Gsk3b (glycogen synthase kinase 3 beta) - Rat Genome Database

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Gene: Gsk3b (glycogen synthase kinase 3 beta) Rattus norvegicus
Analyze
Symbol: Gsk3b
Name: glycogen synthase kinase 3 beta
RGD ID: 70982
Description: Enables several functions, including ATP binding activity; protein serine/threonine kinase binding activity; and signaling receptor binding activity. Involved in several processes, including positive regulation of cell population proliferation; regulation of neuron projection development; and regulation of synapse organization. Located in several cellular components, including axon; dendritic spine; and microtubule. Part of beta-catenin destruction complex. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Used to study several diseases, including middle cerebral artery infarction; myocardial infarction; neurodegenerative disease (multiple); sciatic neuropathy; and vascular dementia. Biomarker of several diseases, including artery disease (multiple); depressive disorder; diabetic encephalopathy; status epilepticus; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Alzheimer's disease; amyotrophic lateral sclerosis; bipolar disorder; oral squamous cell carcinoma; and schizophrenia. Orthologous to human GSK3B (glycogen synthase kinase 3 beta); PARTICIPATES IN long term depression; Wnt signaling, canonical pathway; Bone morphogenetic proteins signaling pathway; INTERACTS WITH (R)-lipoic acid; (R)-salsolinol; (S)-colchicine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: FA; factor A; glycogen synthase kinase-3 beta; GSK-3 beta; serine/threonine-protein kinase GSK3B
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81176,004,502 - 76,154,665 (-)NCBIGRCr8
GRCr8 Ensembl1176,009,507 - 76,153,249 (-)EnsemblGRCr8 Ensembl
mRatBN7.21162,498,997 - 62,648,665 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1162,504,316 - 62,648,646 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1171,316,816 - 71,460,263 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01163,979,039 - 64,122,494 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01163,029,506 - 63,172,937 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01165,060,884 - 65,208,842 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1165,066,235 - 65,209,268 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01166,873,291 - 67,016,640 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41164,284,731 - 64,428,698 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1162,004,680 - 62,147,081 (-)NCBICelera
RGSC_v3.11164,342,319 - 64,486,287 (-)NCBI
RH 3.4 Map11501.41RGD
Cytogenetic Map11q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Gsk3bRatAberrant Crypt Foci treatmentIDA 13210771 RGD 
Gsk3bRatacute myocardial infarction treatmentIEP 13792778 RGD 
Gsk3bRatacute myocardial infarction amelioratesIEP 267358468 RGD 
Gsk3bRatAlzheimer's disease  IDA 10045670 RGD 
Gsk3bRatAlzheimer's disease treatmentIDA 13792736 RGD 
Gsk3bRatAlzheimer's disease treatmentISOGsk3b (Mus musculus)10045669protein:decreased phosphorylation:hippocampus:RGD 
Gsk3bRatAlzheimer's disease  ISOGSK3B (Homo sapiens)10045668DNA:altered methylation:CpG island:RGD 
Gsk3bRatAlzheimer's disease  ISOGSK3B (Homo sapiens)13782364DNA:SNP:promoter:rs334558 (human)RGD 
Gsk3bRatAlzheimer's disease treatmentISOGsk3b (Mus musculus)10401801 RGD 
Gsk3bRatAlzheimer's disease  ISOGsk3b (Mus musculus)1302533 RGD 
Gsk3bRatAlzheimer's disease treatmentIDA 13792777 RGD 
Gsk3bRatamyotrophic lateral sclerosis  ISOGSK3B (Homo sapiens)2301741 RGD 
Gsk3bRatbipolar disorder  ISOGSK3B (Homo sapiens)1641931 RGD 
Gsk3bRatbipolar disorder  ISOGSK3B (Homo sapiens)1641929 RGD 
Gsk3bRatBrain Injuries  IEP 10045646 RGD 
Gsk3bRatBurns  IEP 10045647protein:increased activity,altered phosphorylation:skeletal muscle:RGD 
Gsk3bRatCardiomegaly  IEP 10045585 RGD 
Gsk3bRatcolon cancer treatmentIEP 10045586 RGD 
Gsk3bRatColonic Neoplasms disease_progressionISOGSK3B (Homo sapiens)13210769protein:increased expression:nucleusRGD 
Gsk3bRatColonic Neoplasms treatmentISOGSK3B (Homo sapiens)13210765 RGD 
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Gsk3bRatdilated cardiomyopathy  ISOGSK3B (Homo sapiens)8554872ClinVar Annotator: match by term: Primary dilated cardiomyopathyClinVarPMID:25741868
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Gsk3bRatacute kidney failure  ISOGSK3B (Homo sapiens)11554173CTD Direct Evidence: marker/mechanism|therapeuticCTDPMID:22785175|PMID:38014886
Gsk3bRatAlzheimer's disease  ISOGSK3B (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17409235|PMID:22944069
Gsk3bRatbipolar disorder  ISOGSK3B (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20357757
Gsk3bRatBrain Injuries  ISOGSK3B (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:24675465
Gsk3bRatBreast Neoplasms  ISOGSK3B (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:35639300
Gsk3bRatCardiomegaly  ISOGSK3B (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17901358
Gsk3bRatcognitive disorder  ISOGSK3B (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:24634145
Gsk3bRatcongestive heart failure  ISOGSK3B (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17901358
Gsk3bRatdepressive disorder  ISOGSK3B (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20357757|PMID:20534517
Gsk3bRatExperimental Arthritis  ISOGSK3B (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16713974
Gsk3bRathypertension  ISOGSK3B (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22982863
Gsk3bRatmantle cell lymphoma  ISOGSK3B (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18787224
Gsk3bRatMultiple Abnormalities  ISOGSK3B (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22975441
Gsk3bRatmuscular atrophy  ISOGSK3B (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:18467435
Gsk3bRatmyocardial infarction  ISOGSK3B (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16716347
Gsk3bRatNeoplastic Cell Transformation  ISOGSK3B (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:29626521
Gsk3bRatneuronal ceroid lipofuscinosis 6A  ISOGSK3B (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23516525
Gsk3bRatperitonitis  ISOGSK3B (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16713974
Gsk3bRatPoisoning  ISOGSK3B (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22975441
Gsk3bRatProstatic Neoplasms  ISOGSK3B (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16421604|PMID:25246272
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Gsk3bRat(+)-Tetrandrine decreases expressionISOGSK3B (Homo sapiens)6480464tetrandrine results in decreased expression of GSK3B protein modified formCTDPMID:25266202
Gsk3bRat(-)-Arctigenin multiple interactionsISOGSK3B (Homo sapiens)6480464Quercetin promotes the reaction [arctigenin results in decreased phosphorylation of GSK3B protein]CTDPMID:25380086
Gsk3bRat(-)-Arctigenin decreases phosphorylationISOGSK3B (Homo sapiens)6480464arctigenin results in decreased phosphorylation of GSK3B proteinCTDPMID:25380086
Gsk3bRat(-)-epigallocatechin 3-gallate increases phosphorylationISOGSK3B (Homo sapiens)6480464epigallocatechin gallate results in increased phosphorylation of GSK3B proteinCTDPMID:16968065
Gsk3bRat(-)-epigallocatechin 3-gallate decreases phosphorylationISOGsk3b (Mus musculus)6480464epigallocatechin gallate results in decreased phosphorylation of GSK3B proteinCTDPMID:34600025
Gsk3bRat(-)-epigallocatechin 3-gallate multiple interactionsISOGSK3B (Homo sapiens)6480464[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of GSK3B mRNACTDPMID:22079256
Gsk3bRat(-)-gambogic acid decreases activityISOGSK3B (Homo sapiens)6480464gambogic acid results in decreased activity of GSK3B proteinCTDPMID:19433130
Gsk3bRat(25R)-cholest-5-ene-3beta,26-diol multiple interactionsISOGSK3B (Homo sapiens)648046427-hydroxycholesterol inhibits the reaction [CTNNB1 protein binds to GSK3B protein]; 27-hydroxycholesterol inhibits the reaction [YWHAH more ...CTDPMID:33131013
Gsk3bRat(25R)-cholest-5-ene-3beta,26-diol increases phosphorylationISOGSK3B (Homo sapiens)648046427-hydroxycholesterol results in increased phosphorylation of GSK3B proteinCTDPMID:33131013
Gsk3bRat(R)-lipoic acid increases phosphorylationISOGsk3b (Mus musculus)6480464Thioctic Acid results in increased phosphorylation of GSK3B proteinCTDPMID:19879292
Gsk3bRat(R)-lipoic acid multiple interactionsEXP 6480464Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in decreased phosphorylation of GSK3B protein]; more ...CTDPMID:34133789
Gsk3bRat(R)-lipoic acid multiple interactionsISOGsk3b (Mus musculus)6480464Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of GSK3B mRNA]CTDPMID:27260466
Gsk3bRat(R)-salsolinol decreases phosphorylationEXP 6480464salsolinol results in decreased phosphorylation of GSK3B proteinCTDPMID:23261589
Gsk3bRat(S)-colchicine decreases expressionEXP 6480464Colchicine results in decreased expression of GSK3B mRNACTDPMID:18255150
Gsk3bRat(S)-nicotine multiple interactionsISOGSK3B (Homo sapiens)6480464[Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein] which more ...CTDPMID:12511591
Gsk3bRat(S)-nicotine increases expressionISOGsk3b (Mus musculus)6480464Nicotine results in increased expression of GSK3B mRNACTDPMID:31945395|PMID:35411647
Gsk3bRat(S)-nicotine multiple interactionsISOGsk3b (Mus musculus)6480464Carbon Tetrachloride inhibits the reaction [Nicotine results in decreased expression of GSK3B mRNA]; Carbon Tetrachloride more ...CTDPMID:31945395|PMID:33640489|PMID:35411647
Gsk3bRat(S)-nicotine decreases expressionISOGsk3b (Mus musculus)6480464Nicotine results in decreased expression of GSK3B mRNA; Nicotine results in decreased expression of GSK3B more ...CTDPMID:33640489|PMID:35411647
Gsk3bRat1,2-dimethylhydrazine multiple interactionsEXP 6480464[chlorophyllin affects the reaction [1,2-Dimethylhydrazine results in increased mutagenesis of CTNNB1 gene]] inhibits the reaction more ...CTDPMID:12628520
Gsk3bRat1,2-dimethylhydrazine increases expressionISOGsk3b (Mus musculus)64804641,2-Dimethylhydrazine results in increased expression of GSK3B mRNACTDPMID:22206623

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Biological Process
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Gsk3bRatanimal organ morphogenesis acts_upstream_of_or_withinISOGsk3b (Mus musculus)1624291MGI:1888887 PMID:10894547RGDPMID:10894547
Gsk3bRatautosome genomic imprinting acts_upstream_of_positive_effectISOGsk3b (Mus musculus)1624291 PMID:21047779RGDPMID:21047779
Gsk3bRataxon extension acts_upstream_ofISOGsk3b (Mus musculus)1624291MGI:106658|MGI:98927 PMID:24623780RGDPMID:24623780
Gsk3bRataxonogenesis acts_upstream_of_or_withinISOGsk3b (Mus musculus)1624291MGI:98956 PMID:18716223RGDPMID:18716223
Gsk3bRatbone remodeling  IDA 13792728 RGD 
Gsk3bRatcanonical Wnt signaling pathway involved_inISOGSK3B (Homo sapiens)1624291 PMID:10428961, PMID:16890161RGDPMID:10428961|PMID:16890161
Gsk3bRatcanonical Wnt signaling pathway acts_upstream_of_or_withinISOGsk3b (Mus musculus)1624291MGI:108559 PMID:15282335, PMID:16815997RGDPMID:15282335|PMID:16815997
Gsk3bRatcanonical Wnt signaling pathway involved_inIEAUniProtKB:P49841|ensembl:ENSP000002642351600115GO_REF:0000107EnsemblGO_REF:0000107
Gsk3bRatcell differentiation involved_inIEAUniProtKB-KW:KW-02211600115GO_REF:0000043UniProtGO_REF:0000043
Gsk3bRatcell differentiation involved_inIBAFB:FBgn0003371|MGI:1861437|MGI:2152453|PANTHER:PTN000624299|RGD:70982|SGD:S000004747|SGD:S000005251|TAIR:locus:2124082|UniProtKB:O77344|UniProtKB:P49841|WB:WBGene00001746|ZFIN:ZDB-GENE-990714-3|dictyBase:DDB_G02721101600115GO_REF:0000033GO_CentralGO_REF:0000033
Gsk3bRatcell growth involved in cardiac muscle cell development  IDA 13792737 RGD 
Gsk3bRatcell migration acts_upstream_of_or_withinISOGsk3b (Mus musculus)1624291MGI:98958 PMID:17986005RGDPMID:17986005
Gsk3bRatcellular response to amyloid-beta involved_inIDA 11576284PMID:26224839ARUK-UCL 
Gsk3bRatcellular response to dopamine  IEP 4107027 RGD 
Gsk3bRatcellular response to erythropoietin  IEP 10045542 RGD 
Gsk3bRatcellular response to glucocorticoid stimulus involved_inISOGsk3b (Mus musculus)1624291UniProtKB:Q2NL51 PMID:20371704RGDPMID:20371704
Gsk3bRatcellular response to hepatocyte growth factor stimulus acts_upstream_of_or_withinISOGsk3b (Mus musculus)1624291 PMID:21072211RGDPMID:21072211
Gsk3bRatcellular response to hydrogen peroxide  IEP 10045554 RGD 
Gsk3bRatcellular response to interleukin-3 involved_inISSUniProtKB:Q9WV601600115GO_REF:0000024UniProtGO_REF:0000024
Gsk3bRatcellular response to interleukin-3 involved_inISOGsk3b (Mus musculus)1624291 PMID:16543145RGDPMID:16543145
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Cellular Component
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Original Reference(s)
Gsk3bRataxon  IDA 10045567 RGD 
Gsk3bRataxon is_active_inIBAFB:FBgn0003371|MGI:1861437|PANTHER:PTN001173193|RGD:709821600115GO_REF:0000033GO_CentralGO_REF:0000033
Gsk3bRatbeta-catenin destruction complex part_ofIDA 8553327PMID:10228155BHF-UCL 
Gsk3bRatbeta-catenin destruction complex part_ofISOGsk3b (Mus musculus)1624291 PMID:10318824RGDPMID:10318824
Gsk3bRatbeta-catenin destruction complex part_ofIBAMGI:1861437|PANTHER:PTN002780427|RGD:70982|UniProtKB:P498411600115GO_REF:0000033GO_CentralGO_REF:0000033
Gsk3bRatbeta-catenin destruction complex part_ofISOGSK3B (Homo sapiens)1624291 PMID:16188939, PMID:18593713, PMID:8638126, PMID:9601641RGDPMID:16188939|PMID:18593713|PMID:8638126|PMID:9601641
Gsk3bRatbeta-catenin destruction complex part_ofIEAUniProtKB:P49841|ensembl:ENSP000002642351600115GO_REF:0000107EnsemblGO_REF:0000107
Gsk3bRatcentrosome located_inIEAUniProtKB:P49841|ensembl:ENSP000002642351600115GO_REF:0000107EnsemblGO_REF:0000107
Gsk3bRatcentrosome located_inISOGSK3B (Homo sapiens)1624291 PMID:17139249, PMID:21399614RGDPMID:17139249|PMID:21399614
Gsk3bRatcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Gsk3bRatcytoplasm is_active_inIBAFB:FBgn0003371|MGI:1861437|PANTHER:PTN000624299|TAIR:locus:2074464|TAIR:locus:2124082|UniProtKB:C0H4W5|UniProtKB:P49841|UniProtKB:Q388M1|UniProtKB:Q60EZ2|dictyBase:DDB_G02721101600115GO_REF:0000033GO_CentralGO_REF:0000033
Gsk3bRatcytoplasm located_inISOGSK3B (Homo sapiens)1624291 PMID:12223487, PMID:14744935, PMID:15448698, PMID:18787224, PMID:19038973, PMID:20937854RGDPMID:12223487|PMID:14744935|PMID:15448698|PMID:18787224|PMID:19038973|PMID:20937854
Gsk3bRatcytoplasm located_inISSUniProtKB:P498411600115GO_REF:0000024UniProtGO_REF:0000024
Gsk3bRatcytoplasm located_inIEAUniProtKB:P49841|ensembl:ENSP000002642351600115GO_REF:0000107EnsemblGO_REF:0000107
Gsk3bRatcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Gsk3bRatcytosol is_active_inIBAFB:FBgn0003371|MGI:1861437|PANTHER:PTN001173193|UniProtKB:P498411600115GO_REF:0000033GO_CentralGO_REF:0000033
Gsk3bRatcytosol located_inISOGsk3b (Mus musculus)1624291 PMID:12502791RGDPMID:12502791
Gsk3bRatcytosol located_inISORGD:733891|UniProtKB:P49841-1|UniProtKB:P49841-21624291 RGDGO_REF:0000052
Gsk3bRatcytosol located_inIEAUniProtKB:Q6FI27|ensembl:ENSP000002642351600115GO_REF:0000107EnsemblGO_REF:0000107
Gsk3bRatcytosol located_inIEAUniProtKB:P49841|ensembl:ENSP000002642351600115GO_REF:0000107EnsemblGO_REF:0000107
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Molecular Function
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Gsk3bRatATP binding  IDA 1641844 RGD 
Gsk3bRatATP binding enablesIEAInterPro:IPR000719|InterPro:IPR0174411600115GO_REF:0000002InterProGO_REF:0000002
Gsk3bRatATP binding enablesIEAUniProtKB-KW:KW-00671600115GO_REF:0000043UniProtGO_REF:0000043
Gsk3bRatATP binding enablesIEAUniRule:UR0015033411600115GO_REF:0000104UniProtGO_REF:0000104
Gsk3bRatATP binding  IDA 2298806 RGD 
Gsk3bRatbeta-catenin binding enablesIEAUniProtKB:P49841|ensembl:ENSP000002642351600115GO_REF:0000107EnsemblGO_REF:0000107
Gsk3bRatbeta-catenin binding enablesISOGsk3b (Mus musculus)1624291PR:Q02248 PMID:12874278RGDPMID:12874278
Gsk3bRatbeta-catenin binding enablesIBAMGI:1861437|PANTHER:PTN002780427|UniProtKB:P498411600115GO_REF:0000033GO_CentralGO_REF:0000033
Gsk3bRatbeta-catenin binding enablesISOGSK3B (Homo sapiens)1624291UniProtKB:P35222 PMID:8638126RGDPMID:8638126
Gsk3bRatdynactin binding enablesISOGSK3B (Homo sapiens)1624291UniProtKB:Q13561|UniProtKB:Q14203 PMID:17139249RGDPMID:17139249
Gsk3bRatdynactin binding enablesIEAUniProtKB:P49841|ensembl:ENSP000002642351600115GO_REF:0000107EnsemblGO_REF:0000107
Gsk3bRatdynein complex binding enablesISOGsk3b (Mus musculus)1624291UniProtKB:Q8C0M8 PMID:28057765RGDPMID:28057765
Gsk3bRatintegrin binding  IPIItgb1 (Rattus norvegicus)2325671 RGD 
Gsk3bRationotropic glutamate receptor binding  IPIGria1 (Rattus norvegicus)1641844 RGD 
Gsk3bRationotropic glutamate receptor binding  IPIGria2 (Rattus norvegicus)1641844 RGD 
Gsk3bRatkinase activity  IDA 10045546 RGD 
Gsk3bRatkinase activity enablesIEAUniProtKB:P49841|ensembl:ENSP000002642351600115GO_REF:0000107EnsemblGO_REF:0000107
Gsk3bRatkinase activity enablesIEAUniProtKB-KW:KW-04181600115GO_REF:0000043UniProtGO_REF:0000043
Gsk3bRatkinase activity enablesISOGSK3B (Homo sapiens)1624291 PMID:15448698, PMID:24391509RGDPMID:15448698|PMID:24391509
Gsk3bRatkinase activity enablesISSUniProtKB:P498411600115GO_REF:0000024UniProtGO_REF:0000024
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RGD Manual Annotations


  

Imported Annotations - KEGG (archival)

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Imported Annotations - PID (archival)

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Gsk3bRatneurodegeneration  IDA 1358648 RGD 

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Reference Title
Reference Citation
1. GSK-3ß inhibition suppresses instability-induced osteolysis by a dual action on osteoblast and osteoclast differentiation. Amirhosseini M, etal., J Cell Physiol. 2018 Mar;233(3):2398-2408. doi: 10.1002/jcp.26111. Epub 2017 Sep 28.
2. Insights from studies with oral cleft genes suggest associations between WNT-pathway genes and risk of oral cancer. Andrade Filho PA, etal., J Dent Res. 2011 Jun;90(6):740-6. doi: 10.1177/0022034511401622. Epub 2011 Mar 10.
3. Regulation of dishevelled and beta-catenin in rat skeletal muscle: an alternative exercise-induced GSK-3beta signaling pathway. Aschenbach WG, etal., Am J Physiol Endocrinol Metab. 2006 Jul;291(1):E152-8. Epub 2006 Feb 14.
4. Reelin-mediated signaling locally regulates protein kinase B/Akt and glycogen synthase kinase 3beta. Beffert U, etal., J Biol Chem 2002 Dec 20;277(51):49958-64.
5. Inhibition of glycogen synthase kinase 3 activity with lithium in vitro attenuates sepsis-induced changes in muscle protein turnover. Bertsch S, etal., Shock. 2011 Mar;35(3):266-74. doi: 10.1097/SHK.0b013e3181fd068c.
6. GSK3beta signalling: casting a wide net in Alzheimer's disease. Bhat RV and Budd SL, Neurosignals 2002 Sep-Oct;11(5):251-61.
7. Endoplasmic reticulum stress and trophic factor withdrawal activate distinct signaling cascades that induce glycogen synthase kinase-3 beta and a caspase-9-dependent apoptosis in cerebellar granule neurons. Brewster JL, etal., Mol Cell Neurosci. 2006 Jul;32(3):242-53. Epub 2006 Jun 9.
8. Treadmill training regulates beta-catenin signaling through phosphorylation of GSK-3beta in lumbar vertebrae of ovariectomized rats. Bu S, etal., Eur J Appl Physiol. 2012 Sep;112(9):3295-304. doi: 10.1007/s00421-011-2306-4. Epub 2012 Jan 18.
9. The effect of Scutellaria baicalensis stem-leaf flavonoids on spatial learning and memory in chronic cerebral ischemia-induced vascular dementia of rats. Cao Y, etal., Acta Biochim Biophys Sin (Shanghai). 2016 May;48(5):437-46. doi: 10.1093/abbs/gmw024.
10. GSK-3beta inhibition/beta-catenin stabilization in ventral midbrain precursors increases differentiation into dopamine neurons. Castelo-Branco G, etal., J Cell Sci. 2004 Nov 15;117(Pt 24):5731-7. Epub 2004 Nov 2.
11. [Protective Effects of Cornus Officinalis Total Glycosides and Cornus Polysaccharides on Myocardial Mitochondria of Acute Myocardial Infarction Rats: an Experimental Study]. Chen D, etal., Zhongguo Zhong Xi Yi Jie He Za Zhi. 2015 Sep;35(9):1090-8.
12. The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway. Chen HJ, etal., Genes Dev. 2006 Jul 15;20(14):1933-45. Epub 2006 Jun 30.
13. The role of glycogen synthase kinase-3ß (GSK-3ß) in endometrial carcinoma: A carcinogenesis, progression, prognosis, and target therapy marker. Chen S, etal., Oncotarget. 2016 May 10;7(19):27538-51. doi: 10.18632/oncotarget.8485.
14. Prohibitin confers cytoprotection against ISO-induced hypertrophy in H9c2 cells via attenuation of oxidative stress and modulation of Akt/Gsk-3ß signaling. Chowdhury D, etal., Mol Cell Biochem. 2017 Jan;425(1-2):155-168. doi: 10.1007/s11010-016-2870-3. Epub 2016 Nov 16.
15. Hedgehog signaling update. Cohen MM, Am J Med Genet A. 2010 Aug;152A(8):1875-914. doi: 10.1002/ajmg.a.32909.
16. Dp71f modulates GSK3-beta recruitment to the beta1-integrin adhesion complex. Cortes JC, etal., Neurochem Res. 2009 Mar;34(3):438-44. Epub 2008 Aug 2.
17. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Cross DA, etal., Nature. 1995 Dec 21-28;378(6559):785-9.
18. Structural and functional characterization of Nrf2 degradation by glycogen synthase kinase 3/beta-TrCP. Cuadrado A Free Radic Biol Med. 2015 Nov;88(Pt B):147-57. doi: 10.1016/j.freeradbiomed.2015.04.029. Epub 2015 Apr 30.
19. GSK3β inhibition promotes synaptogenesis in Drosophila and mammalian neurons. Cuesto G, etal., PLoS One. 2015 Mar 12;10(3):e0118475. doi: 10.1371/journal.pone.0118475. eCollection 2015.
20. In vivo P2X7 inhibition reduces amyloid plaques in Alzheimer's disease through GSK3beta and secretases. Diaz-Hernandez JI, etal., Neurobiol Aging. 2012 Aug;33(8):1816-28. doi: 10.1016/j.neurobiolaging.2011.09.040. Epub 2011 Nov 1.
1 to 20 of 131 rows
1 to 10 of 30 rows
PMID:8382613   PMID:8638126   PMID:9072970   PMID:9601641   PMID:10318824   PMID:11104755   PMID:11782539   PMID:11955436   PMID:12130654   PMID:12154096   PMID:12432063   PMID:12526086  
PMID:12750461   PMID:12805290   PMID:12874278   PMID:14660640   PMID:14690523   PMID:14698990   PMID:14730361   PMID:14744935   PMID:14749367   PMID:14976126   PMID:15001529   PMID:15075227  
PMID:15132987   PMID:15192701   PMID:15282335   PMID:15448698   PMID:15456937   PMID:15465828   PMID:15525785   PMID:15574412   PMID:15632182   PMID:15668231   PMID:15731007   PMID:15737742  
PMID:15799972   PMID:15819880   PMID:15950778   PMID:16133867   PMID:16142243   PMID:16155008   PMID:16181430   PMID:16188939   PMID:16300633   PMID:16306159   PMID:16315267   PMID:16343426  
PMID:16365045   PMID:16478771   PMID:16516918   PMID:16537926   PMID:16543145   PMID:16600022   PMID:16645641   PMID:16680013   PMID:16794215   PMID:16810687   PMID:16816118   PMID:16854843  
PMID:16890161   PMID:16912034   PMID:16981698   PMID:16982692   PMID:17026964   PMID:17046157   PMID:17109063   PMID:17114649   PMID:17119919   PMID:17139249   PMID:17157278   PMID:17182001  
PMID:17203200   PMID:17242403   PMID:17292911   PMID:17330951   PMID:17427960   PMID:17450314   PMID:17555552   PMID:17562708   PMID:17675573   PMID:17711861   PMID:17852410   PMID:17931653  
PMID:17986005   PMID:17989287   PMID:17993264   PMID:17996850   PMID:18031715   PMID:18041091   PMID:18089761   PMID:18156211   PMID:18183482   PMID:18195042   PMID:18291594   PMID:18323734  
PMID:18342477   PMID:18348280   PMID:18387957   PMID:18424437   PMID:18437149   PMID:18461448   PMID:18467435   PMID:18508033   PMID:18569012   PMID:18624766   PMID:18643871   PMID:18675800  
PMID:18689794   PMID:18716223   PMID:18723505   PMID:18787224   PMID:18802025   PMID:18805899   PMID:18824542   PMID:18846110   PMID:18983912   PMID:19038973   PMID:19071093   PMID:19141611  
1 to 10 of 30 rows



Gsk3b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81176,004,502 - 76,154,665 (-)NCBIGRCr8
GRCr8 Ensembl1176,009,507 - 76,153,249 (-)EnsemblGRCr8 Ensembl
mRatBN7.21162,498,997 - 62,648,665 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1162,504,316 - 62,648,646 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1171,316,816 - 71,460,263 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01163,979,039 - 64,122,494 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01163,029,506 - 63,172,937 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01165,060,884 - 65,208,842 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1165,066,235 - 65,209,268 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01166,873,291 - 67,016,640 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41164,284,731 - 64,428,698 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1162,004,680 - 62,147,081 (-)NCBICelera
RGSC_v3.11164,342,319 - 64,486,287 (-)NCBI
RH 3.4 Map11501.41RGD
Cytogenetic Map11q21NCBI
GSK3B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383119,821,321 - 120,094,447 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3119,821,321 - 120,094,994 (-)EnsemblGRCh38hg38GRCh38
GRCh373119,540,168 - 119,813,294 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363121,028,233 - 121,295,203 (-)NCBINCBI36Build 36hg18NCBI36
Build 343121,028,237 - 121,295,203NCBI
Celera3117,949,905 - 118,223,017 (-)NCBICelera
Cytogenetic Map3q13.33NCBI
HuRef3116,916,542 - 117,189,344 (-)NCBIHuRef
CHM1_13119,504,331 - 119,776,722 (-)NCBICHM1_1
T2T-CHM13v2.03122,541,048 - 122,814,129 (-)NCBIT2T-CHM13v2.0
Gsk3b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391637,909,363 - 38,066,446 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1637,909,363 - 38,066,446 (+)EnsemblGRCm39 Ensembl
GRCm381638,089,001 - 38,246,084 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1638,089,001 - 38,246,084 (+)EnsemblGRCm38mm10GRCm38
MGSCv371638,089,087 - 38,246,165 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361638,008,240 - 38,165,318 (+)NCBIMGSCv36mm8
Celera1638,497,488 - 38,655,086 (+)NCBICelera
Cytogenetic Map16B3NCBI
cM Map1626.54NCBI
Gsk3b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542719,495,422 - 19,671,137 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542719,489,972 - 19,671,137 (-)NCBIChiLan1.0ChiLan1.0
GSK3B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22117,803,084 - 118,069,881 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13117,803,362 - 118,073,878 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03116,943,205 - 117,215,001 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13123,856,047 - 124,126,747 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3123,861,379 - 124,126,771 (-)Ensemblpanpan1.1panPan2
GSK3B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13323,458,369 - 23,659,878 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3323,463,767 - 23,659,666 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3323,488,457 - 23,689,804 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03323,696,164 - 23,823,688 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3323,714,581 - 23,900,333 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13323,500,322 - 23,702,303 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03323,541,326 - 23,742,436 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03324,104,403 - 24,306,119 (-)NCBIUU_Cfam_GSD_1.0
Gsk3b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602130,628,163 - 130,791,946 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365366,730,062 - 6,894,303 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365366,730,070 - 6,893,818 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GSK3B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13140,136,158 - 140,369,569 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113140,136,109 - 140,370,197 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213149,599,661 - 149,702,154 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.213149,431,156 - 149,510,315 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GSK3B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12260,732,449 - 61,002,735 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2260,733,465 - 60,997,239 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041105,307,531 - 105,584,674 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gsk3b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473128,178,628 - 28,366,420 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473128,178,647 - 28,368,784 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

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Variants in Gsk3b
532 total Variants

Predicted Target Of
Summary Value
Count of predictions:47
Count of miRNA genes:42
Interacting mature miRNAs:47
Transcripts:ENSRNOT00000003867
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 24 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)115980279482566553Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)114545932375190161Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)111945620576331918Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat

1 to 10 of 24 rows
RH129577  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21162,595,373 - 62,595,562 (+)MAPPERmRatBN7.2
Rnor_6.01165,157,244 - 65,157,432NCBIRnor6.0
Rnor_5.01166,926,325 - 66,926,513UniSTSRnor5.0
RGSC_v3.41164,376,234 - 64,376,422UniSTSRGSC3.4
Celera1162,095,610 - 62,095,798UniSTS
RH 3.4 Map11500.3UniSTS
Cytogenetic Map11q21UniSTS
BE114445  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21162,547,085 - 62,547,238 (+)MAPPERmRatBN7.2
Rnor_6.01165,108,966 - 65,109,118NCBIRnor6.0
Rnor_5.01166,973,636 - 66,973,788UniSTSRnor5.0
RGSC_v3.41164,327,687 - 64,327,839UniSTSRGSC3.4
Celera1162,047,384 - 62,047,536UniSTS
RH 3.4 Map11499.4UniSTS
Cytogenetic Map11q21UniSTS
RH94787  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map11501.41UniSTS
Cytogenetic Map11q21UniSTS
BM387580  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21162,644,613 - 62,644,780 (+)MAPPERmRatBN7.2
Rnor_6.01165,205,664 - 65,205,830NCBIRnor6.0
Rnor_5.01166,877,003 - 66,877,169UniSTSRnor5.0
RGSC_v3.41164,425,525 - 64,425,691UniSTSRGSC3.4
Celera1162,143,908 - 62,144,074UniSTS
RH 3.4 Map11500.4UniSTS
Cytogenetic Map11q21UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000003867   ⟹   ENSRNOP00000003867
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1176,009,853 - 76,153,249 (-)Ensembl
mRatBN7.2 Ensembl1162,504,316 - 62,648,646 (-)Ensembl
Rnor_6.0 Ensembl1165,066,235 - 65,208,837 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000077612   ⟹   ENSRNOP00000075708
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1176,017,308 - 76,153,249 (-)Ensembl
mRatBN7.2 Ensembl1162,504,316 - 62,648,643 (-)Ensembl
Rnor_6.0 Ensembl1165,073,691 - 65,209,268 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099641   ⟹   ENSRNOP00000094301
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1176,009,507 - 76,153,249 (-)Ensembl
mRatBN7.2 Ensembl1162,504,316 - 62,648,643 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000137379   ⟹   ENSRNOP00000110454
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1176,018,135 - 76,153,249 (-)Ensembl
RefSeq Acc Id: NM_032080   ⟹   NP_114469
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81176,009,817 - 76,153,249 (-)NCBI
mRatBN7.21162,504,312 - 62,647,785 (-)NCBI
Rnor_6.01165,066,199 - 65,208,837 (-)NCBI
Rnor_5.01166,873,291 - 67,016,640 (+)NCBI
RGSC_v3.41164,284,731 - 64,428,698 (-)RGD
Celera1162,004,680 - 62,147,081 (-)RGD
Sequence:
RefSeq Acc Id: XM_006248373   ⟹   XP_006248435
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81176,004,502 - 76,154,630 (-)NCBI
mRatBN7.21162,498,997 - 62,648,661 (-)NCBI
Rnor_6.01165,060,884 - 65,208,842 (-)NCBI
Rnor_5.01166,873,291 - 67,016,640 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006248375   ⟹   XP_006248437
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81176,018,137 - 76,154,650 (-)NCBI
mRatBN7.21162,512,646 - 62,648,663 (-)NCBI
Rnor_6.01165,074,519 - 65,208,842 (-)NCBI
Rnor_5.01166,873,291 - 67,016,640 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039088668   ⟹   XP_038944596
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81176,004,502 - 76,102,010 (-)NCBI
mRatBN7.21162,498,997 - 62,596,522 (-)NCBI
RefSeq Acc Id: XM_039088669   ⟹   XP_038944597
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81176,004,502 - 76,102,024 (-)NCBI
mRatBN7.21162,498,997 - 62,596,538 (-)NCBI
RefSeq Acc Id: XM_063270791   ⟹   XP_063126861
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81176,017,308 - 76,154,665 (-)NCBI
RefSeq Acc Id: XM_063270792   ⟹   XP_063126862
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81176,018,137 - 76,154,614 (-)NCBI
RefSeq Acc Id: XM_063270793   ⟹   XP_063126863
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81176,004,502 - 76,102,004 (-)NCBI
1 to 5 of 12 rows
1 to 5 of 12 rows
RefSeq Acc Id: NP_114469   ⟸   NM_032080
- UniProtKB: P18266 (UniProtKB/Swiss-Prot),   A6IR80 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248435   ⟸   XM_006248373
- Peptide Label: isoform X1
- UniProtKB: P18266 (UniProtKB/Swiss-Prot),   A0A0G2JSH4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248437   ⟸   XM_006248375
- Peptide Label: isoform X3
- UniProtKB: A0A8I6GL38 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075708   ⟸   ENSRNOT00000077612
Ensembl Acc Id: ENSRNOP00000003867   ⟸   ENSRNOT00000003867
Protein kinase

Name Modeler Protein Id AA Range Protein Structure
AF-P18266-F1-model_v2 AlphaFold P18266 1-420 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13698170
Promoter ID:EPDNEW_R8695
Type:single initiation site
Name:Gsk3b_1
Description:glycogen synthase kinase 3 beta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01165,208,801 - 65,208,861EPDNEW


1 to 32 of 32 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-21266 BioCyc
Ensembl Genes ENSRNOG00000002833 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000003867 ENTREZGENE
  ENSRNOT00000077612 ENTREZGENE
  ENSRNOT00000137379 ENTREZGENE
Gene3D-CATH Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro GSK-3 UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
  STKc_GSK3 UniProtKB/Swiss-Prot
KEGG Report rno:84027 UniProtKB/Swiss-Prot
NCBI Gene 84027 ENTREZGENE
PANTHER GLYCOGEN SYNTHASE KINASE-3 ALPHA UniProtKB/Swiss-Prot
  PTHR24057:SF8 UniProtKB/Swiss-Prot
Pfam Pkinase UniProtKB/Swiss-Prot
PhenoGen Gsk3b PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000002833 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
UniProt A0A0G2JSH4 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2KB98 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GL38 ENTREZGENE, UniProtKB/TrEMBL
  A6IR79_RAT UniProtKB/TrEMBL
  A6IR80 ENTREZGENE, UniProtKB/TrEMBL
  A6IR81_RAT UniProtKB/TrEMBL
  GSK3B_RAT UniProtKB/Swiss-Prot, ENTREZGENE
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Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-07-09 Gsk3b  glycogen synthase kinase 3 beta      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

Note Type Note Reference
gene_function serine/threonine kinase 70606
gene_function phosphorylates several substrates, including b-catenin, glycogen synthase, transcriptional factors and the translation initiation factor Eif2b 70606
gene_process regulates apoptosis downstream of PI3-kinase/Akt signaling 70606
gene_process plays a role in coupling metabolism and protein synthesis to growth factor stimulation 70606