Mgst1 (microsomal glutathione S-transferase 1) - Rat Genome Database

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Gene: Mgst1 (microsomal glutathione S-transferase 1) Rattus norvegicus
Analyze
Symbol: Mgst1
Name: microsomal glutathione S-transferase 1
RGD ID: 70927
Description: Enables glutathione binding activity; glutathione transferase activity; and identical protein binding activity. Involved in Leydig cell differentiation; response to lipopolysaccharide; and response to xenobiotic stimulus. Located in apical part of cell; bounding membrane of organelle; and endoplasmic reticulum. Is active in endoplasmic reticulum membrane and mitochondrion. Orthologous to human MGST1 (microsomal glutathione S-transferase 1); PARTICIPATES IN glutathione metabolic pathway; phase I biotransformation pathway via cytochrome P450; INTERACTS WITH (+)-schisandrin B; (-)-epigallocatechin 3-gallate; (S)-amphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MGC72699; microsomal GST-1; microsomal GST-I
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84172,760,930 - 172,776,157 (+)NCBIGRCr8
mRatBN7.24171,029,666 - 171,044,893 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4171,029,630 - 171,044,892 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4177,324,703 - 177,339,950 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04173,108,869 - 173,124,108 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04171,729,410 - 171,744,649 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04172,119,382 - 172,134,609 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4172,119,331 - 172,134,607 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04236,372,225 - 236,387,452 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44175,248,654 - 175,263,881 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14175,493,783 - 175,509,005 (+)NCBI
Celera4159,602,240 - 159,617,460 (+)NCBICelera
RH 3.4 Map41032.9RGD
Cytogenetic Map4q44NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
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Evidence
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Reference
Notes
Source
Original Reference(s)
Mgst1RatCOVID-19  ISOMGST1 (Homo sapiens)9068941mRNA:increased expression:peripheral blood mononuclear cell (human)RGDPMID:32228226 and REF_RGD_ID:28912744
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Original Reference(s)
Mgst1Ratchronic obstructive pulmonary disease  ISOMGST1 (Homo sapiens)8554872ClinVar Annotator: match by term: Pulmonary disease more ...ClinVar 
Object Symbol
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Original Reference(s)
Mgst1Ratneurodegenerative disease  ISOMGST1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15964507

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Object Symbol
Species
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Evidence
With
Reference
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Original Reference(s)
Mgst1Rat(+)-schisandrin B multiple interactionsEXP 6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of MGST1 mRNA]CTDPMID:31150632
Mgst1Rat(-)-epigallocatechin 3-gallate decreases activityEXP 6480464epigallocatechin gallate results in decreased activity of MGST1 proteinCTDPMID:23010222
Mgst1Rat(E)-cinnamyl alcohol increases expressionISOMGST1 (Homo sapiens)6480464cinnamyl alcohol results in increased expression of MGST1 mRNACTDPMID:20566472
Mgst1Rat(S)-amphetamine increases expressionEXP 6480464Dextroamphetamine results in increased expression of MGST1 mRNACTDPMID:16715494
Mgst1Rat1,1'-azobis(N,N-dimethylformamide) multiple interactionsEXP 6480464[Diamide co-treated with Glutathione] results in increased activity of MGST1 protein more ...CTDPMID:18634816
Mgst1Rat1,1'-azobis(N,N-dimethylformamide) increases activityEXP 6480464Diamide results in increased activity of MGST1 proteinCTDPMID:18634816
Mgst1Rat1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane increases expressionISOMgst1 (Mus musculus)64804642 more ...CTDPMID:11509743
Mgst1Rat1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane multiple interactionsISOMgst1 (Mus musculus)6480464[Estradiol co-treated with 2 more ...CTDPMID:11509743
Mgst1Rat1,2-dimethylhydrazine multiple interactionsISOMgst1 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of MGST1 mRNACTDPMID:22206623
Mgst1Rat1,2-dimethylhydrazine decreases expressionEXP 64804641 and 2-Dimethylhydrazine results in decreased expression of MGST1 mRNACTDPMID:32028820
Mgst1Rat1,2-dimethylhydrazine multiple interactionsEXP 6480464[1 and 2-Dimethylhydrazine co-treated with morin] results in increased expression of MGST1 mRNACTDPMID:32028820
Mgst1Rat1,2-dimethylhydrazine decreases expressionISOMgst1 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of MGST1 mRNACTDPMID:22206623
Mgst1Rat1,4-dithiothreitol multiple interactionsEXP 6480464Dithiothreitol inhibits the reaction [[1-hydroxy-2-oxo-3-(3-aminopropyl)-3-isopropyl-1-triazene results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein] more ...CTDPMID:16125204 more ...
Mgst1Rat1-chloro-2,4-dinitrobenzene increases expressionISOMGST1 (Homo sapiens)6480464Dinitrochlorobenzene results in increased expression of MGST1 mRNACTDPMID:20566472
Mgst1Rat17alpha-ethynylestradiol affects expressionISOMgst1 (Mus musculus)6480464Ethinyl Estradiol affects the expression of MGST1 mRNACTDPMID:17555576
Mgst1Rat17alpha-ethynylestradiol decreases expressionISOMgst1 (Mus musculus)6480464Ethinyl Estradiol results in decreased expression of MGST1 mRNACTDPMID:16174780 and PMID:17942748
Mgst1Rat17alpha-ethynylestradiol decreases expressionEXP 6480464Ethinyl Estradiol results in decreased expression of MGST1 mRNACTDPMID:12075121 and PMID:16174780
Mgst1Rat17alpha-ethynylestradiol increases expressionEXP 6480464Ethinyl Estradiol results in increased expression of MGST1 mRNACTDPMID:17108234
Mgst1Rat17alpha-ethynylestradiol multiple interactionsISOMgst1 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of MGST1 mRNACTDPMID:17942748
Mgst1Rat17beta-estradiol multiple interactionsISOMgst1 (Mus musculus)6480464[Estradiol co-treated with 2 more ...CTDPMID:11509743

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Biological Process
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Original Reference(s)
Mgst1Ratcellular oxidant detoxification involved_inIEAGO:00046021600115GO_REF:0000108GOCGO_REF:0000108
Mgst1Ratcellular response to lipid hydroperoxide involved_inIEAUniProtKB:P10620 and ensembl:ENSP000003795131600115GO_REF:0000107EnsemblGO_REF:0000107
Mgst1Ratcellular response to lipid hydroperoxide involved_inISOMGST1 (Homo sapiens)1624291 PMID:20727966RGDPMID:20727966
Mgst1Ratglutathione metabolic process acts_upstream_of_or_withinISOMgst1 (Mus musculus)1624291 PMID:10767383RGDPMID:10767383
Mgst1Ratglutathione transport involved_inIEAUniProtKB:P10620 and ensembl:ENSP000003795131600115GO_REF:0000107EnsemblGO_REF:0000107
Mgst1Ratglutathione transport involved_inISOMGST1 (Homo sapiens)1624291 PMID:20727966RGDPMID:20727966
Mgst1RatLeydig cell differentiation  IEP 2302287 RGD 
Mgst1Ratresponse to lipopolysaccharide  IDA 2302282 RGD 
Mgst1Ratresponse to xenobiotic stimulus  IDA 2302284 RGD 
1 to 9 of 9 rows

Cellular Component
1 to 17 of 17 rows

  
Object Symbol
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Reference
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Original Reference(s)
Mgst1Ratapical part of cell  IDA 2302291 RGD 
Mgst1Ratendoplasmic reticulum located_inIDA 1580664PMID:14561759HGNC-UCL 
Mgst1Ratendoplasmic reticulum located_inIEAUniProtKB-KW:KW-02561600115GO_REF:0000043UniProtGO_REF:0000043
Mgst1Ratendoplasmic reticulum membrane located_inIEAUniProtKB-SubCell:SL-00971600115GO_REF:0000044UniProtGO_REF:0000044
Mgst1Ratendoplasmic reticulum membrane is_active_inIDA 407430015PMID:27913278FlyBase 
Mgst1Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Mgst1Ratmembrane located_inIEAInterPro:IPR0011291600115GO_REF:0000002InterProGO_REF:0000002
Mgst1Ratmembrane located_inIDA 8553629PMID:16806268UniProt 
Mgst1Ratmitochondrial outer membrane located_inIEAUniProtKB-SubCell:SL-01721600115GO_REF:0000044UniProtGO_REF:0000044
Mgst1Ratmitochondrial outer membrane located_inIEAUniProtKB-KW:KW-10001600115GO_REF:0000043UniProtGO_REF:0000043
Mgst1Ratmitochondrial outer membrane located_inIDA 407429996PMID:2369411FlyBase 
Mgst1Ratmitochondrion is_active_inIDA 407430015PMID:27913278FlyBase 
Mgst1Ratmitochondrion located_inIEAUniProtKB-KW:KW-04961600115GO_REF:0000043UniProtGO_REF:0000043
Mgst1Ratmitochondrion located_inIEAUniProtKB:P10620 and ensembl:ENSP000003795131600115GO_REF:0000107EnsemblGO_REF:0000107
Mgst1Ratmitochondrion is_active_inIBAPANTHER:PTN002581327 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Mgst1Ratmitochondrion located_inISOMGST1 (Homo sapiens)1624291 PMID:20727966RGDPMID:20727966
Mgst1Ratperoxisomal membrane  IDA 2302286 RGD 
1 to 17 of 17 rows

Molecular Function
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1 to 14 of 14 rows

Imported Annotations - KEGG (archival)

Object Symbol
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Qualifier
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Source
Original Reference(s)
Mgst1Ratglutathione metabolic pathway  IEA 6907045 KEGGrno:00480
Mgst1Ratphase I biotransformation pathway via cytochrome P450  IEA 6907045 KEGGrno:00980
Mgst1Ratphase I biotransformation pathway via cytochrome P450  IEA 6907045 KEGGrno:00982

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#
Reference Title
Reference Citation
1. DD-RT-PCR identifies 7-dehydrocholesterol reductase as a key marker of early Leydig cell steroidogenesis. Anbalagan M, etal., Mol Cell Endocrinol. 2004 Apr 30;219(1-2):37-45.
2. [Rat microsomal glutathione S-transferase 1 alters cytotoxic effects of chlorambucil on PC-3, K562, HepG2 and P388D1 cell lines] Chen Z, etal., Zhejiang Da Xue Xue Bao Yi Xue Ban. 2007 May;36(3):236-40.
3. Gene expression of rat and human microsomal glutathione S-transferases. DeJong JL, etal., J Biol Chem 1988 Jun 15;263(17):8430-6.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Structural basis for detoxification and oxidative stress protection in membranes. Holm PJ, etal., J Mol Biol. 2006 Jul 28;360(5):934-45. Epub 2006 Jun 5.
7. Insights into the membrane proteome of rat liver peroxisomes: microsomal glutathione-S-transferase is shared by both subcellular compartments. Islinger M, etal., Proteomics. 2006 Feb;6(3):804-16.
8. Proteomic analysis of rat liver peroxisome: presence of peroxisome-specific isozyme of Lon protease. Kikuchi M, etal., J Biol Chem. 2004 Jan 2;279(1):421-8. Epub 2003 Oct 15.
9. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
10. Novel function of glutathione transferase in rat liver mitochondrial membrane: role for cytochrome c release from mitochondria. Lee KK, etal., Toxicol Appl Pharmacol. 2008 Oct 1;232(1):109-18. Epub 2008 Jun 25.
11. Observation of an intact noncovalent homotrimer of detergent-solubilized rat microsomal glutathione transferase-1 by electrospray mass spectrometry. Lengqvist J, etal., J Biol Chem. 2004 Apr 2;279(14):13311-6. Epub 2004 Jan 14.
12. Gene Data Set MGD Curation, June 12, 2002
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Microsomal glutathione S-transferase. Purification, initial characterization and demonstration that it is not identical to the cytosolic glutathione S-transferases A, B and C. Morgenstern R, etal., Eur J Biochem. 1982 Nov;128(1):243-8.
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. Purification and properties of glutathione S-transferase from outer mitochondrial membrane of rat liver. Nishino H and Ito A, Biochem Int. 1990;20(6):1059-66.
17. Immunolocalization of microsomal glutathione S-transferase in rat tissues. Otieno MA, etal., Drug Metab Dispos. 1997 Jan;25(1):12-20.
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. GOA pipeline RGD automated data pipeline
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
1 to 20 of 22 rows
PMID:3932348   PMID:6439207   PMID:10767383   PMID:12477932   PMID:12865426   PMID:14651853   PMID:15236595   PMID:15489334   PMID:16314419   PMID:16899233   PMID:19111564   PMID:20727966  
PMID:21216258   PMID:21851097   PMID:24419913   PMID:28801553  



Mgst1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84172,760,930 - 172,776,157 (+)NCBIGRCr8
mRatBN7.24171,029,666 - 171,044,893 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4171,029,630 - 171,044,892 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4177,324,703 - 177,339,950 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04173,108,869 - 173,124,108 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04171,729,410 - 171,744,649 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04172,119,382 - 172,134,609 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4172,119,331 - 172,134,607 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04236,372,225 - 236,387,452 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44175,248,654 - 175,263,881 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14175,493,783 - 175,509,005 (+)NCBI
Celera4159,602,240 - 159,617,460 (+)NCBICelera
RH 3.4 Map41032.9RGD
Cytogenetic Map4q44NCBI
MGST1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381216,347,115 - 16,593,331 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1216,347,142 - 16,609,259 (+)EnsemblGRCh38hg38GRCh38
GRCh371216,500,049 - 16,530,126 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361216,391,343 - 16,408,611 (+)NCBINCBI36Build 36hg18NCBI36
Build 341216,391,342 - 16,408,610NCBI
Celera1221,643,859 - 21,661,125 (+)NCBICelera
Cytogenetic Map12p12.3NCBI
HuRef1216,268,374 - 16,298,400 (+)NCBIHuRef
CHM1_11216,465,087 - 16,495,133 (+)NCBICHM1_1
T2T-CHM13v2.01216,224,568 - 16,466,967 (+)NCBIT2T-CHM13v2.0
Mgst1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396138,117,525 - 138,133,753 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6138,117,314 - 138,133,753 (+)EnsemblGRCm39 Ensembl
GRCm386138,140,527 - 138,156,755 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6138,140,316 - 138,156,755 (+)EnsemblGRCm38mm10GRCm38
MGSCv376138,089,058 - 138,105,273 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366138,104,733 - 138,120,948 (+)NCBIMGSCv36mm8
Celera6141,204,105 - 141,221,034 (+)NCBICelera
Cytogenetic Map6G1NCBI
cM Map668.4NCBI
Mgst1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541312,989,935 - 13,007,761 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541312,989,935 - 13,005,203 (+)NCBIChiLan1.0ChiLan1.0
MGST1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21021,793,489 - 21,823,123 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11221,790,250 - 21,819,884 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01216,347,737 - 16,383,776 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11216,743,739 - 16,773,290 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1216,743,739 - 16,773,290 (+)Ensemblpanpan1.1panPan2
MGST1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12730,370,588 - 30,391,898 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2730,370,594 - 30,391,778 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2716,055,808 - 16,077,100 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02730,690,546 - 30,712,016 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2730,690,548 - 30,711,952 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12730,541,771 - 30,563,263 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02730,537,988 - 30,559,272 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02715,775,516 - 15,796,781 (+)NCBIUU_Cfam_GSD_1.0
Mgst1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494591,542,405 - 91,559,526 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365871,269,184 - 1,287,150 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365871,270,030 - 1,287,130 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MGST1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl556,259,557 - 56,283,965 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1556,259,566 - 56,283,823 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MGST1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11116,270,588 - 16,300,446 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1116,277,434 - 16,287,171 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606919,006,137 - 19,023,047 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mgst1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475221,720,012 - 21,737,809 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475221,722,593 - 21,737,826 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Mgst1
101 total Variants


Assembly: Rnor_5.0
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
4 236386959 236386960 G A snv IS-Tlk/Kyo (KyushuU), IS/Kyo (KyushuU) View more Information

Predicted Target Of
Summary Value
Count of predictions:205
Count of miRNA genes:147
Interacting mature miRNAs:155
Transcripts:ENSRNOT00000010579
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 19 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4146565735175236377Rat

1 to 10 of 19 rows
RH142292  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24171,044,542 - 171,044,729 (+)MAPPERmRatBN7.2
Rnor_6.04172,134,259 - 172,134,445NCBIRnor6.0
Rnor_5.04236,387,102 - 236,387,288UniSTSRnor5.0
RGSC_v3.44175,263,531 - 175,263,717UniSTSRGSC3.4
Celera4159,617,110 - 159,617,296UniSTS
RH 3.4 Map41032.9UniSTS
Cytogenetic Map4q44UniSTS
BI277057  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24171,044,355 - 171,044,564 (+)MAPPERmRatBN7.2
Rnor_6.04172,134,072 - 172,134,280NCBIRnor6.0
Rnor_5.04236,386,915 - 236,387,123UniSTSRnor5.0
RGSC_v3.44175,263,344 - 175,263,552UniSTSRGSC3.4
Celera4159,616,923 - 159,617,131UniSTS
RH 3.4 Map41045.0UniSTS
Cytogenetic Map4q44UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31


1 to 23 of 23 rows
RefSeq Transcripts NM_134349 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC063150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP494884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB711033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ179404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209427 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209465 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209591 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210351 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219410 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219581 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J03752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 23 of 23 rows

Ensembl Acc Id: ENSRNOT00000010579   ⟹   ENSRNOP00000010579
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4171,029,630 - 171,044,892 (+)Ensembl
Rnor_6.0 Ensembl4172,119,331 - 172,134,607 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000110483   ⟹   ENSRNOP00000094357
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4171,029,630 - 171,041,090 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000110698   ⟹   ENSRNOP00000091759
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4171,030,786 - 171,044,892 (+)Ensembl
RefSeq Acc Id: NM_134349   ⟹   NP_599176
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84172,760,930 - 172,776,157 (+)NCBI
mRatBN7.24171,029,666 - 171,044,893 (+)NCBI
Rnor_6.04172,119,382 - 172,134,609 (+)NCBI
Rnor_5.04236,372,225 - 236,387,452 (+)NCBI
RGSC_v3.44175,248,654 - 175,263,881 (+)RGD
Celera4159,602,240 - 159,617,460 (+)RGD
Sequence:
1 to 9 of 9 rows
Protein RefSeqs NP_599176 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41281 (Get FASTA)   NCBI Sequence Viewer  
  AAH63150 (Get FASTA)   NCBI Sequence Viewer  
  ACI32121 (Get FASTA)   NCBI Sequence Viewer  
  EDM01574 (Get FASTA)   NCBI Sequence Viewer  
  EDM01575 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000010579
  ENSRNOP00000010579.4
GenBank Protein P08011 (Get FASTA)   NCBI Sequence Viewer  
1 to 9 of 9 rows
RefSeq Acc Id: NP_599176   ⟸   NM_134349
- UniProtKB: P08011 (UniProtKB/Swiss-Prot),   B6DYQ4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000010579   ⟸   ENSRNOT00000010579
Ensembl Acc Id: ENSRNOP00000094357   ⟸   ENSRNOT00000110483
Ensembl Acc Id: ENSRNOP00000091759   ⟸   ENSRNOT00000110698

Name Modeler Protein Id AA Range Protein Structure
AF-P08011-F1-model_v2 AlphaFold P08011 1-155 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13693474
Promoter ID:EPDNEW_R3997
Type:initiation region
Name:Mgst1_1
Description:microsomal glutathione S-transferase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04172,119,388 - 172,119,448EPDNEW


1 to 27 of 27 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-42563 BioCyc
BioCyc Pathway PWY-4061 [glutathione-mediated detoxification I] BioCyc
  PWY-7112 [4-hydroxy-2-nonenal detoxification] BioCyc
BioCyc Pathway Image PWY-4061 BioCyc
  PWY-7112 BioCyc
Ensembl Genes ENSRNOG00000007743 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000010579 ENTREZGENE
  ENSRNOT00000010579.8 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.120.550 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6922267 IMAGE-MGC_LOAD
InterPro MAPEG-like_dom_sf UniProtKB/Swiss-Prot
  Membr-assoc_MAPEG UniProtKB/Swiss-Prot
  MGST1-like UniProtKB/Swiss-Prot
KEGG Report rno:171341 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72699 IMAGE-MGC_LOAD
NCBI Gene 171341 ENTREZGENE
PANTHER MICROSOMAL GLUTATHIONE S-TRANSFERASE 1 UniProtKB/Swiss-Prot
  PTHR10689 UniProtKB/Swiss-Prot
Pfam MAPEG UniProtKB/Swiss-Prot
PhenoGen Mgst1 PhenoGen
RatGTEx ENSRNOG00000007743 RatGTEx
Superfamily-SCOP SSF161084 UniProtKB/Swiss-Prot
UniProt A0A8I6ACC0_RAT UniProtKB/TrEMBL
  A0A8I6ALY9_RAT UniProtKB/TrEMBL
  A6IML5_RAT UniProtKB/TrEMBL
  B6DYQ4 ENTREZGENE, UniProtKB/TrEMBL
  MGST1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 27 of 27 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-07-09 Mgst1  microsomal glutathione S-transferase 1      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

Note Type Note Reference
gene_protein 154 amino acids 70791