Mapk1 (mitogen activated protein kinase 1) - Rat Genome Database

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Gene: Mapk1 (mitogen activated protein kinase 1) Rattus norvegicus
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Symbol: Mapk1
Name: mitogen activated protein kinase 1
RGD ID: 70500
Description: Enables several functions, including ATP binding activity; MAP kinase activity; and mitogen-activated protein kinase kinase kinase binding activity. Involved in several processes, including ERK1 and ERK2 cascade; cellular response to cAMP; and positive regulation of macromolecule biosynthetic process. Acts upstream of or within peptidyl-serine phosphorylation. Located in several cellular components, including caveola; dendrite cytoplasm; and perikaryon. Part of protein-containing complex. Is active in postsynaptic density. Used to study several diseases, including alcohol dependence; cocaine abuse; coronary artery disease (multiple); drug dependence (multiple); and gastric ulcer. Biomarker of alcohol use disorder; colon cancer; renal fibrosis; urethral obstruction; and vascular dementia. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome 13; Parkinson's disease; adenocarcinoma (multiple); pulmonary hypertension; and renal cell carcinoma. Orthologous to human MAPK1 (mitogen-activated protein kinase 1); PARTICIPATES IN the extracellular signal-regulated Raf/Mek/Erk signaling pathway; adenosine signaling pathway; Bone morphogenetic proteins signaling pathway; INTERACTS WITH (+)-catechin; (+)-dihydromyricetin; (+)-pilocarpine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ERK-2; Erk2; ERT1; extracellular signal-regulated kinase 2; extracellular-signal-regulated kinase 1; extracellular-signal-regulated kinase 2; MAP kinase 1; MAP kinase 2; MAP kinase isoform p42; MAPK 1; MAPK 2; mitogen-activated protein kinase 1; mitogen-activated protein kinase 2; p42-MAPK
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81197,462,025 - 97,529,193 (-)NCBIGRCr8
mRatBN7.21183,957,813 - 84,023,629 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1183,957,813 - 84,023,616 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1192,681,387 - 92,746,630 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01185,342,529 - 85,407,764 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01184,396,110 - 84,461,350 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01188,203,863 - 88,273,301 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1188,211,599 - 88,273,254 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01191,260,412 - 91,325,570 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41185,968,732 - 86,030,387 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11186,009,328 - 86,070,984 (-)NCBI
Celera1182,713,470 - 82,779,260 (-)NCBICelera
Cytogenetic Map11q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
Mapk1RatAberrant Crypt Foci  ISOMAPK1 (Homo sapiens)13210776 RGD 
Mapk1Ratalcohol dependence treatmentIDA 401959604 RGD 
Mapk1Ratalcohol use disorder  IEP 401959334protein:increased expression:liverRGD 
Mapk1RatAlzheimer's disease treatmentISOMapk1 (Mus musculus)13800563 RGD 
Mapk1RatAlzheimer's disease onsetISOMAPK1 (Homo sapiens)13800868mRNA:increased expression: CA2 field of hippocampus and pyramidal neuronRGD 
Mapk1Ratbrain ischemia  ISOMapk1 (Mus musculus)1582281 RGD 
Mapk1Ratbreast cancer  ISOMAPK1 (Homo sapiens)2314939protein:increased expression and increased phosphorylation:breastRGD 
Mapk1RatCardiomegaly  IDA 1582283 RGD 
Mapk1Ratchildhood pilocytic astrocytoma  ISOMAPK1 (Homo sapiens)13702864protein:increased expression:brain:RGD 
Mapk1Ratcocaine abuse  IDA 401851063protein:increased phosphorylation:nucleus accumbensRGD 
Mapk1Ratcocaine dependence  IDA 401851078protein:increased phosphorylation:brainRGD 
Mapk1Ratcolon adenocarcinoma  ISOMAPK1 (Homo sapiens)13210775 RGD 
Mapk1Ratcolon cancer treatmentIEP 401976467 RGD 
Mapk1Ratcolorectal adenocarcinoma treatmentISOMAPK1 (Homo sapiens)13210782 RGD 
Mapk1RatColorectal Neoplasms  ISOMAPK1 (Homo sapiens)13210794 RGD 
Mapk1Ratcoronary restenosis  IDA 1582284 RGD 
Mapk1Ratdemyelinating disease  ISOMapk1 (Mus musculus)13800879 RGD 
Mapk1Ratdepressive disorder  ISOMAPK1 (Homo sapiens)401966883 RGD 
Mapk1RatDiabetic Cardiomyopathies treatmentIDA 13800893associated with Diabetes Mellitus and ExperimentalRGD 
Mapk1RatDiabetic Nephropathies  ISOMAPK1 (Homo sapiens)7243957 RGD 
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Mapk1Ratchromosome 22q11.2 deletion syndrome, distal  ISOMAPK1 (Homo sapiens)8554872ClinVar Annotator: match by term: Chromosome 22q11.2 deletion syndrome and distalClinVarPMID:21681106 more ...
Mapk1Ratcongenital heart disease  ISOMAPK1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:25741868 and PMID:32721402
Mapk1Ratcongenital heart disease  ISOMAPK1 (Homo sapiens)8554872ClinVar Annotator: match by term: Heart and malformation ofClinVarPMID:25741868 more ...
Mapk1RatDiGeorge syndrome  ISOMAPK1 (Homo sapiens)8554872ClinVar Annotator: match by term: DiGeorge syndromeClinVarPMID:32581362
Mapk1RatDwarfism  ISOMAPK1 (Homo sapiens)8554872ClinVar Annotator: match by term: Short statureClinVarPMID:25741868 and PMID:32721402
Mapk1Ratgenetic disease  ISOMAPK1 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868
Mapk1Ratintellectual disability  ISOMAPK1 (Homo sapiens)8554872ClinVar Annotator: match by term: intellectual disabilitiesClinVarPMID:25741868 and PMID:32721402
Mapk1RatNoonan syndrome 13  ISOMAPK1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:20301303 more ...
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Mapk1RatAnimal Disease Models  ISOMAPK1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:27093858
Mapk1Ratbrain ischemia  ISOMAPK1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17901229
Mapk1Ratcardiomyopathy  ISOMAPK1 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:10620750
Mapk1RatCocaine-Related Disorders  ISOMAPK1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16407894 and PMID:20692647
Mapk1RatCoronavirus infectious disease  ISOMAPK1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20484496
Mapk1RatExperimental Liver Neoplasms  ISOMAPK1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:28100771
Mapk1RatExperimental Radiation Injuries  ISOMAPK1 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:22247605
Mapk1Ratextrahepatic cholestasis  ISOMAPK1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:28789951
Mapk1RatFemale Infertility  ISOMAPK1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21177758
Mapk1RatGliosis  ISOMAPK1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19402951
Mapk1RatHead and Neck Neoplasms  ISOMAPK1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15342401
Mapk1RatHodgkin's lymphoma  ISOMAPK1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:7545087
Mapk1RatHyperalgesia  ISOMAPK1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12941468 and PMID:27093858
Mapk1RatHypertrophy  ISOMAPK1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12237323
Mapk1Ratjuvenile rheumatoid arthritis  ISOMAPK1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19565504
Mapk1RatKidney Neoplasms  ISOMAPK1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21813464
Mapk1RatLung Neoplasms  ISOMAPK1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:11884234 and PMID:12376484
Mapk1RatNeoplasm Invasiveness  ISOMAPK1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22580338
Mapk1RatNeoplasm Metastasis  ISOMAPK1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22580338
Mapk1RatNerve Degeneration  ISOMAPK1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19911010
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Mapk1Ratautism spectrum disorder  ISSMapk1 (Mus musculus)13592920 MouseDO 
Mapk1Ratvelocardiofacial syndrome  ISSMapk1 (Mus musculus)13592920OMIM:192430MouseDO 
Mapk1RatWeissenbacher-Zweymuller syndrome  ISSMapk1 (Mus musculus)13592920OMIM:261800MouseDO 
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Mapk1RatNoonan syndrome 13  ISOMAPK1 (Homo sapiens)7240710 OMIM 

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Mapk1Rat(+)-catechin multiple interactionsEXP 6480464Catechin inhibits the reaction [EDN1 protein results in increased phosphorylation of MAPK1 protein]CTDPMID:20977430
Mapk1Rat(+)-catechin multiple interactionsISOMapk1 (Mus musculus)6480464Catechin inhibits the reaction [Cisplatin results in increased phosphorylation of and results in increased activity of MAPK1 protein]CTDPMID:20883750
Mapk1Rat(+)-catechin increases phosphorylationISOMapk1 (Mus musculus)6480464Catechin results in increased phosphorylation of MAPK1 proteinCTDPMID:15879681
Mapk1Rat(+)-catechin increases phosphorylationISOMAPK1 (Homo sapiens)6480464Catechin results in increased phosphorylation of MAPK1 proteinCTDPMID:17379280
Mapk1Rat(+)-catechin decreases phosphorylationISOMAPK1 (Homo sapiens)6480464Catechin analog results in decreased phosphorylation of MAPK1 proteinCTDPMID:16413414
Mapk1Rat(+)-catechin multiple interactionsISOMAPK1 (Homo sapiens)6480464Catechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased phosphorylation of MAPK1 protein] and Catechin inhibits the reaction [Glucose results in increased phosphorylation of MAPK1 protein]CTDPMID:19557821 and PMID:21882252
Mapk1Rat(+)-dihydromyricetin multiple interactionsEXP 6480464ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of MAPK1 protein]CTDPMID:21871475
Mapk1Rat(+)-epicatechin-3-O-gallate increases phosphorylationISOMAPK1 (Homo sapiens)6480464epicatechin gallate results in increased phosphorylation of MAPK1 proteinCTDPMID:21945981
Mapk1Rat(+)-pilocarpine increases phosphorylationISOMapk1 (Mus musculus)6480464Pilocarpine results in increased phosphorylation of MAPK1 proteinCTDPMID:19402951
Mapk1Rat(+)-pilocarpine increases phosphorylationEXP 6480464Pilocarpine results in increased phosphorylation of MAPK1 proteinCTDPMID:18988310 and PMID:22824136
Mapk1Rat(+)-pilocarpine multiple interactionsEXP 6480464Celecoxib inhibits the reaction [Pilocarpine results in increased phosphorylation of MAPK1 protein] and ifenprodil inhibits the reaction [Pilocarpine results in increased phosphorylation of MAPK1 protein]CTDPMID:18988310 and PMID:22824136
Mapk1Rat(+)-pilocarpine multiple interactionsISOMapk1 (Mus musculus)6480464Pilocarpine results in increased phosphorylation of and results in increased activity of MAPK1 protein more ...CTDPMID:12091480 more ...
Mapk1Rat(+)-Pimaric acid multiple interactionsISOMAPK1 (Homo sapiens)6480464pimaric acid inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]CTDPMID:22705379
Mapk1Rat(+)-schisandrin B increases activityISOMapk1 (Mus musculus)6480464schizandrin B results in increased activity of MAPK1 proteinCTDPMID:21250784
Mapk1Rat(+)-schisandrin B multiple interactionsISOMapk1 (Mus musculus)6480464schizandrin B promotes the reaction [Vitamin K 3 results in increased activity of MAPK1 protein]CTDPMID:21250784
Mapk1Rat(+)-Tetrandrine multiple interactionsEXP 6480464tetrandrine inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK1 protein]CTDPMID:22001142
Mapk1Rat(+)-Tetrandrine increases phosphorylationISOMAPK1 (Homo sapiens)6480464tetrandrine results in increased phosphorylation of MAPK1 proteinCTDPMID:31934280
Mapk1Rat(+)-Tetrandrine multiple interactionsISOMAPK1 (Homo sapiens)6480464[arsenite co-treated with tetrandrine] results in increased phosphorylation of MAPK1 protein more ...CTDPMID:31934280
Mapk1Rat(-)-anisomycin increases activityISOMapk1 (Mus musculus)6480464Anisomycin results in increased activity of MAPK1 proteinCTDPMID:11551972
Mapk1Rat(-)-anisomycin increases phosphorylationISOMapk1 (Mus musculus)6480464Anisomycin results in increased phosphorylation of MAPK1 proteinCTDPMID:15772366 and PMID:9671412

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Biological Process
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Original Reference(s)
Mapk1Ratandrogen receptor signaling pathway involved_inIEAUniProtKB:P28482 and ensembl:ENSP000002158321600115GO_REF:0000107EnsemblGO_REF:0000107
Mapk1Ratanimal organ morphogenesis acts_upstream_of_or_withinISOMapk1 (Mus musculus)1624291 PMID:11684667RGDPMID:11684667
Mapk1Ratanimal organ morphogenesis acts_upstream_of_or_withinIEAUniProtKB:P63085 and ensembl:ENSMUSP000000659831600115GO_REF:0000107EnsemblGO_REF:0000107
Mapk1Ratapoptotic process involved_inIEAUniProtKB-KW:KW-00531600115GO_REF:0000043UniProtGO_REF:0000043
Mapk1RatB cell receptor signaling pathway acts_upstream_of_or_withinIEAUniProtKB:P63085 and ensembl:ENSMUSP000000659831600115GO_REF:0000107EnsemblGO_REF:0000107
Mapk1RatB cell receptor signaling pathway acts_upstream_of_or_withinISOMapk1 (Mus musculus)1624291 PMID:9254656RGDPMID:9254656
Mapk1RatBergmann glial cell differentiation acts_upstream_of_or_withinIEAUniProtKB:P63085 and ensembl:ENSMUSP000000659831600115GO_REF:0000107EnsemblGO_REF:0000107
Mapk1RatBergmann glial cell differentiation acts_upstream_of_or_withinISOMapk1 (Mus musculus)1624291MGI:1346859 PMID:24431450RGDPMID:24431450
Mapk1Ratcardiac neural crest cell development involved in heart development acts_upstream_of_or_withinISOMapk1 (Mus musculus)1624291MGI:1346859 PMID:18952847RGDPMID:18952847
Mapk1Ratcardiac neural crest cell development involved in heart development acts_upstream_of_or_withinIEAUniProtKB:P63085 and ensembl:ENSMUSP000000659831600115GO_REF:0000107EnsemblGO_REF:0000107
Mapk1Ratcaveolin-mediated endocytosis involved_inIEAARBA:ARBA000286931600115GO_REF:0000117UniProtGO_REF:0000117
Mapk1Ratcaveolin-mediated endocytosis involved_inTAS 8553538PMID:19565474UniProt 
Mapk1Ratcell surface receptor signaling pathway involved_inIBAFB:FBgn0003256 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Mapk1Ratcellular response to amino acid starvation involved_inIEAUniProtKB:P28482 and ensembl:ENSP000002158321600115GO_REF:0000107EnsemblGO_REF:0000107
Mapk1Ratcellular response to amino acid starvation involved_inISOMAPK1 (Homo sapiens)1624291 PMID:11096076RGDPMID:11096076
Mapk1Ratcellular response to cAMP  IEP 405096661 RGD 
Mapk1Ratcellular response to epidermal growth factor stimulus  IEP 401976489 RGD 
Mapk1Ratcellular response to insulin-like growth factor stimulus  IEP 401976279 RGD 
Mapk1Ratcellular response to methionine  IEP 405100711 RGD 
Mapk1Ratcellular response to platelet-derived growth factor stimulus  IEP 401976489 RGD 
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Cellular Component
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Original Reference(s)
Mapk1Ratanchoring junction located_inIEAUniProtKB-KW:KW-09651600115GO_REF:0000043UniProtGO_REF:0000043
Mapk1Rataxon  IDA 2293331axon cytoplasmRGD 
Mapk1Ratcaveola located_inIDA 12907554PMID:24567387UniProt 
Mapk1Ratcaveola located_inTAS 8553538PMID:19565474UniProt 
Mapk1Ratcaveola located_inIEAUniProtKB-SubCell:SL-00351600115GO_REF:0000044UniProtGO_REF:0000044
Mapk1Ratcentrosome located_inIEAUniProtKB-SubCell:SL-00481600115GO_REF:0000044UniProtGO_REF:0000044
Mapk1Ratciliary basal body located_inIEAUniProtKB:P28482 and ensembl:ENSP000002158321600115GO_REF:0000107EnsemblGO_REF:0000107
Mapk1Ratciliary basal body located_inISOMAPK1 (Homo sapiens) and UniProtKB:P28482-11624291 RGDGO_REF:0000052
Mapk1Ratciliary basal body located_inIEAUniProtKB:Q1HBJ4 and ensembl:ENSP000002158321600115GO_REF:0000107EnsemblGO_REF:0000107
Mapk1Ratcilium located_inIEAUniProtKB:Q1HBJ4 and ensembl:ENSP000002158321600115GO_REF:0000107EnsemblGO_REF:0000107
Mapk1Ratcilium located_inIEAUniProtKB:P28482 and ensembl:ENSP000002158321600115GO_REF:0000107EnsemblGO_REF:0000107
Mapk1Ratcilium located_inISOMAPK1 (Homo sapiens) and UniProtKB:P28482-11624291 RGDGO_REF:0000052
Mapk1Ratcytoplasm located_inISOMapk1 (Mus musculus)1624291 PMID:11726647 more ...RGDPMID:11726647 more ...
Mapk1Ratcytoplasm located_inIEAUniProtKB:P28482 and ensembl:ENSP000002158321600115GO_REF:0000107EnsemblGO_REF:0000107
Mapk1Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Mapk1Ratcytoplasm is_active_inIBACGD:CAL0000197240 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Mapk1Ratcytoplasm located_inIEAUniProtKB:P63085 and ensembl:ENSMUSP000000659831600115GO_REF:0000107EnsemblGO_REF:0000107
Mapk1Ratcytoplasm located_inISOMAPK1 (Homo sapiens)1624291 PMID:18794356 and PMID:32721402RGDPMID:18794356 and PMID:32721402
Mapk1Ratcytoplasm located_inIDA 12907554PMID:24567387UniProt 
Mapk1Ratcytoplasm located_inISSUniProtKB:P266961600115GO_REF:0000024UniProtGO_REF:0000024
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Molecular Function
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Mapk1RatATP binding  IDA 1626220 RGD 
Mapk1RatATP binding enablesIEAUniProtKB-KW:KW-00671600115GO_REF:0000043UniProtGO_REF:0000043
Mapk1RatATP binding enablesIEAInterPro:IPR000719 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Mapk1RatATP binding enablesIEAUniRule:UR0015033411600115GO_REF:0000104UniProtGO_REF:0000104
Mapk1Ratdouble-stranded DNA binding  IDA 13800883 RGD 
Mapk1Ratidentical protein binding enablesISOMapk1 (Mus musculus)1624291UniProtKB:P63085 and PMID:26267534RGDPMID:26267534
Mapk1Ratidentical protein binding enablesISOMAPK1 (Homo sapiens)1624291UniProtKB:P28482 more ...RGDPMID:16627622 and PMID:26267534
Mapk1Ratidentical protein binding enablesIEAUniProtKB:P63085 and ensembl:ENSMUSP000000659831600115GO_REF:0000107EnsemblGO_REF:0000107
Mapk1Ratidentical protein binding enablesIEAUniProtKB:P28482 and ensembl:ENSP000002158321600115GO_REF:0000107EnsemblGO_REF:0000107
Mapk1Ratkinase activity  TAS 70572 RGD 
Mapk1Ratkinase activity enablesIEAUniProtKB-KW:KW-04181600115GO_REF:0000043UniProtGO_REF:0000043
Mapk1Ratkinase activity enablesIEAUniProtKB:P63085 and ensembl:ENSMUSP000000659831600115GO_REF:0000107EnsemblGO_REF:0000107
Mapk1Ratkinase activity enablesISOMapk1 (Mus musculus)1624291 PMID:12808090 and PMID:15284227RGDPMID:12808090 and PMID:15284227
Mapk1RatMAP kinase activity  TAS 70317 RGD 
Mapk1RatMAP kinase activity enablesIEAUniProtKB:P28482 and ensembl:ENSP000002158321600115GO_REF:0000107EnsemblGO_REF:0000107
Mapk1RatMAP kinase activity enablesIEAEC:2.7.11.241600115GO_REF:0000003UniProtGO_REF:0000003
Mapk1RatMAP kinase activity enablesISOMapk1 (Mus musculus)1624291 PMID:11841548 more ...RGDPMID:11841548 more ...
Mapk1RatMAP kinase activity enablesISOMAPK1 (Homo sapiens)1624291 PMID:38503280RGDPMID:38503280
Mapk1RatMAP kinase activity enablesIEAUniProtKB:P63085 and ensembl:ENSMUSP000000659831600115GO_REF:0000107EnsemblGO_REF:0000107
Mapk1RatMAP kinase activity enablesIEAInterPro:IPR003527 and InterPro:IPR0083491600115GO_REF:0000002InterProGO_REF:0000002
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RGD Manual Annotations


  

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

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Mapk1Ratacute myeloid leukemia pathway  IEA 6907045 KEGGrno:05221
Mapk1Rataldosterone signaling pathway   IEA 6907045 KEGGrno:04960
Mapk1RatAlzheimer's disease pathway   IEA 6907045 KEGGrno:05010
Mapk1RatB cell receptor signaling pathway  IEA 6907045 KEGGrno:04662
Mapk1Ratceramide signaling pathway  IEA 6907045 KEGGrno:05212
Mapk1RatChagas disease pathway  IEA 6907045 KEGGrno:05142
Mapk1Ratchemokine mediated signaling pathway  IEA 6907045 KEGGrno:04062
Mapk1Ratchronic myeloid leukemia pathway  IEA 6907045 KEGGrno:05220
Mapk1Ratcolorectal cancer pathway   IEA 6907045 KEGGrno:05210
Mapk1Ratendometrial cancer pathway   IEA 6907045 KEGGrno:05213
Mapk1Ratepidermal growth factor/neuregulin signaling pathway   IEA 6907045 KEGGrno:04012
Mapk1RatFc epsilon receptor mediated signaling pathway  IEA 6907045 KEGGrno:04664
Mapk1RatFc gamma receptor mediated signaling pathway  IEA 6907045 KEGGrno:04666
Mapk1Ratglioma pathway  IEA 6907045 KEGGrno:05214
Mapk1Ratglutamate signaling pathway  IEA 6907045 KEGGrno:04724
Mapk1Ratgonadotropin-releasing hormone signaling pathway  IEA 6907045 KEGGrno:04912
Mapk1Rathepatitis C pathway  IEA 6907045 KEGGrno:05160
Mapk1Ratinfluenza A pathway  IEA 6907045 KEGGrno:05164
Mapk1Ratinsulin signaling pathway   IEA 6907045 KEGGrno:04910
Mapk1RatLeishmaniasis pathway  IEA 6907045 KEGGrno:05140
1 to 20 of 41 rows

Imported Annotations - PID (archival)

1 to 19 of 19 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mapk1RatBone morphogenetic proteins signaling pathway  ISOMAPK1 (Homo sapiens)6484113 PIDPID:200144
Mapk1Ratceramide signaling pathway  ISOMAPK1 (Homo sapiens)6484113 PIDPID:200119
Mapk1Ratendothelin signaling pathway  ISOMAPK1 (Homo sapiens)6484113 PIDPID:200005
Mapk1Ratephrin - ephrin receptor bidirectional signaling axis  ISOMAPK1 (Homo sapiens)6484113 PIDPID:200052
Mapk1Ratepidermal growth factor/neuregulin signaling pathway   ISOMAPK1 (Homo sapiens)6484113 PIDPID:200101
Mapk1Ratfibroblast growth factor signaling pathway  ISOMAPK1 (Homo sapiens)6484113 PIDPID:200220
Mapk1Ratgranulocyte-macrophage colony-stimulating factor signaling pathway  ISOMAPK1 (Homo sapiens)6484113 PIDPID:200019
Mapk1Ratinterleukin-2 signaling pathway  ISOMAPK1 (Homo sapiens)6484113 PIDPID:200098
Mapk1RatmTOR signaling pathway   ISOMAPK1 (Homo sapiens)6484113 PIDPID:200096
Mapk1Ratplatelet-derived growth factor signaling pathway  ISOMAPK1 (Homo sapiens)6484113 PIDPID:200149
Mapk1Ratsphingosine 1-phosphate signaling pathway  ISOMAPK1 (Homo sapiens)6484113 PIDPID:200046
Mapk1Ratsphingosine 1-phosphate signaling pathway  ISOMAPK1 (Homo sapiens)6484113 PIDPID:200054
Mapk1Ratsphingosine 1-phosphate signaling pathway  ISOMAPK1 (Homo sapiens)6484113 PIDPID:200085
Mapk1Ratsphingosine 1-phosphate signaling pathway  ISOMAPK1 (Homo sapiens)6484113 PIDPID:200211
Mapk1Ratsyndecan signaling pathway  ISOMAPK1 (Homo sapiens)6484113 PIDPID:200156
Mapk1Ratsyndecan signaling pathway  ISOMAPK1 (Homo sapiens)6484113 PIDPID:200192
Mapk1RatTrail mediated signaling pathway   ISOMAPK1 (Homo sapiens)6484113 PIDPID:200068
Mapk1Rattype II interferon signaling pathway  ISOMAPK1 (Homo sapiens)6484113 PIDPID:200129
Mapk1Ratvascular endothelial growth factor signaling pathway   ISOMAPK1 (Homo sapiens)6484113 PIDPID:200188
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1 to 20 of 151 rows
#
Reference Title
Reference Citation
1. Proteomics studies of childhood pilocytic astrocytoma. Anagnostopoulos AK, etal., J Proteome Res. 2011 May 6;10(5):2555-65. doi: 10.1021/pr200024m. Epub 2011 Apr 14.
2. Elevated activation of ERK1 and ERK2 accompany enhanced liver injury following alcohol binge in chronically ethanol-fed rats. Aroor AR, etal., Alcohol Clin Exp Res. 2011 Dec;35(12):2128-38. doi: 10.1111/j.1530-0277.2011.01577.x. Epub 2011 Jul 25.
3. Cyclic changes in estradiol regulate synaptic plasticity through the MAP kinase pathway. Bi R, etal., Proc Natl Acad Sci U S A 2001 Nov 6;98(23):13391-5.
4. Signaling pathway adaptations and novel protein kinase A substrates related to behavioral sensitization to cocaine. Boudreau AC, etal., J Neurochem. 2009 Jul;110(1):363-77. Epub 2009 May 3.
5. ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF. Boulton TG, etal., Cell 1991 May 17;65(4):663-75.
6. P2X7 receptors activate protein kinase D and p42/p44 mitogen-activated protein kinase (MAPK) downstream of protein kinase C. Bradford MD and Soltoff SP, Biochem J 2002 Sep 15;366(Pt 3):745-55.
7. 17-Beta estradiol rapidly enhances extracellular signal-regulated kinase 2 phosphorylation in the rat brain. Bryant DN, etal., Neuroscience. 2005;133(1):343-52. doi: 10.1016/j.neuroscience.2005.02.024. Epub 2005 Apr 22.
8. cAMP antagonizes p21ras-directed activation of extracellular signal-regulated kinase 2 and phosphorylation of mSos nucleotide exchange factor. Burgering BM, etal., EMBO J. 1993 Nov;12(11):4211-20. doi: 10.1002/j.1460-2075.1993.tb06105.x.
9. Epidermal growth factor induces phosphorylation of extracellular signal-regulated kinase 2 via multiple pathways. Burgering BM, etal., Mol Cell Biol. 1993 Dec;13(12):7248-56. doi: 10.1128/mcb.13.12.7248-7256.1993.
10. Extracellular signal-regulated kinase 2 signaling in the hippocampal dentate gyrus mediates the antidepressant effects of testosterone. Carrier N and Kabbaj M, Biol Psychiatry. 2012 Apr 1;71(7):642-51. doi: 10.1016/j.biopsych.2011.11.028. Epub 2012 Jan 20.
11. Sex differences in social interaction behaviors in rats are mediated by extracellular signal-regulated kinase 2 expression in the medial prefrontal cortex. Carrier N and Kabbaj M, Neuroscience. 2012 Jun 14;212:86-92. doi: 10.1016/j.neuroscience.2012.03.041. Epub 2012 Apr 18.
12. PDGF-BB-mediated activation of p42(MAPK) is independent of PDGF beta-receptor tyrosine phosphorylation. Cartel NJ, etal., Am J Physiol Lung Cell Mol Physiol 2001 Oct;281(4):L786-98.
13. Bradykinin reduces growth factor-induced glomerular ERK1/2 phosphorylation. Cellier E, etal., Am J Physiol Renal Physiol 2003 Feb;284(2):F282-92.
14. Anti-tumorigenic action of 2-[piperidinoethoxyphenyl]-3-[4-hydroxyphenyl]-2H-benzo(b)pyran: evidence for involvement of GPR30/EGFR signaling pathway. Chandra V, etal., Gynecol Oncol. 2013 May;129(2):433-42. doi: 10.1016/j.ygyno.2013.02.005. Epub 2013 Feb 8.
15. Epigallocatechin-3-gallate attenuates cardiac hypertrophy partly via MAPKs signals in hypertensive rats. Chen DD, etal., Clin Exp Pharmacol Physiol. 2009 Mar 2.
16. Systemic dexmedetomidine attenuates mechanical allodynia through extracellular sign db type 2 diabetic mice. Chen H, etal., Neurosci Lett. 2017 Sep 14;657:126-133. doi: 10.1016/j.neulet.2017.07.048. Epub 2017 Jul 28.
17. Dopamine promotes striatal neuronal apoptotic death via ERK signaling cascades. Chen J, etal., Eur J Neurosci. 2009 Jan;29(2):287-306.
18. Alterations in mammalian target of rapamycin signaling pathways after traumatic brain injury. Chen S, etal., J Cereb Blood Flow Metab. 2007 May;27(5):939-49. Epub 2006 Aug 30.
19. SRC kinase and mitogen-activated protein kinases in the progression from normal to malignant endometrium. Desouki MM and Rowan BG, Clin Cancer Res. 2004 Jan 15;10(2):546-55.
20. Elastase-released epidermal growth factor recruits epidermal growth factor receptor and extracellular signal-regulated kinases to down-regulate tropoelastin mRNA in lung fibroblasts. DiCamillo SJ, etal., J Biol Chem 2002 May 24;277(21):18938-46. Epub 2002 Mar 11.
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1 to 10 of 47 rows
PMID:1712480   PMID:7939721   PMID:8043507   PMID:8107865   PMID:8221888   PMID:8617731   PMID:8626447   PMID:9064344   PMID:9254656   PMID:9298898   PMID:9447983   PMID:9722539  
PMID:9872331   PMID:9915826   PMID:10551817   PMID:11096076   PMID:11684667   PMID:11726647   PMID:11805112   PMID:11823456   PMID:11832339   PMID:11839761   PMID:11841548   PMID:11844932  
PMID:11854404   PMID:11884367   PMID:11994045   PMID:11994544   PMID:12006386   PMID:12121979   PMID:12213812   PMID:12223545   PMID:12349907   PMID:12435482   PMID:12535947   PMID:12623863  
PMID:12645629   PMID:12663469   PMID:12699904   PMID:12721286   PMID:12730054   PMID:12783880   PMID:12800247   PMID:12808090   PMID:12810726   PMID:12821670   PMID:12849998   PMID:12871576  
PMID:12872135   PMID:12925581   PMID:12930843   PMID:12935895   PMID:12952860   PMID:12971962   PMID:14501944   PMID:14534235   PMID:14552884   PMID:14575703   PMID:14580718   PMID:14593093  
PMID:14605008   PMID:14622137   PMID:14636584   PMID:14707138   PMID:14744933   PMID:14769808   PMID:14963006   PMID:14970190   PMID:14983993   PMID:14984009   PMID:14988413   PMID:15026121  
PMID:15030400   PMID:15030409   PMID:15051723   PMID:15052686   PMID:15054132   PMID:15059773   PMID:15072963   PMID:15133037   PMID:15143154   PMID:15157810   PMID:15203192   PMID:15229233  
PMID:15242988   PMID:15249196   PMID:15257182   PMID:15258148   PMID:15284227   PMID:15314156   PMID:15322069   PMID:15351692   PMID:15371543   PMID:15383658   PMID:15469737   PMID:15489642  
PMID:15498890   PMID:15537896   PMID:15542607   PMID:15569628   PMID:15574735   PMID:15617763   PMID:15729360   PMID:15731359   PMID:15748847   PMID:15753041   PMID:15811423   PMID:15850461  
PMID:15865443   PMID:15896720   PMID:15899886   PMID:15964695   PMID:15964902   PMID:15975921   PMID:15975997   PMID:15991247   PMID:16044092   PMID:16106045   PMID:16126730   PMID:16139272  
1 to 10 of 47 rows



Mapk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81197,462,025 - 97,529,193 (-)NCBIGRCr8
mRatBN7.21183,957,813 - 84,023,629 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1183,957,813 - 84,023,616 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1192,681,387 - 92,746,630 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01185,342,529 - 85,407,764 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01184,396,110 - 84,461,350 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01188,203,863 - 88,273,301 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1188,211,599 - 88,273,254 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01191,260,412 - 91,325,570 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41185,968,732 - 86,030,387 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11186,009,328 - 86,070,984 (-)NCBI
Celera1182,713,470 - 82,779,260 (-)NCBICelera
Cytogenetic Map11q23NCBI
MAPK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382221,759,657 - 21,867,680 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2221,759,657 - 21,867,680 (-)EnsemblGRCh38hg38GRCh38
GRCh372222,113,946 - 22,221,970 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362220,443,946 - 20,551,970 (-)NCBINCBI36Build 36hg18NCBI36
Build 342220,447,885 - 20,546,524NCBI
Celera225,931,476 - 6,039,519 (-)NCBICelera
Cytogenetic Map22q11.22NCBI
HuRef225,071,209 - 5,179,617 (-)NCBIHuRef
CHM1_12222,114,127 - 22,222,150 (-)NCBICHM1_1
T2T-CHM13v2.02222,173,148 - 22,281,196 (-)NCBIT2T-CHM13v2.0
Mapk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391616,801,246 - 16,865,317 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1616,801,246 - 16,865,317 (+)EnsemblGRCm39 Ensembl
GRCm381616,983,382 - 17,047,453 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1616,983,382 - 17,047,453 (+)EnsemblGRCm38mm10GRCm38
MGSCv371616,983,475 - 17,047,546 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361616,896,945 - 16,961,016 (+)NCBIMGSCv36mm8
Celera1617,555,561 - 17,620,101 (+)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1610.53NCBI
Mapk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544217,284,232 - 17,380,020 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544217,284,232 - 17,380,026 (+)NCBIChiLan1.0ChiLan1.0
MAPK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22331,305,712 - 31,412,963 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12233,856,753 - 33,961,672 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0223,883,119 - 3,990,368 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12220,365,480 - 20,412,561 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2220,365,487 - 20,450,335 (-)Ensemblpanpan1.1panPan2
MAPK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12631,013,607 - 31,132,998 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2631,013,607 - 31,132,998 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2630,970,465 - 31,089,387 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02632,419,917 - 32,539,219 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2632,418,294 - 32,539,230 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12630,468,306 - 30,587,833 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02630,092,195 - 30,211,589 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02631,182,673 - 31,302,626 (-)NCBIUU_Cfam_GSD_1.0
Mapk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118140,821,508 - 140,866,521 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366191,889,708 - 1,932,646 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366191,889,841 - 1,932,646 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAPK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1450,082,896 - 50,165,513 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11450,083,079 - 50,165,528 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21453,590,429 - 53,613,224 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MAPK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1194,246,144 - 4,352,648 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl194,246,122 - 4,353,325 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660852,649,654 - 2,756,271 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mapk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247471,296,221 - 1,389,757 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247471,296,062 - 1,389,674 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Mapk1
252 total Variants

Predicted Target Of
Summary Value
Count of predictions:306
Count of miRNA genes:181
Interacting mature miRNAs:230
Transcripts:ENSRNOT00000002533
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116642214886241447Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116642214886241447Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat

BI279621  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21183,966,149 - 83,966,329 (+)MAPPERmRatBN7.2
Rnor_6.01188,215,832 - 88,216,011NCBIRnor6.0
Rnor_5.01191,268,115 - 91,268,294UniSTSRnor5.0
RGSC_v3.41185,972,965 - 85,973,144UniSTSRGSC3.4
Celera1182,721,807 - 82,721,986UniSTS
RH 3.4 Map11691.12UniSTS
Cytogenetic Map11q23UniSTS
RH126332  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21183,960,756 - 83,960,999 (+)MAPPERmRatBN7.2
Rnor_6.01188,210,439 - 88,210,681NCBIRnor6.0
Rnor_5.01191,262,722 - 91,262,964UniSTSRnor5.0
RGSC_v3.41185,967,572 - 85,967,814UniSTSRGSC3.4
Celera1182,716,414 - 82,716,656UniSTS
Cytogenetic Map11q23UniSTS
AW742788  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21183,960,592 - 83,960,839 (+)MAPPERmRatBN7.2
Rnor_6.01188,210,275 - 88,210,521NCBIRnor6.0
Rnor_5.01191,262,558 - 91,262,804UniSTSRnor5.0
RGSC_v3.41185,967,408 - 85,967,654UniSTSRGSC3.4
Celera1182,716,250 - 82,716,496UniSTS
Cytogenetic Map11q23UniSTS
RH133391  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21183,960,747 - 83,960,949 (+)MAPPERmRatBN7.2
Rnor_6.01188,210,430 - 88,210,631NCBIRnor6.0
Rnor_5.01191,262,713 - 91,262,914UniSTSRnor5.0
RGSC_v3.41185,967,563 - 85,967,764UniSTSRGSC3.4
Celera1182,716,405 - 82,716,606UniSTS
RH 3.4 Map11726.22UniSTS
Cytogenetic Map11q23UniSTS
RH142687  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21184,015,358 - 84,015,473 (+)MAPPERmRatBN7.2
Rnor_6.01188,265,037 - 88,265,151NCBIRnor6.0
Rnor_5.01191,317,318 - 91,317,432UniSTSRnor5.0
RGSC_v3.41186,022,172 - 86,022,286UniSTSRGSC3.4
Celera1182,771,003 - 82,771,117UniSTS
RH 3.4 Map11726.62UniSTS
Cytogenetic Map11q23UniSTS
AW534207  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21183,977,223 - 83,977,373 (+)MAPPERmRatBN7.2
Rnor_6.01188,226,906 - 88,227,055NCBIRnor6.0
Rnor_5.01191,279,189 - 91,279,338UniSTSRnor5.0
RGSC_v3.41185,984,039 - 85,984,188UniSTSRGSC3.4
Celera1182,732,881 - 82,733,030UniSTS
RH 3.4 Map11728.92UniSTS
Cytogenetic Map11q23UniSTS
BF404647  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21184,021,834 - 84,021,964 (+)MAPPERmRatBN7.2
Rnor_6.01188,271,513 - 88,271,642NCBIRnor6.0
Rnor_5.01191,323,794 - 91,323,923UniSTSRnor5.0
RGSC_v3.41186,028,648 - 86,028,777UniSTSRGSC3.4
Celera1182,777,479 - 82,777,608UniSTS
RH 3.4 Map11724.52UniSTS
Cytogenetic Map11q23UniSTS
RH136232  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21183,960,748 - 83,960,962 (+)MAPPERmRatBN7.2
Rnor_6.01188,210,431 - 88,210,644NCBIRnor6.0
Rnor_5.01191,262,714 - 91,262,927UniSTSRnor5.0
RGSC_v3.41185,967,564 - 85,967,777UniSTSRGSC3.4
Celera1182,716,406 - 82,716,619UniSTS
Cytogenetic Map11q23UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000002533   ⟹   ENSRNOP00000002533
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1183,957,813 - 84,023,616 (-)Ensembl
Rnor_6.0 Ensembl1188,211,599 - 88,273,254 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111524   ⟹   ENSRNOP00000086878
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1183,957,813 - 84,023,521 (-)Ensembl
RefSeq Acc Id: NM_053842   ⟹   NP_446294
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81197,462,025 - 97,527,825 (-)NCBI
mRatBN7.21183,957,813 - 84,023,616 (-)NCBI
Rnor_6.01188,207,495 - 88,273,294 (-)NCBI
Rnor_5.01191,260,412 - 91,325,570 (-)NCBI
RGSC_v3.41185,968,732 - 86,030,387 (-)RGD
Celera1182,713,470 - 82,779,260 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006248658   ⟹   XP_006248720
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81197,462,659 - 97,527,855 (-)NCBI
mRatBN7.21183,958,447 - 84,023,629 (-)NCBI
Rnor_6.01188,208,129 - 88,273,300 (-)NCBI
Rnor_5.01191,260,412 - 91,325,570 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006248659   ⟹   XP_006248721
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81197,469,371 - 97,527,845 (-)NCBI
mRatBN7.21183,962,134 - 84,023,629 (-)NCBI
Rnor_6.01188,214,846 - 88,273,301 (-)NCBI
Rnor_5.01191,260,412 - 91,325,570 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063270242   ⟹   XP_063126312
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81197,462,659 - 97,529,193 (-)NCBI
1 to 9 of 9 rows
Protein RefSeqs NP_446294 (Get FASTA)   NCBI Sequence Viewer  
  XP_006248720 (Get FASTA)   NCBI Sequence Viewer  
  XP_006248721 (Get FASTA)   NCBI Sequence Viewer  
  XP_063126312 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41124 (Get FASTA)   NCBI Sequence Viewer  
  EDL77868 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000002533
  ENSRNOP00000002533.6
GenBank Protein P63086 (Get FASTA)   NCBI Sequence Viewer  
1 to 9 of 9 rows
RefSeq Acc Id: NP_446294   ⟸   NM_053842
- UniProtKB: P63086 (UniProtKB/Swiss-Prot),   A6JSN9 (UniProtKB/TrEMBL),   A0A8I6A252 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248720   ⟸   XM_006248658
- Peptide Label: isoform X1
- UniProtKB: P63086 (UniProtKB/Swiss-Prot),   A6JSN9 (UniProtKB/TrEMBL),   A0A8I6A252 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248721   ⟸   XM_006248659
- Peptide Label: isoform X1
- UniProtKB: P63086 (UniProtKB/Swiss-Prot),   A6JSN9 (UniProtKB/TrEMBL),   A0A8I6A252 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000002533   ⟸   ENSRNOT00000002533
Ensembl Acc Id: ENSRNOP00000086878   ⟸   ENSRNOT00000111524
Protein kinase

Name Modeler Protein Id AA Range Protein Structure
AF-P63086-F1-model_v2 AlphaFold P63086 1-358 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13698339
Promoter ID:EPDNEW_R8864
Type:multiple initiation site
Name:Mapk1_1
Description:mitogen activated protein kinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01188,273,291 - 88,273,351EPDNEW


1 to 31 of 31 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-20565 BioCyc
Ensembl Genes ENSRNOG00000001849 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000002533 ENTREZGENE
  ENSRNOT00000002533.8 UniProtKB/Swiss-Prot
Gene3D-CATH Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot
  MAP_kinase UniProtKB/Swiss-Prot
  MAP_kinase_CS UniProtKB/Swiss-Prot
  MAPK_ERK1/2 UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
KEGG Report rno:116590 UniProtKB/Swiss-Prot
NCBI Gene 116590 ENTREZGENE
PANTHER MITOGEN-ACTIVATED PROTEIN KINASE UniProtKB/Swiss-Prot
Pfam Pkinase UniProtKB/Swiss-Prot
PharmGKB MAPK1 RGD
PhenoGen Mapk1 PhenoGen
PRINTS ERK1ERK2MAPK UniProtKB/Swiss-Prot
PROSITE MAPK UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000001849 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
UniProt A0A8I6A252 ENTREZGENE, UniProtKB/TrEMBL
  A6JSN9 ENTREZGENE, UniProtKB/TrEMBL
  MK01_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary P27703 UniProtKB/Swiss-Prot
1 to 31 of 31 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Mapk1  mitogen activated protein kinase 1      Symbol and Name status set to approved 629479 APPROVED
2002-06-10 Mapk1  mitogen activated protein kinase 1      Symbol and Name status set to provisional 70585 PROVISIONAL

Note Type Note Reference
gene_cellular_localization enters the nucleus by diffusion without binding to a carrier 625413
gene_disease active in breast cancer cells 625413
gene_disease G-alpha-q/11 mediates Mapk signaling in the ischemic hippocampus 70672
gene_expression expression in cardiac ventricle decreases 20-50 days after birth 70317
gene_expression protein specific activity decreases with age 70317
gene_expression expressed in all tissues 70317
gene_expression carbachol, a muscarinic antagonist, increases phosphorylation of Mapk3/Mapk1 in contra lateral hippocampus but not in ipsilateral hippocampus 70672
gene_function phosphorylates protein serine/threonine residues 70317
gene_pathway estrogen-mediated activation of the Erk/MAP kinase pathway immediately affects NMDA receptors and long term potentiation (LTP) 70572
gene_pathway 17 beta estradiol activates the extracellular regulated kinase/mitogen-activated protein kinase pathway at cellular level 70572
gene_process functions in mitogenic signaling, activation is associated with cardiomyocyte hypertrophy 70317
gene_process mediates long-term memory and long-term potentiation (LTP) 631303
gene_process translocation to the nucleus is associated with the induction of late long-term potentiation (LTP); translocation activates transcription of immediate early genes (IEGs) after plasticity-inducing stimulation of neurons 631303
gene_product 41 kDa protein 625413
gene_regulation activated protein undergoes nuclear translocation for phosphorylation 70672
gene_regulation downregulation by ovariectomy 70572
gene_regulation activated by estrogen and progestins 625452
gene_regulation activated by Map2k1, Mek2 phosphorylation; nitric oxide enhances phosphorylation 70310
gene_regulation activated by Endothelin-1 (ET-1)in glomerular mesangial cells 727457
gene_regulation 1-alpha,25-dihydroxyvitamin D3 (1a,25-(OH)2D3) increases the kinase activity via phospholipase C in growth zone (GC) cells of growth plate chondrocytes 631303
gene_regulation activation requires platelet-derived growth factor (PDGF)-BB binding with platelet-derived growth factor receptor beta (Pdgrfb), but no activation is observed when there is ligand induced phosphorylation of the receptor 631303
gene_regulation 24R,25-dihydroxyvitamin D3 (24R,25-(OH)2D3) increases kinase activity via phospholipase D in resting zone (RC) cells 631303
gene_regulation induced by glutamate, acetylcholine, and BDNF in neurons 631303
gene_regulation ouabain induces activation in cardiac myocytes 631303