Mgst1 (microsomal glutathione S-transferase 1) - Rat Genome Database

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Gene: Mgst1 (microsomal glutathione S-transferase 1) Rattus norvegicus
Analyze
Symbol: Mgst1
Name: microsomal glutathione S-transferase 1
RGD ID: 70927
Description: Enables glutathione binding activity; glutathione transferase activity; and identical protein binding activity. Involved in several processes, including Leydig cell differentiation; response to lipopolysaccharide; and response to xenobiotic stimulus. Located in apical part of cell; endoplasmic reticulum; and peroxisomal membrane. Orthologous to human MGST1 (microsomal glutathione S-transferase 1); PARTICIPATES IN glutathione metabolic pathway; phase I biotransformation pathway via cytochrome P450; INTERACTS WITH (+)-schisandrin B; (-)-epigallocatechin 3-gallate; (S)-amphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MGC72699; microsomal GST-1; microsomal GST-I
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84172,760,930 - 172,776,157 (+)NCBIGRCr8
mRatBN7.24171,029,666 - 171,044,893 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4171,029,630 - 171,044,892 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4177,324,703 - 177,339,950 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04173,108,869 - 173,124,108 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04171,729,410 - 171,744,649 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04172,119,382 - 172,134,609 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4172,119,331 - 172,134,607 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04236,372,225 - 236,387,452 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44175,248,654 - 175,263,881 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14175,493,783 - 175,509,005 (+)NCBI
Celera4159,602,240 - 159,617,460 (+)NCBICelera
RH 3.4 Map41032.9RGD
Cytogenetic Map4q44NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (EXP)
(E)-cinnamyl alcohol  (ISO)
(S)-amphetamine  (EXP)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1,4-dithiothreitol  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetamide  (EXP)
aconitine  (EXP)
acrolein  (EXP)
aflatoxin B1  (ISO)
aflatoxin M1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-hexylcinnamaldehyde  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
antimonite  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
Azaspiracid  (ISO)
Bandrowski's base  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bosentan  (ISO)
buta-1,3-diene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chenodeoxycholic acid  (ISO)
chlordecone  (ISO)
chlorogenic acid  (EXP)
cinnamyl alcohol  (ISO)
ciprofibrate  (ISO)
cis-caffeic acid  (EXP)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
cumene hydroperoxide  (EXP)
curcumin  (EXP)
cyclophosphamide  (EXP)
cyclosporin A  (EXP,ISO)
deoxycholic acid  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP)
dichlorine  (EXP)
dichloromethane  (ISO)
dimethylarsinic acid  (EXP)
dinophysistoxin 1  (ISO)
dioxygen  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diquat  (ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP)
ellagic acid  (EXP)
emamectin benzoate  (ISO)
endosulfan  (EXP)
ethoxyquin  (ISO)
eugenol  (ISO)
flutamide  (ISO)
folic acid  (ISO)
furan  (EXP)
gallic acid  (EXP)
genistein  (EXP,ISO)
gentamycin  (EXP)
glutathione  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
hemin  (EXP)
hydrogen peroxide  (EXP)
hydroquinone  (ISO)
inulin  (ISO)
iron trichloride  (EXP)
isoeugenol  (ISO)
isoniazide  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
ketoconazole  (EXP)
kojic acid  (EXP)
L-1,4-dithiothreitol  (EXP)
L-ascorbic acid  (EXP)
lead diacetate  (EXP)
lead nitrate  (ISO)
leukotriene A4  (EXP)
leukotriene B4  (EXP)
leukotriene C4  (EXP)
leukotriene D4  (EXP)
leukotriene E4  (EXP)
lutein  (ISO)
manganese(II) chloride  (EXP)
medroxyprogesterone acetate  (ISO)
methimazole  (ISO)
methoxyacetic acid  (EXP)
methoxychlor  (EXP,ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
microcystin  (EXP)
morin  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
nitric oxide  (EXP)
nitrofen  (EXP)
O-acetyl-L-carnitine  (EXP)
ochratoxin A  (EXP,ISO)
ozone  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
peroxynitrous acid  (EXP)
phenobarbital  (EXP)
PhIP  (EXP)
phlorizin  (ISO)
pirinixic acid  (ISO)
progesterone  (EXP,ISO)
propiconazole  (ISO)
protein kinase inhibitor  (ISO)
pyrimidin-2-amine  (EXP)
quercetin  (EXP)
rac-1,2-dichloropropane  (ISO)
reactive oxygen species  (EXP)
retinyl acetate  (ISO)
rotenone  (EXP,ISO)
S-nitroso-L-cysteine  (EXP)
S-nitrosoglutathione  (EXP)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
spironolactone  (ISO)
sunitinib  (ISO)
Sunset Yellow FCF  (ISO)
tamoxifen  (ISO)
tartrazine  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP,ISO)
tolcapone  (EXP)
Tolmetin glucuronide  (ISO)
toluene 2,4-diisocyanate  (ISO)
trans-caffeic acid  (EXP)
trans-isoeugenol  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triethylenediamine  (EXP)
trimellitic anhydride  (ISO)
triptonide  (ISO)
triticonazole  (EXP)
troglitazone  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zileuton  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. DD-RT-PCR identifies 7-dehydrocholesterol reductase as a key marker of early Leydig cell steroidogenesis. Anbalagan M, etal., Mol Cell Endocrinol. 2004 Apr 30;219(1-2):37-45.
2. [Rat microsomal glutathione S-transferase 1 alters cytotoxic effects of chlorambucil on PC-3, K562, HepG2 and P388D1 cell lines] Chen Z, etal., Zhejiang Da Xue Xue Bao Yi Xue Ban. 2007 May;36(3):236-40.
3. Gene expression of rat and human microsomal glutathione S-transferases. DeJong JL, etal., J Biol Chem 1988 Jun 15;263(17):8430-6.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Structural basis for detoxification and oxidative stress protection in membranes. Holm PJ, etal., J Mol Biol. 2006 Jul 28;360(5):934-45. Epub 2006 Jun 5.
7. Insights into the membrane proteome of rat liver peroxisomes: microsomal glutathione-S-transferase is shared by both subcellular compartments. Islinger M, etal., Proteomics. 2006 Feb;6(3):804-16.
8. Proteomic analysis of rat liver peroxisome: presence of peroxisome-specific isozyme of Lon protease. Kikuchi M, etal., J Biol Chem. 2004 Jan 2;279(1):421-8. Epub 2003 Oct 15.
9. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
10. Novel function of glutathione transferase in rat liver mitochondrial membrane: role for cytochrome c release from mitochondria. Lee KK, etal., Toxicol Appl Pharmacol. 2008 Oct 1;232(1):109-18. Epub 2008 Jun 25.
11. Observation of an intact noncovalent homotrimer of detergent-solubilized rat microsomal glutathione transferase-1 by electrospray mass spectrometry. Lengqvist J, etal., J Biol Chem. 2004 Apr 2;279(14):13311-6. Epub 2004 Jan 14.
12. Gene Data Set MGD Curation, June 12, 2002
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Microsomal glutathione S-transferase. Purification, initial characterization and demonstration that it is not identical to the cytosolic glutathione S-transferases A, B and C. Morgenstern R, etal., Eur J Biochem. 1982 Nov;128(1):243-8.
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. Immunolocalization of microsomal glutathione S-transferase in rat tissues. Otieno MA, etal., Drug Metab Dispos. 1997 Jan;25(1):12-20.
17. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
18. GOA pipeline RGD automated data pipeline
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. The role of glutathione-S-transferase in anti-cancer drug resistance. Townsend DM and Tew KD, Oncogene 2003 Oct 20;22(47):7369-75.
Additional References at PubMed
PMID:3932348   PMID:6439207   PMID:10767383   PMID:12477932   PMID:12865426   PMID:14651853   PMID:15236595   PMID:15489334   PMID:16314419   PMID:16899233   PMID:19111564   PMID:20727966  
PMID:21216258   PMID:21851097   PMID:24419913   PMID:28801553  


Genomics

Comparative Map Data
Mgst1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84172,760,930 - 172,776,157 (+)NCBIGRCr8
mRatBN7.24171,029,666 - 171,044,893 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4171,029,630 - 171,044,892 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4177,324,703 - 177,339,950 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04173,108,869 - 173,124,108 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04171,729,410 - 171,744,649 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04172,119,382 - 172,134,609 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4172,119,331 - 172,134,607 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04236,372,225 - 236,387,452 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44175,248,654 - 175,263,881 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14175,493,783 - 175,509,005 (+)NCBI
Celera4159,602,240 - 159,617,460 (+)NCBICelera
RH 3.4 Map41032.9RGD
Cytogenetic Map4q44NCBI
MGST1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381216,347,115 - 16,593,331 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1216,347,142 - 16,609,259 (+)EnsemblGRCh38hg38GRCh38
GRCh371216,500,049 - 16,530,126 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361216,391,343 - 16,408,611 (+)NCBINCBI36Build 36hg18NCBI36
Build 341216,391,342 - 16,408,610NCBI
Celera1221,643,859 - 21,661,125 (+)NCBICelera
Cytogenetic Map12p12.3NCBI
HuRef1216,268,374 - 16,298,400 (+)NCBIHuRef
CHM1_11216,465,087 - 16,495,133 (+)NCBICHM1_1
T2T-CHM13v2.01216,224,568 - 16,466,967 (+)NCBIT2T-CHM13v2.0
Mgst1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396138,117,525 - 138,133,753 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6138,117,314 - 138,133,753 (+)EnsemblGRCm39 Ensembl
GRCm386138,140,527 - 138,156,755 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6138,140,316 - 138,156,755 (+)EnsemblGRCm38mm10GRCm38
MGSCv376138,089,058 - 138,105,273 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366138,104,733 - 138,120,948 (+)NCBIMGSCv36mm8
Celera6141,204,105 - 141,221,034 (+)NCBICelera
Cytogenetic Map6G1NCBI
cM Map668.4NCBI
Mgst1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541312,989,935 - 13,007,761 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541312,989,935 - 13,005,203 (+)NCBIChiLan1.0ChiLan1.0
MGST1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21021,793,489 - 21,823,123 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11221,790,250 - 21,819,884 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01216,347,737 - 16,383,776 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11216,743,739 - 16,773,290 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1216,743,739 - 16,773,290 (+)Ensemblpanpan1.1panPan2
MGST1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12730,370,588 - 30,391,898 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2730,370,594 - 30,391,778 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2716,055,808 - 16,077,100 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02730,690,546 - 30,712,016 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2730,690,548 - 30,711,952 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12730,541,771 - 30,563,263 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02730,537,988 - 30,559,272 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02715,775,516 - 15,796,781 (+)NCBIUU_Cfam_GSD_1.0
Mgst1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494591,542,405 - 91,559,526 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365871,269,184 - 1,287,150 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365871,270,030 - 1,287,130 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MGST1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl556,259,557 - 56,283,965 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1556,259,566 - 56,283,823 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MGST1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11116,270,588 - 16,300,446 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1116,277,434 - 16,287,171 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606919,006,137 - 19,023,047 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mgst1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475221,720,012 - 21,737,809 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475221,722,593 - 21,737,826 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mgst1
101 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:205
Count of miRNA genes:147
Interacting mature miRNAs:155
Transcripts:ENSRNOT00000010579
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4146565735175236377Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4155561574182687754Rat
1300109Rf13Renal function QTL 133.91renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)4157710145182687754Rat

Markers in Region
RH142292  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24171,044,542 - 171,044,729 (+)MAPPERmRatBN7.2
Rnor_6.04172,134,259 - 172,134,445NCBIRnor6.0
Rnor_5.04236,387,102 - 236,387,288UniSTSRnor5.0
RGSC_v3.44175,263,531 - 175,263,717UniSTSRGSC3.4
Celera4159,617,110 - 159,617,296UniSTS
RH 3.4 Map41032.9UniSTS
Cytogenetic Map4q44UniSTS
BI277057  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24171,044,355 - 171,044,564 (+)MAPPERmRatBN7.2
Rnor_6.04172,134,072 - 172,134,280NCBIRnor6.0
Rnor_5.04236,386,915 - 236,387,123UniSTSRnor5.0
RGSC_v3.44175,263,344 - 175,263,552UniSTSRGSC3.4
Celera4159,616,923 - 159,617,131UniSTS
RH 3.4 Map41045.0UniSTS
Cytogenetic Map4q44UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 23 23 23
Medium 3 33 32 16 19 16 5 5 30 35 39 11 5
Low 10 2 2 2 3 6 44 2 3
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_134349 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC063150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP494884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB711033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ179404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209427 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209465 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209591 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210351 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219410 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219581 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J03752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000010579   ⟹   ENSRNOP00000010579
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4171,029,630 - 171,044,892 (+)Ensembl
Rnor_6.0 Ensembl4172,119,331 - 172,134,607 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000110483   ⟹   ENSRNOP00000094357
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4171,029,630 - 171,041,090 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000110698   ⟹   ENSRNOP00000091759
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4171,030,786 - 171,044,892 (+)Ensembl
RefSeq Acc Id: NM_134349   ⟹   NP_599176
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84172,760,930 - 172,776,157 (+)NCBI
mRatBN7.24171,029,666 - 171,044,893 (+)NCBI
Rnor_6.04172,119,382 - 172,134,609 (+)NCBI
Rnor_5.04236,372,225 - 236,387,452 (+)NCBI
RGSC_v3.44175,248,654 - 175,263,881 (+)RGD
Celera4159,602,240 - 159,617,460 (+)RGD
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_599176   ⟸   NM_134349
- UniProtKB: P08011 (UniProtKB/Swiss-Prot),   B6DYQ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000010579   ⟸   ENSRNOT00000010579
RefSeq Acc Id: ENSRNOP00000094357   ⟸   ENSRNOT00000110483
RefSeq Acc Id: ENSRNOP00000091759   ⟸   ENSRNOT00000110698

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P08011-F1-model_v2 AlphaFold P08011 1-155 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693474
Promoter ID:EPDNEW_R3997
Type:initiation region
Name:Mgst1_1
Description:microsomal glutathione S-transferase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04172,119,388 - 172,119,448EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70927 AgrOrtholog
BioCyc Gene G2FUF-42563 BioCyc
BioCyc Pathway PWY-4061 [glutathione-mediated detoxification I] BioCyc
  PWY-7112 [4-hydroxy-2-nonenal detoxification] BioCyc
BioCyc Pathway Image PWY-4061 BioCyc
  PWY-7112 BioCyc
Ensembl Genes ENSRNOG00000007743 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055026264 UniProtKB/Swiss-Prot
  ENSRNOG00060009437 UniProtKB/Swiss-Prot
  ENSRNOG00065011937 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000010579 ENTREZGENE
  ENSRNOT00000010579.8 UniProtKB/Swiss-Prot
  ENSRNOT00000110483.1 UniProtKB/TrEMBL
  ENSRNOT00000110698.1 UniProtKB/TrEMBL
  ENSRNOT00055045380 UniProtKB/Swiss-Prot
  ENSRNOT00060015966 UniProtKB/Swiss-Prot
  ENSRNOT00065019403 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.120.550 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:6922267 IMAGE-MGC_LOAD
InterPro MAPEG-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Membr-assoc_MAPEG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MGST1-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:171341 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72699 IMAGE-MGC_LOAD
NCBI Gene 171341 ENTREZGENE
PANTHER MICROSOMAL GLUTATHIONE S-TRANSFERASE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10689 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MAPEG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mgst1 PhenoGen
RatGTEx ENSRNOG00000007743 RatGTEx
  ENSRNOG00055026264 RatGTEx
  ENSRNOG00060009437 RatGTEx
  ENSRNOG00065011937 RatGTEx
Superfamily-SCOP SSF161084 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6ACC0_RAT UniProtKB/TrEMBL
  A0A8I6ALY9_RAT UniProtKB/TrEMBL
  A6IML5_RAT UniProtKB/TrEMBL
  B6DYQ4 ENTREZGENE, UniProtKB/TrEMBL
  MGST1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-07-09 Mgst1  microsomal glutathione S-transferase 1      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_protein 154 amino acids 70791