Mapk14 (mitogen activated protein kinase 14) - Rat Genome Database

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Gene: Mapk14 (mitogen activated protein kinase 14) Rattus norvegicus
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Symbol: Mapk14
Name: mitogen activated protein kinase 14
RGD ID: 70496
Description: Enables ATP binding activity and MAP kinase activity. Involved in several processes, including cellular response to transforming growth factor beta stimulus; protein autophosphorylation; and stress-activated MAPK cascade. Predicted to be located in mitochondrion; nuclear speck; and spindle pole. Predicted to be active in cytosol; glutamatergic synapse; and nucleus. Used to study diabetic neuropathy and osteoporosis. Biomarker of Alzheimer's disease; anti-basement membrane glomerulonephritis; and interstitial cystitis. Human ortholog(s) of this gene implicated in colon cancer; colorectal carcinoma; nasopharynx carcinoma; and rectum cancer. Orthologous to human MAPK14 (mitogen-activated protein kinase 14); PARTICIPATES IN p38 MAPK signaling pathway; eicosanoid signaling pathway; endothelin signaling pathway; INTERACTS WITH (-)-anisomycin; (R)-lipoic acid; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CRK1; Csaids binding protein; CSBP; Csbp1; Csbp2; CSPB1; cytokine suppressive anti-inflammatory drug binding protein; cytokine-supressive anti-inflammatory drug binding protein; Exip; Hog; MAP kinase 14; MAP kinase 2; MAP kinase Mxi2; MAP kinase p38 alpha; MAPK 14; MAX-interacting protein 2; MGC105413; mitogen-activated protein kinase 14; mitogen-activated protein kinase 14A; mitogen-activated protein kinase p38 alpha; Mxi2; p38; p38 MAP kinase; p38 mitogen activated protein kinase; p38alpha; p38alpha Exip; p38Hog; Prkm14; Prkm15; reactive kinase; RK; Sapk2A; stress-activated protein kinase 2A
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8206,751,288 - 6,812,294 (+)NCBIGRCr8
GRCr8 Ensembl206,751,357 - 6,812,294 (+)EnsemblGRCr8 Ensembl
mRatBN7.2206,749,646 - 6,810,590 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl206,749,670 - 6,810,589 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx207,462,299 - 7,522,955 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0206,824,146 - 6,884,804 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0207,305,502 - 7,366,242 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0205,933,290 - 5,995,137 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl205,933,303 - 5,995,137 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0207,968,528 - 8,028,708 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4206,939,249 - 7,000,378 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera208,305,853 - 8,366,371 (+)NCBICelera
RGSC_v3.1206,939,475 - 7,000,605 (+)NCBI
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
Mapk14Ratalcohol use disorder  ISOMapk14 (Mus musculus)401959334protein:increased expression, increased phosphorylation:liverRGD 
Mapk14RatAlzheimer's disease  IEP 10047076mRNA:increased expression:frontal lobe cortex, hippocampus CA2 (rat)RGD 
Mapk14RatAlzheimer's disease treatmentISOMapk14 (Mus musculus)10047104 RGD 
Mapk14Ratamyotrophic lateral sclerosis  ISOMapk14 (Mus musculus)10412312protein:hyperphosphorylation:motor neuron:RGD 
Mapk14Ratanti-basement membrane glomerulonephritis  IEP 6218988 RGD 
Mapk14RatCarcinoma, Lewis Lung amelioratesISOMapk14 (Mus musculus)151665504mouse cell line in a mouse modelRGD 
Mapk14RatChronic Cerebral Hypoperfusion  ISOMapk14 (Mus musculus)10412307protein:hyperphosphorylation:corpus callosum, endothelial cell, astrocyte: RGD 
Mapk14Ratcognitive disorder  ISOMapk14 (Mus musculus)10412307associated with Chronic Cerebral Hypoperfusion;RGD 
Mapk14RatColitis-Associated Neoplasms amelioratesISOMapk14 (Mus musculus)151665504 RGD 
Mapk14RatColitis-Associated Neoplasms exacerbatesISOMapk14 (Mus musculus)151665506 RGD 
Mapk14RatColitis-Associated Neoplasms amelioratesISOMapk14 (Mus musculus)151665503 RGD 
Mapk14Ratcolon cancer susceptibilityISOMAPK14 (Homo sapiens)13217411DNA:SNP:intron: (rs851016) (human)RGD 
Mapk14Ratcolon cancer susceptibilityISOMAPK14 (Homo sapiens)150573807DNA:SNP:intron: (rs10807156) (human)RGD 
Mapk14Ratcolorectal cancer exacerbatesISOMapk14 (Mus musculus)151665346associated with experimental colitisRGD 
Mapk14Ratcolorectal carcinoma amelioratesISOMAPK14 (Homo sapiens)151665507human cell line in a mouse modelRGD 
Mapk14Ratcolorectal carcinoma amelioratesISOMAPK14 (Homo sapiens)151665508human cell line in a mouse modelRGD 
Mapk14Ratcolorectal carcinoma treatmentISOMAPK14 (Homo sapiens)151665352 RGD 
Mapk14RatDiabetic Nephropathies  ISOMapk14 (Mus musculus)2311566associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased activity:kidneyRGD 
Mapk14Ratdiabetic neuropathy  IDA 2311567associated with Diabetes Mellitus, ExperimentalRGD 
Mapk14RatDrug-Related Side Effects and Adverse Reactions susceptibilityISOMAPK14 (Homo sapiens)151665351associated with lung non-small cell carcinoma;DNA:SNP:3' utr, intron: (rs3804451) (human)RGD 
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Mapk14Ratproteasome-associated autoinflammatory syndrome 1  ISOMAPK14 (Homo sapiens)8554872ClinVar Annotator: match by term: Proteasome-associated autoinflammatory syndrome 1ClinVarPMID:28492532
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Mapk14Ratcardiomyopathy  ISOMAPK14 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:10620750
Mapk14Ratcholestasis  ISOMAPK14 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20626112
Mapk14Ratchronic myeloid leukemia  ISOMAPK14 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:16818652
Mapk14Ratextrahepatic cholestasis  ISOMAPK14 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:30026087
Mapk14RatHepatic Insufficiency  ISOMAPK14 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:30026087
Mapk14RatHepatomegaly  ISOMAPK14 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:30026087
Mapk14RatLiver Neoplasms  ISOMAPK14 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17468757
Mapk14RatLung Neoplasms  ISOMAPK14 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17468755
Mapk14RatMyocardial Ischemia  ISOMAPK14 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16214533
Mapk14Ratprimary biliary cholangitis  ISOMAPK14 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:30026087
Mapk14Ratpulmonary edema  ISOMAPK14 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:39142713
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Mapk14Rat(+)-catechin multiple interactionsISOMapk14 (Mus musculus)6480464Catechin binds to and results in decreased activity of MAPK14 protein; Catechin inhibits the reaction more ...CTDPMID:30453148
Mapk14Rat(-)-anisomycin multiple interactionsISOMAPK14 (Homo sapiens)6480464Anisomycin results in increased phosphorylation of and results in increased activity of MAPK14 proteinCTDPMID:16364386
Mapk14Rat(-)-anisomycin increases phosphorylationISOMapk14 (Mus musculus)6480464Anisomycin results in increased phosphorylation of MAPK14 proteinCTDPMID:10704466|PMID:16038797
Mapk14Rat(-)-anisomycin multiple interactionsISOMapk14 (Mus musculus)6480464MAPK14 protein affects the reaction [Anisomycin results in increased activity of MAPKAPK2 protein]CTDPMID:10704466
Mapk14Rat(-)-anisomycin multiple interactionsEXP 6480464Anisomycin results in increased phosphorylation of and results in increased activity of MAPK14 proteinCTDPMID:15961565
Mapk14Rat(-)-epigallocatechin 3-gallate multiple interactionsISOMAPK14 (Homo sapiens)6480464[epigallocatechin gallate co-treated with Celecoxib] results in increased activity of MAPK14 protein; [potassium chromate(VI) co-treated more ...CTDPMID:16463383|PMID:22079256
Mapk14Rat(-)-epigallocatechin 3-gallate increases expressionISOMAPK14 (Homo sapiens)6480464epigallocatechin gallate results in increased expression of MAPK14 mRNACTDPMID:35701726
Mapk14Rat(1->4)-beta-D-glucan multiple interactionsISOMapk14 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of MAPK14 mRNACTDPMID:36331819
Mapk14Rat(R)-lipoic acid multiple interactionsEXP 6480464[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of MAPK14 mRNACTDPMID:23830814
Mapk14Rat(R,R,R)-alpha-tocopherol multiple interactionsISOMAPK14 (Homo sapiens)6480464alpha-Tocopherol inhibits the reaction [[4-hydroxy-2-nonenal co-treated with Hydrogen Peroxide] results in increased activity of MAPK14 more ...CTDPMID:12684028|PMID:14645110
Mapk14Rat(R,R,R)-alpha-tocopherol multiple interactionsISOMapk14 (Mus musculus)6480464alpha-Tocopherol inhibits the reaction [[Ovalbumin co-treated with Ozone] results in increased phosphorylation of MAPK14 protein]CTDPMID:29284473
Mapk14Rat1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane multiple interactionsISOMAPK14 (Homo sapiens)6480464MAPK14 protein promotes the reaction [o,p'-DDT results in increased activity of NOTCH1 protein]CTDPMID:18791200
Mapk14Rat1,2-dimethylhydrazine decreases expressionEXP 64804641,2-Dimethylhydrazine results in decreased expression of MAPK14 mRNACTDPMID:32387197
Mapk14Rat1,2-dimethylhydrazine decreases expressionISOMapk14 (Mus musculus)64804641,2-Dimethylhydrazine results in decreased expression of MAPK14 mRNACTDPMID:22206623
Mapk14Rat1-[(2,3,4-trimethoxyphenyl)methyl]piperazine multiple interactionsISOMapk14 (Mus musculus)6480464Trimetazidine inhibits the reaction [Paclitaxel results in increased phosphorylation of MAPK14 protein]CTDPMID:36898573
Mapk14Rat1-chloro-2,4-dinitrobenzene increases phosphorylationISOMAPK14 (Homo sapiens)6480464Dinitrochlorobenzene results in increased phosphorylation of MAPK14 proteinCTDPMID:15737199
Mapk14Rat1-chloro-2,4-dinitrobenzene affects bindingISOMAPK14 (Homo sapiens)6480464Dinitrochlorobenzene binds to MAPK14 proteinCTDPMID:32991956
Mapk14Rat1-fluoro-2,4-dinitrobenzene increases phosphorylationISOMAPK14 (Homo sapiens)6480464Dinitrofluorobenzene results in increased phosphorylation of MAPK14 proteinCTDPMID:19427879
Mapk14Rat1-nitropyrene increases phosphorylationISOMAPK14 (Homo sapiens)64804641-nitropyrene results in increased phosphorylation of MAPK14 proteinCTDPMID:37993079
Mapk14Rat17alpha-ethynylestradiol increases expressionISOMapk14 (Mus musculus)6480464Ethinyl Estradiol results in increased expression of MAPK14 mRNACTDPMID:17942748

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Biological Process
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Mapk14Ratangiogenesis acts_upstream_of_or_withinIEAUniProtKB:P47811|ensembl:ENSMUSP000000049901600115GO_REF:0000107EnsemblGO_REF:0000107
Mapk14Ratangiogenesis acts_upstream_of_or_withinISOMapk14 (Mus musculus)1624291MGI:2177832 PMID:10973481RGDPMID:10973481
Mapk14Ratapoptotic process involved_inIEAUniProtKB-KW:KW-00531600115GO_REF:0000043UniProtGO_REF:0000043
Mapk14Ratbone development involved_inIEAUniProtKB:P47811|ensembl:ENSMUSP000000049901600115GO_REF:0000107EnsemblGO_REF:0000107
Mapk14Ratbone development involved_inISOMapk14 (Mus musculus)1624291MGI:3696052 PMID:20551513RGDPMID:20551513
Mapk14Ratcartilage condensation involved_inIEAUniProtKB:P47811|ensembl:ENSMUSP000000049901600115GO_REF:0000107EnsemblGO_REF:0000107
Mapk14Ratcartilage condensation involved_inISOMapk14 (Mus musculus)1624291 PMID:17202865RGDPMID:17202865
Mapk14Ratcell morphogenesis acts_upstream_of_or_withinIEAUniProtKB:P47811|ensembl:ENSMUSP000000049901600115GO_REF:0000107EnsemblGO_REF:0000107
Mapk14Ratcell morphogenesis acts_upstream_of_or_withinISOMapk14 (Mus musculus)1624291MGI:107708 PMID:17686994RGDPMID:17686994
Mapk14Ratcell surface receptor protein serine/threonine kinase signaling pathway acts_upstream_of_or_withinISOMapk14 (Mus musculus)1624291MGI:107191|MGI:1927616|MGI:95688 PMID:18363966RGDPMID:18363966
Mapk14Ratcell surface receptor protein serine/threonine kinase signaling pathway acts_upstream_of_or_withinIEAUniProtKB:P47811|ensembl:ENSMUSP000000049901600115GO_REF:0000107EnsemblGO_REF:0000107
Mapk14Ratcellular response to acetaldehyde  IEP 598108049 RGD 
Mapk14Ratcellular response to ionizing radiation involved_inIEAUniProtKB:Q16539|ensembl:ENSP000002297941600115GO_REF:0000107EnsemblGO_REF:0000107
Mapk14Ratcellular response to ionizing radiation involved_inISOMAPK14 (Homo sapiens)1624291 PMID:20160708RGDPMID:20160708
Mapk14Ratcellular response to lipopolysaccharide acts_upstream_of_or_withinISOMAPK14 (Homo sapiens)1624291 PMID:23776175RGDPMID:23776175
Mapk14Ratcellular response to lipopolysaccharide acts_upstream_of_or_withinIEAUniProtKB:Q16539|ensembl:ENSP000002297941600115GO_REF:0000107EnsemblGO_REF:0000107
Mapk14Ratcellular response to lipoteichoic acid involved_inISOMAPK14 (Homo sapiens)1624291 PMID:26649771RGDPMID:26649771
Mapk14Ratcellular response to lipoteichoic acid involved_inIEAUniProtKB:Q16539|ensembl:ENSP000002297941600115GO_REF:0000107EnsemblGO_REF:0000107
Mapk14Ratcellular response to transforming growth factor beta stimulus  IEP 401794430 RGD 
Mapk14Ratcellular response to tumor necrosis factor acts_upstream_of_or_withinIEAUniProtKB:P47811|ensembl:ENSMUSP000000049901600115GO_REF:0000107EnsemblGO_REF:0000107
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Cellular Component
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Mapk14Ratcytoplasm located_inIEAUniProtKB:P47811|ensembl:ENSMUSP000000049901600115GO_REF:0000107EnsemblGO_REF:0000107
Mapk14Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Mapk14Ratcytoplasm located_inISOMapk14 (Mus musculus)1624291 PMID:10601328, PMID:15304486RGDPMID:10601328|PMID:15304486
Mapk14Ratcytoplasm located_inISSUniProtKB:P478118554361PMID:10601328UniProt 
Mapk14Ratcytoplasm is_active_inIBACGD:CAL0000197240|FB:FBgn0003256|FB:FBgn0052703|FB:FBgn0267339|MGI:1338024|MGI:1346347|MGI:1346858|MGI:1346859|MGI:1346861|MGI:1346862|MGI:1346863|MGI:1346865|MGI:1354946|MGI:2444559|MGI:96913|PANTHER:PTN000622075|PomBase:SPAC24B11.06c|PomBase:SPBC119.08|RGD:3046|RGD:3663|RGD:621506|RGD:628847|RGD:70500|RGD:70975|RGD:71050|SGD:S000000112|SGD:S000001072|SGD:S000004103|TAIR:locus:2024887|TAIR:locus:2043904|TAIR:locus:2085632|TAIR:locus:2092717|TAIR:locus:2124943|UniProtKB:A0A0A7R535|UniProtKB:A0A1L8FXY5|UniProtKB:A9T142|UniProtKB:P20794|UniProtKB:P27361|UniProtKB:P28482|UniProtKB:P45984|UniProtKB:Q10N20|UniProtKB:Q13164|UniProtKB:Q16539|UniProtKB:Q16659|UniProtKB:Q586V3|UniProtKB:Q8TD08|WB:WBGene00002178|WB:WBGene00002187|WB:WBGene00003048|WB:WBGene00003401|WB:WBGene00004055|WB:WBGene00004056|WB:WBGene00004057|WB:WBGene00015478|dictyBase:DDB_G0283903|dictyBase:DDB_G02863531600115GO_REF:0000033GO_CentralGO_REF:0000033
Mapk14Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Mapk14Ratcytoplasm located_inIEAARBA:ARBA000269711600115GO_REF:0000117UniProtGO_REF:0000117
Mapk14Ratcytosol is_active_inISOMAPK14 (Homo sapiens)1624291 PMID:7535770RGDPMID:7535770
Mapk14Ratcytosol located_inISOMapk14 (Mus musculus)1624291 PMID:11884367RGDPMID:11884367
Mapk14Ratcytosol located_inTAS 1600115Reactome:R-RNO-187682ReactomeReactome:R-RNO-187682
Mapk14Ratcytosol located_inIEAUniProtKB:P47811|ensembl:ENSMUSP000000049901600115GO_REF:0000107EnsemblGO_REF:0000107
Mapk14Ratcytosol is_active_inISOMapk14 (Mus musculus)1624291 PMID:21976273RGDPMID:21976273
Mapk14Ratcytosol is_active_inIEAUniProtKB:Q16539|ensembl:ENSP000002297941600115GO_REF:0000107EnsemblGO_REF:0000107
Mapk14Ratcytosol located_inISORGD:619564|UniProtKB:Q16539-1|UniProtKB:Q16539-21624291 RGDGO_REF:0000052
Mapk14Ratglutamatergic synapse is_active_inISOMapk14 (Mus musculus)1624291 PMID:17988630RGDPMID:17988630
Mapk14Ratglutamatergic synapse is_active_inIEAUniProtKB:P47811|ensembl:ENSMUSP000000049901600115GO_REF:0000107EnsemblGO_REF:0000107
Mapk14Ratmitochondrion located_inIEAUniProtKB:P47811|ensembl:ENSMUSP000000049901600115GO_REF:0000107EnsemblGO_REF:0000107
Mapk14Ratmitochondrion located_inISOMapk14 (Mus musculus)1624291 PMID:11884367RGDPMID:11884367
Mapk14Ratnuclear speck located_inIEAUniProtKB:Q16539|ensembl:ENSP000002297941600115GO_REF:0000107EnsemblGO_REF:0000107
Mapk14Ratnuclear speck located_inISORGD:619564|UniProtKB:Q16539-1|UniProtKB:Q16539-21624291 RGDGO_REF:0000052
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Molecular Function
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Mapk14RatATP binding  IDA 2298806 RGD 
Mapk14RatATP binding enablesIEAInterPro:IPR000719|InterPro:IPR008352|InterPro:IPR0174411600115GO_REF:0000002InterProGO_REF:0000002
Mapk14RatATP binding enablesIEAUniProtKB-KW:KW-00671600115GO_REF:0000043UniProtGO_REF:0000043
Mapk14RatATP binding enablesIEAInterPro:IPR000719|InterPro:IPR003527|InterPro:IPR008352|InterPro:IPR0174411600115GO_REF:0000002InterProGO_REF:0000002
Mapk14RatATP binding enablesIEAUniRule:UR0015033411600115GO_REF:0000104UniProtGO_REF:0000104
Mapk14Ratenzyme binding enablesISOMAPK14 (Homo sapiens)1624291UniProtKB:Q99873 PMID:23483889RGDPMID:23483889
Mapk14Ratenzyme binding enablesIEAUniProtKB:Q16539|ensembl:ENSP000002297941600115GO_REF:0000107EnsemblGO_REF:0000107
Mapk14Ratkinase activity enablesIEAUniProtKB:P47811|ensembl:ENSMUSP000000049901600115GO_REF:0000107EnsemblGO_REF:0000107
Mapk14Ratkinase activity enablesISOMapk14 (Mus musculus)1624291 PMID:12808090, PMID:15767678RGDPMID:12808090|PMID:15767678
Mapk14Ratkinase activity enablesIEAUniProtKB-KW:KW-04181600115GO_REF:0000043UniProtGO_REF:0000043
Mapk14RatMAP kinase activity  IDA 5508182 RGD 
Mapk14RatMAP kinase activity enablesIEAUniProtKB:Q16539|ensembl:ENSP000002297941600115GO_REF:0000107EnsemblGO_REF:0000107
Mapk14RatMAP kinase activity enablesIEAInterPro:IPR003527|InterPro:IPR008352|InterPro:IPR0387841600115GO_REF:0000002InterProGO_REF:0000002
Mapk14RatMAP kinase activity enablesIEAUniProtKB:P47811|ensembl:ENSMUSP000000049901600115GO_REF:0000107EnsemblGO_REF:0000107
Mapk14RatMAP kinase activity enablesIEAEC:2.7.11.241600115GO_REF:0000003UniProtGO_REF:0000003
Mapk14RatMAP kinase activity enablesISOMAPK14 (Homo sapiens)1624291 PMID:10330143, PMID:20932473, PMID:7997261RGDPMID:10330143|PMID:20932473|PMID:7997261
Mapk14RatMAP kinase activity enablesISSUniProtKB:P478118554460PMID:7914033UniProt 
Mapk14RatMAP kinase activity enablesIEAInterPro:IPR0083521600115GO_REF:0000002InterProGO_REF:0000002
Mapk14RatMAP kinase activity enablesIEAInterPro:IPR003527|InterPro:IPR0083521600115GO_REF:0000002InterProGO_REF:0000002
Mapk14RatMAP kinase activity enablesISOMapk14 (Mus musculus)1624291 PMID:11593045, PMID:15304486, PMID:19289495, PMID:20551513, PMID:7914033RGDPMID:11593045|PMID:15304486|PMID:19289495|PMID:20551513|PMID:7914033
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RGD Manual Annotations


  
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Mapk14Ratp38 MAPK signaling pathway   IDA 1580544 RGD 
Mapk14Ratp38 MAPK signaling pathway   ISOMAPK14 (Homo sapiens)2293891 RGD 

Imported Annotations - SMPDB

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Mapk14RatFc epsilon receptor mediated signaling pathway  ISOMAPK14 (Homo sapiens)10402751 SMPDBSMP:00358

Imported Annotations - KEGG (archival)

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Reference Title
Reference Citation
1. Essential role of p38alpha MAP kinase in placental but not embryonic cardiovascular development. Adams RH, etal., Mol Cell 2000 Jul;6(1):109-16.
2. p38 MAPK down-regulates fibulin 3 expression through methylation of gene regulatory sequences: role in migration and invasion. Arechederra M, etal., J Biol Chem. 2015 Feb 13;290(7):4383-97. doi: 10.1074/jbc.M114.582239. Epub 2014 Dec 29.
3. Cyclic changes in estradiol regulate synaptic plasticity through the MAP kinase pathway. Bi R, etal., Proc Natl Acad Sci U S A 2001 Nov 6;98(23):13391-5.
4. A novel regulatory mechanism of MAP kinases activation and nuclear translocation mediated by PKA and the PTP-SL tyrosine phosphatase. Blanco-Aparicio C, etal., J Cell Biol. 1999 Dec 13;147(6):1129-36.
5. Prevention of trabecular bone loss induced by estrogen deficiency by a selective p38alpha inhibitor. Caverzasio J, etal., J Bone Miner Res. 2008 Sep;23(9):1389-97. doi: 10.1359/jbmr.080410.
6. Continuous delta-opioid receptor activation reduces neuronal voltage-gated sodium channel (NaV1.7) levels through activation of protein kinase C in painful diabetic neuropathy. Chattopadhyay M, etal., J Neurosci. 2008 Jun 25;28(26):6652-8.
7. Neuregulin-1-ErbB signaling promotes microglia activation contributing to mechanical allodynia of cyclophosphamide-induced cystitis. Chen JL, etal., Neurourol Urodyn. 2019 Jun;38(5):1250-1260. doi: 10.1002/nau.24005. Epub 2019 Apr 15.
8. The synthetic flavonoid WYC02-9 inhibits colorectal cancer cell growth through ROS-mediated activation of MAPK14 pathway. Chen YJ, etal., Life Sci. 2013 Jun 13;92(22):1081-92. doi: 10.1016/j.lfs.2013.04.007. Epub 2013 Apr 26.
9. p38 MAP-kinases pathway regulation, function and role in human diseases. Cuenda A and Rousseau S, Biochim Biophys Acta. 2007 Aug;1773(8):1358-75. Epub 2007 Mar 24.
10. Interaction of p38 and Sp1 in a mechanical force-induced, beta 1 integrin-mediated transcriptional circuit that regulates the actin-binding protein filamin-A. D'Addario M, etal., J Biol Chem 2002 Dec 6;277(49):47541-50.
11. Magnesium Lithospermate B Protects Cardiomyocytes from Ischemic Injury Via Inhibition of TAB1-p38 Apoptosis Signaling. Du CS, etal., Front Pharmacol. 2010;1:111. Epub 2010 Aug 24.
12. Rac and p38 kinase mediate 5-lipoxygenase translocation and cell death. Eom YW, etal., Biochem Biophys Res Commun 2001 Jun 1;284(1):126-32.
13. Inhibitory effect of baicalin on iNOS and NO expression in intestinal mucosa of rats with acute endotoxemia. Feng A, etal., PLoS One. 2013 Dec 2;8(12):e80997. doi: 10.1371/journal.pone.0080997. eCollection 2013.
14. Berberine hydrochloride attenuates cyclooxygenase-2 expression in rat small intestinal mucosa during acute endotoxemia. Feng AW, etal., Fitoterapia. 2011 May 27.
15. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
16. ATF-1 mediates protease-activated receptor-1 but not receptor tyrosine kinase-induced DNA synthesis in vascular smooth muscle cells.PG - Ghosh SK, etal., J Biol Chem 2002 Jun 14;277(24):21325-31.
17. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
18. Dual function of p38α MAPK in colon cancer: suppression of colitis-associated tumor initiation but requirement for cancer cell survival. Gupta J, etal., Cancer Cell. 2014 Apr 14;25(4):484-500. doi: 10.1016/j.ccr.2014.02.019. Epub 2014 Mar 27.
19. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Han J, etal., Science. 1994 Aug 5;265(5173):808-11.
20. Activation of the stress-activated MAP kinase, p38, but not JNK in cortical motor neurons during early presymptomatic stages of amyotrophic lateral sclerosis in transgenic mice. Holasek SS, etal., Brain Res. 2005 May 31;1045(1-2):185-98. Epub 2005 Apr 25.
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1 to 10 of 46 rows
PMID:7997261   PMID:9513091   PMID:9688607   PMID:10330143   PMID:10391943   PMID:10838079   PMID:10973481   PMID:11035004   PMID:11374881   PMID:11466386   PMID:11790788   PMID:11884367  
PMID:11884615   PMID:11989977   PMID:11994045   PMID:12076985   PMID:12076986   PMID:12091394   PMID:12096921   PMID:12181122   PMID:12225963   PMID:12349907   PMID:12369731   PMID:12409219  
PMID:12409227   PMID:12419320   PMID:12444545   PMID:12477932   PMID:12538734   PMID:12558602   PMID:12564765   PMID:12606350   PMID:12609991   PMID:12637564   PMID:12724128   PMID:12744493  
PMID:12800247   PMID:12802337   PMID:12808090   PMID:12808350   PMID:12837681   PMID:12842450   PMID:12849998   PMID:12857463   PMID:12869527   PMID:12872135   PMID:12876381   PMID:12881212  
PMID:12883833   PMID:12928445   PMID:12937170   PMID:12944406   PMID:12952860   PMID:12957486   PMID:12970901   PMID:14522818   PMID:14530261   PMID:14593093   PMID:14593211   PMID:14602083  
PMID:14606087   PMID:14617573   PMID:14631143   PMID:14633134   PMID:14645111   PMID:14648549   PMID:14660488   PMID:14752292   PMID:14762791   PMID:14764603   PMID:14962831   PMID:14970194  
PMID:14988658   PMID:15001568   PMID:15007040   PMID:15051668   PMID:15051723   PMID:15081310   PMID:15084475   PMID:15167682   PMID:15220210   PMID:15251176   PMID:15271927   PMID:15297444  
PMID:15304486   PMID:15309413   PMID:15365619   PMID:15465893   PMID:15489642   PMID:15509711   PMID:15539417   PMID:15545827   PMID:15590660   PMID:15591055   PMID:15617763   PMID:15634764  
PMID:15647278   PMID:15649892   PMID:15650391   PMID:15664670   PMID:15692051   PMID:15721267   PMID:15748291   PMID:15755725   PMID:15767678   PMID:15826721   PMID:15831522   PMID:15851690  
PMID:15857906   PMID:15883033   PMID:15890335   PMID:15896702   PMID:15937334   PMID:15948190   PMID:15948714   PMID:15994754   PMID:16014723   PMID:16037234   PMID:16040713   PMID:16043884  
1 to 10 of 46 rows



Mapk14
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8206,751,288 - 6,812,294 (+)NCBIGRCr8
GRCr8 Ensembl206,751,357 - 6,812,294 (+)EnsemblGRCr8 Ensembl
mRatBN7.2206,749,646 - 6,810,590 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl206,749,670 - 6,810,589 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx207,462,299 - 7,522,955 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0206,824,146 - 6,884,804 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0207,305,502 - 7,366,242 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0205,933,290 - 5,995,137 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl205,933,303 - 5,995,137 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0207,968,528 - 8,028,708 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4206,939,249 - 7,000,378 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera208,305,853 - 8,366,371 (+)NCBICelera
RGSC_v3.1206,939,475 - 7,000,605 (+)NCBI
Cytogenetic Map20p12NCBI
MAPK14
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38636,027,808 - 36,124,214 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl636,027,752 - 36,122,511 (+)EnsemblGRCh38hg38GRCh38
GRCh37635,995,585 - 36,079,013 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36636,103,551 - 36,186,513 (+)NCBINCBI36Build 36hg18NCBI36
Build 34636,103,550 - 36,186,513NCBI
Celera637,550,014 - 37,633,560 (+)NCBICelera
Cytogenetic Map6p21.31NCBI
HuRef635,715,466 - 35,798,847 (+)NCBIHuRef
CHM1_1635,997,235 - 36,080,771 (+)NCBICHM1_1
T2T-CHM13v2.0635,848,088 - 35,944,528 (+)NCBIT2T-CHM13v2.0
Mapk14
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391728,910,316 - 28,967,379 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1728,910,303 - 28,967,380 (+)EnsemblGRCm39 Ensembl
GRCm381728,691,342 - 28,748,405 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1728,691,329 - 28,748,406 (+)EnsemblGRCm38mm10GRCm38
MGSCv371728,828,287 - 28,885,350 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361728,419,034 - 28,475,994 (+)NCBIMGSCv36mm8
Celera1729,246,340 - 29,303,175 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1714.85NCBI
Mapk14
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554373,838,232 - 3,884,083 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554373,836,331 - 3,884,083 (+)NCBIChiLan1.0ChiLan1.0
MAPK14
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2550,493,097 - 50,588,368 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1646,363,113 - 46,457,826 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0635,586,847 - 35,683,041 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1636,788,233 - 36,871,114 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl636,788,233 - 36,871,114 (+)Ensemblpanpan1.1panPan2
MAPK14
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1125,145,647 - 5,221,558 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl125,146,037 - 5,220,603 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha125,166,000 - 5,239,239 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0125,493,681 - 5,569,596 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl125,493,440 - 5,569,596 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1125,148,463 - 5,221,682 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0125,227,753 - 5,300,687 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0125,327,755 - 5,400,924 (+)NCBIUU_Cfam_GSD_1.0
Mapk14
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494640,650,066 - 40,722,468 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647623,237,277 - 23,310,232 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647623,237,762 - 23,310,211 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAPK14
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl731,790,877 - 31,862,031 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1731,791,398 - 31,861,544 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2736,725,706 - 36,795,314 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MAPK14
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11736,012,164 - 36,095,542 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1736,014,454 - 36,095,138 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604435,975,418 - 36,065,487 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mapk14
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475421,527,333 - 21,597,733 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475421,528,121 - 21,598,064 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Mapk14
371 total Variants

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir24-1rno-miR-24-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI19499150

Predicted Target Of
Summary Value
Count of predictions:1030
Count of miRNA genes:299
Interacting mature miRNAs:389
Transcripts:ENSRNOT00000000617, ENSRNOT00000000618
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 23 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20126123605Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20460660717617956Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)20362164910078919Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat

1 to 10 of 23 rows
RH134442  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2206,807,058 - 6,807,257 (+)MAPPERmRatBN7.2
Rnor_6.0205,991,611 - 5,991,809NCBIRnor6.0
Rnor_5.0208,025,182 - 8,025,380UniSTSRnor5.0
RGSC_v3.4206,996,847 - 6,997,045UniSTSRGSC3.4
Celera208,362,840 - 8,363,038UniSTS
RH 3.4 Map2077.1UniSTS
Cytogenetic Map20p12UniSTS
RH144423  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2206,760,549 - 6,760,820 (+)MAPPERmRatBN7.2
Rnor_6.0205,944,184 - 5,944,454NCBIRnor6.0
Rnor_5.0207,979,420 - 7,979,690UniSTSRnor5.0
RGSC_v3.4206,950,132 - 6,950,402UniSTSRGSC3.4
Celera208,316,740 - 8,317,010UniSTS
RH 3.4 Map2077.8UniSTS
Cytogenetic Map20p12UniSTS
RH141341  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2206,810,320 - 6,810,537 (+)MAPPERmRatBN7.2
Rnor_6.0205,994,868 - 5,995,084NCBIRnor6.0
Rnor_5.0208,028,439 - 8,028,655UniSTSRnor5.0
RGSC_v3.4207,000,109 - 7,000,325UniSTSRGSC3.4
Celera208,366,102 - 8,366,318UniSTS
RH 3.4 Map2076.7UniSTS
Cytogenetic Map20p12UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000000617   ⟹   ENSRNOP00000000617
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl206,751,359 - 6,812,294 (+)Ensembl
mRatBN7.2 Ensembl206,749,670 - 6,810,589 (+)Ensembl
Rnor_6.0 Ensembl205,933,303 - 5,995,137 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000000618   ⟹   ENSRNOP00000000618
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl206,751,357 - 6,812,293 (+)Ensembl
mRatBN7.2 Ensembl206,749,962 - 6,810,587 (+)Ensembl
Rnor_6.0 Ensembl205,933,595 - 5,995,134 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095202   ⟹   ENSRNOP00000080462
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl206,751,357 - 6,812,293 (+)Ensembl
mRatBN7.2 Ensembl206,749,670 - 6,810,589 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098053   ⟹   ENSRNOP00000090625
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl206,751,357 - 6,808,890 (+)Ensembl
mRatBN7.2 Ensembl206,749,670 - 6,807,186 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000100696   ⟹   ENSRNOP00000082534
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl206,751,357 - 6,804,704 (+)Ensembl
mRatBN7.2 Ensembl206,749,670 - 6,803,000 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102158   ⟹   ENSRNOP00000096423
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl206,751,357 - 6,812,293 (+)Ensembl
mRatBN7.2 Ensembl206,749,670 - 6,810,589 (+)Ensembl
RefSeq Acc Id: NM_031020   ⟹   NP_112282
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8206,751,359 - 6,812,294 (+)NCBI
mRatBN7.2206,749,653 - 6,810,590 (+)NCBI
Rnor_6.0205,933,303 - 5,995,137 (+)NCBI
Rnor_5.0207,968,528 - 8,028,708 (+)NCBI
RGSC_v3.4206,939,249 - 7,000,378 (+)RGD
Celera208,305,853 - 8,366,371 (+)RGD
Sequence:
RefSeq Acc Id: XM_006256142   ⟹   XP_006256204
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8206,751,328 - 6,812,294 (+)NCBI
mRatBN7.2206,749,646 - 6,810,590 (+)NCBI
Rnor_6.0205,933,296 - 5,995,137 (+)NCBI
Rnor_5.0207,968,528 - 8,028,708 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063279559   ⟹   XP_063135629
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8206,751,288 - 6,808,890 (+)NCBI
RefSeq Acc Id: NP_112282   ⟸   NM_031020
- UniProtKB: Q56A33 (UniProtKB/TrEMBL),   A8C151 (UniProtKB/TrEMBL),   A0A8I5ZT48 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256204   ⟸   XM_006256142
- Peptide Label: isoform X1
- UniProtKB: Q99MG4 (UniProtKB/Swiss-Prot),   P70618 (UniProtKB/Swiss-Prot),   O08594 (UniProtKB/Swiss-Prot),   G3V617 (UniProtKB/TrEMBL),   A6JJR8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000000617   ⟸   ENSRNOT00000000617
Ensembl Acc Id: ENSRNOP00000000618   ⟸   ENSRNOT00000000618
Ensembl Acc Id: ENSRNOP00000096423   ⟸   ENSRNOT00000102158
Protein kinase

Name Modeler Protein Id AA Range Protein Structure
AF-P70618-F1-model_v2 AlphaFold P70618 1-360 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13701435
Promoter ID:EPDNEW_R11957
Type:initiation region
Name:Mapk14_1
Description:mitogen activated protein kinase 14
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0205,933,300 - 5,933,360EPDNEW


1 to 40 of 41 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-4407 BioCyc
Ensembl Genes ENSRNOG00000000513 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000000617 ENTREZGENE
  ENSRNOT00000000618 ENTREZGENE
  ENSRNOT00000098053 ENTREZGENE
Gene3D-CATH Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7313217 IMAGE-MGC_LOAD
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot
  MAP_kinase UniProtKB/Swiss-Prot
  MAP_kinase_CS UniProtKB/Swiss-Prot
  MAPK_p38-like UniProtKB/Swiss-Prot
  p38alpha UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
MGC_CLONE MGC:105413 IMAGE-MGC_LOAD
NCBI Gene 81649 ENTREZGENE
PANTHER MITOGEN-ACTIVATED PROTEIN KINASE UniProtKB/Swiss-Prot
Pfam Pkinase UniProtKB/Swiss-Prot
PhenoGen Mapk14 PhenoGen
PRINTS P38MAPKINASE UniProtKB/Swiss-Prot
PROSITE MAPK UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000000513 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
UniProt A0A8I5ZT48 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZV37 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AEN7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GLL1_RAT UniProtKB/TrEMBL
  A6JJR8 ENTREZGENE, UniProtKB/TrEMBL
  A8C151 ENTREZGENE, UniProtKB/TrEMBL
  G3V617 ENTREZGENE, UniProtKB/TrEMBL
  MK14_RAT UniProtKB/Swiss-Prot
  O08594 ENTREZGENE
  P70618 ENTREZGENE
  Q56A33 ENTREZGENE, UniProtKB/TrEMBL
  Q99MG4 ENTREZGENE
UniProt Secondary O08594 UniProtKB/Swiss-Prot
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Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Mapk14  mitogen activated protein kinase 14    p38 mitogen activated protein kinase  Name updated 629478 APPROVED
2002-06-10 Mapk14  p38 mitogen activated protein kinase      Symbol and Name status set to provisional 70585 PROVISIONAL

Note Type Note Reference
gene_expression highly expressed in heart ventricle 70317
gene_function phosphorylates and activates Mapkapk2 70317
gene_pathway estrogen-mediated activation of the Erk/MAP kinase pathway immediately affects NMDA receptors and long term potentiation (LTP) 70572
gene_pathway 17 beta estradiol activates the extracellular regulated kinase/mitogen-activated protein kinase pathway at cellular level 70572
gene_process mediates hypertrophic agonist-induced GATA-4 binding and expression of B-type natriuretic peptide gene in cultured neonatal cardiac myocytes 625524
gene_process important for cytokine production 70317
gene_process important for cytokine production 70572
gene_process functions in stress related transcription and cell cycle regulation as well as in genotoxic stress response 70317
gene_process functions in stress related transcription and cell cycle regulation as well as in genotoxic stress response 70572
gene_product MAP kinase family member 70317
gene_regulation responds to changes in extracellular osmolarity 70572
gene_regulation responds to changes in extracellular osmolarity 625524
gene_regulation activated by estrogen in hippocampus, downregulated by ovariectomy 70572
gene_regulation activated by both receptor tyrosine kinase (RTK) and G protein-coupled receptor (GPCR) agonists 625519
gene_regulation activation requires NADH/NADPH-like oxidase activity in vascular smooth muscle cells (VSMC) 625519