Mapk1 (mitogen activated protein kinase 1) - Rat Genome Database

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Gene: Mapk1 (mitogen activated protein kinase 1) Rattus norvegicus
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Symbol: Mapk1
Name: mitogen activated protein kinase 1
RGD ID: 70500
Description: Enables several functions, including ATP binding activity; MAP kinase activity; and mitogen-activated protein kinase kinase kinase binding activity. Involved in several processes, including ERK1 and ERK2 cascade; cellular response to cAMP; and positive regulation of macromolecule biosynthetic process. Acts upstream of or within peptidyl-serine phosphorylation. Located in several cellular components, including caveola; dendrite cytoplasm; and perikaryon. Part of protein-containing complex. Is active in postsynaptic density. Used to study several diseases, including alcohol dependence; cocaine abuse; coronary artery disease (multiple); drug dependence (multiple); and gastric ulcer. Biomarker of alcohol use disorder; colon cancer; renal fibrosis; urethral obstruction; and vascular dementia. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome 13; Parkinson's disease; adenocarcinoma (multiple); pulmonary hypertension; and renal cell carcinoma. Orthologous to human MAPK1 (mitogen-activated protein kinase 1); PARTICIPATES IN the extracellular signal-regulated Raf/Mek/Erk signaling pathway; adenosine signaling pathway; Bone morphogenetic proteins signaling pathway; INTERACTS WITH (+)-catechin; (+)-dihydromyricetin; (+)-pilocarpine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ERK-2; Erk2; ERT1; extracellular signal-regulated kinase 2; extracellular-signal-regulated kinase 1; extracellular-signal-regulated kinase 2; MAP kinase 1; MAP kinase 2; MAP kinase isoform p42; MAPK 1; MAPK 2; mitogen-activated protein kinase 1; mitogen-activated protein kinase 2; p42-MAPK
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81197,462,025 - 97,529,193 (-)NCBIGRCr8
mRatBN7.21183,957,813 - 84,023,629 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1183,957,813 - 84,023,616 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1192,681,387 - 92,746,630 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01185,342,529 - 85,407,764 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01184,396,110 - 84,461,350 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01188,203,863 - 88,273,301 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1188,211,599 - 88,273,254 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01191,260,412 - 91,325,570 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41185,968,732 - 86,030,387 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11186,009,328 - 86,070,984 (-)NCBI
Celera1182,713,470 - 82,779,260 (-)NCBICelera
Cytogenetic Map11q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Aberrant Crypt Foci  (ISO)
alcohol dependence  (IDA)
alcohol use disorder  (IEP)
Alzheimer's disease  (ISO)
Animal Disease Models  (ISO)
autism spectrum disorder  (ISS)
brain ischemia  (ISO)
breast cancer  (ISO)
Cardiomegaly  (IDA)
cardiomyopathy  (ISO)
childhood pilocytic astrocytoma  (ISO)
chromosome 22q11.2 deletion syndrome, distal  (ISO)
cocaine abuse  (IDA)
cocaine dependence  (IDA)
Cocaine-Related Disorders  (ISO)
colon adenocarcinoma  (ISO)
colon cancer  (IEP)
colorectal adenocarcinoma  (ISO)
Colorectal Neoplasms  (ISO)
congenital heart disease  (ISO)
coronary restenosis  (IDA)
Coronavirus infectious disease  (ISO)
demyelinating disease  (ISO)
depressive disorder  (ISO)
Diabetic Cardiomyopathies  (IDA)
Diabetic Nephropathies  (ISO)
DiGeorge syndrome  (ISO)
Dwarfism  (ISO)
endometrial adenocarcinoma  (ISO)
endometrial carcinoma  (ISO)
Endometrioid Carcinomas  (ISO)
Experimental Colitis  (IEP)
Experimental Diabetes Mellitus  (IDA,IEP)
Experimental Liver Cirrhosis  (IEP)
Experimental Liver Neoplasms  (ISO)
Experimental Mammary Neoplasms  (IDA)
Experimental Radiation Injuries  (ISO)
extrahepatic cholestasis  (ISO)
Female Infertility  (ISO)
gastric ulcer  (IDA)
genetic disease  (ISO)
Gliosis  (ISO)
glomerulonephritis  (ISO)
Head and Neck Neoplasms  (ISO)
Hemorrhagic Shock  (IEP)
hepatocellular carcinoma  (ISO)
Hodgkin's lymphoma  (ISO)
Hyperalgesia  (ISO)
Hypertrophy  (ISO)
intellectual disability  (ISO)
Intimal Hyperplasia  (IEP,IMP)
juvenile rheumatoid arthritis  (ISO)
kidney disease  (ISO)
Kidney Neoplasms  (ISO)
Left Ventricular Hypertrophy  (IEP)
Lung Neoplasms  (ISO)
melanoma  (ISO)
Memory Disorders  (IDA,ISO)
middle cerebral artery infarction  (IDA)
morphine dependence  (IDA,ISO)
Multiple Organ Failure  (IEP)
myocardial infarction  (IDA)
Myocardial Reperfusion Injury  (IDA)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Nerve Degeneration  (ISO)
neuronal ceroid lipofuscinosis 6A  (ISO)
Noonan syndrome 13  (ISO)
obesity  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic adenocarcinoma  (ISO)
Parkinson's disease  (ISO)
Pneumococcal Pneumonia  (ISO)
portal hypertension  (IDA)
Postoperative Cognitive Dysfunction  (IDA,ISO)
prostate adenocarcinoma  (ISO)
pulmonary hypertension  (ISO)
renal cell carcinoma  (ISO)
renal fibrosis  (IEP,IMP)
Sepsis  (ISO)
severe acute respiratory syndrome  (ISO)
Sezary's disease  (ISO)
Shock  (IDA)
squamous cell carcinoma  (ISO)
Stomach Neoplasms  (ISO)
Testis Reperfusion Injury  (IMP)
thyroid cancer  (ISO)
Thyroid Neoplasms  (ISO)
trigeminal neuralgia  (ISO)
type 2 diabetes mellitus  (IDA,ISO)
ureteral obstruction  (IDA)
urethral obstruction  (IEP)
Urinary Incontinence  (IEP)
vascular dementia  (IEP)
velocardiofacial syndrome  (ISS)
Weissenbacher-Zweymuller syndrome  (ISS)
withdrawal disorder  (IDA,ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP,ISO)
(+)-dihydromyricetin  (EXP)
(+)-epicatechin-3-O-gallate  (ISO)
(+)-pilocarpine  (EXP,ISO)
(+)-Pimaric acid  (ISO)
(+)-schisandrin B  (ISO)
(+)-Tetrandrine  (EXP,ISO)
(-)-anisomycin  (EXP,ISO)
(-)-Arctigenin  (ISO)
(-)-citrinin  (EXP,ISO)
(-)-cotinine  (ISO)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(-)-lobeline  (ISO)
(-)-matairesinol  (ISO)
(-)-selegiline  (EXP,ISO)
(-)-trans-epsilon-viniferin  (ISO)
(1->4)-beta-D-glucan  (ISO)
(1S)-bornane-2,3-dione  (ISO)
(20R)-protopanaxadiol  (ISO)
(20S)-ginsenoside Rh2  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(5Z,8Z,11Z,13E)-15-HETE  (ISO)
(9R)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20-dione  (EXP)
(D-Ala(2)-mephe(4)-gly-ol(5))enkephalin  (ISO)
(R)-adrenaline  (EXP,ISO)
(R)-lipoic acid  (EXP)
(R)-noradrenaline  (EXP,ISO)
(R,R,R)-alpha-tocopherol  (EXP,ISO)
(S)-(-)-perillyl alcohol  (ISO)
(S)-3,5-dihydroxyphenylglycine  (EXP,ISO)
(S)-AMPA  (EXP)
(S)-amphetamine  (EXP,ISO)
(S)-naringenin  (EXP,ISO)
(S)-nicotine  (EXP,ISO)
(S)-timolol (anhydrous)  (EXP,ISO)
(Z)-ligustilide  (EXP)
1'-acetoxychavicol acetate  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1,2-naphthoquinone  (ISO)
1,3-dichloropropan-2-ol  (EXP,ISO)
1,3-dinitrobenzene  (ISO)
1,4-benzoquinone  (ISO)
1,4-dithiothreitol  (ISO)
1,4-naphthoquinone  (ISO)
1,4-phenylenediamine  (ISO)
1-(propan-2-ylamino)-3-(2-prop-2-enoxyphenoxy)-2-propanol  (ISO)
1-[(2,3,4-trimethoxyphenyl)methyl]piperazine  (EXP)
1-bromopropane  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-hydroxy-2-naphthoic acid  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
1-nitropyrene  (ISO)
1-O-palmitoyl-2-O-(5-oxovaleryl)-sn-glycero-3-phosphocholine  (EXP)
1-octadec-9-enoylglycero-3-phosphate  (EXP,ISO)
14,15-EET  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP,ISO)
17-hydroxyjolkinolide B  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (EXP,ISO)
2''-galloylhyperin  (ISO)
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone  (ISO)
2,2',3,3',6,6'-hexachlorobiphenyl  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2',4,4'-tetrachlorobiphenyl  (EXP,ISO)
2,2',4,5-tetrachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3',5-trichlorobiphenyl  (EXP)
2,3,3',4,4',5,5'-Heptachlorobiphenyl  (ISO)
2,3,3',4,4',5-Hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-bis(4-hydroxyphenyl)propionitrile  (EXP,ISO)
2,3-Dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline  (ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (EXP)
2-amino-14,16-dimethyloctadecan-3-ol  (ISO)
2-amino-2-deoxy-D-galactopyranose  (EXP,ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-aminobiphenyl  (ISO)
2-aminopurine  (ISO)
2-arachidonoylglycerol  (EXP,ISO)
2-chloroethanol  (EXP)
2-deoxy-D-glucose  (ISO)
2-ethoxyethanol  (EXP)
2-methoxyethanol  (EXP)
2-methyl-6-(phenylethynyl)pyridine  (EXP,ISO)
2-methylcholine  (ISO)
2-tert-butylhydroquinone  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
2-trans,6-trans-farnesyl diphosphate  (ISO)
26-hydroxycholesterol  (ISO)
3',4'-dimethoxyflavone  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3'-O-(4-Benzoyl)benzoyl ATP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,3',5,5'-tetraiodothyroacetic acid  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3,3'-diindolylmethane  (ISO)
3,4-dihydroxybenzoic acid  (ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide  (ISO)
3,5-dichlorobiphenyl  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP,ISO)
3-bromopyruvic acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
3-Methoxynobiletin  (EXP,ISO)
3-methyladenine  (ISO)
3-methylcholanthrene  (ISO)
3-Nitrobenzanthrone  (ISO)
3-Nitrofluoranthene  (ISO)
3-nitropropanoic acid  (EXP)
3-O-Caffeoyl-1-O-methylquinic acid  (ISO)
3-phenylprop-2-enal  (EXP,ISO)
3alpha-hydroxy-5beta-pregnan-20-one  (ISO)
4'-epidoxorubicin  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4,4'-thiodiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-[1-hydroxy-2-[4-(phenylmethyl)-1-piperidinyl]propyl]phenol  (EXP)
4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid  (ISO)
4-\{[4-(dimethylamino)phenyl]diazenyl\}phenyl-beta-lactoside  (ISO)
4-aminopyridine  (EXP,ISO)
4-chlorobiphenyl  (EXP)
4-ethylphenol  (EXP,ISO)
4-hydroxy-17beta-estradiol  (ISO)
4-Hydroxy-N-desmethyltamoxifen  (ISO)
4-hydroxy-TEMPO  (EXP)
4-hydroxynon-2-enal  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
4-methoxy-TEMPO  (ISO)
4-nonylphenol  (EXP,ISO)
4-octylphenol  (EXP,ISO)
4-phenylbutyric acid  (EXP,ISO)
4-Propylphenol  (EXP,ISO)
4-tert-Octylphenol  (ISO)
5,6alpha-epoxy-5alpha-cholestan-3beta-ol  (EXP)
5,7-dihydroxy-4'-methoxyflavone  (ISO)
5-(2-chloroethyl)-4-methylthiazole  (ISO)
5-aminolevulinic acid  (EXP)
5-aza-2'-deoxycytidine  (EXP,ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
5-fluorouracil  (ISO)
5-methoxypsoralen  (ISO)
5-Nitro-2-(3-phenylpropylamino)benzoic acid  (ISO)
6,7-dimethoxy-2-phenylquinoxaline  (ISO)
6-aminohexanoate  (ISO)
6-aminohexanoic acid  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
6-Cyano-7-nitroquinoxaline-2,3-dione  (EXP,ISO)
6alpha-methylprednisolone  (EXP)
7,12-dimethyltetraphene  (EXP,ISO)
7,8-dihydroxycoumarin  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (EXP)
7-ketocholesterol  (EXP,ISO)
7alpha-hydroxycholesterol  (ISO)
8-Br-cAMP  (EXP,ISO)
8-bromo-3',5'-cyclic GMP  (ISO)
9,10-phenanthroquinone  (ISO)
9-cis-retinoic acid  (EXP,ISO)
[6]-Shogaol  (ISO)
AACOCF3  (ISO)
Abemaciclib  (ISO)
acadesine  (EXP)
acamprosate  (ISO)
acebutolol  (ISO)
acetaldehyde  (EXP,ISO)
acetic acid  (EXP)
acetochlor  (ISO)
acetylsalicylic acid  (ISO)
aconitine  (EXP)
acrolein  (EXP,ISO)
acrylamide  (EXP,ISO)
acrylonitrile  (ISO)
acteoside  (ISO)
actinomycin D  (EXP,ISO)
adenosine  (ISO)
Adenosine, cyclic 3',5'-[hydrogen [p(s)]-phosphorothioate]  (EXP)
ADP  (ISO)
afimoxifene  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
AH23848  (ISO)
AICA ribonucleotide  (EXP,ISO)
AL 8810  (ISO)
albuterol  (EXP,ISO)
alcohol  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
aldosterone  (ISO)
aldrithiol  (EXP)
alendronic acid  (ISO)
Alisol B  (ISO)
alizarin  (EXP,ISO)
all-trans-acitretin  (ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (EXP)
allethrin  (EXP)
allicin  (ISO)
allopurinol  (ISO)
alloxan  (EXP)
allyl isothiocyanate  (ISO)
Allylamine  (EXP)
alpha-D-galactose  (EXP)
alpha-hexachlorocyclohexane  (EXP)
alpha-mangostin  (ISO)
alpha-melanocyte stimulating hormone  (ISO)
alpha-naphthoflavone  (ISO)
alpha-Zearalanol  (ISO)
alprenolol  (ISO)
alvocidib  (ISO)
AM-251  (ISO)
AM6545  (ISO)
amentoflavone  (ISO)
amidotrizoic acid  (ISO)
amiloride  (ISO)
amino acid  (ISO)
aminoguanidine  (EXP)
amiodarone  (EXP,ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
Ammothamnine  (ISO)
amodiaquine  (ISO)
amosite asbestos  (EXP,ISO)
amosulalol  (EXP)
amoxicillin  (ISO)
amphetamine  (EXP,ISO)
amphibole asbestos  (EXP,ISO)
amsacrine  (ISO)
anandamide  (EXP,ISO)
andrographolide  (ISO)
Anemoside B4  (ISO)
anethole  (ISO)
aniline  (EXP)
aniracetam  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antigen  (ISO)
antimonite  (ISO)
antimony trichloride  (ISO)
antimony(0)  (EXP)
antirheumatic drug  (ISO)
Antrocin  (ISO)
antroquinonol  (ISO)
apigenin  (EXP,ISO)
apocynin  (EXP,ISO)
apremilast  (EXP)
arachidonic acid  (EXP,ISO)
arachidonyl-2'-chloroethylamide  (EXP,ISO)
Arctiin  (ISO)
arecoline  (EXP,ISO)
Arg-Gly-Asp  (EXP,ISO)
argipressin  (EXP)
aristolochic acid A  (ISO)
aristolochic acids  (ISO)
arjunolic acid  (EXP)
Aroclor 1254  (EXP)
ARS-1620  (ISO)
arsane  (EXP,ISO)
arsenic acid  (ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
asbestos  (ISO)
ascofuranone  (ISO)
asoxime chloride  (EXP)
aspalathin  (ISO)
aspartame  (ISO)
astaxanthin  (ISO)
astilbin  (ISO)
astragaloside IV  (ISO)
astressin  (EXP)
atenolol  (ISO)
atorvastatin calcium  (EXP,ISO)
ATP  (EXP,ISO)
atrasentan  (EXP)
atrazine  (EXP,ISO)
atropine  (EXP)
aucubin  (ISO)
auranofin  (ISO)
aureusidin  (EXP)
Auriculasin  (ISO)
avermectin  (ISO)
avobenzone  (ISO)
axitinib  (ISO)
azadirachtin A  (ISO)
azathioprine  (ISO)
AZD4547  (ISO)
azetidine  (ISO)
Azoxymethane  (ISO)
baclofen  (EXP)
bafilomycin A1  (ISO)
baicalein  (ISO)
baicalin  (EXP)
bathocuproine disulfonic acid  (EXP,ISO)
batimastat  (ISO)
BAY 60-6583  (ISO)
beauvericin  (EXP)
benazepril  (EXP)
benzamide  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[a]pyrene-7,8-dione  (ISO)
benzofurans  (ISO)
benzyl isothiocyanate  (ISO)
berberine  (EXP)
beta-carotene  (EXP,ISO)
beta-cyclodextrin  (ISO)
beta-D-fructofuranose 1,6-bisphosphate  (ISO)
beta-D-glucosamine  (ISO)
beta-D-glucosamine 6-sulfate  (ISO)
beta-endorphin  (ISO)
beta-hexachlorocyclohexane  (ISO)
beta-ionone  (ISO)
beta-naphthoflavone  (EXP,ISO)
betulin  (ISO)
betulinic acid  (ISO)
Betulonic acid  (ISO)
bezafibrate  (EXP)
bicalutamide  (ISO)
bicuculline  (EXP,ISO)
bifenthrin  (ISO)
bilirubin IXalpha  (ISO)
bilobalide  (EXP)
biotin  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisdemethoxycurcumin  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (EXP,ISO)
bisphenol F  (EXP,ISO)
bleomycin A2  (ISO)
boric acid  (ISO)
bortezomib  (ISO)
Botulinum toxin type A  (EXP)
brefeldin A  (EXP)
bromocriptine  (EXP)
Bruceantinol  (ISO)
bucladesine  (ISO)
bufalin  (ISO)
bupivacaine  (ISO)
buprenorphine  (ISO)
busulfan  (ISO)
butan-1-ol  (EXP,ISO)
butane-2,3-dione  (ISO)
butylated hydroxyanisole  (ISO)
Butylbenzyl phthalate  (EXP,ISO)
Butylparaben  (ISO)
butyric acid  (ISO)
C.I. Natural Red 20  (ISO)
cadmium acetate  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium selenide  (ISO)
cadmium sulfate  (EXP,ISO)
cadmium telluride  (ISO)
caffeine  (ISO)
calcidiol  (ISO)
Calcimycin  (EXP,ISO)
calcitriol  (ISO)
calcium atom  (EXP,ISO)
calcium dichloride  (EXP)
calcium silicate  (ISO)
calcium(0)  (EXP,ISO)
Calphostin C  (EXP,ISO)
calycosin  (ISO)
camostat  (ISO)
camptothecin  (ISO)
candesartan  (EXP)
canertinib  (ISO)
cannabidiol  (ISO)
cantharidic acid  (ISO)
cantharidin  (ISO)
capsaicin  (EXP,ISO)
capsanthin  (EXP)
capsazepine  (EXP,ISO)
carbachol  (EXP,ISO)
carbamazepine  (ISO)
carbendazim  (ISO)
CARBENOXOLONE  (ISO)
carbon dioxide  (EXP)
carbon nanotube  (ISO)
carfilzomib  (EXP)
Carnosol  (ISO)
carrageenan  (ISO)
carteolol  (ISO)
carvedilol  (EXP,ISO)
Cassine  (ISO)
cefaloridine  (EXP)
celastrol  (EXP)
celecoxib  (EXP,ISO)
ceric oxide  (ISO)
ceritinib  (ISO)
cetrorelix  (ISO)
CGP 12177  (ISO)
chaetocin  (ISO)
chaetoglobosin A  (EXP,ISO)
chalcone  (ISO)
chelerythrine  (EXP,ISO)
chenodeoxycholic acid  (ISO)
chitosan  (ISO)
chlorogenic acid  (ISO)
chlorohydrocarbon  (ISO)
chloropicrin  (ISO)
chloroquine  (ISO)
chlorothalonil  (ISO)
chlorpromazine  (EXP,ISO)
chlorpyrifos  (EXP,ISO)
cholic acid  (ISO)
chromium atom  (ISO)
chromium trioxide  (ISO)
chromium(6+)  (EXP,ISO)
chrysin  (EXP,ISO)
chrysophanol  (ISO)
ciclopirox  (ISO)
ciglitazone  (EXP,ISO)
ciprofloxacin  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP,ISO)
clothianidin  (ISO)
clozapine  (EXP,ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
cobimetinib  (ISO)
cocaine  (EXP,ISO)
coenzyme Q10  (EXP)
colforsin daropate hydrochloride  (EXP,ISO)
compound 48/80  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (EXP)
copper(II) sulfate  (ISO)
cordycepin  (EXP,ISO)
corn oil  (ISO)
corosolic acid  (ISO)
corticosterone  (EXP,ISO)
cortisone  (ISO)
coumestrol  (EXP)
crizotinib  (ISO)
crocidolite asbestos  (EXP,ISO)
crocin-1  (EXP,ISO)
CU-O LINKAGE  (ISO)
cucurbitacin E  (EXP)
cudraflavone B  (ISO)
cudratricusxanthone A  (ISO)
curcumin  (EXP,ISO)
cyanocob(III)alamin  (ISO)
cycloheximide  (EXP,ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
Cyclosporin H  (ISO)
cyfluthrin  (ISO)
cyhalothrin  (EXP)
cypermethrin  (ISO)
cyprodinil  (ISO)
cytochalasin B  (ISO)
D-aspartic acid  (EXP,ISO)
D-cycloserine  (EXP)
D-fructofuranose 1,6-bisphosphate  (ISO)
D-glucose  (EXP,ISO)
D-mannitol  (ISO)
dabrafenib  (ISO)
dacarbazine  (ISO)
dactolisib  (ISO)
daidzein  (EXP,ISO)
dapsone  (ISO)
daunorubicin  (EXP,ISO)
DDE  (EXP,ISO)
DDT  (EXP,ISO)
decabromodiphenyl ether  (ISO)
Decursin  (ISO)
deferiprone  (EXP,ISO)
deguelin  (ISO)
dehydroacetic acid  (EXP)
dehydroepiandrosterone sulfate  (ISO)
delphinidin  (ISO)
Delta(9)-tetrahydrocannabinolic acid  (ISO)
demethoxycurcumin  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
Deoxyschizandrin  (ISO)
desferrioxamine B  (EXP,ISO)
desipramine  (ISO)
dexamethasone  (EXP,ISO)
dexmedetomidine  (EXP)
dextran sulfate  (EXP,ISO)
dextromethorphan  (ISO)
Di-n-hexyl phthalate  (EXP)
Di-n-octyl phthalate  (EXP,ISO)
diallyl disulfide  (EXP,ISO)
Diallyl sulfide  (EXP,ISO)
diallyl trisulfide  (EXP,ISO)
diarsenic trioxide  (EXP,ISO)
diazepam  (EXP,ISO)
diazinon  (EXP,ISO)
dibenziodolium  (EXP,ISO)
dibenzo[a,l]pyrene  (EXP)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP)
diclofenac  (ISO)
dicoumarol  (ISO)
Dictamnine  (ISO)
Dicyclohexyl phthalate  (EXP)
Didymin  (ISO)
dieckol  (ISO)
dieldrin  (EXP,ISO)
diepoxybutane  (ISO)
diethyl malate  (ISO)
diethyl phthalate  (ISO)
diethyldithiocarbamic acid  (EXP)
diethylstilbestrol  (EXP,ISO)
digitoxin  (ISO)
digoxin  (EXP)
dihydroartemisinin  (ISO)
dihydrocapsaicin  (ISO)
dihydrolipoic acid  (EXP)
Dihydrotanshinone I  (ISO)
dihydroxyacetone  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
diisopropyl fluorophosphate  (ISO)
diltiazem  (EXP)
dimethoate  (ISO)
dimethylarsinic acid  (EXP,ISO)
diminazene diaceturate  (ISO)
dinaciclib  (ISO)
Dinitramine  (ISO)
dinitrogen  (ISO)
dioscin  (EXP,ISO)
diosmetin  (ISO)
dioxygen  (EXP,ISO)
diphenyl diselenide  (EXP,ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (EXP,ISO)
diquat  (ISO)
disodium cromoglycate  (ISO)
disodium selenite  (EXP,ISO)
disulfiram  (ISO)
divanadium pentaoxide  (ISO)
dizocilpine maleate  (EXP,ISO)
dobutamine  (EXP,ISO)
donepezil hydrochloride  (EXP)
dopamine  (EXP,ISO)
dorsomorphin  (EXP,ISO)
doxazosin  (EXP)
doxorubicin  (EXP,ISO)
DPCPX  (EXP)
ebselen  (EXP,ISO)
eckol  (ISO)
elemental selenium  (ISO)
ellagic acid  (EXP,ISO)
ellipticine  (ISO)
emetine  (ISO)
emodin  (EXP,ISO)
endosulfan  (EXP,ISO)
Enterolactone  (ISO)
enzacamene  (ISO)
enzyme inhibitor  (ISO)
eplerenone  (ISO)
equol  (ISO)
erastin  (ISO)
erdosteine  (EXP)
erlotinib hydrochloride  (EXP,ISO)
Erucin  (ISO)
esculetin  (EXP,ISO)
estragole  (EXP)
estriol  (EXP,ISO)
estrogen  (EXP)
estrone  (EXP,ISO)
ethanol  (EXP,ISO)
ether  (EXP)
ethyl methanesulfonate  (ISO)
Ethyl pyruvate  (EXP,ISO)
ethyl trans-caffeate  (ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (EXP,ISO)
eticlopride(1+)  (ISO)
etoposide  (ISO)
etoxazole  (ISO)
EUK-134  (ISO)
euscaphic acid  (ISO)
Evodiamine  (EXP,ISO)
excitatory amino acid agonist  (EXP,ISO)
famotidine  (ISO)
farnesyl diphosphate  (ISO)
farrerol  (EXP,ISO)
fenoterol  (ISO)
fentanyl  (ISO)
fenvalerate  (EXP,ISO)
ferric ammonium citrate  (ISO)
ferric oxide  (EXP,ISO)
ferroheme b  (ISO)
ferrosoferric oxide  (ISO)
ferulic acid  (EXP,ISO)
Fexofenadine hydrochloride  (ISO)
Fidarestat  (ISO)
filipin III  (EXP)
finasteride  (EXP)
fingolimod hydrochloride  (ISO)
fipronil  (ISO)
fisetin  (EXP,ISO)
flavanones  (ISO)
flavonoids  (EXP)
flavonol  (ISO)
flavonols  (ISO)
flufenoxuron  (ISO)
fluoranthene  (ISO)
fluorescein 5-isothiocyanate  (ISO)
fluoxetine  (EXP,ISO)
fluprostenol  (ISO)
flurbiprofen  (ISO)
flutamide  (EXP)
folic acid  (EXP,ISO)
fomepizole  (ISO)
formaldehyde  (ISO)
formononetin  (ISO)
formoterol fumarate  (ISO)
FR900359  (ISO)
fructose  (EXP)
fucoxanthin  (ISO)
fulvestrant  (EXP,ISO)
Fulvic acid  (ISO)
furan  (EXP,ISO)
furazolidone  (ISO)
furfural  (ISO)
gadodiamide hydrate  (ISO)
gadolinium atom  (EXP)
gadolinium trichloride  (EXP,ISO)
galactose  (EXP)
galangin  (EXP)
gallein  (EXP)
gallic acid  (EXP,ISO)
gamma-hexachlorocyclohexane  (EXP,ISO)
Garcinol  (ISO)
gefitinib  (EXP,ISO)
geldanamycin  (ISO)
gemcitabine  (ISO)
Genipin  (ISO)
Geniposide pentaacetate  (EXP)
genistein  (EXP,ISO)
gentamycin  (EXP,ISO)
Gentiopicrin  (ISO)
Geraniin  (ISO)
geraniol  (ISO)
GGTI-2133  (EXP)
Gingerenone A  (EXP,ISO)
ginkgolide B  (ISO)
ginsenoside Rd  (ISO)
ginsenoside Re  (ISO)
ginsenoside Rg1  (ISO)
Ginsenoside Rh4  (EXP)
Glabrene  (ISO)
glabridin  (ISO)
gliclazide  (EXP)
gliotoxin  (EXP)
glucose  (EXP,ISO)
glutathione  (EXP,ISO)
Glutathione ethyl ester  (ISO)
glyburide  (EXP)
glycine  (EXP)
glycitein  (ISO)
glycochenodeoxycholic acid  (EXP,ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
glycyrrhizinic acid  (ISO)
glyphosate  (EXP,ISO)
Goe 6976  (EXP,ISO)
gossypol  (ISO)
GSK-J4  (ISO)
guanosine  (ISO)
GW 1929  (ISO)
haloperidol  (EXP,ISO)
halothane  (ISO)
harmine  (ISO)
helioxanthin  (ISO)
heme b  (ISO)
hemin  (ISO)
heparan sulfate  (ISO)
heparin  (EXP,ISO)
heptachlor  (EXP,ISO)
herbicide  (EXP)
herbimycin  (ISO)
hesperetin  (ISO)
hexachlorobenzene  (EXP,ISO)
hexadecanoic acid  (EXP,ISO)
Hexamethonium  (ISO)
hexamethylene diisocyanate  (ISO)
high-density lipoprotein cholesterol  (ISO)
hinokiflavone  (ISO)
hispidulin  (EXP,ISO)
histamine  (EXP,ISO)
homocysteine  (ISO)
Honokiol  (ISO)
hyaluronic acid  (ISO)
hydralazine  (EXP)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (ISO)
hydroquinone  (ISO)
hydroxyflutamide  (EXP,ISO)
hydroxytyrosol  (ISO)
hydroxyurea  (EXP)
hyperforin  (ISO)
hypochlorous acid  (ISO)
ibuprofen  (ISO)
IC-87114  (ISO)
icariin  (EXP,ISO)
icariside II  (ISO)
ICI 118551  (EXP,ISO)
ICI-164384  (ISO)
icosanoid  (ISO)
Ilimaquinone  (ISO)
iloprost  (ISO)
imidacloprid  (ISO)
imipramine  (EXP)
imiquimod  (ISO)
imperatorin  (ISO)
indapamide  (EXP)
indole-3-methanol  (ISO)
indometacin  (ISO)
indoprofen  (ISO)
indoxyl sulfate  (EXP,ISO)
Inotodiol  (ISO)
iohexol  (ISO)
ionomycin  (EXP,ISO)
iopromide  (ISO)
Ioversol  (ISO)
ioxynil  (EXP)
irinotecan  (EXP,ISO)
iron atom  (EXP,ISO)
iron dextran  (EXP,ISO)
iron dichloride  (ISO)
iron trichloride  (EXP)
iron(0)  (EXP,ISO)
iron(2+) sulfate (anhydrous)  (EXP)
isocarbophos  (ISO)
isoeugenol  (ISO)
isoflurane  (EXP)
isoliquiritigenin  (ISO)
isoniazide  (ISO)
isoorientin  (ISO)
isoprenaline  (EXP,ISO)
isoprene  (ISO)
isorhapontigenin  (EXP)
isothiocyanate  (ISO)
ivermectin  (ISO)
JTE-013  (ISO)
juglone  (ISO)
Jujuboside A  (ISO)
kaempferol  (EXP,ISO)
kahweol  (ISO)
kainic acid  (ISO)
ketamine  (ISO)
ketanserin  (ISO)
keto-D-fructose 1,6-bisphosphate  (ISO)
KN-93  (EXP,ISO)
kojic acid  (ISO)
KT 5720  (ISO)
KT 5823  (EXP,ISO)
Kukoamine B  (ISO)
L-1,4-dithiothreitol  (ISO)
L-ascorbic acid  (EXP,ISO)
L-cysteine  (EXP)
L-cystine  (ISO)
L-glutamic acid  (EXP,ISO)
L-methionine  (EXP,ISO)
labetalol  (ISO)
lactacystin  (ISO)
lactucin  (ISO)
lansoprazole  (EXP)
lapatinib  (ISO)
latrunculin B  (EXP)
lead diacetate  (EXP,ISO)
lead nitrate  (ISO)
lead(0)  (EXP,ISO)
leflunomide  (EXP,ISO)
lentinan  (ISO)
leptomycin B  (ISO)
lercanidipine  (EXP,ISO)
letrozole  (EXP,ISO)
leukotriene B4  (ISO)
leukotriene C4  (ISO)
leukotriene D4  (ISO)
Licochalcone A  (ISO)
Licochalcone B  (ISO)
lidocaine  (EXP)
Liensinine  (ISO)
linagliptin  (EXP)
linalool  (ISO)
lipoic acid  (EXP)
lipopolysaccharide  (EXP,ISO)
lipoteichoic acid  (EXP,ISO)
lipoxin A4  (ISO)
lithium atom  (EXP,ISO)
lithium chloride  (EXP)
lithium hydride  (EXP,ISO)
lithocholic acid  (ISO)
LM-1685  (ISO)
loliolide  (ISO)
lonidamine  (ISO)
loperamide  (ISO)
losartan  (EXP,ISO)
lovastatin  (EXP,ISO)
loxoprofen  (ISO)
Lupalbigenin  (ISO)
luteolin  (EXP,ISO)
luteolin 7-O-beta-D-glucoside  (ISO)
LY 117018  (ISO)
LY 379268  (EXP)
LY294002  (EXP,ISO)
lycopene  (EXP,ISO)
lysophosphatidylcholine  (EXP)
madecassoside  (ISO)
Maduramicin  (EXP)
Magnolol  (EXP,ISO)
Malonoben  (ISO)
malvidin  (ISO)
mancozeb  (ISO)
maneb  (ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
mangiferin  (EXP,ISO)
Maprotiline  (ISO)
marimastat  (EXP)
masoprocol  (ISO)
mebendazole  (ISO)
Mecamylamine  (ISO)
mechlorethamine  (ISO)
medroxyprogesterone acetate  (ISO)
melamine  (ISO)
melatonin  (EXP,ISO)
melittin  (EXP,ISO)
meloxicam  (ISO)
melphalan  (ISO)
memantine  (EXP)
menadione  (EXP,ISO)
mepyramine  (ISO)
mercury atom  (ISO)
mercury dichloride  (EXP,ISO)
mercury(0)  (ISO)
Mesaconitine  (EXP)
metacetamol  (ISO)
metam  (ISO)
metformin  (EXP,ISO)
methadone  (ISO)
methamphetamine  (EXP,ISO)
Methanandamide  (EXP,ISO)
methidathion  (ISO)
methimazole  (EXP,ISO)
methoctramine tetrahydrochloride  (EXP)
methohexital  (ISO)
methotrexate  (EXP,ISO)
methoxyacetic acid  (ISO)
methoxychlor  (EXP,ISO)
methyl beta-cyclodextrin  (ISO)
methyl caffeate  (ISO)
methyl methanesulfonate  (ISO)
methyl tert-butyl ether  (EXP)
methylarsonic acid  (ISO)
methylglyoxal  (ISO)
methyllycaconitine  (ISO)
methylmercury chloride  (EXP,ISO)
methylparaben  (ISO)
methylphenidate  (EXP)
methylseleninic acid  (ISO)
Methylthiouracil  (ISO)
mevalonic acid  (EXP,ISO)
microcystin-LR  (ISO)
midazolam  (ISO)
midostaurin  (ISO)
mifepristone  (EXP,ISO)
minocycline  (ISO)
mitomycin C  (ISO)
MitoTEMPO  (ISO)
MK 571  (ISO)
MK-2206  (ISO)
ML-7  (ISO)
mocetinostat  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
Monobutylphthalate  (EXP)
monocrotaline  (EXP)
monodansylcadaverine  (ISO)
montelukast  (ISO)
morin  (EXP)
morphine  (EXP,ISO)
Morroniside  (EXP)
morusin  (ISO)
moxifloxacin  (ISO)
Muconic dialdehyde  (EXP)
muscimol  (EXP)
mycophenolic acid  (ISO)
myo-inositol hexakisphosphate  (EXP,ISO)
myricetin  (ISO)
myricitrin  (ISO)
N(6)-butyryl-cAMP  (ISO)
N,N'-diphenyl-1,4-phenylenediamine  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (EXP,ISO)
N,N-diethyl-m-toluamide  (EXP)
N,N-dimethylformamide  (ISO)
N,O-dimethyltyramine  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP,ISO)
N-[2-(diethylamino)ethyl]-2-methoxy-5-methylsulfonylbenzamide  (EXP)
N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexanecarboxamide  (EXP)
N-acetyl-1,4-benzoquinone imine  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-acetylsphingosine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethylmaleimide  (ISO)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-D-aspartic acid  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-methylnicotinate  (ISO)
N-Nitroso-N-methylurethane  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP,ISO)
N-phenylthiourea  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
naloxone  (EXP,ISO)
naringin  (EXP,ISO)
NCX-4040  (ISO)
nectandrin B  (ISO)
nefazodone  (EXP,ISO)
Neferine  (ISO)
neoastilbin  (ISO)
neomycin  (ISO)
nerolidol  (EXP)
nicardipine  (EXP)
nickel atom  (EXP,ISO)
nickel dichloride  (ISO)
nickel sulfate  (EXP,ISO)
niclosamide  (ISO)
nicotine  (EXP,ISO)
nicotinic acid  (ISO)
nifedipine  (ISO)
nimesulide  (ISO)
nimodipine  (ISO)
nimustine  (ISO)
nintedanib  (ISO)
nitrates  (ISO)
nitric oxide  (EXP)
nitroprusside  (EXP,ISO)
Nivalenol  (ISO)
NMN zwitterion  (ISO)
nocodazole  (EXP,ISO)
Nodularin  (EXP)
nonanedioic acid  (ISO)
Nonylphenol  (EXP,ISO)
Nookatone  (EXP)
norathyriol  (ISO)
Norbinaltorphimine  (ISO)
NORCANTHARIDIN  (ISO)
notoginsenoside R1  (EXP,ISO)
NS-398  (EXP,ISO)
nystatin  (EXP)
obeticholic acid  (ISO)
ochratoxin A  (EXP,ISO)
okadaic acid  (EXP,ISO)
oleanolic acid  (ISO)
oleic acid  (ISO)
oleuropein  (ISO)
oligopeptide  (ISO)
olmesartan  (ISO)
omacetaxine mepesuccinate  (ISO)
omipalisib  (ISO)
organoselenium compound  (EXP)
orlistat  (ISO)
oroxylin A  (ISO)
Ortho-topolin riboside  (ISO)
osimertinib  (ISO)
osthole  (ISO)
ouabain  (EXP,ISO)
oxaliplatin  (EXP,ISO)
oxidopamine  (EXP,ISO)
oxycodone  (EXP)
oxytocin  (EXP)
ozone  (EXP,ISO)
p-tert-Amylphenol  (ISO)
p-tolualdehyde  (ISO)
paclitaxel  (EXP,ISO)
paeoniflorin  (ISO)
palmatine  (EXP)
palytoxin  (ISO)
pamidronate  (ISO)
pamoic acid  (ISO)
Panaxynol  (EXP)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parecoxib  (ISO)
paroxetine  (ISO)
Parthenin  (ISO)
patchouli alcohol  (ISO)
patulin  (EXP,ISO)
pazopanib  (ISO)
PCB138  (ISO)
PD 0325901  (EXP,ISO)
PD 168393  (ISO)
PD123319  (ISO)
PD173074  (EXP,ISO)
pelargonidin  (ISO)
pentachlorophenol  (ISO)
pentobarbital  (EXP,ISO)
Pentoxifylline  (ISO)
peptidoglycan  (ISO)
perfluorobutanesulfonic acid  (ISO)
perfluorodecanoic acid  (ISO)
perfluoroheptanoic acid  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoroundecanoic acid  (EXP)
perifosine  (ISO)
perillyl alcohol  (ISO)
permethrin  (EXP,ISO)
peroxides  (EXP)
peroxynitrous acid  (EXP)
PF-3758309  (ISO)
PHA-665752  (ISO)
phenanthrolines  (ISO)
phenethyl caffeate  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP,ISO)
phenols  (ISO)
phentolamine  (ISO)
phenylarsine oxide  (EXP,ISO)
phenylephrine  (EXP,ISO)
phenytoin  (ISO)
PhIP  (ISO)
phloretin  (EXP)
phlorizin chalcone  (ISO)
phorbol 12,13-dibutanoate  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phosgene  (EXP)
phosphatidic acid  (ISO)
phosphoramidon  (ISO)
phylloquinone  (ISO)
phytol  (ISO)
phytosphingosine  (ISO)
picropodophyllotoxin  (ISO)
Picroside ii  (ISO)
picrotoxin  (EXP)
picrotoxinin  (ISO)
pifithrin-alpha hydrobromide  (EXP,ISO)
pindolol  (ISO)
pinocembrin  (ISO)
pioglitazone  (EXP,ISO)
piperine  (ISO)
pipoxolan  (ISO)
Pirarubicin  (EXP)
pirinixic acid  (EXP,ISO)
platinum  (ISO)
platinum(0)  (ISO)
platycodin D  (EXP,ISO)
plumbagin  (ISO)
poly(I:C)  (ISO)
poly(vinylpyrrolidone)  (ISO)
Polygodial  (EXP)
polymyxin B2  (ISO)
polyphosphates  (ISO)
ponatinib  (ISO)
potassium atom  (EXP)
potassium bromate  (ISO)
potassium chloride  (EXP)
potassium chromate  (ISO)
potassium dichromate  (EXP,ISO)
practolol  (ISO)
Praeruptorin A  (ISO)
prazosin  (EXP,ISO)
prednisolone  (EXP)
prednisone  (ISO)
probenecid  (EXP)
procaine  (ISO)
prochloraz  (ISO)
procyanidin B2  (ISO)
procymidone  (EXP)
prodigiosin  (ISO)
progesterone  (EXP,ISO)
promegestone  (EXP,ISO)
propacetamol  (ISO)
propan-2-ol  (ISO)
propane-1,2-diol  (ISO)
propazine  (ISO)
propiconazole  (ISO)
propofol  (EXP,ISO)
propranolol  (EXP,ISO)
propylparaben  (ISO)
prostaglandin D2  (ISO)
prostaglandin E2  (EXP,ISO)
prostaglandin F2alpha  (EXP,ISO)
prostaglandin I2  (ISO)
protein kinase inhibitor  (EXP,ISO)
pterostilbene  (ISO)
puerarin  (EXP,ISO)
pyocyanine  (ISO)
pyrazines  (ISO)
pyridazines  (ISO)
Pyridostigmine bromide  (EXP)
pyrithione  (ISO)
pyrrolidine dithiocarbamate  (EXP,ISO)
pyrroloquinoline quinone  (ISO)
quercetagetin  (EXP)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-galactopyranoside  (ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
quinacrine  (ISO)
quinazolines  (ISO)
quinpirole  (ISO)
quizartinib  (ISO)
raloxifene  (EXP,ISO)
ranitidine  (ISO)
razoxane  (EXP)
reactive oxygen species  (EXP,ISO)
Rebamipide  (ISO)
regorafenib  (ISO)
reparixin  (ISO)
resiniferatoxin  (ISO)
resveratrol  (EXP,ISO)
RGFP966  (ISO)
rimonabant  (EXP,ISO)
Risedronate sodium  (ISO)
Ro 31-8220  (EXP,ISO)
roflumilast  (ISO)
rolipram  (EXP)
romidepsin  (ISO)
ropinirole  (ISO)
rosmarinic acid  (EXP)
rotenone  (EXP,ISO)
rottlerin  (EXP,ISO)
Ruscogenin  (ISO)
ruthenium red  (EXP,ISO)
rutin  (EXP,ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
S-nitroso-N-acetyl-D-penicillamine  (EXP)
saccharin  (EXP)
Salidroside  (ISO)
Salinomycin  (ISO)
Salmeterol xinafoate  (ISO)
salubrinal  (EXP,ISO)
Salvianolic acid A  (ISO)
salvianolic acid B  (ISO)
Sanggenon C  (ISO)
sanguinarine  (ISO)
sapanisertib  (ISO)
SB 203580  (EXP,ISO)
SB 431542  (ISO)
SB-239063  (EXP)
SCH 23390  (ISO)
SCH772984  (EXP,ISO)
sclareol  (ISO)
scopoletin  (EXP)
secobarbital  (ISO)
selenic acid  (ISO)
selenium atom  (ISO)
selenocystine  (ISO)
selenomethionine  (ISO)
selumetinib  (ISO)
semilicoisoflavone B  (ISO)
sepantronium  (ISO)
serotonin  (ISO)
serpentine asbestos  (EXP,ISO)
sertraline  (EXP,ISO)
sevoflurane  (EXP,ISO)
Shikonin  (ISO)
silibinin  (ISO)
silicon dioxide  (EXP,ISO)
silmitasertib  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
silver(1+) nitrate  (ISO)
simazine  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (EXP,ISO)
sirtinol  (ISO)
SKF-96365 hydrochloride  (ISO)
SL-327  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chlorate  (ISO)
sodium chloride  (EXP,ISO)
sodium cholate  (ISO)
sodium chromate  (ISO)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (EXP,ISO)
Sodium salicylate  (EXP,ISO)
Soman  (EXP)
sorafenib  (EXP,ISO)
sorbinil  (ISO)
sotorasib  (ISO)
sotrastaurin  (ISO)
sphingosine 1-phosphate  (EXP,ISO)
SR 144528  (ISO)
staurosporine  (EXP,ISO)
StemRegenin 1  (ISO)
stilbenoid  (ISO)
streptozocin  (EXP,ISO)
SU6656  (ISO)
sucrose  (EXP,ISO)
sulfasalazine  (EXP)
sulfonyldimethane  (ISO)
sulforaphane  (ISO)
sulindac  (EXP,ISO)
sulindac sulfide  (ISO)
sulindac sulfone  (ISO)
sunitinib  (ISO)
superoxide  (EXP,ISO)
suramin  (EXP,ISO)
surfactin  (ISO)
surfactin C  (ISO)
suvorexant  (ISO)
swainsonine  (ISO)
Swertiamarin  (ISO)
syringic acid  (ISO)
T-2 toxin  (ISO)
tadalafil  (ISO)
taiwanin C  (ISO)
tamibarotene  (EXP,ISO)
tamoxifen  (EXP,ISO)
tanespimycin  (EXP,ISO)
taurine  (EXP,ISO)
taurocholic acid  (ISO)
tauroursodeoxycholic acid  (ISO)
tazarotene  (ISO)
telmisartan  (EXP,ISO)
temozolomide  (ISO)
Temsirolimus  (ISO)
tephrosin  (ISO)
terbinafine  (ISO)
terbutaline  (EXP,ISO)
terbutylazine  (ISO)
tert-butyl hydroperoxide  (EXP,ISO)
testosterone  (EXP,ISO)
tetracaine  (EXP)
Tetrachlorobisphenol A  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
tetraethylammonium  (EXP)
tetramethylpyrazine  (ISO)
tetrathiomolybdate(2-)  (EXP,ISO)
tetrodotoxin  (EXP,ISO)
thalidomide  (ISO)
thapsigargin  (EXP,ISO)
Theaflavin 3,3'-digallate  (EXP,ISO)
theophylline  (ISO)
thiamylal  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP,ISO)
Thiorphan  (ISO)
thiostrepton  (ISO)
Thrombin  (ISO)
thymoquinone  (ISO)
thyroxine  (EXP,ISO)
tibolone  (ISO)
tipifarnib  (ISO)
Tiron  (ISO)
titanium dioxide  (ISO)
tofacitinib  (ISO)
toluene 2,4-diisocyanate  (ISO)
tomatidine  (ISO)
Tomentosin  (ISO)
toosendanin  (ISO)
topotecan  (EXP)
Tormentic acid  (ISO)
trametinib  (ISO)
trans-anethole  (ISO)
trans-caffeic acid  (ISO)
trans-chalcone  (ISO)
trans-isoeugenol  (ISO)
trans-piceid  (ISO)
triadimefon  (EXP)
tributylstannane  (EXP,ISO)
Tributyltin oxide  (EXP,ISO)
tributyrin  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
trifluoperazine  (EXP,ISO)
trimellitic anhydride  (ISO)
trimethyltin  (ISO)
triphenyl phosphate  (ISO)
triphenylstannane  (EXP)
Triptolide  (EXP)
triptonide  (ISO)
troglitazone  (EXP,ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (EXP)
trovafloxacin  (ISO)
tubocurarine  (ISO)
Tungsten carbide  (ISO)
tunicamycin  (EXP,ISO)
Typhaneoside  (EXP)
tyrphostin AG 1478  (EXP,ISO)
U-73122  (EXP,ISO)
U0126  (EXP)
U69593  (ISO)
UDP  (ISO)
umbelliferone  (EXP)
urethane  (EXP,ISO)
ursodeoxycholic acid  (ISO)
ursolic acid  (EXP)
Ursonic acid  (ISO)
usnic acid  (ISO)
UTP  (EXP,ISO)
valproic acid  (EXP,ISO)
valsartan  (ISO)
vanadium atom  (EXP,ISO)
vanadium(0)  (EXP,ISO)
vanadyl sulfate  (ISO)
varenicline  (ISO)
vecuronium bromide  (ISO)
vemurafenib  (ISO)
venetoclax  (ISO)
venlafaxine hydrochloride  (EXP)
verapamil  (ISO)
Vernodalin  (ISO)
vildagliptin  (ISO)
vinclozolin  (EXP)
vitamin D  (EXP)
vitamin E  (ISO)
Vitisin A  (EXP,ISO)
vorinostat  (ISO)
warfarin  (ISO)
WIN 55212-2  (EXP,ISO)
withaferin A  (ISO)
Withanone  (ISO)
wogonin  (ISO)
wortmannin  (EXP,ISO)
Xamoterol  (ISO)
xanthohumol  (ISO)
xanthones  (ISO)
xenon atom  (EXP)
xenon(0)  (EXP)
xestospongin C  (ISO)
XMU-MP-1  (ISO)
Y-27632  (EXP,ISO)
YM-254890  (ISO)
zearalenone  (EXP,ISO)
zebularine  (ISO)
zerumbone  (ISO)
zileuton  (ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (EXP,ISO)
zinc oxide  (ISO)
zinc protoporphyrin  (ISO)
zinc sulfate  (EXP,ISO)
zinc(0)  (EXP,ISO)
zingerone  (EXP)
ziram  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
androgen receptor signaling pathway  (IEA)
animal organ morphogenesis  (IEA,ISO)
apoptotic process  (IEA)
B cell receptor signaling pathway  (IEA,ISO)
Bergmann glial cell differentiation  (IEA,ISO)
cardiac neural crest cell development involved in heart development  (IEA,ISO)
caveolin-mediated endocytosis  (IEA,TAS)
cell surface receptor signaling pathway  (IBA)
cellular response to amino acid starvation  (IEA,ISO)
cellular response to cAMP  (IEP)
cellular response to epidermal growth factor stimulus  (IEP)
cellular response to insulin-like growth factor stimulus  (IEP)
cellular response to methionine  (IEP)
cellular response to platelet-derived growth factor stimulus  (IEP)
cellular response to prostaglandin E stimulus  (IEP)
cellular response to toxic substance  (IDA)
cellular response to tumor necrosis factor  (IEA,ISO)
cytosine metabolic process  (IEA,ISO)
decidualization  (IDA)
diadenosine tetraphosphate biosynthetic process  (IMP)
DNA damage response  (IEA,ISO)
epidermal growth factor receptor signaling pathway  (IEA,ISO)
ERBB signaling pathway  (IEA,ISO)
ERBB2-ERBB3 signaling pathway  (IEA,ISO)
ERK1 and ERK2 cascade  (IEA,IMP,ISO)
estrous cycle  (IEP)
face development  (IEA,ISO)
heart development  (IEA,ISO)
insulin receptor signaling pathway  (IEA,ISO)
insulin-like growth factor receptor signaling pathway  (IEA,ISO)
interleukin-34-mediated signaling pathway  (IEA,ISO)
intracellular signal transduction  (IBA,IDA,TAS)
labyrinthine layer blood vessel development  (IEA,ISO)
lipopolysaccharide-mediated signaling pathway  (IEA,ISO)
long-term synaptic potentiation  (IEA,ISO)
lung morphogenesis  (IEA,ISO)
mammary gland epithelial cell proliferation  (IEA,ISO)
MAPK cascade  (IEA,IMP,ISO)
myelination  (IEA,ISO)
negative regulation of cell differentiation  (IEA,ISO)
neural crest cell development  (IEA,ISO)
outer ear morphogenesis  (IEA,ISO)
peptidyl-serine phosphorylation  (IDA,IMP,ISO)
peptidyl-threonine phosphorylation  (ISO,ISS)
positive regulation of cardiac muscle cell proliferation  (IMP)
positive regulation of cell migration  (IEP)
positive regulation of cell population proliferation  (IEP)
positive regulation of cholesterol biosynthetic process  (IEA,ISO)
positive regulation of DNA-templated transcription  (IMP)
positive regulation of macrophage chemotaxis  (IEA,ISO)
positive regulation of macrophage proliferation  (IEA,ISO)
positive regulation of peptidyl-threonine phosphorylation  (ISO)
positive regulation of protein import into nucleus  (IMP)
positive regulation of telomere maintenance  (IEA,ISO)
positive regulation of translation  (IMP)
progesterone receptor signaling pathway  (IEA)
protein phosphorylation  (IDA,IMP,ISO,TAS)
regulation of cellular pH  (IEA,ISO)
regulation of cytoskeleton organization  (IEA,TAS)
regulation of early endosome to late endosome transport  (IEA,TAS)
regulation of Golgi inheritance  (IEA,TAS)
regulation of ossification  (IEA,ISO)
regulation of protein stability  (ISS)
regulation of stress-activated MAPK cascade  (IEA,TAS)
regulation of transcription by RNA polymerase II  (IEA)
response to alcohol  (IEP)
response to cocaine  (IEP)
response to epidermal growth factor  (IEA,ISO,ISS)
response to estradiol  (IEP)
response to estrogen  (IDA)
response to exogenous dsRNA  (IEA,ISO)
response to hydrogen peroxide  (IEP)
response to lipopolysaccharide  (IEA,ISO)
response to nicotine  (IEA,IGI,ISO)
response to testosterone  (IEP)
response to toxic substance  (IDA)
Schwann cell development  (IEA,ISO)
sensory perception of pain  (IMP)
steroid hormone receptor signaling pathway  (IEA)
stress-activated MAPK cascade  (IEA,ISO)
T cell receptor signaling pathway  (IEA,ISO)
thymus development  (IEA,ISO)
thyroid gland development  (IEA,ISO)
trachea formation  (IEA,ISO)

Cellular Component
anchoring junction  (IEA)
axon  (IDA)
caveola  (IDA,IEA,TAS)
centrosome  (IEA)
ciliary basal body  (IEA,ISO)
cilium  (IEA,ISO)
cytoplasm  (IBA,IDA,IEA,ISO,ISS)
cytoskeleton  (IEA,TAS)
cytosol  (IEA,ISO,TAS)
dendrite cytoplasm  (IDA)
early endosome  (IEA,TAS)
focal adhesion  (IEA,TAS)
Golgi apparatus  (IEA,TAS)
late endosome  (IEA,TAS)
membrane  (IEA)
microtubule cytoskeleton  (IEA,ISO)
mitochondrion  (IEA,ISO,TAS)
mitotic spindle  (ISS)
nucleoplasm  (IDA,IEA,ISO,TAS)
nucleus  (IBA,IEA,ISO,TAS)
perikaryon  (IDA)
plasma membrane  (IDA)
postsynaptic density  (IDA,IEP)
protein-containing complex  (IDA)
pseudopodium  (IEA,ISO)
spindle  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
acute myeloid leukemia pathway  (IEA)
adenosine signaling pathway   (ISO)
aldosterone signaling pathway   (IEA)
Alzheimer's disease pathway  (IEA)
B cell receptor signaling pathway  (IEA)
Bone morphogenetic proteins signaling pathway  (ISO)
ceramide signaling pathway  (IEA,ISO)
Chagas disease pathway  (IEA)
chemokine mediated signaling pathway  (IEA)
chronic myeloid leukemia pathway   (IEA)
colorectal cancer pathway   (IEA)
endometrial cancer pathway  (IEA)
endothelin signaling pathway  (ISO)
ephrin - ephrin receptor bidirectional signaling axis   (ISO)
epidermal growth factor/neuregulin signaling pathway  (IEA,ISO)
Fc epsilon receptor mediated signaling pathway  (IEA,ISO)
Fc gamma receptor mediated signaling pathway  (IEA)
fibroblast growth factor signaling pathway  (ISO)
glioma pathway  (IEA)
glutamate signaling pathway  (IEA)
gonadotropin-releasing hormone signaling pathway  (IEA)
granulocyte-macrophage colony-stimulating factor signaling pathway  (ISO)
hepatitis C pathway  (IEA)
influenza A pathway   (IEA)
insulin signaling pathway  (IEA,ISO)
interleukin-2 signaling pathway  (ISO)
Leishmaniasis pathway  (IEA)
long term depression  (IEA)
long term potentiation  (IEA)
melanoma pathway   (IEA)
mitogen activated protein kinase signaling pathway   (IEA)
mTOR signaling pathway  (IEA,ISO)
neurotrophic factor signaling pathway  (IEA)
NOD-like receptor signaling pathway   (IEA)
non-small cell lung carcinoma pathway   (IEA)
pancreatic cancer pathway  (IEA)
platelet-derived growth factor signaling pathway  (ISO)
prion disease pathway   (IEA)
prostate cancer pathway   (IEA)
renal cell carcinoma pathway  (IEA)
sphingosine 1-phosphate signaling pathway  (ISO)
syndecan signaling pathway  (ISO)
T cell receptor signaling pathway   (IEA)
the extracellular signal-regulated Raf/Mek/Erk signaling pathway  (IDA,IMP)
thyroid cancer pathway   (IEA)
Toll-like receptor signaling pathway  (IEA)
toxoplasmosis pathway   (IEA)
Trail mediated signaling pathway  (ISO)
transforming growth factor-beta superfamily mediated signaling pathway  (IEA)
tuberculosis pathway   (IEA)
type 2 diabetes mellitus pathway  (IEA)
type II interferon signaling pathway  (ISO)
urinary bladder cancer pathway   (IEA)
vascular endothelial growth factor signaling pathway  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Proteomics studies of childhood pilocytic astrocytoma. Anagnostopoulos AK, etal., J Proteome Res. 2011 May 6;10(5):2555-65. doi: 10.1021/pr200024m. Epub 2011 Apr 14.
2. Elevated activation of ERK1 and ERK2 accompany enhanced liver injury following alcohol binge in chronically ethanol-fed rats. Aroor AR, etal., Alcohol Clin Exp Res. 2011 Dec;35(12):2128-38. doi: 10.1111/j.1530-0277.2011.01577.x. Epub 2011 Jul 25.
3. Cyclic changes in estradiol regulate synaptic plasticity through the MAP kinase pathway. Bi R, etal., Proc Natl Acad Sci U S A 2001 Nov 6;98(23):13391-5.
4. Signaling pathway adaptations and novel protein kinase A substrates related to behavioral sensitization to cocaine. Boudreau AC, etal., J Neurochem. 2009 Jul;110(1):363-77. Epub 2009 May 3.
5. ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF. Boulton TG, etal., Cell 1991 May 17;65(4):663-75.
6. P2X7 receptors activate protein kinase D and p42/p44 mitogen-activated protein kinase (MAPK) downstream of protein kinase C. Bradford MD and Soltoff SP, Biochem J 2002 Sep 15;366(Pt 3):745-55.
7. 17-Beta estradiol rapidly enhances extracellular signal-regulated kinase 2 phosphorylation in the rat brain. Bryant DN, etal., Neuroscience. 2005;133(1):343-52. doi: 10.1016/j.neuroscience.2005.02.024. Epub 2005 Apr 22.
8. cAMP antagonizes p21ras-directed activation of extracellular signal-regulated kinase 2 and phosphorylation of mSos nucleotide exchange factor. Burgering BM, etal., EMBO J. 1993 Nov;12(11):4211-20. doi: 10.1002/j.1460-2075.1993.tb06105.x.
9. Epidermal growth factor induces phosphorylation of extracellular signal-regulated kinase 2 via multiple pathways. Burgering BM, etal., Mol Cell Biol. 1993 Dec;13(12):7248-56. doi: 10.1128/mcb.13.12.7248-7256.1993.
10. Extracellular signal-regulated kinase 2 signaling in the hippocampal dentate gyrus mediates the antidepressant effects of testosterone. Carrier N and Kabbaj M, Biol Psychiatry. 2012 Apr 1;71(7):642-51. doi: 10.1016/j.biopsych.2011.11.028. Epub 2012 Jan 20.
11. Sex differences in social interaction behaviors in rats are mediated by extracellular signal-regulated kinase 2 expression in the medial prefrontal cortex. Carrier N and Kabbaj M, Neuroscience. 2012 Jun 14;212:86-92. doi: 10.1016/j.neuroscience.2012.03.041. Epub 2012 Apr 18.
12. PDGF-BB-mediated activation of p42(MAPK) is independent of PDGF beta-receptor tyrosine phosphorylation. Cartel NJ, etal., Am J Physiol Lung Cell Mol Physiol 2001 Oct;281(4):L786-98.
13. Bradykinin reduces growth factor-induced glomerular ERK1/2 phosphorylation. Cellier E, etal., Am J Physiol Renal Physiol 2003 Feb;284(2):F282-92.
14. Anti-tumorigenic action of 2-[piperidinoethoxyphenyl]-3-[4-hydroxyphenyl]-2H-benzo(b)pyran: evidence for involvement of GPR30/EGFR signaling pathway. Chandra V, etal., Gynecol Oncol. 2013 May;129(2):433-42. doi: 10.1016/j.ygyno.2013.02.005. Epub 2013 Feb 8.
15. Epigallocatechin-3-gallate attenuates cardiac hypertrophy partly via MAPKs signals in hypertensive rats. Chen DD, etal., Clin Exp Pharmacol Physiol. 2009 Mar 2.
16. Systemic dexmedetomidine attenuates mechanical allodynia through extracellular sign db type 2 diabetic mice. Chen H, etal., Neurosci Lett. 2017 Sep 14;657:126-133. doi: 10.1016/j.neulet.2017.07.048. Epub 2017 Jul 28.
17. Dopamine promotes striatal neuronal apoptotic death via ERK signaling cascades. Chen J, etal., Eur J Neurosci. 2009 Jan;29(2):287-306.
18. Alterations in mammalian target of rapamycin signaling pathways after traumatic brain injury. Chen S, etal., J Cereb Blood Flow Metab. 2007 May;27(5):939-49. Epub 2006 Aug 30.
19. SRC kinase and mitogen-activated protein kinases in the progression from normal to malignant endometrium. Desouki MM and Rowan BG, Clin Cancer Res. 2004 Jan 15;10(2):546-55.
20. Elastase-released epidermal growth factor recruits epidermal growth factor receptor and extracellular signal-regulated kinases to down-regulate tropoelastin mRNA in lung fibroblasts. DiCamillo SJ, etal., J Biol Chem 2002 May 24;277(21):18938-46. Epub 2002 Mar 11.
21. Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease. Dineley KT, etal., J Neurosci. 2001 Jun 15;21(12):4125-33.
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Additional References at PubMed
PMID:1712480   PMID:7939721   PMID:8043507   PMID:8107865   PMID:8221888   PMID:8617731   PMID:8626447   PMID:9064344   PMID:9254656   PMID:9298898   PMID:9447983   PMID:9722539  
PMID:9872331   PMID:9915826   PMID:10551817   PMID:11096076   PMID:11684667   PMID:11726647   PMID:11805112   PMID:11823456   PMID:11832339   PMID:11839761   PMID:11841548   PMID:11844932  
PMID:11854404   PMID:11884367   PMID:11994045   PMID:11994544   PMID:12006386   PMID:12121979   PMID:12213812   PMID:12223545   PMID:12349907   PMID:12435482   PMID:12535947   PMID:12623863  
PMID:12645629   PMID:12663469   PMID:12699904   PMID:12721286   PMID:12730054   PMID:12783880   PMID:12800247   PMID:12808090   PMID:12810726   PMID:12821670   PMID:12849998   PMID:12871576  
PMID:12872135   PMID:12925581   PMID:12930843   PMID:12935895   PMID:12952860   PMID:12971962   PMID:14501944   PMID:14534235   PMID:14552884   PMID:14575703   PMID:14580718   PMID:14593093  
PMID:14605008   PMID:14622137   PMID:14636584   PMID:14707138   PMID:14744933   PMID:14769808   PMID:14963006   PMID:14970190   PMID:14983993   PMID:14984009   PMID:14988413   PMID:15026121  
PMID:15030400   PMID:15030409   PMID:15051723   PMID:15052686   PMID:15054132   PMID:15059773   PMID:15072963   PMID:15133037   PMID:15143154   PMID:15157810   PMID:15203192   PMID:15229233  
PMID:15242988   PMID:15249196   PMID:15257182   PMID:15258148   PMID:15284227   PMID:15314156   PMID:15322069   PMID:15351692   PMID:15371543   PMID:15383658   PMID:15469737   PMID:15489642  
PMID:15498890   PMID:15537896   PMID:15542607   PMID:15569628   PMID:15574735   PMID:15617763   PMID:15729360   PMID:15731359   PMID:15748847   PMID:15753041   PMID:15811423   PMID:15850461  
PMID:15865443   PMID:15896720   PMID:15899886   PMID:15964695   PMID:15964902   PMID:15975921   PMID:15975997   PMID:15991247   PMID:16044092   PMID:16106045   PMID:16126730   PMID:16139272  
PMID:16173113   PMID:16251435   PMID:16272159   PMID:16314496   PMID:16322063   PMID:16510265   PMID:16535835   PMID:16595703   PMID:16627622   PMID:16641100   PMID:16641227   PMID:16707097  
PMID:16714296   PMID:16791210   PMID:16795048   PMID:16831126   PMID:16837555   PMID:16873684   PMID:16877348   PMID:16888810   PMID:16893669   PMID:16897752   PMID:16934944   PMID:16944316  
PMID:16978658   PMID:17005865   PMID:17046812   PMID:17050000   PMID:17074386   PMID:17088403   PMID:17107949   PMID:17113581   PMID:17114285   PMID:17161379   PMID:17175230   PMID:17183546  
PMID:17244536   PMID:17265428   PMID:17284314   PMID:17285312   PMID:17308007   PMID:17309799   PMID:17333127   PMID:17363453   PMID:17371162   PMID:17447135   PMID:17467311   PMID:17504975  
PMID:17505812   PMID:17548467   PMID:17583725   PMID:17600551   PMID:17616751   PMID:17620366   PMID:17628608   PMID:17644565   PMID:17647269   PMID:17654493   PMID:17658891   PMID:17674030  
PMID:17675293   PMID:17687004   PMID:17698050   PMID:17720772   PMID:17805973   PMID:17822405   PMID:17890845   PMID:17906102   PMID:17928626   PMID:17936747   PMID:17942284   PMID:17945186  
PMID:17960568   PMID:17965278   PMID:17984113   PMID:17991709   PMID:17996850   PMID:18006605   PMID:18039182   PMID:18077694   PMID:18084034   PMID:18096574   PMID:18163378   PMID:18177419  
PMID:18185106   PMID:18187539   PMID:18195168   PMID:18208547   PMID:18210138   PMID:18306298   PMID:18313047   PMID:18330685   PMID:18338254   PMID:18339311   PMID:18357518   PMID:18367547  
PMID:18373519   PMID:18407464   PMID:18411006   PMID:18414498   PMID:18434506   PMID:18460465   PMID:18460826   PMID:18463245   PMID:18499741   PMID:18535289   PMID:18536752   PMID:18571434  
PMID:18573356   PMID:18604197   PMID:18615585   PMID:18632735   PMID:18635668   PMID:18650426   PMID:18653716   PMID:18664382   PMID:18667434   PMID:18723505   PMID:18723771   PMID:18725270  
PMID:18757484   PMID:18768402   PMID:18768926   PMID:18769070   PMID:18775851   PMID:18783396   PMID:18785628   PMID:18794356   PMID:18824646   PMID:18832099   PMID:18952607   PMID:18952847  
PMID:18975057   PMID:18982462   PMID:19047410   PMID:19111554   PMID:19151362   PMID:19176891   PMID:19177593   PMID:19194552   PMID:19238810   PMID:19249349   PMID:19279034   PMID:19286949  
PMID:19295173   PMID:19298845   PMID:19327173   PMID:19356729   PMID:19389804   PMID:19403379   PMID:19404732   PMID:19427362   PMID:19437547   PMID:19438724   PMID:19447520   PMID:19494114  
PMID:19505325   PMID:19531493   PMID:19531642   PMID:19539699   PMID:19544110   PMID:19560459   PMID:19570883   PMID:19638304   PMID:19684181   PMID:19728154   PMID:19787459   PMID:19885844  
PMID:19901158   PMID:19910580   PMID:19948989   PMID:19996110   PMID:20039534   PMID:20044047   PMID:20053668   PMID:20056918   PMID:20074256   PMID:20105174   PMID:20139360   PMID:20180400  
PMID:20181592   PMID:20181831   PMID:20333648   PMID:20369692   PMID:20383584   PMID:20398468   PMID:20404059   PMID:20518702   PMID:20536329   PMID:20554783   PMID:20568456   PMID:20568963  
PMID:20661302   PMID:20669351   PMID:20714296   PMID:20725141   PMID:20807796   PMID:20808940   PMID:20821260   PMID:20822476   PMID:20851839   PMID:21075822   PMID:21090343   PMID:21104457  
PMID:21106911   PMID:21134288   PMID:21151572   PMID:21162283   PMID:21166678   PMID:21168220   PMID:21178121   PMID:21180072   PMID:21196724   PMID:21246051   PMID:21251262   PMID:21302440  
PMID:21367774   PMID:21368416   PMID:21408155   PMID:21449613   PMID:21468590   PMID:21474451   PMID:21487005   PMID:21531765   PMID:21558470   PMID:21660462   PMID:21660950   PMID:21666544  
PMID:21677150   PMID:21701583   PMID:21819443   PMID:21822733   PMID:21863308   PMID:21871514   PMID:21909393   PMID:21917714   PMID:21929693   PMID:21943492   PMID:22116522   PMID:22198514  
PMID:22227582   PMID:22280975   PMID:22304864   PMID:22349022   PMID:22363435   PMID:22366512   PMID:22379036   PMID:22407386   PMID:22451653   PMID:22454534   PMID:22465949   PMID:22479579  
PMID:22493236   PMID:22508518   PMID:22521290   PMID:22521762   PMID:22543102   PMID:22618309   PMID:22659623   PMID:22702339   PMID:22705154   PMID:22724288   PMID:22784206   PMID:22797318  
PMID:22811014   PMID:22827283   PMID:22851861   PMID:22878563   PMID:22886408   PMID:22890232   PMID:22913624   PMID:22960015   PMID:23055268   PMID:23109389   PMID:23184662   PMID:23192020  
PMID:23219970   PMID:23242737   PMID:23328768   PMID:23374450   PMID:23376485   PMID:23438934   PMID:23450427   PMID:23484128   PMID:23500014   PMID:23518767   PMID:23526217   PMID:23546948  
PMID:23564451   PMID:23576434   PMID:23610142   PMID:23611777   PMID:23611784   PMID:23680829   PMID:23686869   PMID:23712012   PMID:23715865   PMID:23720316   PMID:23847209   PMID:23880531  
PMID:23987506   PMID:24001592   PMID:24049436   PMID:24136195   PMID:24182621   PMID:24225419   PMID:24228599   PMID:24349514   PMID:24358311   PMID:24411019   PMID:24431450   PMID:24467360  
PMID:24498195   PMID:24550275   PMID:24555431   PMID:24562313   PMID:24567082   PMID:24634418   PMID:24761931   PMID:24835217   PMID:24908085   PMID:25008120   PMID:25100655   PMID:25107837  
PMID:25118288   PMID:25162639   PMID:25170617   PMID:25178280   PMID:25245272   PMID:25246357   PMID:25280940   PMID:25281485   PMID:25352744   PMID:25450615   PMID:25517116   PMID:25601753  
PMID:25624461   PMID:25636810   PMID:25639353   PMID:25695672   PMID:25697003   PMID:25736434   PMID:25800444   PMID:26006040   PMID:26022182   PMID:26075533   PMID:26088607   PMID:26116232  
PMID:26132046   PMID:26138882   PMID:26267534   PMID:26303491   PMID:26363522   PMID:26371374   PMID:26375174   PMID:26398857   PMID:26415098   PMID:26435497   PMID:26467923   PMID:26491907  
PMID:26514923   PMID:26549199   PMID:26573710   PMID:26574547   PMID:26617793   PMID:26636577   PMID:26742689   PMID:26754294   PMID:26827493   PMID:26858248   PMID:26996940   PMID:27009047  
PMID:27025157   PMID:27068861   PMID:27091075   PMID:27118769   PMID:27145370   PMID:27212270   PMID:27351177   PMID:27492718   PMID:27693962   PMID:27796752   PMID:27835878   PMID:27837432  
PMID:27924795   PMID:28017206   PMID:28158734   PMID:28216156   PMID:28230313   PMID:28272757   PMID:28278052   PMID:28295305   PMID:28494959   PMID:28579512   PMID:28623179   PMID:28688765  
PMID:28730748   PMID:28738742   PMID:28758954   PMID:28836382   PMID:28839270   PMID:28987634   PMID:29101749   PMID:29441602   PMID:29466698   PMID:29592783   PMID:29631367   PMID:29742816  
PMID:29845273   PMID:29901080   PMID:30053369   PMID:30138615   PMID:30907619   PMID:31135041   PMID:31913744   PMID:32105707   PMID:32357304   PMID:32392404   PMID:32643366   PMID:33448307  
PMID:33881378   PMID:34151707   PMID:34204888   PMID:34316004   PMID:35499794   PMID:35982617   PMID:36122168   PMID:36282438   PMID:36890454   PMID:37000151   PMID:37338759   PMID:38791516  
PMID:39285628  


Genomics

Comparative Map Data
Mapk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81197,462,025 - 97,529,193 (-)NCBIGRCr8
mRatBN7.21183,957,813 - 84,023,629 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1183,957,813 - 84,023,616 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1192,681,387 - 92,746,630 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01185,342,529 - 85,407,764 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01184,396,110 - 84,461,350 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01188,203,863 - 88,273,301 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1188,211,599 - 88,273,254 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01191,260,412 - 91,325,570 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41185,968,732 - 86,030,387 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11186,009,328 - 86,070,984 (-)NCBI
Celera1182,713,470 - 82,779,260 (-)NCBICelera
Cytogenetic Map11q23NCBI
MAPK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382221,759,657 - 21,867,680 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2221,759,657 - 21,867,680 (-)EnsemblGRCh38hg38GRCh38
GRCh372222,113,946 - 22,221,970 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362220,443,946 - 20,551,970 (-)NCBINCBI36Build 36hg18NCBI36
Build 342220,447,885 - 20,546,524NCBI
Celera225,931,476 - 6,039,519 (-)NCBICelera
Cytogenetic Map22q11.22NCBI
HuRef225,071,209 - 5,179,617 (-)NCBIHuRef
CHM1_12222,114,127 - 22,222,150 (-)NCBICHM1_1
T2T-CHM13v2.02222,173,148 - 22,281,196 (-)NCBIT2T-CHM13v2.0
Mapk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391616,801,246 - 16,865,317 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1616,801,246 - 16,865,317 (+)EnsemblGRCm39 Ensembl
GRCm381616,983,382 - 17,047,453 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1616,983,382 - 17,047,453 (+)EnsemblGRCm38mm10GRCm38
MGSCv371616,983,475 - 17,047,546 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361616,896,945 - 16,961,016 (+)NCBIMGSCv36mm8
Celera1617,555,561 - 17,620,101 (+)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1610.53NCBI
Mapk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544217,284,232 - 17,380,020 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544217,284,232 - 17,380,026 (+)NCBIChiLan1.0ChiLan1.0
MAPK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22331,305,712 - 31,412,963 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12233,856,753 - 33,961,672 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0223,883,119 - 3,990,368 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12220,365,480 - 20,412,561 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2220,365,487 - 20,450,335 (-)Ensemblpanpan1.1panPan2
MAPK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12631,013,607 - 31,132,998 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2631,013,607 - 31,132,998 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2630,970,465 - 31,089,387 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02632,419,917 - 32,539,219 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2632,418,294 - 32,539,230 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12630,468,306 - 30,587,833 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02630,092,195 - 30,211,589 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02631,182,673 - 31,302,626 (-)NCBIUU_Cfam_GSD_1.0
Mapk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118140,821,508 - 140,866,521 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366191,889,708 - 1,932,646 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366191,889,841 - 1,932,646 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAPK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1450,082,896 - 50,165,513 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11450,083,079 - 50,165,528 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21453,590,429 - 53,613,224 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MAPK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1194,246,144 - 4,352,648 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl194,246,122 - 4,353,325 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660852,649,654 - 2,756,271 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mapk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247471,296,221 - 1,389,757 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247471,296,062 - 1,389,674 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mapk1
252 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:306
Count of miRNA genes:181
Interacting mature miRNAs:230
Transcripts:ENSRNOT00000002533
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116642214886241447Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116642214886241447Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat

Markers in Region
BI279621  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21183,966,149 - 83,966,329 (+)MAPPERmRatBN7.2
Rnor_6.01188,215,832 - 88,216,011NCBIRnor6.0
Rnor_5.01191,268,115 - 91,268,294UniSTSRnor5.0
RGSC_v3.41185,972,965 - 85,973,144UniSTSRGSC3.4
Celera1182,721,807 - 82,721,986UniSTS
RH 3.4 Map11691.12UniSTS
Cytogenetic Map11q23UniSTS
RH126332  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21183,960,756 - 83,960,999 (+)MAPPERmRatBN7.2
Rnor_6.01188,210,439 - 88,210,681NCBIRnor6.0
Rnor_5.01191,262,722 - 91,262,964UniSTSRnor5.0
RGSC_v3.41185,967,572 - 85,967,814UniSTSRGSC3.4
Celera1182,716,414 - 82,716,656UniSTS
Cytogenetic Map11q23UniSTS
AW742788  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21183,960,592 - 83,960,839 (+)MAPPERmRatBN7.2
Rnor_6.01188,210,275 - 88,210,521NCBIRnor6.0
Rnor_5.01191,262,558 - 91,262,804UniSTSRnor5.0
RGSC_v3.41185,967,408 - 85,967,654UniSTSRGSC3.4
Celera1182,716,250 - 82,716,496UniSTS
Cytogenetic Map11q23UniSTS
RH133391  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21183,960,747 - 83,960,949 (+)MAPPERmRatBN7.2
Rnor_6.01188,210,430 - 88,210,631NCBIRnor6.0
Rnor_5.01191,262,713 - 91,262,914UniSTSRnor5.0
RGSC_v3.41185,967,563 - 85,967,764UniSTSRGSC3.4
Celera1182,716,405 - 82,716,606UniSTS
RH 3.4 Map11726.22UniSTS
Cytogenetic Map11q23UniSTS
RH142687  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21184,015,358 - 84,015,473 (+)MAPPERmRatBN7.2
Rnor_6.01188,265,037 - 88,265,151NCBIRnor6.0
Rnor_5.01191,317,318 - 91,317,432UniSTSRnor5.0
RGSC_v3.41186,022,172 - 86,022,286UniSTSRGSC3.4
Celera1182,771,003 - 82,771,117UniSTS
RH 3.4 Map11726.62UniSTS
Cytogenetic Map11q23UniSTS
AW534207  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21183,977,223 - 83,977,373 (+)MAPPERmRatBN7.2
Rnor_6.01188,226,906 - 88,227,055NCBIRnor6.0
Rnor_5.01191,279,189 - 91,279,338UniSTSRnor5.0
RGSC_v3.41185,984,039 - 85,984,188UniSTSRGSC3.4
Celera1182,732,881 - 82,733,030UniSTS
RH 3.4 Map11728.92UniSTS
Cytogenetic Map11q23UniSTS
BF404647  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21184,021,834 - 84,021,964 (+)MAPPERmRatBN7.2
Rnor_6.01188,271,513 - 88,271,642NCBIRnor6.0
Rnor_5.01191,323,794 - 91,323,923UniSTSRnor5.0
RGSC_v3.41186,028,648 - 86,028,777UniSTSRGSC3.4
Celera1182,777,479 - 82,777,608UniSTS
RH 3.4 Map11724.52UniSTS
Cytogenetic Map11q23UniSTS
RH136232  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21183,960,748 - 83,960,962 (+)MAPPERmRatBN7.2
Rnor_6.01188,210,431 - 88,210,644NCBIRnor6.0
Rnor_5.01191,262,714 - 91,262,927UniSTSRnor5.0
RGSC_v3.41185,967,564 - 85,967,777UniSTSRGSC3.4
Celera1182,716,406 - 82,716,619UniSTS
Cytogenetic Map11q23UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000002533   ⟹   ENSRNOP00000002533
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1183,957,813 - 84,023,616 (-)Ensembl
Rnor_6.0 Ensembl1188,211,599 - 88,273,254 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111524   ⟹   ENSRNOP00000086878
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1183,957,813 - 84,023,521 (-)Ensembl
RefSeq Acc Id: NM_053842   ⟹   NP_446294
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81197,462,025 - 97,527,825 (-)NCBI
mRatBN7.21183,957,813 - 84,023,616 (-)NCBI
Rnor_6.01188,207,495 - 88,273,294 (-)NCBI
Rnor_5.01191,260,412 - 91,325,570 (-)NCBI
RGSC_v3.41185,968,732 - 86,030,387 (-)RGD
Celera1182,713,470 - 82,779,260 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006248658   ⟹   XP_006248720
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81197,462,659 - 97,527,855 (-)NCBI
mRatBN7.21183,958,447 - 84,023,629 (-)NCBI
Rnor_6.01188,208,129 - 88,273,300 (-)NCBI
Rnor_5.01191,260,412 - 91,325,570 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006248659   ⟹   XP_006248721
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81197,469,371 - 97,527,845 (-)NCBI
mRatBN7.21183,962,134 - 84,023,629 (-)NCBI
Rnor_6.01188,214,846 - 88,273,301 (-)NCBI
Rnor_5.01191,260,412 - 91,325,570 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063270242   ⟹   XP_063126312
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81197,462,659 - 97,529,193 (-)NCBI
RefSeq Acc Id: NP_446294   ⟸   NM_053842
- UniProtKB: P63086 (UniProtKB/Swiss-Prot),   A6JSN9 (UniProtKB/TrEMBL),   A0A8I6A252 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248720   ⟸   XM_006248658
- Peptide Label: isoform X1
- UniProtKB: P63086 (UniProtKB/Swiss-Prot),   A6JSN9 (UniProtKB/TrEMBL),   A0A8I6A252 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248721   ⟸   XM_006248659
- Peptide Label: isoform X1
- UniProtKB: P63086 (UniProtKB/Swiss-Prot),   A6JSN9 (UniProtKB/TrEMBL),   A0A8I6A252 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000002533   ⟸   ENSRNOT00000002533
Ensembl Acc Id: ENSRNOP00000086878   ⟸   ENSRNOT00000111524
RefSeq Acc Id: XP_063126312   ⟸   XM_063270242
- Peptide Label: isoform X1
- UniProtKB: P63086 (UniProtKB/Swiss-Prot),   A6JSN9 (UniProtKB/TrEMBL),   A0A8I6A252 (UniProtKB/TrEMBL)
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P63086-F1-model_v2 AlphaFold P63086 1-358 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698339
Promoter ID:EPDNEW_R8864
Type:multiple initiation site
Name:Mapk1_1
Description:mitogen activated protein kinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01188,273,291 - 88,273,351EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70500 AgrOrtholog
BioCyc Gene G2FUF-20565 BioCyc
Ensembl Genes ENSRNOG00000001849 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000002533 ENTREZGENE
  ENSRNOT00000002533.8 UniProtKB/Swiss-Prot
Gene3D-CATH Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot
  MAP_kinase UniProtKB/Swiss-Prot
  MAP_kinase_CS UniProtKB/Swiss-Prot
  MAPK_ERK1/2 UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
KEGG Report rno:116590 UniProtKB/Swiss-Prot
NCBI Gene 116590 ENTREZGENE
PANTHER MITOGEN-ACTIVATED PROTEIN KINASE UniProtKB/Swiss-Prot
Pfam Pkinase UniProtKB/Swiss-Prot
PharmGKB MAPK1 RGD
PhenoGen Mapk1 PhenoGen
PRINTS ERK1ERK2MAPK UniProtKB/Swiss-Prot
PROSITE MAPK UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000001849 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
UniProt A0A8I6A252 ENTREZGENE, UniProtKB/TrEMBL
  A6JSN9 ENTREZGENE, UniProtKB/TrEMBL
  MK01_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary P27703 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Mapk1  mitogen activated protein kinase 1      Symbol and Name status set to approved 629479 APPROVED
2002-06-10 Mapk1  mitogen activated protein kinase 1      Symbol and Name status set to provisional 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization enters the nucleus by diffusion without binding to a carrier 625413
gene_disease active in breast cancer cells 625413
gene_disease G-alpha-q/11 mediates Mapk signaling in the ischemic hippocampus 70672
gene_expression expression in cardiac ventricle decreases 20-50 days after birth 70317
gene_expression protein specific activity decreases with age 70317
gene_expression expressed in all tissues 70317
gene_expression carbachol, a muscarinic antagonist, increases phosphorylation of Mapk3/Mapk1 in contra lateral hippocampus but not in ipsilateral hippocampus 70672
gene_function phosphorylates protein serine/threonine residues 70317
gene_pathway estrogen-mediated activation of the Erk/MAP kinase pathway immediately affects NMDA receptors and long term potentiation (LTP) 70572
gene_pathway 17 beta estradiol activates the extracellular regulated kinase/mitogen-activated protein kinase pathway at cellular level 70572
gene_process functions in mitogenic signaling, activation is associated with cardiomyocyte hypertrophy 70317
gene_process mediates long-term memory and long-term potentiation (LTP) 631303
gene_process translocation to the nucleus is associated with the induction of late long-term potentiation (LTP); translocation activates transcription of immediate early genes (IEGs) after plasticity-inducing stimulation of neurons 631303
gene_product 41 kDa protein 625413
gene_regulation activated protein undergoes nuclear translocation for phosphorylation 70672
gene_regulation downregulation by ovariectomy 70572
gene_regulation activated by estrogen and progestins 625452
gene_regulation activated by Map2k1, Mek2 phosphorylation; nitric oxide enhances phosphorylation 70310
gene_regulation activated by Endothelin-1 (ET-1)in glomerular mesangial cells 727457
gene_regulation 1-alpha,25-dihydroxyvitamin D3 (1a,25-(OH)2D3) increases the kinase activity via phospholipase C in growth zone (GC) cells of growth plate chondrocytes 631303
gene_regulation activation requires platelet-derived growth factor (PDGF)-BB binding with platelet-derived growth factor receptor beta (Pdgrfb), but no activation is observed when there is ligand induced phosphorylation of the receptor 631303
gene_regulation 24R,25-dihydroxyvitamin D3 (24R,25-(OH)2D3) increases kinase activity via phospholipase D in resting zone (RC) cells 631303
gene_regulation induced by glutamate, acetylcholine, and BDNF in neurons 631303
gene_regulation ouabain induces activation in cardiac myocytes 631303