Tfrc (transferrin receptor) - Rat Genome Database

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Gene: Tfrc (transferrin receptor) Rattus norvegicus
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Symbol: Tfrc
Name: transferrin receptor
RGD ID: 70488
Description: Enables Hsp70 protein binding activity and transferrin receptor activity. Involved in several processes, including response to copper ion; response to manganese ion; and response to retinoic acid. Located in several cellular components, including cell surface; extracellular space; and recycling endosome membrane. Is active in glutamatergic synapse and postsynaptic recycling endosome membrane. Biomarker of duodenal ulcer; hepatocellular carcinoma; metabolic dysfunction-associated steatotic liver disease; muscular atrophy; and nutrition disease. Human ortholog(s) of this gene implicated in breast carcinoma; immunodeficiency 46; multiple myeloma; and ovarian cancer. Orthologous to human TFRC (transferrin receptor); PARTICIPATES IN forkhead class A signaling pathway; hypoxia inducible factor pathway; iron uptake pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: NOT NULL; tfR; tfR1; TR; transferrin receptor protein 1; Trfr
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81181,668,478 - 81,690,318 (-)NCBIGRCr8
mRatBN7.21168,163,413 - 68,185,257 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1168,163,413 - 68,185,257 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1177,000,479 - 77,022,314 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01169,663,759 - 69,685,697 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01168,689,586 - 68,711,424 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01171,397,423 - 71,419,263 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1171,397,383 - 71,419,223 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01174,479,841 - 74,502,561 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41169,976,258 - 69,998,098 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11170,034,788 - 70,049,347 (-)NCBI
Celera1167,596,761 - 67,618,555 (-)NCBICelera
Cytogenetic Map11q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
TfrcRatAcute-Phase Reaction  IEP 1601529 RGD 
TfrcRatbeta thalassemia  ISOTfrc (Mus musculus)11062138mRNA:increased expression:liver:RGD 
TfrcRatbreast cancer  ISOTFRC (Homo sapiens)2292018protein:increased expression:breastRGD 
TfrcRatbreast cancer severityISOTFRC (Homo sapiens)2292021mRNA:increased expression:breastRGD 
TfrcRatbreast carcinoma  ISOTFRC (Homo sapiens)2292020 RGD 
TfrcRatceliac disease  ISOTfrc (Mus musculus)11062102mRNA and protein:increased expression:duodenum:RGD 
TfrcRatcervical adenocarcinoma  ISOTFRC (Homo sapiens)2292022protein:increased expression:uterine cervixRGD 
TfrcRatChronic Cerebral Hypoperfusion  IEP 11541085protein:increased expression:hippocampusRGD 
TfrcRatduodenal ulcer  IEP 11541091protein:increased expression:duodenal mucosa RGD 
TfrcRathepatocellular carcinoma  IEP 2292036mRNA:increased expression:liverRGD 
TfrcRathypochromic microcytic anemia  ISOTfrc (Mus musculus)11062089mRNA and protein:decreased expression: erythrocyte:RGD 
TfrcRatiron deficiency anemia  ISOTfrc (Mus musculus)11062104 RGD 
TfrcRatiron deficiency anemia  ISOTFRC (Homo sapiens)11062105mRNA:increased expression:placenta:RGD 
TfrcRatiron deficiency anemia  ISOTFRC (Homo sapiens)11062096protein:increased expression:serum:RGD 
TfrcRatLymphoma, AIDS-Related treatmentISOTFRC (Homo sapiens)11062098 RGD 
TfrcRatmetabolic dysfunction-associated steatotic liver disease  IEP 11541090protein:increased expression:liverRGD 
TfrcRatmultiple myeloma treatmentISOTFRC (Homo sapiens)11062101 RGD 
TfrcRatmuscular atrophy  IEP 2292027mRNA:decreased expression:gastrocnemiusRGD 
TfrcRatnutrition disease  IEP 2292028protein:decreased expression:T cellRGD 
TfrcRatovarian cancer  ISOTFRC (Homo sapiens)2298574 RGD 
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TfrcRatautistic disorder  ISOTFRC (Homo sapiens)8554872ClinVar Annotator: match by term: AutismClinVarPMID:21681106 and PMID:30208311
TfrcRatchromosome 3q29 microdeletion syndrome  ISOTFRC (Homo sapiens)8554872ClinVar Annotator: match by term: Chromosome 3q29 microdeletion syndromeClinVar 
TfrcRatcombined immunodeficiency  ISOTFRC (Homo sapiens)8554872ClinVar Annotator: match by term: Combined immunodeficiencyClinVarPMID:25741868 more ...
TfrcRatcombined T cell and B cell immunodeficiency  ISOTFRC (Homo sapiens)8554872ClinVar Annotator: match by term: Combined T and B cell immunodeficiencyClinVarPMID:25741868 more ...
TfrcRatgenetic disease  ISOTFRC (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:28492532
TfrcRathereditary breast ovarian cancer syndrome  ISOTFRC (Homo sapiens)8554872ClinVar Annotator: match by term: Hereditary breast ovarian cancer syndromeClinVarPMID:25741868
TfrcRatimmunodeficiency 46  ISOTFRC (Homo sapiens)8554872ClinVar more ...ClinVarPMID:17576681 more ...
TfrcRatschizophrenia  ISOTFRC (Homo sapiens)8554872ClinVar Annotator: match by term: SchizophreniaClinVarPMID:21681106 and PMID:30208311
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TfrcRatArenaviridae infectious disease  ISOTFRC (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:17287727
TfrcRatautism spectrum disorder  ISOTFRC (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:35663546
TfrcRatB-Cell Chronic Lymphocytic Leukemia  ISOTFRC (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16904380
TfrcRatbeta thalassemia  ISOTFRC (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16755567
TfrcRatBreast Neoplasms  ISOTFRC (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16904380 and PMID:19238537
TfrcRatColorectal Neoplasms  ISOTFRC (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16111806
TfrcRatHelicobacter Infections  ISOTFRC (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16733738 and PMID:17163184
TfrcRathigh grade glioma  ISOTFRC (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16904380
TfrcRatInflammation  ISOTFRC (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16603144
TfrcRatiron deficiency anemia  ISOTFRC (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16733738 more ...
TfrcRatiron metabolism disease  ISOTFRC (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17163184 and PMID:17254562
TfrcRatLung Neoplasms  ISOTFRC (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16904380
TfrcRatMyocardial Ischemia  ISOTFRC (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16214533
TfrcRatMyocardial Reperfusion Injury  ISOTFRC (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18549825
TfrcRatNeoplastic Cell Transformation  ISOTFRC (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21785164
TfrcRatnon-Hodgkin lymphoma  ISOTFRC (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16904380
TfrcRatobesity  ISOTFRC (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17062801 and PMID:20882379
TfrcRatpolycystic ovary syndrome  ISOTFRC (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21411543
TfrcRatsevere combined immunodeficiency  ISOTFRC (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:26642240
TfrcRatSpontaneous Abortions  ISOTFRC (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18539642
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TfrcRatWeissenbacher-Zweymuller syndrome  ISSTfrc (Mus musculus)13592920OMIM:261800MouseDO 
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TfrcRatimmunodeficiency 46  ISOTFRC (Homo sapiens)7240710 OMIM 

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Original Reference(s)
TfrcRat(1->4)-beta-D-glucan multiple interactionsISOTfrc (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of TFRC mRNACTDPMID:36331819
TfrcRat(S)-nicotine multiple interactionsISOTfrc (Mus musculus)6480464[Nicotine co-treated with 1-Methyl-4-phenyl-1 more ...CTDPMID:20230807
TfrcRat(S)-nicotine multiple interactionsISOTFRC (Homo sapiens)6480464[Nicotine co-treated with Propylene Glycol co-treated with Glycerol] results in increased expression of TFRC mRNACTDPMID:28065790
TfrcRat(S)-nicotine increases expressionISOTFRC (Homo sapiens)6480464Nicotine results in increased expression of TFRC mRNACTDPMID:16949557
TfrcRat1,10-phenanthroline increases expressionISOTFRC (Homo sapiens)64804641 and 10-phenanthroline results in increased expression of TFRC mRNACTDPMID:19502547
TfrcRat1,2-dimethylhydrazine decreases expressionISOTfrc (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of TFRC mRNACTDPMID:22206623
TfrcRat1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine increases expressionISOTfrc (Mus musculus)64804641-Methyl-4-phenyl-1 more ...CTDPMID:20230807
TfrcRat1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine multiple interactionsISOTfrc (Mus musculus)6480464[Caffeine co-treated with 1-Methyl-4-phenyl-1 more ...CTDPMID:20230807
TfrcRat1-naphthyl isothiocyanate increases expressionEXP 64804641-Naphthylisothiocyanate results in increased expression of TFRC mRNACTDPMID:30723492
TfrcRat1-octadec-9-enoylglycero-3-phosphate multiple interactionsISOTFRC (Homo sapiens)64804642-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[lysophosphatidic acid co-treated with KITLG protein co-treated with EPO protein] results in increased expression of TFRC protein] more ...CTDPMID:21915944
TfrcRat17alpha-ethynylestradiol multiple interactionsISOTFRC (Homo sapiens)6480464[Ethinyl Estradiol co-treated with Cyproterone Acetate] results in decreased expression of TFRC proteinCTDPMID:16002536
TfrcRat17alpha-ethynylestradiol multiple interactionsISOTfrc (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TFRC mRNACTDPMID:17942748
TfrcRat17beta-estradiol affects expressionISOTfrc (Mus musculus)6480464Estradiol affects the expression of TFRC mRNACTDPMID:16684588
TfrcRat17beta-estradiol decreases expressionEXP 6480464Estradiol results in decreased expression of TFRC mRNACTDPMID:35192832
TfrcRat17beta-estradiol increases expressionISOTfrc (Mus musculus)6480464Estradiol results in increased expression of TFRC mRNACTDPMID:39298647
TfrcRat17beta-estradiol multiple interactionsISOTfrc (Mus musculus)6480464[Estradiol co-treated with Progesterone] results in increased expression of TFRC mRNACTDPMID:18556351
TfrcRat17beta-estradiol increases expressionISOTFRC (Homo sapiens)6480464Estradiol results in increased expression of TFRC mRNACTDPMID:18556351 more ...
TfrcRat2,2',4,4'-Tetrabromodiphenyl ether increases expressionISOTFRC (Homo sapiens)64804642 more ...CTDPMID:19095052
TfrcRat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOTFRC (Homo sapiens)6480464Tetrachlorodibenzodioxin results in increased expression of TFRC mRNACTDPMID:18061397
TfrcRat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOTfrc (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of TFRC mRNA and Tetrachlorodibenzodioxin results in increased expression of TFRC proteinCTDPMID:19770486 more ...

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Biological Process
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Original Reference(s)
TfrcRatacute-phase response  IEP 1601529 RGD 
TfrcRatacute-phase response  IEP 11062091 RGD 
TfrcRatcell surface receptor signaling pathway involved_inISOTFRC (Homo sapiens)1624291 PMID:9465039RGDPMID:9465039
TfrcRatcellular response to leukemia inhibitory factor acts_upstream_of_or_withinISOTfrc (Mus musculus)1624291 PMID:20439489RGDPMID:20439489
TfrcRatcellular response to leukemia inhibitory factor acts_upstream_of_or_withinIEAUniProtKB:Q62351 and ensembl:ENSMUSP000000234861600115GO_REF:0000107EnsemblGO_REF:0000107
TfrcRatcellular response to xenobiotic stimulus acts_upstream_of_or_withinISOTFRC (Homo sapiens)1624291 PMID:16254249RGDPMID:16254249
TfrcRatcellular response to xenobiotic stimulus acts_upstream_of_or_withinIEAUniProtKB:P02786 and ensembl:ENSP000003532241600115GO_REF:0000107EnsemblGO_REF:0000107
TfrcRatendocytosis involved_inIEAUniProtKB-KW:KW-02541600115GO_REF:0000043UniProtGO_REF:0000043
TfrcRatintracellular iron ion homeostasis involved_inIEAUniRule:UR0014537821600115GO_REF:0000104UniProtGO_REF:0000104
TfrcRatintracellular iron ion homeostasis acts_upstream_of_or_withinIEAUniProtKB:Q62351 and ensembl:ENSMUSP000000234861600115GO_REF:0000107EnsemblGO_REF:0000107
TfrcRatintracellular iron ion homeostasis acts_upstream_of_or_withinISOTfrc (Mus musculus)1624291MGI:1859944 PMID:10192390RGDPMID:10192390
TfrcRatintracellular iron ion homeostasis involved_inIBAMGI:98822 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
TfrcRatintracellular signal transduction involved_inISOTFRC (Homo sapiens)1624291 PMID:26214738RGDPMID:26214738
TfrcRatintracellular signal transduction involved_inIEAUniProtKB:P02786 and ensembl:ENSP000003532241600115GO_REF:0000107EnsemblGO_REF:0000107
TfrcRatiron ion transport involved_inISOTFRC (Homo sapiens)1624291 PMID:7556058RGDPMID:7556058
TfrcRatiron ion transport involved_inIBAPANTHER:PTN002572056 and UniProtKB:P027861600115GO_REF:0000033GO_CentralGO_REF:0000033
TfrcRatiron ion transport involved_inIEAUniProtKB:P02786 and ensembl:ENSP000003532241600115GO_REF:0000107EnsemblGO_REF:0000107
TfrcRatmulticellular organismal-level iron ion homeostasis involved_inISOTFRC (Homo sapiens)1624291 PMID:26642240RGDPMID:26642240
TfrcRatmulticellular organismal-level iron ion homeostasis involved_inIEAUniProtKB:P02786 and ensembl:ENSP000003532241600115GO_REF:0000107EnsemblGO_REF:0000107
TfrcRatnegative regulation of apoptotic process involved_inISOTFRC (Homo sapiens)1624291 PMID:23016877RGDPMID:23016877
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Cellular Component
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Original Reference(s)
TfrcRatbasolateral plasma membrane located_inISOTFRC (Homo sapiens)1624291 PMID:9990067RGDPMID:9990067
TfrcRatbasolateral plasma membrane located_inIEAUniProtKB:P02786 and ensembl:ENSP000003532241600115GO_REF:0000107EnsemblGO_REF:0000107
TfrcRatcell surface located_inIDA 8553977PMID:19029245MGI 
TfrcRatcell surface located_inISOTfrc (Mus musculus)1624291 PMID:17716972 and PMID:23416069RGDPMID:17716972 and PMID:23416069
TfrcRatcell surface located_inIEAUniProtKB:Q62351 and ensembl:ENSMUSP000000234861600115GO_REF:0000107EnsemblGO_REF:0000107
TfrcRatcell surface located_inIEAUniProtKB:P02786 and ensembl:ENSP000003532241600115GO_REF:0000107EnsemblGO_REF:0000107
TfrcRatcell surface  IDA 151665813 RGD 
TfrcRatcell surface located_inISOTFRC (Homo sapiens)1624291 PMID:7556058RGDPMID:7556058
TfrcRatcell surface located_inIDA 2301072PMID:18619525ARUK-UCL 
TfrcRatcell surface  IDA 1601530 RGD 
TfrcRatclathrin-coated pit located_inISOTFRC (Homo sapiens)1624291 PMID:12857860RGDPMID:12857860
TfrcRatclathrin-coated pit located_inIEAUniProtKB:P02786 and ensembl:ENSP000003532241600115GO_REF:0000107EnsemblGO_REF:0000107
TfrcRatclathrin-coated pit located_inISOTfrc (Mus musculus)1624291 PMID:18434600RGDPMID:18434600
TfrcRatclathrin-coated pit located_inIEAUniProtKB:Q62351 and ensembl:ENSMUSP000000234861600115GO_REF:0000107EnsemblGO_REF:0000107
TfrcRatcytoplasmic vesicle located_inISOTFRC (Homo sapiens)1624291 PMID:15229288RGDPMID:15229288
TfrcRatcytoplasmic vesicle located_inIEAUniProtKB:P02786 and ensembl:ENSP000003532241600115GO_REF:0000107EnsemblGO_REF:0000107
TfrcRatearly endosome located_inISOTfrc (Mus musculus)1624291 PMID:26432893RGDPMID:26432893
TfrcRatearly endosome located_inIEAUniProtKB:Q62351 and ensembl:ENSMUSP000000234861600115GO_REF:0000107EnsemblGO_REF:0000107
TfrcRatendosome located_inISOTFRC (Homo sapiens)1624291 PMID:14612438RGDPMID:14612438
TfrcRatendosome located_inISOTfrc (Mus musculus)1624291 PMID:11092755 more ...RGDPMID:11092755 more ...
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Molecular Function
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TfrcRatdouble-stranded RNA binding enablesISOTFRC (Homo sapiens)1624291 PMID:21266579RGDPMID:21266579
TfrcRatdouble-stranded RNA binding enablesIEAUniProtKB:P02786 and ensembl:ENSP000003532241600115GO_REF:0000107EnsemblGO_REF:0000107
TfrcRatHsp70 protein binding  IPIHspa8 (Rattus norvegicus)2326097 RGD 
TfrcRatidentical protein binding enablesISOTFRC (Homo sapiens)1624291UniProtKB:P02786 more ...RGDPMID:20208545 more ...
TfrcRatidentical protein binding enablesIEAUniProtKB:P02786 and ensembl:ENSP000003532241600115GO_REF:0000107EnsemblGO_REF:0000107
TfrcRatprotein binding enablesIPIUniProtKB:O1486312903241PMID:26728129IntAct 
TfrcRatprotein binding enablesISOTfrc (Mus musculus)1624291PR:O70492 more ...RGDPMID:16893896 and PMID:23416069
TfrcRatprotein binding enablesIPIUniProtKB:Q9BRI312903241PMID:26728129IntAct 
TfrcRatprotein binding enablesISOTFRC (Homo sapiens)1624291UniProtKB:A5K736 more ...RGDPMID:10638746 more ...
TfrcRatprotein homodimerization activity enablesISOTFRC (Homo sapiens)1624291UniProtKB:P02786 and PMID:9546397RGDPMID:9546397
TfrcRatprotein homodimerization activity enablesIEAUniProtKB:P02786 and ensembl:ENSP000003532241600115GO_REF:0000107EnsemblGO_REF:0000107
TfrcRatprotein kinase binding enablesISOTFRC (Homo sapiens)1624291UniProtKB:O14920 more ...RGDPMID:23016877
TfrcRatprotein kinase binding enablesIEAUniProtKB:P02786 and ensembl:ENSP000003532241600115GO_REF:0000107EnsemblGO_REF:0000107
TfrcRatprotein-containing complex binding enablesISOTFRC (Homo sapiens)1624291ComplexPortal:CPX-3269 PMID:23016877RGDPMID:23016877
TfrcRatprotein-containing complex binding enablesIEAUniProtKB:P02786 and ensembl:ENSP000003532241600115GO_REF:0000107EnsemblGO_REF:0000107
TfrcRatprotein-folding chaperone binding  IPIHspa8 (Rattus norvegicus)2326097 RGD 
TfrcRattransferrin receptor activity  IDA 737675 RGD 
TfrcRattransferrin receptor activity enablesISOTFRC (Homo sapiens)1624291 PMID:18353247 more ...RGDPMID:18353247 more ...
TfrcRattransferrin receptor activity enablesIEAUniProtKB:P02786 and ensembl:ENSP000003532241600115GO_REF:0000107EnsemblGO_REF:0000107
TfrcRattransferrin receptor activity enablesIEAInterPro:IPR0373241600115GO_REF:0000002InterProGO_REF:0000002
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RGD Manual Annotations


  
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TfrcRatiron uptake pathway  ISOTFRC (Homo sapiens)11554199 RGD 

Imported Annotations - KEGG (archival)

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TfrcRatendocytosis pathway  IEA 6907045 KEGGrno:04144
TfrcRatphagocytosis pathway  IEA 6907045 KEGGrno:04145

Imported Annotations - PID (archival)

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Original Reference(s)
TfrcRatforkhead class A signaling pathway  ISOTFRC (Homo sapiens)6484113 PIDPID:200087
TfrcRathypoxia inducible factor pathway   ISOTFRC (Homo sapiens)6484113 PIDPID:200202

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Reference Title
Reference Citation
1. Cyto-protective and immunomodulating effect of Curcuma longa in Wistar rats subjected to carbon tetrachloride-induced oxidative stress. Abu-Rizq HA, etal., Inflammopharmacology. 2008 Mar 18;.
2. [Serum transferrin receptor in healthy children. Diagnostic yield in ferropenic and infectious anemia]. Aleo Lujan E, etal., An Pediatr (Barc). 2004 May;60(5):428-35.
3. Effect of dietary copper deficiency on iron metabolism in the pregnant rat. Andersen HS, etal., Br J Nutr. 2007 Feb;97(2):239-46.
4. Adaptive changes of duodenal iron transport proteins in celiac disease. Barisani D, etal., Physiol Genomics. 2004 May 19;17(3):316-25.
5. Identification and characterization of the hepatic stellate cell transferrin receptor. Bridle KR, etal., Am J Pathol 2003 May;162(5):1661-7.
6. The effect of feeding a low iron diet prior to and during gestation on fetal and maternal iron homeostasis in two strains of rat. Cornock R, etal., Reprod Biol Endocrinol. 2013 May 1;11:32. doi: 10.1186/1477-7827-11-32.
7. Effects of moderate and severe malnutrition in rats on splenic T lymphocyte subsets and activation assessed by flow cytometry. Cortes-Barberena E, etal., Clin Exp Immunol. 2008 Mar 28;.
8. An antibody-based multifaceted approach targeting the human transferrin receptor for the treatment of B-cell malignancies. Daniels TR, etal., J Immunother. 2011 Jul-Aug;34(6):500-8. doi: 10.1097/CJI.0b013e318222ffc8.
9. Efficacy of an Anti-transferrin Receptor 1 Antibody Against AIDS-related Non-Hodgkin Lymphoma: A Brief Communication. Daniels-Wells TR, etal., J Immunother. 2015 Oct;38(8):307-10. doi: 10.1097/CJI.0000000000000092.
10. Transferrin in normal and neoplastic endocervical tissues: distribution and receptor expression. Farley J, etal., Anal Quant Cytol Histol. 1998 Aug;20(4):238-49.
11. Antitumor activity of an immunotoxin in a nude mouse model of human ovarian cancer. FitzGerald DJ, etal., Cancer Res. 1987 Mar 1;47(5):1407-10.
12. Iron deficient and manganese supplemented diets alter metals and transporters in the developing rat brain. Garcia SJ, etal., Toxicol Sci. 2007 Jan;95(1):205-14. Epub 2006 Oct 23.
13. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
14. Characteristics of the interaction between Hsc70 and the transferrin receptor in exosomes released during reticulocyte maturation. Geminard C, etal., J Biol Chem. 2001 Mar 30;276(13):9910-6. Epub 2000 Dec 22.
15. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
16. Increased iron content and RNA oxidative damage in skeletal muscle with aging and disuse atrophy. Hofer T, etal., Exp Gerontol. 2008 Feb 29;.
17. The transferrin receptor: a potential molecular imaging marker for human cancer. Hogemann-Savellano D, etal., Neoplasia. 2003 Nov-Dec;5(6):495-506.
18. Expression of iron regulatory genes in a rat model of hepatocellular carcinoma. Holmstrom P, etal., Liver Int. 2006 Oct;26(8):976-85.
19. Expression of tranferrin receptors in the pineal gland of postnatal and adult rats and its alteration in hypoxia and melatonin treatment. Kaur C, etal., Glia. 2007 Feb;55(3):263-73.
20. Role of iron in the pathogenesis of cysteamine-induced duodenal ulceration in rats. Khomenko T, etal., Am J Physiol Gastrointest Liver Physiol. 2009 Jun;296(6):G1277-86. doi: 10.1152/ajpgi.90257.2008. Epub 2009 Apr 2.
1 to 20 of 61 rows
PMID:1871153   PMID:7556058   PMID:8889548   PMID:9465039   PMID:9546397   PMID:9990067   PMID:10192390   PMID:10444069   PMID:11092755   PMID:12085354   PMID:12608731   PMID:12739130  
PMID:12857860   PMID:14562105   PMID:14612438   PMID:14668490   PMID:14718562   PMID:14752097   PMID:15009675   PMID:15086793   PMID:15229288   PMID:16227996   PMID:16254249   PMID:16380373  
PMID:16893896   PMID:17716972   PMID:18321981   PMID:18353247   PMID:18434600   PMID:19066835   PMID:19252502   PMID:19724054   PMID:20080761   PMID:20091025   PMID:20202662   PMID:20208545  
PMID:20424607   PMID:20439489   PMID:20458337   PMID:20711497   PMID:20726229   PMID:21266579   PMID:21499258   PMID:21700773   PMID:22207220   PMID:22456507   PMID:22516433   PMID:22658674  
PMID:22664934   PMID:22871113   PMID:23016877   PMID:23303939   PMID:23384347   PMID:23395379   PMID:23416069   PMID:23447582   PMID:24561039   PMID:24683533   PMID:24769233   PMID:25007852  
PMID:25115800   PMID:26214738   PMID:26432893   PMID:26642240   PMID:27226592   PMID:29302006   PMID:31810121   PMID:35038133   PMID:37105375   PMID:37683766   PMID:38241836   PMID:39251905  



Tfrc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81181,668,478 - 81,690,318 (-)NCBIGRCr8
mRatBN7.21168,163,413 - 68,185,257 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1168,163,413 - 68,185,257 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1177,000,479 - 77,022,314 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01169,663,759 - 69,685,697 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01168,689,586 - 68,711,424 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01171,397,423 - 71,419,263 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1171,397,383 - 71,419,223 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01174,479,841 - 74,502,561 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41169,976,258 - 69,998,098 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11170,034,788 - 70,049,347 (-)NCBI
Celera1167,596,761 - 67,618,555 (-)NCBICelera
Cytogenetic Map11q22NCBI
TFRC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383196,049,284 - 196,082,090 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3196,012,511 - 196,082,153 (-)EnsemblGRCh38hg38GRCh38
GRCh373195,776,155 - 195,808,961 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363197,260,744 - 197,293,338 (-)NCBINCBI36Build 36hg18NCBI36
Build 343197,264,659 - 197,297,251NCBI
Celera3194,360,605 - 194,393,477 (-)NCBICelera
Cytogenetic Map3q29NCBI
HuRef3193,076,917 - 193,109,375 (-)NCBIHuRef
CHM1_13195,747,516 - 195,780,405 (-)NCBICHM1_1
T2T-CHM13v2.03198,738,962 - 198,802,440 (-)NCBIT2T-CHM13v2.0
Tfrc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391632,427,714 - 32,451,612 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1632,427,738 - 32,451,612 (+)EnsemblGRCm39 Ensembl
GRCm381632,608,896 - 32,632,794 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1632,608,920 - 32,632,794 (+)EnsemblGRCm38mm10GRCm38
MGSCv371632,608,982 - 32,632,880 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361632,528,768 - 32,552,537 (+)NCBIMGSCv36mm8
Celera1633,088,313 - 33,112,331 (+)NCBICelera
Cytogenetic Map16B3NCBI
cM Map1623.06NCBI
Tfrc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542012,348,821 - 12,372,691 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542012,348,392 - 12,372,714 (-)NCBIChiLan1.0ChiLan1.0
TFRC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22193,908,901 - 193,941,619 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13193,913,621 - 193,946,338 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03193,384,817 - 193,417,532 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13203,333,953 - 203,365,586 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3203,333,953 - 203,373,998 (-)Ensemblpanpan1.1panPan2
TFRC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13329,206,024 - 29,237,221 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3329,208,609 - 29,238,242 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3329,234,803 - 29,256,627 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03329,440,415 - 29,471,780 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3329,440,415 - 29,471,756 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13329,229,617 - 29,251,398 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03329,284,382 - 29,306,157 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03329,905,548 - 29,927,547 (-)NCBIUU_Cfam_GSD_1.0
Tfrc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602125,156,856 - 125,188,523 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936784696,713 - 728,543 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936784696,738 - 728,385 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TFRC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13133,970,985 - 134,000,276 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113133,976,765 - 133,997,554 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213143,414,634 - 143,435,426 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TFRC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11591,102,153 - 91,134,994 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1591,102,817 - 91,135,584 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604164,945,566 - 64,977,969 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tfrc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473061,285,334 - 61,313,550 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473061,282,650 - 61,313,487 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Tfrc
89 total Variants

Predicted Target Of
Summary Value
Count of predictions:307
Count of miRNA genes:203
Interacting mature miRNAs:228
Transcripts:ENSRNOT00000002407
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 25 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)115980279482566553Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)114545932375190161Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)111945620576331918Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116611332182169223Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat

1 to 10 of 25 rows



alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31


1 to 20 of 20 rows
RefSeq Transcripts NM_022712 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006248462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006248463 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088614 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC136847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI029320 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP500872 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA509549 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB700894 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB762571 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB809947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO398424 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CV111368 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CV117299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CV117527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM033330 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM123390 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M58040 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 20 of 20 rows

Ensembl Acc Id: ENSRNOT00000002407   ⟹   ENSRNOP00000002407
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1168,163,413 - 68,185,257 (-)Ensembl
Rnor_6.0 Ensembl1171,397,383 - 71,419,223 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000105908   ⟹   ENSRNOP00000097197
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1168,163,413 - 68,179,995 (-)Ensembl
RefSeq Acc Id: NM_022712   ⟹   NP_073203
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81181,668,478 - 81,690,318 (-)NCBI
mRatBN7.21168,163,413 - 68,185,257 (-)NCBI
Rnor_6.01171,397,423 - 71,419,263 (-)NCBI
Rnor_5.01174,479,841 - 74,502,561 (-)NCBI
RGSC_v3.41169,976,258 - 69,998,098 (-)RGD
Celera1167,596,761 - 67,618,555 (-)RGD
Sequence:
RefSeq Acc Id: XM_006248462   ⟹   XP_006248524
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81181,668,480 - 81,690,256 (-)NCBI
mRatBN7.21168,163,413 - 68,185,228 (-)NCBI
Rnor_6.01171,397,424 - 71,419,234 (-)NCBI
Rnor_5.01174,479,841 - 74,502,561 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006248463   ⟹   XP_006248525
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81181,668,480 - 81,690,254 (-)NCBI
mRatBN7.21168,163,413 - 68,184,986 (-)NCBI
Rnor_6.01171,397,424 - 71,418,972 (-)NCBI
Rnor_5.01174,479,841 - 74,502,561 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039088614   ⟹   XP_038944542
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81181,668,480 - 81,689,845 (-)NCBI
mRatBN7.21168,163,413 - 68,184,781 (-)NCBI
RefSeq Acc Id: NP_073203   ⟸   NM_022712
- UniProtKB: Q99376 (UniProtKB/Swiss-Prot),   G3V679 (UniProtKB/Swiss-Prot),   A0A8I6AS83 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248524   ⟸   XM_006248462
- Peptide Label: isoform X1
- UniProtKB: Q99376 (UniProtKB/Swiss-Prot),   G3V679 (UniProtKB/Swiss-Prot),   A0A8I6AS83 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248525   ⟸   XM_006248463
- Peptide Label: isoform X1
- UniProtKB: Q99376 (UniProtKB/Swiss-Prot),   G3V679 (UniProtKB/Swiss-Prot),   A0A8I6AS83 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000002407   ⟸   ENSRNOT00000002407
RefSeq Acc Id: XP_038944542   ⟸   XM_039088614
- Peptide Label: isoform X1
- UniProtKB: Q99376 (UniProtKB/Swiss-Prot),   G3V679 (UniProtKB/Swiss-Prot),   A0A8I6AS83 (UniProtKB/TrEMBL)
PA   Peptidase M28   Transferrin receptor-like dimerisation

Name Modeler Protein Id AA Range Protein Structure
AF-Q99376-F1-model_v2 AlphaFold Q99376 1-761 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13698208
Promoter ID:EPDNEW_R8732
Type:multiple initiation site
Name:Tfrc_1
Description:transferrin receptor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01171,419,206 - 71,419,266EPDNEW


1 to 33 of 33 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-21108 BioCyc
Ensembl Genes ENSRNOG00000001766 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000002407 ENTREZGENE
  ENSRNOT00000002407.6 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.930.40 UniProtKB/Swiss-Prot
  3.50.30.30 UniProtKB/Swiss-Prot
  Zn peptidases UniProtKB/Swiss-Prot
InterPro PA_dom_sf UniProtKB/Swiss-Prot
  PA_domain UniProtKB/Swiss-Prot
  Peptidase_M28 UniProtKB/Swiss-Prot
  Peptidase_M28B UniProtKB/Swiss-Prot
  TFR-like_dimer_dom UniProtKB/Swiss-Prot
  TFR-like_dimer_dom_sf UniProtKB/Swiss-Prot
  TfR1/2_PA UniProtKB/Swiss-Prot
KEGG Report rno:64678 UniProtKB/Swiss-Prot
NCBI Gene Tfrc ENTREZGENE
PANTHER PTHR10404 UniProtKB/Swiss-Prot
  PTHR10404:SF26 UniProtKB/Swiss-Prot
Pfam Peptidase_M28 UniProtKB/Swiss-Prot
  PF02225 UniProtKB/Swiss-Prot
  TFR_dimer UniProtKB/Swiss-Prot
PhenoGen Tfrc PhenoGen
RatGTEx ENSRNOG00000001766 RatGTEx
Superfamily-SCOP PA domain UniProtKB/Swiss-Prot
  SSF47672 UniProtKB/Swiss-Prot
  Zn-dependent exopeptidases UniProtKB/Swiss-Prot
UniProt A0A8I6AS83 ENTREZGENE, UniProtKB/TrEMBL
  A6IRQ3_RAT UniProtKB/TrEMBL
  A6IRQ4_RAT UniProtKB/TrEMBL
  A6IRQ5_RAT UniProtKB/TrEMBL
  G3V679 ENTREZGENE
  Q99376 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary G3V679 UniProtKB/Swiss-Prot
1 to 33 of 33 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-26 Tfrc  Transferrin receptor    transferrin receptor  Symbol and Name status set to approved 625702 APPROVED
2002-06-10 Tfrc  transferrin receptor      Symbol and Name status set to provisional 70585 PROVISIONAL

Note Type Note Reference
gene_expression mRNA expression levels in brain remain unaffected by iron status 737676
gene_process delivers of serum iron to developing germinal cells in the seminiferous epithelium 70300
gene_process delivers of serum iron to developing germinal cells in the seminiferous epithelium 70322
gene_process involved in iron homeostasis 70300
gene_process involved in iron homeostasis 70322