872ClinVar Annotator: match by term: Tricho-dento-osseous syndromeClinVarPMID:25741868
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Original Reference(s)
Abcc3Ratautism spectrum disorder  ISOABCC3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:35663546
Abcc3Ratcholestasis  ISOABCC3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22461449
Abcc3RatColorectal Neoplasms  ISOABCC3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22294766
Abcc3RatHepatomegaly  ISOABCC3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:28108177
Abcc3Ratrheumatoid arthritis  ISOABCC3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23897011

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Abcc3Rat(+)-artemisinin multiple interactionsISOABCC3 (Homo sapiens)6480464artemisinin inhibits the reaction [Simvastatin results in increased nitrosation of ABCC3 protein]CTDPMID:18463201
Abcc3Rat(+/-)-Aegeline multiple interactionsISOAbcc3 (Mus musculus)6480464[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of ABCC3 mRNACTDPMID:28843594
Abcc3Rat(-)-anisomycin increases expressionISOABCC3 (Homo sapiens)6480464Anisomycin results in increased expression of ABCC3 mRNACTDPMID:27507784
Abcc3Rat(-)-anisomycin multiple interactionsISOABCC3 (Homo sapiens)6480464SB 203580 inhibits the reaction [Anisomycin results in increased expression of ABCC3 mRNA]CTDPMID:27507784
Abcc3Rat(1->4)-beta-D-glucan multiple interactionsISOAbcc3 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of ABCC3 mRNACTDPMID:36331819
Abcc3Rat(RS)-coclaurine multiple interactionsISOAbcc3 (Mus musculus)6480464[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of ABCC3 mRNACTDPMID:28843594
Abcc3Rat(RS)-norcoclaurine multiple interactionsISOAbcc3 (Mus musculus)6480464[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of ABCC3 mRNACTDPMID:28843594
Abcc3Rat(S)-coclaurine multiple interactionsISOAbcc3 (Mus musculus)6480464[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of ABCC3 mRNACTDPMID:28843594
Abcc3Rat(S)-colchicine affects localizationEXP 6480464Colchicine affects the localization of ABCC3 proteinCTDPMID:12702492
Abcc3Rat1,2-dimethylhydrazine decreases expressionISOAbcc3 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of ABCC3 mRNACTDPMID:22206623
Abcc3Rat1,2-dimethylhydrazine multiple interactionsISOAbcc3 (Mus musculus)6480464Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in decreased expression of ABCC3 mRNA]CTDPMID:22206623
Abcc3Rat1,4-phenylenediamine increases expressionISOABCC3 (Homo sapiens)64804644-phenylenediamine results in increased expression of ABCC3 mRNACTDPMID:16314067
Abcc3Rat1-naphthyl isothiocyanate multiple interactionsISOAbcc3 (Mus musculus)648046418alpha-glycyrrhetinic acid affects the reaction [1-Naphthylisothiocyanate affects the expression of ABCC3 mRNA] more ...CTDPMID:19181614 more ...
Abcc3Rat1-naphthyl isothiocyanate decreases expressionISOAbcc3 (Mus musculus)64804641-Naphthylisothiocyanate results in decreased expression of ABCC3 mRNACTDPMID:30517764
Abcc3Rat1-naphthyl isothiocyanate affects expressionISOAbcc3 (Mus musculus)64804641-Naphthylisothiocyanate affects the expression of ABCC3 mRNACTDPMID:28549656
Abcc3Rat1-naphthyl isothiocyanate increases expressionISOAbcc3 (Mus musculus)64804641-Naphthylisothiocyanate results in increased expression of ABCC3 mRNA and 1-Naphthylisothiocyanate results in increased expression of ABCC3 proteinCTDPMID:19181614 more ...
Abcc3Rat1-naphthyl isothiocyanate multiple interactionsEXP 6480464resveratrol inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of ABCC3 mRNA] more ...CTDPMID:25418378
Abcc3Rat1-naphthyl isothiocyanate increases expressionEXP 64804641-Naphthylisothiocyanate results in increased expression of ABCC3 mRNA and 1-Naphthylisothiocyanate results in increased expression of ABCC3 proteinCTDPMID:14623915 more ...
Abcc3Rat15-deoxy-Delta(12,14)-prostaglandin J2 affects exportISOABCC3 (Homo sapiens)6480464ABCC3 protein affects the export of 15-deoxy-delta(12 and 14)-prostaglandin J2 analogCTDPMID:14979731
Abcc3Rat17alpha-ethynylestradiol increases uptakeISOABCC3 (Homo sapiens)6480464ABCC3 protein results in increased uptake of Ethinyl Estradiol metaboliteCTDPMID:14722317

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Biological Process
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Original Reference(s)
Abcc3Ratbile acid and bile salt transport involved_inIMP 40902972PMID:10644759UniProt 
Abcc3Ratcanalicular bile acid transport acts_upstream_of_or_withinIDA 8553810PMID:10362653MGI 
Abcc3Ratglucuronoside transport involved_inIEAGO:00151641600115GO_REF:0000108GOCGO_REF:0000108
Abcc3Ratleukotriene transport involved_inIEAUniProtKB:O15438 and ensembl:ENSP000002852381600115GO_REF:0000107EnsemblGO_REF:0000107
Abcc3Ratleukotriene transport involved_inISOABCC3 (Homo sapiens)1624291 PMID:11581266RGDPMID:11581266
Abcc3Ratleukotriene transport involved_inISSUniProtKB:O154381600115GO_REF:0000024UniProtGO_REF:0000024
Abcc3Ratlipid transport involved_inIEAUniProtKB-KW:KW-04451600115GO_REF:0000043UniProtGO_REF:0000043
Abcc3Ratmonoatomic anion transmembrane transport  IDA 2301070 RGD 
Abcc3Ratresponse to estradiol  IEP 2301068 RGD 
Abcc3Ratresponse to lipopolysaccharide  IEP 2301058 RGD 
Abcc3Ratresponse to tetrachloromethane  IEP 2301066 RGD 
Abcc3Rattransmembrane transport  IMP 1304418 RGD 
Abcc3Rattransmembrane transport involved_inIBACGD:CAL0000178329 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Abcc3Rattransmembrane transport involved_inIEAInterPro:IPR005292 and InterPro:IPR0115271600115GO_REF:0000002InterProGO_REF:0000002
Abcc3Ratxenobiotic transmembrane transport involved_inIEAUniProtKB:O15438 and ensembl:ENSP000002852381600115GO_REF:0000107EnsemblGO_REF:0000107
Abcc3Ratxenobiotic transmembrane transport involved_inISOABCC3 (Homo sapiens)1624291 PMID:11581266 and PMID:18245269RGDPMID:11581266 and PMID:18245269
Abcc3Ratxenobiotic transport involved_inISOABCC3 (Homo sapiens)1624291 PMID:18698235 and PMID:19334674RGDPMID:18698235 and PMID:19334674
Abcc3Ratxenobiotic transport involved_inIEAUniProtKB:O15438 and ensembl:ENSP000002852381600115GO_REF:0000107EnsemblGO_REF:0000107
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Cellular Component
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Original Reference(s)
Abcc3Ratbasal plasma membrane located_inISOABCC3 (Homo sapiens)1624291 PMID:35307651RGDPMID:35307651
Abcc3Ratbasal plasma membrane located_inIEAUniProtKB:O15438 and ensembl:ENSP000002852381600115GO_REF:0000107EnsemblGO_REF:0000107
Abcc3Ratbasal plasma membrane located_inIEAUniProtKB-SubCell:SL-00241600115GO_REF:0000044UniProtGO_REF:0000044
Abcc3Ratbasolateral plasma membrane  IDA 1304418 RGD 
Abcc3Ratbasolateral plasma membrane located_inISOAbcc3 (Mus musculus)1624291 PMID:16225954RGDPMID:16225954
Abcc3Ratbasolateral plasma membrane located_inIEAUniProtKB-SubCell:SL-00261600115GO_REF:0000044UniProtGO_REF:0000044
Abcc3Ratbasolateral plasma membrane located_inISOABCC3 (Homo sapiens)1624291 PMID:28408210RGDPMID:28408210
Abcc3Ratbasolateral plasma membrane located_inIEAUniProtKB:O15438 and ensembl:ENSP000002852381600115GO_REF:0000107EnsemblGO_REF:0000107
Abcc3Ratbasolateral plasma membrane located_inIEAUniProtKB:B2RX12 and ensembl:ENSMUSP000001363431600115GO_REF:0000107EnsemblGO_REF:0000107
Abcc3Ratbasolateral plasma membrane located_inIDA 724754PMID:11897632UniProt 
Abcc3Ratciliary basal body located_inIEAUniProtKB:O15438 and ensembl:ENSP000002852381600115GO_REF:0000107EnsemblGO_REF:0000107
Abcc3Ratciliary basal body located_inISOABCC3 (Homo sapiens) and UniProtKB:O15438-11624291 RGDGO_REF:0000052
Abcc3Ratmembrane is_active_inIBACGD:CAL0000178329 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Abcc3Ratmembrane located_inIEAInterPro:IPR005292 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Abcc3Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Abcc3Ratplasma membrane located_inISOABCC3 (Homo sapiens) and UniProtKB:O15438-11624291 RGDGO_REF:0000052
Abcc3Ratplasma membrane located_inIEAUniProtKB:B2RX12 and ensembl:ENSMUSP000001363431600115GO_REF:0000107EnsemblGO_REF:0000107
Abcc3Ratplasma membrane located_inIEAUniProtKB-KW:KW-10031600115GO_REF:0000043UniProtGO_REF:0000043
Abcc3Ratplasma membrane located_inIEAUniProtKB:O15438 and ensembl:ENSP000002852381600115GO_REF:0000107EnsemblGO_REF:0000107
Abcc3Ratplasma membrane located_inIDA 14929201PMID:18698235ARUK-UCL 
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Molecular Function
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Original Reference(s)
Abcc3RatABC-type bile acid transporter activity enablesIDA 40902972PMID:10644759UniProt 
Abcc3RatABC-type glutathione S-conjugate transporter activity enablesIEAEC:7.6.2.31600115GO_REF:0000003UniProtGO_REF:0000003
Abcc3RatABC-type glutathione S-conjugate transporter activity enablesIEAUniProtKB:O15438 and ensembl:ENSP000002852381600115GO_REF:0000107EnsemblGO_REF:0000107
Abcc3RatABC-type glutathione S-conjugate transporter activity enablesISOABCC3 (Homo sapiens)1624291 PMID:15083066RGDPMID:15083066
Abcc3RatABC-type glutathione S-conjugate transporter activity enablesISSUniProtKB:O154381600115GO_REF:0000024UniProtGO_REF:0000024
Abcc3RatABC-type transporter activity enablesIEAInterPro:IPR0115271600115GO_REF:0000002InterProGO_REF:0000002
Abcc3RatABC-type xenobiotic transporter activity enablesIEAUniProtKB:O15438 and ensembl:ENSP000002852381600115GO_REF:0000107EnsemblGO_REF:0000107
Abcc3RatABC-type xenobiotic transporter activity enablesIEAEC:7.6.2.21600115GO_REF:0000003UniProtGO_REF:0000003
Abcc3RatABC-type xenobiotic transporter activity enablesISOABCC3 (Homo sapiens)1624291 PMID:11581266 more ...RGDPMID:11581266 more ...
Abcc3RatATP binding enablesIEAUniProtKB-KW:KW-00671600115GO_REF:0000043UniProtGO_REF:0000043
Abcc3RatATP binding enablesIEAInterPro:IPR003439 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Abcc3RatATP hydrolysis activity enablesIEAInterPro:IPR003439 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Abcc3RatATPase-coupled transmembrane transporter activity enablesISOABCC3 (Homo sapiens)1624291 PMID:19334674RGDPMID:19334674
Abcc3RatATPase-coupled transmembrane transporter activity enablesIBAFB:FBgn0032026 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Abcc3RatATPase-coupled transmembrane transporter activity enablesIEAUniProtKB:O15438 and ensembl:ENSP000002852381600115GO_REF:0000107EnsemblGO_REF:0000107
Abcc3RatATPase-coupled transmembrane transporter activity enablesIDA 8553810PMID:10362653MGI 
Abcc3Ratglucuronoside transmembrane transporter activity enablesIEAUniProtKB:O15438 and ensembl:ENSP000002852381600115GO_REF:0000107EnsemblGO_REF:0000107
Abcc3Ratglucuronoside transmembrane transporter activity enablesISOABCC3 (Homo sapiens)1624291 PMID:18698235RGDPMID:18698235
Abcc3Raticosanoid transmembrane transporter activity enablesIEAUniProtKB:O15438 and ensembl:ENSP000002852381600115GO_REF:0000107EnsemblGO_REF:0000107
Abcc3Raticosanoid transmembrane transporter activity enablesISOABCC3 (Homo sapiens)1624291 PMID:19334674RGDPMID:19334674
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RGD Manual Annotations


  

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

Object Symbol
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Original Reference(s)
Abcc3Ratbile acid transport pathway  IEA 6907045 KEGGrno:04976

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#
Reference Title
Reference Citation
1. Transport activity of human MRP3 expressed in Sf9 cells: comparative studies with rat MRP3. Akita H, etal., Pharm Res. 2002 Jan;19(1):34-41.
2. Manifestation of multidrug resistance protein 3 (MRP3) in liver and kidney cells in cholestasis: effects of hyperprolactinemia. Aleksandrova MI, etal., Bull Exp Biol Med. 2013 Feb;154(4):508-11.
3. Coexpression of Multiple ABC-Transporters is Strongly Associated with Treatment Response in Childhood Acute Myeloid Leukemia. Bartholomae S, etal., Pediatr Blood Cancer. 2016 Feb;63(2):242-7. doi: 10.1002/pbc.25785. Epub 2015 Oct 29.
4. Differential modulation of the human liver conjugate transporters MRP2 and MRP3 by bile acids and organic anions. Bodo A, etal., J Biol Chem 2003 Jun 27;278(26):23529-37.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Transport of xenobiotics across the blood-brain barrier. Hagenbuch B, etal., News Physiol Sci 2002 Dec;17:231-4.
8. Molecular mechanism of altered ezetimibe disposition in nonalcoholic steatohepatitis. Hardwick RN, etal., Drug Metab Dispos. 2012 Mar;40(3):450-60. doi: 10.1124/dmd.111.041095. Epub 2011 Nov 23.
9. The pharmacokinetics of morphine and its glucuronide conjugate in a rat model of streptozotocin-induced diabetes and the expression of MRP2, MRP3 and UGT2B1 in the liver. Hasegawa Y, etal., J Pharm Pharmacol. 2010 Mar;62(3):310-4. doi: 10.1211/jpp.62.03.0004.
10. ATP-dependent transport of bile salts by rat multidrug resistance-associated protein 3 (Mrp3). Hirohashi T, etal., J Biol Chem. 2000 Jan 28;275(4):2905-10. doi: 10.1074/jbc.275.4.2905.
11. Hepatic expression of multidrug resistance-associated protein-like proteins maintained in eisai hyperbilirubinemic rats. Hirohashi T, etal., Mol Pharmacol 1998 Jun;53(6):1068-75.
12. Functional analysis of nonsynonymous single nucleotide polymorphism type ATP-binding cassette transmembrane transporter subfamily C member 3. Kobayashi K, etal., Pharmacogenet Genomics. 2008 Sep;18(9):823-33. doi: 10.1097/FPC.0b013e328306e9ae.
13. Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane. Konig J, etal., Hepatology 1999 Apr;29(4):1156-63.
14. Expression and localization of human multidrug resistance protein (ABCC) family members in pancreatic carcinoma. Konig J, etal., Int J Cancer. 2005 Jun 20;115(3):359-67.
15. Increased hepatic and renal expressions of multidrug resistance-associated protein 3 in Eisai hyperbilirubinuria rats. Kuroda M, etal., J Gastroenterol Hepatol. 2004 Feb;19(2):146-53.
16. Transport of fluorescein methotrexate by multidrug resistance-associated protein 3 in IEC-6 cells. Li T, etal., Am J Physiol Gastrointest Liver Physiol 2003 Sep;285(3):G602-10.
17. Efflux transporter expression and acetaminophen metabolite excretion are altered in rodent models of nonalcoholic fatty liver disease. Lickteig AJ, etal., Drug Metab Dispos. 2007 Oct;35(10):1970-8. Epub 2007 Jul 19.
18. Gender differences in mRNA expression of ATP-binding cassette efflux and bile acid transporters in kidney, liver, and intestine of 5/6 nephrectomized rats. Lu H and Klaassen C, Drug Metab Dispos. 2008 Jan;36(1):16-23. Epub 2007 Sep 12.
19. Metabolism and disposition of acetaminophen: recent advances in relation to hepatotoxicity and diagnosis. McGill MR and Jaeschke H, Pharm Res. 2013 Sep;30(9):2174-87. doi: 10.1007/s11095-013-1007-6. Epub 2013 Mar 6.
20. Induction of drug metabolism enzymes and transporters by oltipraz in rats. Merrell MD, etal., J Biochem Mol Toxicol. 2008;22(2):128-35.
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PMID:11846400   PMID:12951053   PMID:14724430   PMID:14981926   PMID:16946557   PMID:19334674   PMID:22015764   PMID:23077105   PMID:25931508   PMID:26337276  



Abcc3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81079,793,571 - 79,839,528 (-)NCBIGRCr8
mRatBN7.21079,296,681 - 79,342,749 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1079,296,693 - 79,342,595 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1083,901,889 - 83,947,612 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01083,400,010 - 83,445,731 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01078,914,311 - 78,960,418 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01082,047,308 - 82,116,928 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1082,047,863 - 82,117,109 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01081,879,487 - 81,880,151 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01081,896,621 - 81,938,192 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41082,986,552 - 83,030,799 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1078,085,499 - 78,131,465 (-)NCBICelera
Cytogenetic Map10q26NCBI
ABCC3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381750,634,881 - 50,692,253 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1750,634,777 - 50,692,253 (+)EnsemblGRCh38hg38GRCh38
GRCh371748,712,242 - 48,769,614 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361746,067,227 - 46,124,062 (+)NCBINCBI36Build 36hg18NCBI36
Build 341746,067,226 - 46,124,061NCBI
Celera1745,173,593 - 45,230,401 (+)NCBICelera
Cytogenetic Map17q21.33NCBI
HuRef1744,080,218 - 44,136,477 (+)NCBIHuRef
CHM1_11748,776,209 - 48,833,053 (+)NCBICHM1_1
T2T-CHM13v2.01751,502,046 - 51,559,449 (+)NCBIT2T-CHM13v2.0
Abcc3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391194,234,121 - 94,283,843 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1194,234,121 - 94,283,823 (-)EnsemblGRCm39 Ensembl
GRCm381194,343,295 - 94,393,017 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1194,343,295 - 94,392,997 (-)EnsemblGRCm38mm10GRCm38
MGSCv371194,204,609 - 94,254,290 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361194,159,385 - 94,209,066 (-)NCBIMGSCv36mm8
Celera11103,962,067 - 104,011,589 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1158.9NCBI
Abcc3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545111,087,570 - 11,130,482 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545111,087,246 - 11,130,108 (-)NCBIChiLan1.0ChiLan1.0
ABCC3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21966,826,417 - 66,883,666 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11771,633,385 - 71,690,669 (+)NCBINHGRI_mPanPan1
PanPan1.1 Ensembl1749,603,268 - 49,659,318 (+)Ensemblpanpan1.1panPan2
ABCC3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1926,551,953 - 26,596,330 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl926,551,268 - 26,595,646 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha925,944,553 - 25,988,893 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0927,346,054 - 27,390,624 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl927,345,878 - 27,390,257 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1926,113,720 - 26,158,047 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0926,372,406 - 26,416,803 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0926,502,563 - 26,547,109 (+)NCBIUU_Cfam_GSD_1.0
Abcc3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560225,988,457 - 26,035,171 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649011,040,445 - 11,086,566 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649011,039,968 - 11,086,670 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ABCC3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1226,920,821 - 26,979,602 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11226,920,764 - 26,978,389 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21227,060,930 - 27,117,540 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ABCC3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11642,646,316 - 42,703,124 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1642,646,812 - 42,702,852 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607713,362,436 - 13,419,564 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Abcc3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247956,516,224 - 6,557,892 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247956,516,384 - 6,558,332 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Abcc3
161 total Variants

Predicted Target Of
Summary Value
Count of predictions:220
Count of miRNA genes:133
Interacting mature miRNAs:143
Transcripts:ENSRNOT00000003977, ENSRNOT00000051497
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 86 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)104944455181709989Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat

1 to 10 of 86 rows
RH136767  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21079,296,715 - 79,296,805 (+)MAPPERmRatBN7.2
Rnor_6.01082,047,331 - 82,047,420NCBIRnor6.0
Rnor_5.01081,879,510 - 81,879,599UniSTSRnor5.0
RGSC_v3.41082,986,575 - 82,986,664UniSTSRGSC3.4
Celera1078,085,522 - 78,085,611UniSTS
RH 3.4 Map10720.4UniSTS
Cytogenetic Map10q26UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31


1 to 19 of 19 rows
RefSeq Transcripts NM_080581 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268341 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001840004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005489679 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005489680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010055119 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010055120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010055121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB010467 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF072816 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY039030 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 19 of 19 rows

Ensembl Acc Id: ENSRNOT00000003977   ⟹   ENSRNOP00000003977
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1079,296,693 - 79,327,604 (-)Ensembl
Rnor_6.0 Ensembl1082,047,863 - 82,116,621 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000051497   ⟹   ENSRNOP00000041502
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1079,296,693 - 79,327,604 (-)Ensembl
Rnor_6.0 Ensembl1082,047,863 - 82,116,621 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000079711   ⟹   ENSRNOP00000073075
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1082,074,211 - 82,117,109 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000085451   ⟹   ENSRNOP00000069018
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1079,296,693 - 79,342,595 (-)Ensembl
Rnor_6.0 Ensembl1082,050,695 - 82,116,679 (-)Ensembl
RefSeq Acc Id: NM_080581   ⟹   NP_542148
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81079,793,583 - 79,839,484 (-)NCBI
mRatBN7.21079,296,693 - 79,342,595 (-)NCBI
Rnor_6.01082,047,308 - 82,116,669 (-)NCBI
Rnor_5.01081,879,487 - 81,880,151 (-)NCBI
Rnor_5.01081,896,621 - 81,938,192 (-)NCBI
RGSC_v3.41082,986,552 - 83,030,799 (-)RGD
Celera1078,085,499 - 78,131,465 (-)RGD
Sequence:
RefSeq Acc Id: XM_017596968   ⟹   XP_017452457
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81079,807,717 - 79,839,528 (-)NCBI
mRatBN7.21079,310,561 - 79,342,748 (-)NCBI
Rnor_6.01082,083,094 - 82,116,928 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017596970   ⟹   XP_017452459
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81079,807,717 - 79,839,528 (-)NCBI
mRatBN7.21079,310,792 - 79,342,748 (-)NCBI
Rnor_6.01082,083,332 - 82,116,928 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017596971   ⟹   XP_017452460
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81079,807,717 - 79,839,528 (-)NCBI
mRatBN7.21079,310,787 - 79,342,748 (-)NCBI
Rnor_6.01082,083,314 - 82,116,928 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039085087   ⟹   XP_038941015
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81079,793,571 - 79,820,659 (-)NCBI
mRatBN7.21079,296,681 - 79,323,774 (-)NCBI
RefSeq Acc Id: XM_063268341   ⟹   XP_063124411
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81079,793,571 - 79,822,897 (-)NCBI
RefSeq Acc Id: XR_001840004
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81079,803,037 - 79,839,528 (-)NCBI
mRatBN7.21079,306,149 - 79,342,748 (-)NCBI
Rnor_6.01082,078,648 - 82,116,928 (-)NCBI
Sequence:
RefSeq Acc Id: XR_005489679
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81079,807,717 - 79,839,528 (-)NCBI
mRatBN7.21079,310,916 - 79,342,749 (-)NCBI
RefSeq Acc Id: XR_005489680
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81079,807,717 - 79,839,528 (-)NCBI
mRatBN7.21079,310,889 - 79,342,748 (-)NCBI
RefSeq Acc Id: XR_010055119
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81079,807,717 - 79,839,528 (-)NCBI
RefSeq Acc Id: XR_010055120
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81079,807,717 - 79,839,528 (-)NCBI
RefSeq Acc Id: XR_010055121
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81079,807,717 - 79,839,528 (-)NCBI
1 to 5 of 10 rows
1 to 5 of 10 rows
RefSeq Acc Id: NP_542148   ⟸   NM_080581
- UniProtKB: O88563 (UniProtKB/Swiss-Prot),   O88270 (UniProtKB/Swiss-Prot),   A0A0G2JU97 (UniProtKB/TrEMBL),   A6HI45 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452457   ⟸   XM_017596968
- Peptide Label: isoform X2
- UniProtKB: A6HI46 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452460   ⟸   XM_017596971
- Peptide Label: isoform X3
- UniProtKB: A6HI46 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452459   ⟸   XM_017596970
- Peptide Label: isoform X3
- UniProtKB: A6HI46 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073075   ⟸   ENSRNOT00000079711
ABC transmembrane type-1   ABC transporter

Name Modeler Protein Id AA Range Protein Structure
AF-O88563-F1-model_v2 AlphaFold O88563 1-1522 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13697603
Promoter ID:EPDNEW_R8126
Type:initiation region
Name:Abcc3_1
Description:ATP binding cassette subfamily C member 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01082,116,680 - 82,116,740EPDNEW


1 to 37 of 37 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-23623 BioCyc
Ensembl Genes ENSRNOG00000002948 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000085451 ENTREZGENE
Gene3D-CATH 1.20.1560.10 UniProtKB/Swiss-Prot
  3.40.50.300 UniProtKB/Swiss-Prot
InterPro AAA+_ATPase UniProtKB/Swiss-Prot
  ABC1_TM_dom UniProtKB/Swiss-Prot
  ABC1_TM_sf UniProtKB/Swiss-Prot
  ABC_transporter-like UniProtKB/Swiss-Prot
  ABC_transporter_C UniProtKB/Swiss-Prot
  ABC_transporter_CS UniProtKB/Swiss-Prot
  Multidrug-R_assoc UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
KEGG Report rno:140668 UniProtKB/Swiss-Prot
NCBI Gene 140668 ENTREZGENE
PANTHER ATP-BINDING CASSETTE SUB-FAMILY C UniProtKB/Swiss-Prot
  ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 3 UniProtKB/Swiss-Prot
Pfam ABC_membrane UniProtKB/Swiss-Prot
  ABC_tran UniProtKB/Swiss-Prot
PharmGKB ABCC3 RGD
PhenoGen Abcc3 PhenoGen
PROSITE ABC_TM1F UniProtKB/Swiss-Prot
  ABC_TRANSPORTER_1 UniProtKB/Swiss-Prot
  ABC_TRANSPORTER_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000002948 RatGTEx
SMART AAA UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
  SSF90123 UniProtKB/Swiss-Prot
UniProt A0A0G2JU97 ENTREZGENE, UniProtKB/TrEMBL
  A6HI45 ENTREZGENE, UniProtKB/TrEMBL
  A6HI46 ENTREZGENE, UniProtKB/TrEMBL
  D3ZF64_RAT UniProtKB/TrEMBL
  F1LMJ7_RAT UniProtKB/TrEMBL
  MRP3_RAT UniProtKB/Swiss-Prot
  O88270 ENTREZGENE
  O88563 ENTREZGENE
UniProt Secondary O88270 UniProtKB/Swiss-Prot
1 to 37 of 37 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-19 Abcc3  ATP binding cassette subfamily C member 3  Abcc3  ATP-binding cassette, subfamily C (CFTR/MRP), member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-11-16 Abcc3  ATP-binding cassette, subfamily C (CFTR/MRP), member 3  Abcc3  ATP-binding cassette, sub-family C (CFTR/MRP), member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Abcc3  ATP-binding cassette, sub-family C (CFTR/MRP), member 3      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

Note Type Note Reference
gene_process may act as an inducible transporter in the biliary and intestinal excretion of organic anions 724707
gene_regulation upregulated in hepatocytes during liver regeneration after 90% but not after 70% partial hepatectomy 1304286