Eif2ak3 (eukaryotic translation initiation factor 2 alpha kinase 3) - Rat Genome Database

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Gene: Eif2ak3 (eukaryotic translation initiation factor 2 alpha kinase 3) Rattus norvegicus
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Symbol: Eif2ak3
Name: eukaryotic translation initiation factor 2 alpha kinase 3
RGD ID: 70884
Description: Enables Hsp90 protein binding activity and eukaryotic translation initiation factor 2alpha kinase activity. Involved in negative regulation of translation in response to stress; protein autophosphorylation; and response to manganese-induced endoplasmic reticulum stress. Located in perinuclear region of cytoplasm. Biomarker of pulmonary venoocclusive disease. Human ortholog(s) of this gene implicated in Wolcott-Rallison syndrome and type 1 diabetes mellitus. Orthologous to human EIF2AK3 (eukaryotic translation initiation factor 2 alpha kinase 3); PARTICIPATES IN endoplasmic reticulum stress - the unfolded protein response pathway; Alzheimer's disease pathway; Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH (S)-nicotine; 1,2,4-trimethylbenzene; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: eukaryotic translation initiation factor 2-alpha kinase 3; pancreatic eIF2-alpha kinase; PEK; PRKR-like endoplasmic reticulum kinase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84104,363,838 - 104,425,271 (+)NCBIGRCr8
GRCr8 Ensembl4104,363,833 - 104,425,268 (+)EnsemblGRCr8 Ensembl
mRatBN7.24102,805,495 - 102,866,914 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4102,805,510 - 102,866,911 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4108,196,337 - 108,257,766 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04103,971,422 - 104,032,857 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04102,575,411 - 102,636,807 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0498,648,513 - 98,709,695 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl498,648,545 - 98,709,694 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04163,428,182 - 163,488,914 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44104,016,940 - 104,078,261 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera491,981,676 - 92,042,995 (+)NCBICelera
RGSC_v3.14104,261,420 - 104,322,741 (+)NCBI
Cytogenetic Map4q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Eif2ak3RatAcute-On-Chronic Liver Failure  ISOEIF2AK3 (Homo sapiens)32716425protein:hypophosphorylation:liver:RGD 
Eif2ak3RatChronic Hepatitis B  ISOEIF2AK3 (Homo sapiens)32716425 RGD 
Eif2ak3RatLiver Reperfusion Injury amelioratesISOEif2ak3 (Mus musculus)329812011 RGD 
Eif2ak3Ratpulmonary venoocclusive disease  IEP 38549370protein:increased expression:lungRGD 
Eif2ak3RatReperfusion Injury  IDA 1581062protein:increased phosphorylation:kidneyRGD 
Eif2ak3Ratsteatotic liver disease treatmentISOEif2ak3 (Mus musculus)401842386 RGD 
Eif2ak3RatTemporomandibular Joint Osteoarthritis  IEP 34888237mRNA,protein:increased expression:chondrocyteRGD 
Eif2ak3Rattype 1 diabetes mellitus  ISOEIF2AK3 (Homo sapiens)1601017DNA:polymorphismRGD 
Eif2ak3RatWolcott-Rallison syndrome  ISOEIF2AK3 (Homo sapiens)734923DNA:insertion, missense mutation:1103insT, 1832G>A (p.R587Q) (human)RGD 
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Eif2ak3Ratconnective tissue disease  ISOEIF2AK3 (Homo sapiens)8554872ClinVar Annotator: match by term: Connective tissue disease | ClinVar Annotator: match by term: Connective more ...ClinVarPMID:25741868|PMID:28492532
Eif2ak3Ratdiabetes mellitus  ISOEIF2AK3 (Homo sapiens)8554872ClinVar Annotator: match by term: Monogenic diabetesClinVarPMID:25741868|PMID:28492532
Eif2ak3Ratgenetic disease  ISOEIF2AK3 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868|PMID:28492532
Eif2ak3RatMenkes disease  ISOEIF2AK3 (Homo sapiens)8554872ClinVar Annotator: match by term: Menkes kinky-hair syndromeClinVarPMID:25741868
Eif2ak3RatWolcott-Rallison syndrome  ISOEIF2AK3 (Homo sapiens)8554872ClinVar Annotator: match by term: EIF2AK3-related condition | ClinVar Annotator: match by term: Wolcott-Rallison dysplasiaClinVarPMID:10932183|PMID:11997520|PMID:12960215|PMID:15220213|PMID:16199547|PMID:16813601|PMID:17576681|PMID:19837917|PMID:23771172|PMID:24411943|PMID:24825091|PMID:25741868|PMID:26380986|PMID:26860746|PMID:28492532|PMID:28652565|PMID:28843469|PMID:31183082|PMID:31264968|PMID:31638168|PMID:34426871|PMID:7551159|PMID:9536098
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Eif2ak3RatMyocardial Ischemia  ISOEIF2AK3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19041636
Eif2ak3Ratprogressive supranuclear palsy  ISOEIF2AK3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21685912
Eif2ak3Ratstatus epilepticus  ISOEIF2AK3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16492139
Eif2ak3RatWolcott-Rallison syndrome  ISOEIF2AK3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
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Eif2ak3RatWolcott-Rallison syndrome  ISSEif2ak3 (Mus musculus)13592920OMIM:226980MouseDO 
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Eif2ak3RatWolcott-Rallison syndrome  ISOEIF2AK3 (Homo sapiens)7240710 OMIM 

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Eif2ak3Rat(+)-pilocarpine multiple interactionsISOEif2ak3 (Mus musculus)6480464Pilocarpine promotes the reaction [EIF2AK3 protein modified form results in increased phosphorylation of EIF2S1 protein]CTDPMID:16492139
Eif2ak3Rat(+)-pilocarpine increases activityISOEif2ak3 (Mus musculus)6480464Pilocarpine results in increased activity of EIF2AK3 proteinCTDPMID:16492139
Eif2ak3Rat(20S)-ginsenoside Rg3 multiple interactionsISOEif2ak3 (Mus musculus)6480464ginsenoside Rg3 inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased phosphorylation of more ...CTDPMID:39579577
Eif2ak3Rat(20S)-ginsenoside Rg3 multiple interactionsISOEIF2AK3 (Homo sapiens)64804642-(1,3-benzodioxol-5-yl)-N-(5-methyl-4-(1-(2-methylbenzoyl)-2,3-dihydroindol-5-yl)-1,3-thiazol-2-yl)acetamide inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Glucose results in increased phosphorylation of more ...CTDPMID:39579577
Eif2ak3Rat(S)-nicotine multiple interactionsEXP 6480464Mecamylamine inhibits the reaction [Nicotine results in increased phosphorylation of EIF2AK3 protein]; ursodoxicoltaurine inhibits the more ...CTDPMID:26803847
Eif2ak3Rat(S)-nicotine increases phosphorylationEXP 6480464Nicotine results in increased phosphorylation of EIF2AK3 proteinCTDPMID:26803847
Eif2ak3Rat1,2,4-trimethylbenzene decreases expressionEXP 6480464pseudocumene results in decreased expression of EIF2AK3 proteinCTDPMID:17337753
Eif2ak3Rat1,2-dichloroethane increases expressionISOEif2ak3 (Mus musculus)6480464ethylene dichloride results in increased expression of EIF2AK3 mRNACTDPMID:28973639
Eif2ak3Rat1,2-dimethylhydrazine multiple interactionsEXP 6480464[1,2-Dimethylhydrazine co-treated with morin] results in increased expression of EIF2AK3 protein; p-coumaric acid inhibits the more ...CTDPMID:29879413|PMID:32028820
Eif2ak3Rat1,2-dimethylhydrazine decreases expressionISOEif2ak3 (Mus musculus)64804641,2-Dimethylhydrazine results in decreased expression of EIF2AK3 mRNACTDPMID:22206623
Eif2ak3Rat1,2-dimethylhydrazine decreases phosphorylationEXP 64804641,2-Dimethylhydrazine results in decreased phosphorylation of EIF2AK3 proteinCTDPMID:29879413|PMID:32028820
Eif2ak3Rat1,4-dithiothreitol multiple interactionsEXP 6480464Dithiothreitol results in increased phosphorylation of and results in increased activity of EIF2AK3 proteinCTDPMID:12486162
Eif2ak3Rat1,4-dithiothreitol increases phosphorylationISOEIF2AK3 (Homo sapiens)6480464Dithiothreitol results in increased phosphorylation of EIF2AK3 proteinCTDPMID:25321315
Eif2ak3Rat17beta-estradiol increases expressionISOEIF2AK3 (Homo sapiens)6480464Estradiol results in increased expression of EIF2AK3 mRNACTDPMID:20106945
Eif2ak3Rat17beta-estradiol increases expressionISOEif2ak3 (Mus musculus)6480464Estradiol results in increased expression of EIF2AK3 mRNACTDPMID:39298647
Eif2ak3Rat17beta-estradiol decreases expressionISOEIF2AK3 (Homo sapiens)6480464Estradiol results in decreased expression of EIF2AK3 mRNACTDPMID:19167446
Eif2ak3Rat17beta-hydroxy-5alpha-androstan-3-one increases expressionISOEIF2AK3 (Homo sapiens)6480464Dihydrotestosterone results in increased expression of EIF2AK3 mRNACTDPMID:29581250
Eif2ak3Rat2,2',4,4'-Tetrabromodiphenyl ether increases expressionISOEIF2AK3 (Homo sapiens)64804642,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of EIF2AK3 mRNACTDPMID:19095052
Eif2ak3Rat2,2',4,4'-Tetrabromodiphenyl ether affects expressionISOEif2ak3 (Mus musculus)64804642,2',4,4'-tetrabromodiphenyl ether affects the expression of EIF2AK3 mRNACTDPMID:30294300
Eif2ak3Rat2,2',4,4'-Tetrabromodiphenyl ether multiple interactionsISOEif2ak3 (Mus musculus)6480464[2,2',4,4'-tetrabromodiphenyl ether co-treated with Ceruletide] results in increased expression of and results in increased phosphorylation more ...CTDPMID:25639565|PMID:38407484

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Biological Process
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Eif2ak3Ratangiogenesis involved_inISOEIF2AK3 (Homo sapiens)1624291 PMID:22915762RGDPMID:22915762
Eif2ak3Ratangiogenesis involved_inIEAUniProtKB:Q9NZJ5|ensembl:ENSP000003072351600115GO_REF:0000107EnsemblGO_REF:0000107
Eif2ak3Ratbone mineralization acts_upstream_of_or_withinISOEif2ak3 (Mus musculus)1624291MGI:2183829 PMID:11997520RGDPMID:11997520
Eif2ak3Ratcalcium-mediated signaling acts_upstream_of_or_withinISOEif2ak3 (Mus musculus)1624291MGI:2177666 PMID:16352659RGDPMID:16352659
Eif2ak3Ratcellular response to amino acid starvation involved_inISSUniProtKB:Q9NZJ51600115GO_REF:0000024UniProtGO_REF:0000024
Eif2ak3Ratcellular response to amino acid starvation involved_inIEAUniProtKB:Q9NZJ5|ensembl:ENSP000003072351600115GO_REF:0000107EnsemblGO_REF:0000107
Eif2ak3Ratcellular response to amino acid starvation involved_inISOEIF2AK3 (Homo sapiens)1624291 PMID:25329545RGDPMID:25329545
Eif2ak3Ratcellular response to cold involved_inISOEIF2AK3 (Homo sapiens)1624291 PMID:25329545RGDPMID:25329545
Eif2ak3Ratcellular response to cold involved_inIEAUniProtKB:Q9NZJ5|ensembl:ENSP000003072351600115GO_REF:0000107EnsemblGO_REF:0000107
Eif2ak3Ratcellular response to cold involved_inISSUniProtKB:Q9NZJ51600115GO_REF:0000024UniProtGO_REF:0000024
Eif2ak3Ratcellular response to glucose starvation involved_inISOEif2ak3 (Mus musculus)1624291 PMID:22915762RGDPMID:22915762
Eif2ak3Ratcellular response to glucose starvation involved_inIEAUniProtKB:Q9NZJ5|ensembl:ENSP000003072351600115GO_REF:0000107EnsemblGO_REF:0000107
Eif2ak3Ratcellular response to glucose starvation involved_inISOEIF2AK3 (Homo sapiens)1624291 PMID:22915762RGDPMID:22915762
Eif2ak3Ratchondrocyte development acts_upstream_of_or_withinISOEif2ak3 (Mus musculus)1624291MGI:2183829 PMID:12865332RGDPMID:12865332
Eif2ak3RateiF2alpha phosphorylation in response to endoplasmic reticulum stress involved_inISOEif2ak3 (Mus musculus)1624291 PMID:17707796RGDPMID:17707796
Eif2ak3Ratendocrine pancreas development involved_inISSUniProtKB:Q9NZJ51600115GO_REF:0000024UniProtGO_REF:0000024
Eif2ak3Ratendocrine pancreas development involved_inIEAUniProtKB:Q9NZJ5|ensembl:ENSP000003072351600115GO_REF:0000107EnsemblGO_REF:0000107
Eif2ak3Ratendocrine pancreas development involved_inISOEIF2AK3 (Homo sapiens)1624291 PMID:12086964RGDPMID:12086964
Eif2ak3Ratendoplasmic reticulum organization acts_upstream_of_or_withinISOEif2ak3 (Mus musculus)1624291MGI:2177666 PMID:11430819RGDPMID:11430819
Eif2ak3Ratendoplasmic reticulum unfolded protein response involved_inISSUniProtKB:Q9NZJ51600115GO_REF:0000024UniProtGO_REF:0000024
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Cellular Component
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Eif2ak3Ratcytoplasm located_inISOEif2ak3 (Mus musculus)1624291 PMID:11747369RGDPMID:11747369
Eif2ak3Ratcytoplasm is_active_inIBAFB:FBgn0037327|FB:FBgn0040298|MGI:103075|MGI:1341830|MGI:1353427|MGI:1353448|MGI:2137630|MGI:3027899|PANTHER:PTN000113601|PomBase:SPCC18B5.03|RGD:70884|SGD:S000002691|UniProtKB:A0A8J1MGT9|UniProtKB:P0C1S8|UniProtKB:P19525|UniProtKB:Q583N6|UniProtKB:Q99640|UniProtKB:Q9BQI3|WB:WBGene000069401600115GO_REF:0000033GO_CentralGO_REF:0000033
Eif2ak3Ratendoplasmic reticulum located_inISOEif2ak3 (Mus musculus)1624291 PMID:11430819, PMID:14517290RGDPMID:11430819|PMID:14517290
Eif2ak3Ratendoplasmic reticulum located_inIEAUniProtKB-KW:KW-02561600115GO_REF:0000043UniProtGO_REF:0000043
Eif2ak3Ratendoplasmic reticulum membrane located_inISOEif2ak3 (Mus musculus)1624291 PMID:9930704RGDPMID:9930704
Eif2ak3Ratendoplasmic reticulum membrane located_inIEAUniProtKB-SubCell:SL-00971600115GO_REF:0000044UniProtGO_REF:0000044
Eif2ak3Ratendoplasmic reticulum quality control compartment located_inISOEif2ak3 (Mus musculus)1624291 PMID:17707796RGDPMID:17707796
Eif2ak3Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Eif2ak3Ratmitochondria-associated endoplasmic reticulum membrane contact site is_active_inISOEIF2AK3 (Homo sapiens)1624291 PMID:39116259RGDPMID:39116259
Eif2ak3Ratmitochondria-associated endoplasmic reticulum membrane contact site is_active_inIEAUniProtKB:Q9NZJ5|ensembl:ENSP000003072351600115GO_REF:0000107EnsemblGO_REF:0000107
Eif2ak3Ratnucleus is_active_inIBAFB:FBgn0011737|MGI:2137630|MGI:3027899|PANTHER:PTN000113601|PomBase:SPCC18B5.03|SGD:S000003723|UniProtKB:A0A8J1MGT9|UniProtKB:A4PES0|UniProtKB:P0C1S8|UniProtKB:P19525|UniProtKB:P30291|UniProtKB:Q583N6|UniProtKB:Q8N165|UniProtKB:Q8TDR2|UniProtKB:Q99640|WB:WBGene000069401600115GO_REF:0000033GO_CentralGO_REF:0000033
Eif2ak3Ratperinuclear region of cytoplasm  IDA 1581062 RGD 
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Molecular Function
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Eif2ak3RatATP binding enablesIEAUniProtKB-KW:KW-00671600115GO_REF:0000043UniProtGO_REF:0000043
Eif2ak3RatATP binding enablesIEAInterPro:IPR0007191600115GO_REF:0000002InterProGO_REF:0000002
Eif2ak3Ratenzyme binding enablesISOEIF2AK3 (Homo sapiens)1624291UniProtKB:Q8N5Y8 PMID:23103912RGDPMID:23103912
Eif2ak3Ratenzyme binding enablesIEAUniProtKB:Q9NZJ5|ensembl:ENSP000003072351600115GO_REF:0000107EnsemblGO_REF:0000107
Eif2ak3Rateukaryotic translation initiation factor 2alpha kinase activity  IDA 70729 RGD 
Eif2ak3Rateukaryotic translation initiation factor 2alpha kinase activity enablesIBACGD:CAL0000185174|FB:FBgn0037327|MGI:1341830|PANTHER:PTN008315216|PomBase:SPAC20G4.03c|PomBase:SPAC222.07c|RGD:70883|RGD:70884|UniProtKB:P19525|UniProtKB:Q9BQI3|UniProtKB:Q9NZJ5|WB:WBGene000039701600115GO_REF:0000033GO_CentralGO_REF:0000033
Eif2ak3Rateukaryotic translation initiation factor 2alpha kinase activity enablesIEAUniProtKB:Q9NZJ5|ensembl:ENSP000003072351600115GO_REF:0000107EnsemblGO_REF:0000107
Eif2ak3Rateukaryotic translation initiation factor 2alpha kinase activity enablesIEAARBA:ARBA000444211600115GO_REF:0000117UniProtGO_REF:0000117
Eif2ak3Rateukaryotic translation initiation factor 2alpha kinase activity enablesISOEIF2AK3 (Homo sapiens)1624291 PMID:10026192, PMID:10677345, PMID:11907036, PMID:12086964, PMID:25329545, PMID:25925385, PMID:31023583, PMID:39116259RGDPMID:10026192|PMID:10677345|PMID:11907036|PMID:12086964|PMID:25329545|PMID:25925385|PMID:31023583|PMID:39116259
Eif2ak3Rateukaryotic translation initiation factor 2alpha kinase activity enablesISSUniProtKB:Q9NZJ51600115GO_REF:0000024UniProtGO_REF:0000024
Eif2ak3Rateukaryotic translation initiation factor 2alpha kinase activity enablesISOEif2ak3 (Mus musculus)1624291UniProtKB:Q9Z2B5 PMID:10882126, PMID:14729979, PMID:16418533, PMID:17998206, PMID:21954288, PMID:9930704RGDPMID:10882126|PMID:14729979|PMID:16418533|PMID:17998206|PMID:21954288|PMID:9930704
Eif2ak3RatHsp90 protein binding enablesIDA 10047277PMID:12446770ParkinsonsUK-UCL 
Eif2ak3Ratidentical protein binding enablesISOEif2ak3 (Mus musculus)1624291UniProtKB:Q9Z2B5 PMID:16973740RGDPMID:16973740
Eif2ak3Ratidentical protein binding enablesIEAUniProtKB:Q9NZJ5|ensembl:ENSP000003072351600115GO_REF:0000107EnsemblGO_REF:0000107
Eif2ak3Ratidentical protein binding enablesISOEIF2AK3 (Homo sapiens)1624291UniProtKB:Q9NZJ5 PMID:11907036RGDPMID:11907036
Eif2ak3Ratkinase activity enablesIEAUniProtKB-KW:KW-04181600115GO_REF:0000043UniProtGO_REF:0000043
Eif2ak3Ratmisfolded protein binding enablesISOEif2ak3 (Mus musculus)1624291 PMID:29386355RGDPMID:29386355
Eif2ak3Ratmisfolded protein binding enablesIEAUniProtKB:Q9NZJ5|ensembl:ENSP000003072351600115GO_REF:0000107EnsemblGO_REF:0000107
Eif2ak3Ratmisfolded protein binding enablesISOEIF2AK3 (Homo sapiens)1624291 PMID:27917829RGDPMID:27917829
Eif2ak3Ratmisfolded protein binding enablesISSUniProtKB:Q9Z2B51600115GO_REF:0000024UniProtGO_REF:0000024
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RGD Manual Annotations


  
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Eif2ak3Ratendoplasmic reticulum stress - the unfolded protein response pathway  ISOEIF2AK3 (Homo sapiens)10450872 RGD 

Imported Annotations - KEGG (archival)

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Eif2ak3RatAlzheimer's disease pathway   IEA 6907045 KEGGrno:05010
Eif2ak3RatEndoplasmic Reticulum-associated degradation pathway  IEA 6907045 KEGGrno:04141
Eif2ak3Rathepatitis C pathway  IEA 6907045 KEGGrno:05160
Eif2ak3Ratinfluenza A pathway  IEA 6907045 KEGGrno:05164
Eif2ak3Ratmeasles pathway  IEA 6907045 KEGGrno:05162

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Reference Title
Reference Citation
1. The EIF2AK3 gene region and type I diabetes in subjects from South India. Allotey RA, etal., Genes Immun. 2004 Dec;5(8):648-52.
2. EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndrome. Delepine M, etal., Nat Genet 2000 Aug;25(4):406-9.
3. Translation mediated by the internal ribosome entry site of the cat-1 mRNA is regulated by glucose availability in a PERK kinase-dependent manner. Fernandez J, etal., J Biol Chem 2002 Apr 5;277(14):11780-7.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
6. Cellular communication network factor 1 (CCN1) knockdown exerts a protective effect for hepatic ischemia/reperfusion injury by deactivating the MEK/ERK pathway. Liu H, etal., Clin Res Hepatol Gastroenterol. 2021 Sep;45(5):101737. doi: 10.1016/j.clinre.2021.101737. Epub 2021 Jun 16.
7. Comparison of Human and Experimental Pulmonary Veno-Occlusive Disease. Manaud G, etal., Am J Respir Cell Mol Biol. 2020 Jul;63(1):118-131. doi: 10.1165/rcmb.2019-0015OC.
8. Heat shock protein 90 modulates the unfolded protein response by stabilizing IRE1alpha. Marcu MG, etal., Mol Cell Biol. 2002 Dec;22(24):8506-13.
9. Gene Data Set MGD Curation, June 12, 2002
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Renal ischemia and reperfusion activates the eIF 2 alpha kinase PERK. Montie HL, etal., Biochim Biophys Acta. 2005 Sep 25;1741(3):314-24.
12. Naltrexone changes the expression of lipid metabolism-related proteins in the endoplasmic reticulum stress induced hepatic steatosis in mice. Moslehi A, etal., Clin Exp Pharmacol Physiol. 2017 Feb;44(2):207-212. doi: 10.1111/1440-1681.12695.
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. The dysregulation of endoplasmic reticulum stress response in acute-on-chronic liver failure patients caused by acute exacerbation of chronic hepatitis B. Ren F, etal., J Viral Hepat. 2016 Jan;23(1):23-31. doi: 10.1111/jvh.12438. Epub 2015 Jul 31.
17. GOA pipeline RGD automated data pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control. Shi Y, etal., Mol Cell Biol 1998 Dec;18(12):7499-509.
1 to 20 of 23 rows
PMID:9930704   PMID:10026192   PMID:10677345   PMID:10854322   PMID:10882126   PMID:11106749   PMID:11430819   PMID:11747369   PMID:11907036   PMID:11997520   PMID:12086964   PMID:12388085  
PMID:12610133   PMID:12865332   PMID:14517290   PMID:14676213   PMID:14729979   PMID:14978030   PMID:15542627   PMID:15911877   PMID:16176978   PMID:16352659   PMID:16973740   PMID:18550523  
PMID:18852460   PMID:19061639   PMID:19732428   PMID:19875812   PMID:19946888   PMID:21059295   PMID:21193559   PMID:21525936   PMID:21767604   PMID:22169477   PMID:22240901   PMID:22915762  
PMID:23000344   PMID:23103912   PMID:23152784   PMID:23787763   PMID:24114838   PMID:24180212   PMID:24223705   PMID:24636620   PMID:25012492   PMID:25132241   PMID:25329545   PMID:27785700  
PMID:28178380   PMID:28641278   PMID:29653943   PMID:30005895   PMID:32304741   PMID:33635524   PMID:35315506  



Eif2ak3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84104,363,838 - 104,425,271 (+)NCBIGRCr8
GRCr8 Ensembl4104,363,833 - 104,425,268 (+)EnsemblGRCr8 Ensembl
mRatBN7.24102,805,495 - 102,866,914 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4102,805,510 - 102,866,911 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4108,196,337 - 108,257,766 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04103,971,422 - 104,032,857 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04102,575,411 - 102,636,807 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0498,648,513 - 98,709,695 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl498,648,545 - 98,709,694 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04163,428,182 - 163,488,914 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44104,016,940 - 104,078,261 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera491,981,676 - 92,042,995 (+)NCBICelera
RGSC_v3.14104,261,420 - 104,322,741 (+)NCBI
Cytogenetic Map4q32NCBI
EIF2AK3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38288,556,741 - 88,628,145 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl288,556,741 - 88,691,518 (-)EnsemblGRCh38hg38GRCh38
GRCh37288,856,259 - 88,926,982 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36288,637,374 - 88,708,109 (-)NCBINCBI36Build 36hg18NCBI36
Build 34288,695,522 - 88,766,221NCBI
Celera287,859,255 - 87,930,028 (+)NCBICelera
Cytogenetic Map2p11.2NCBI
HuRef287,778,073 - 87,848,926 (-)NCBIHuRef
CHM1_1288,785,816 - 88,856,644 (-)NCBICHM1_1
T2T-CHM13v2.0288,568,747 - 88,640,715 (-)NCBIT2T-CHM13v2.0
Eif2ak3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39670,821,468 - 70,882,225 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl670,821,499 - 70,882,229 (+)EnsemblGRCm39 Ensembl
GRCm38670,844,484 - 70,905,241 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl670,844,515 - 70,905,245 (+)EnsemblGRCm38mm10GRCm38
MGSCv37670,794,521 - 70,855,234 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36670,774,114 - 70,834,817 (+)NCBIMGSCv36mm8
Celera672,929,631 - 72,983,380 (+)NCBICelera
Cytogenetic Map6C1NCBI
cM Map632.09NCBI
Eif2ak3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955424226,038 - 280,593 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955424210,867 - 279,267 (+)NCBIChiLan1.0ChiLan1.0
EIF2AK3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21238,675,784 - 38,746,531 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A38,678,745 - 38,749,291 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A87,688,732 - 87,759,580 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A89,596,833 - 89,667,468 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A89,596,833 - 89,667,468 (-)Ensemblpanpan1.1panPan2
EIF2AK3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11737,886,397 - 37,950,671 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1737,886,601 - 37,949,812 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1737,569,354 - 37,633,691 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01738,616,654 - 38,681,115 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1738,616,628 - 38,681,104 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11737,783,596 - 37,848,117 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01737,820,035 - 37,884,543 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01738,169,639 - 38,234,208 (+)NCBIUU_Cfam_GSD_1.0
Eif2ak3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629280,404,001 - 80,450,064 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936712414,446 - 454,449 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936712413,602 - 454,443 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EIF2AK3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl357,423,943 - 57,506,245 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1357,423,894 - 57,506,247 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2360,029,999 - 60,114,512 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EIF2AK3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11418,135,973 - 18,209,471 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1418,136,291 - 18,209,457 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660801,565,866 - 1,639,604 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Eif2ak3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474915,869,569 - 15,950,757 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474915,867,444 - 15,950,757 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Eif2ak3
159 total Variants


Assembly: Rnor_6.0
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
4 98708616 98708617 G A snv WKY/NHsd (RGD) View more Information

Predicted Target Of
Summary Value
Count of predictions:550
Count of miRNA genes:276
Interacting mature miRNAs:329
Transcripts:ENSRNOT00000008451
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 55 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
631689Scl4Serum cholesterol level QTL 41.90.008blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)495174120140174120Rat
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)485253748148090731Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
1549843Bw53Body weight QTL 530.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658103194791Rat
1578655Bmd11Bone mineral density QTL 1111femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)490850165135850165Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)426775591168368347Rat
1357342Bw40Body weight QTL 400.001body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat
631556Bp135Blood pressure QTL 1350.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)478881294117676292Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)470362013132642728Rat
70167Bw22Body weight QTL 223.1body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat

1 to 10 of 55 rows



alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000008451   ⟹   ENSRNOP00000008451
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4104,363,872 - 104,425,268 (+)Ensembl
mRatBN7.2 Ensembl4102,805,510 - 102,866,911 (+)Ensembl
Rnor_6.0 Ensembl498,648,545 - 98,709,694 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000094657   ⟹   ENSRNOP00000090000
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4104,363,833 - 104,383,024 (+)Ensembl
mRatBN7.2 Ensembl4102,805,510 - 102,824,666 (+)Ensembl
RefSeq Acc Id: NM_031599   ⟹   NP_113787
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84104,363,872 - 104,425,271 (+)NCBI
mRatBN7.24102,805,510 - 102,866,914 (+)NCBI
Rnor_6.0498,648,545 - 98,709,695 (+)NCBI
Rnor_5.04163,428,182 - 163,488,914 (+)NCBI
RGSC_v3.44104,016,940 - 104,078,261 (+)RGD
Celera491,981,676 - 92,042,995 (+)RGD
Sequence:
RefSeq Acc Id: XM_006236624   ⟹   XP_006236686
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84104,363,838 - 104,416,649 (+)NCBI
mRatBN7.24102,805,495 - 102,858,283 (+)NCBI
Rnor_6.0498,648,513 - 98,701,045 (+)NCBI
Rnor_5.04163,428,182 - 163,488,914 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008762977   ⟹   XP_008761199
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84104,377,254 - 104,425,271 (+)NCBI
mRatBN7.24102,818,888 - 102,866,914 (+)NCBI
Rnor_6.0498,663,549 - 98,709,695 (+)NCBI
Sequence:
1 to 9 of 9 rows
Protein RefSeqs NP_113787 (Get FASTA)   NCBI Sequence Viewer  
  XP_006236686 (Get FASTA)   NCBI Sequence Viewer  
  XP_008761199 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC83801 (Get FASTA)   NCBI Sequence Viewer  
  EDL90978 (Get FASTA)   NCBI Sequence Viewer  
  EDL90979 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000008451
  ENSRNOP00000008451.4
GenBank Protein Q9Z1Z1 (Get FASTA)   NCBI Sequence Viewer  
1 to 9 of 9 rows
RefSeq Acc Id: NP_113787   ⟸   NM_031599
- Peptide Label: precursor
- UniProtKB: Q9Z1Z1 (UniProtKB/Swiss-Prot),   A6IA60 (UniProtKB/TrEMBL),   A6IA61 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006236686   ⟸   XM_006236624
- Peptide Label: isoform X2
- UniProtKB: A6IA61 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008761199   ⟸   XM_008762977
- Peptide Label: isoform X1
- UniProtKB: A6IA61 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000008451   ⟸   ENSRNOT00000008451
Ensembl Acc Id: ENSRNOP00000090000   ⟸   ENSRNOT00000094657
Protein kinase

Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z1Z1-F1-model_v2 AlphaFold Q9Z1Z1 1-1108 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13693106
Promoter ID:EPDNEW_R3631
Type:initiation region
Name:Eif2ak3_1
Description:eukaryotic translation initiation factor 2 alpha kinase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0498,648,586 - 98,648,646EPDNEW


1 to 29 of 29 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-44201 BioCyc
Ensembl Genes ENSRNOG00000006069 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000008451 ENTREZGENE
  ENSRNOT00000008451.6 UniProtKB/Swiss-Prot
Gene3D-CATH 2.130.10.10 UniProtKB/Swiss-Prot
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro CC_SR_Kinase UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Quinoprotein_ADH-like_supfam UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
  WD40/YVTN_repeat-like_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:29702 UniProtKB/Swiss-Prot
NCBI Gene 29702 ENTREZGENE
PANTHER EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE 3 UniProtKB/Swiss-Prot
  EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED UniProtKB/Swiss-Prot
Pfam Pkinase UniProtKB/Swiss-Prot
PhenoGen Eif2ak3 PhenoGen
PROSITE PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000006069 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50998 UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
UniProt A0A8I6AAY3_RAT UniProtKB/TrEMBL
  A6IA60 ENTREZGENE, UniProtKB/TrEMBL
  A6IA61 ENTREZGENE, UniProtKB/TrEMBL
  E2AK3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 29 of 29 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-07-09 Eif2ak3  eukaryotic translation initiation factor 2 alpha kinase 3      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

Note Type Note Reference
gene_regulation autophosphorylated on both serine and threonine residues 70729