Cdkn1a (cyclin-dependent kinase inhibitor 1A) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Cdkn1a (cyclin-dependent kinase inhibitor 1A) Rattus norvegicus
Analyze
Symbol: Cdkn1a
Name: cyclin-dependent kinase inhibitor 1A
RGD ID: 69328
Description: Predicted to enable several functions, including cyclin binding activity; enzyme binding activity; and protein kinase regulator activity. Involved in several processes, including intestinal epithelial cell maturation; response to hyperoxia; and response to mineralocorticoid. Located in perinuclear region of cytoplasm. Biomarker of several diseases, including autosomal dominant polycystic kidney disease; hypertension (multiple); lipoid nephrosis; liver benign neoplasm; and pre-malignant neoplasm. Human ortholog(s) of this gene implicated in high grade glioma; ocular hypertension; oral mucosa leukoplakia; oral squamous cell carcinoma; and primary open angle glaucoma. Orthologous to human CDKN1A (cyclin dependent kinase inhibitor 1A); PARTICIPATES IN G1/S transition pathway; Notch signaling pathway; nuclear factor, erythroid 2 like 2 signaling pathway; INTERACTS WITH (+)-dexrazoxane; (+)-schisandrin B; (R,R,R)-alpha-tocopherol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Cip1; cyclin-dependent kinase inhibitor 1; cyclin-dependent kinase inhibitor 1A (P21); cyclin-dependent kinase inhibitor 1A (p21, Cip1); UV96; Waf1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   BUF.ACI-(D20Img2-Cdkn1a)/Ncc   ACI.BUF-(D20Img2-Cdkn1a)/Ncc  
Candidate Gene For: Prcs2
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8207,150,820 - 7,161,373 (+)NCBIGRCr8
mRatBN7.2207,149,177 - 7,159,727 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl207,149,217 - 7,159,585 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx207,860,502 - 7,870,951 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0207,222,359 - 7,232,808 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0207,697,344 - 7,707,907 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0206,348,422 - 6,358,864 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl206,351,458 - 6,358,864 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0208,592,437 - 8,602,879 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4207,376,325 - 7,386,778 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1207,379,612 - 7,385,803 (+)NCBI
Celera208,699,290 - 8,709,718 (+)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 20 of 94 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cdkn1aRatacoustic neuroma  ISOCDKN1A (Homo sapiens)8661792mRNA and protein:decreased expression:myelinated nerve:RGD 
Cdkn1aRatAcute Experimental Pancreatitis  IEP 10043817 RGD 
Cdkn1aRatAnimal Mammary Neoplasms onsetISOCdkn1a (Mus musculus)8662404 RGD 
Cdkn1aRatArsenic Poisoning  ISOCDKN1A (Homo sapiens)8662429protein:increased expression:skin:RGD 
Cdkn1aRatatrial fibrillation  ISOCDKN1A (Homo sapiens)8662360mRNA and protein:increased expression:atriimRGD 
Cdkn1aRatautosomal dominant polycystic kidney disease  IEP 2289666protein:decreased expression:kidneyRGD 
Cdkn1aRatBarrett's esophagus  ISOCDKN1A (Homo sapiens)8662398protein:increased expression:nucleus of esophagus mucosa:RGD 
Cdkn1aRatBowen's Disease  ISOCDKN1A (Homo sapiens)8662826protein:increased expression:skin:RGD 
Cdkn1aRatBrain Injuries  IEP 8662346protein:increased expression:nucleus:RGD 
Cdkn1aRatBreast Neoplasms  ISOCDKN1A (Homo sapiens)2289652DNA:snp: :rs3176336RGD 
Cdkn1aRatBreast Neoplasms disease_progressionISOCDKN1A (Homo sapiens)2289656 RGD 
Cdkn1aRatcarcinoma  ISOCdkn1a (Mus musculus)8662432 RGD 
Cdkn1aRatcervix uteri carcinoma in situ  ISOCDKN1A (Homo sapiens)8662446protein:increased expression:epithelial cell:RGD 
Cdkn1aRatcholesteatoma of middle ear  ISOCDKN1A (Homo sapiens)8661795protein:increased expression:RGD 
Cdkn1aRatCongenital Cholesteatoma  ISOCDKN1A (Homo sapiens)8661795protein:increased expression:RGD 
Cdkn1aRatductal carcinoma in situ disease_progressionISOCDKN1A (Homo sapiens)2289659protein:increased expression:breastRGD 
Cdkn1aRatEndometrial Neoplasms susceptibilityISOCDKN1A (Homo sapiens)2296047DNA:polymorphism:cds:p.S31RRGD 
Cdkn1aRatEndometrial Neoplasms  ISOCDKN1A (Homo sapiens)2289683protein:increased expression:endometriumRGD 
Cdkn1aRatEsophageal Neoplasms disease_progressionISOCDKN1A (Homo sapiens)8662379 RGD 
Cdkn1aRatExperimental Diabetes Mellitus  IEP 8662307protein:increased expression:testes:RGD 
1 to 20 of 94 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cdkn1aRatproteasome-associated autoinflammatory syndrome 1  ISOCDKN1A (Homo sapiens)8554872ClinVar Annotator: match by term: Proteasome-associated autoinflammatory syndrome 1ClinVarPMID:28492532
Cdkn1aRaturinary bladder cancer  ISOCDKN1A (Homo sapiens)8554872ClinVar Annotator: match by term: Malignant tumor of urinary bladderClinVar 
1 to 20 of 22 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cdkn1aRatatrial fibrillation  ISOCDKN1A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:29892015
Cdkn1aRatchronic obstructive pulmonary disease  ISOCDKN1A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:35303175
Cdkn1aRatColonic Neoplasms  ISOCDKN1A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20876807
Cdkn1aRatDiabetic Nephropathies  ISOCDKN1A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:27652271
Cdkn1aRatEmbryo Loss  ISOCDKN1A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:35038060
Cdkn1aRatesophagus squamous cell carcinoma  ISOCDKN1A (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:15375580
Cdkn1aRatExperimental Liver Cirrhosis  ISOCDKN1A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25380136
Cdkn1aRatfacioscapulohumeral muscular dystrophy  ISOCDKN1A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12868502
Cdkn1aRatHabitual Abortions  ISOCDKN1A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:35038060
Cdkn1aRathuman immunodeficiency virus infectious disease  ISOCDKN1A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12878215
Cdkn1aRatHypertrophy  ISOCDKN1A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:27652271
Cdkn1aRatIntestinal Neoplasms  ISOCDKN1A (Homo sapiens)11554173CTD more ...CTDPMID:11535846 and PMID:12468628
Cdkn1aRatkidney disease  ISOCDKN1A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16968891
Cdkn1aRatLiver Neoplasms  ISOCDKN1A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:33010264
Cdkn1aRatLung Neoplasms  ISOCDKN1A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12466968 and PMID:18508827
Cdkn1aRatmalignant mesothelioma  ISOCDKN1A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:11453316
Cdkn1aRatpapilloma  ISOCDKN1A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12151359
Cdkn1aRatProstatic Neoplasms  ISOCDKN1A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12727815 and PMID:15598783
Cdkn1aRatReperfusion Injury  ISOCDKN1A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16968891
Cdkn1aRatStomach Neoplasms  ISOCDKN1A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:14647439
1 to 20 of 22 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cdkn1aRathepatocellular carcinoma  ISSCdkn1a (Mus musculus)13592920OMIM:114550MouseDO 
Cdkn1aRatsystemic lupus erythematosus  ISSCdkn1a (Mus musculus)13592920OMIM:152700 more ...MouseDO 

1 to 20 of 1790 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cdkn1aRat(+)-dexrazoxane multiple interactionsISOCdkn1a (Mus musculus)6480464Dexrazoxane inhibits the reaction [Idarubicin results in increased expression of CDKN1A mRNA]CTDPMID:28973540
Cdkn1aRat(+)-dexrazoxane multiple interactionsEXP 6480464Dexrazoxane inhibits the reaction [Daunorubicin results in increased expression of CDKN1A mRNA]CTDPMID:38290791
Cdkn1aRat(+)-schisandrin B multiple interactionsEXP 6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of CDKN1A mRNA]CTDPMID:31150632
Cdkn1aRat(+)-Tetrandrine increases expressionISOCDKN1A (Homo sapiens)6480464tetrandrine results in increased expression of CDKN1ACTDPMID:19840446
Cdkn1aRat(+)-Tetrandrine affects expressionISOCDKN1A (Homo sapiens)6480464tetrandrine affects the expression of CDKN1A proteinCTDPMID:30123091
Cdkn1aRat(+)-Tetrandrine multiple interactionsISOCDKN1A (Homo sapiens)6480464[sodium arsenite co-treated with tetrandrine] affects the expression of CDKN1A proteinCTDPMID:30123091
Cdkn1aRat(-)-alpha-phellandrene increases expressionISOCDKN1A (Homo sapiens)6480464alpha phellandrene results in increased expression of CDKN1A mRNACTDPMID:25075043
Cdkn1aRat(-)-citrinin increases expressionISOCdkn1a (Mus musculus)6480464Citrinin results in increased expression of CDKN1A proteinCTDPMID:21622943
Cdkn1aRat(-)-citrinin increases expressionISOCDKN1A (Homo sapiens)6480464Citrinin results in increased expression of CDKN1A proteinCTDPMID:20929984
Cdkn1aRat(-)-demecolcine increases expressionISOCDKN1A (Homo sapiens)6480464Demecolcine results in increased expression of CDKN1A mRNACTDPMID:23649840
Cdkn1aRat(-)-demecolcine decreases expressionISOCDKN1A (Homo sapiens)6480464Demecolcine results in decreased expression of CDKN1A mRNACTDPMID:24211769
Cdkn1aRat(-)-epigallocatechin 3-gallate multiple interactionsISOCDKN1A (Homo sapiens)6480464[epigallocatechin gallate co-treated with leptomycin B] results in increased expression of CDKN1A mRNA more ...CTDPMID:12628509 and PMID:25922640
Cdkn1aRat(-)-epigallocatechin 3-gallate multiple interactionsISOCdkn1a (Mus musculus)6480464[epigallocatechin gallate co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9 more ...CTDPMID:23717041
Cdkn1aRat(-)-epigallocatechin 3-gallate increases expressionISOCDKN1A (Homo sapiens)6480464epigallocatechin gallate results in increased expression of CDKN1A proteinCTDPMID:15764647 and PMID:32512070
Cdkn1aRat(-)-epigallocatechin 3-gallate decreases expressionISOCDKN1A (Homo sapiens)6480464epigallocatechin gallate results in decreased expression of CDKN1A mRNACTDPMID:18851785
Cdkn1aRat(-)-epigallocatechin 3-gallate increases response to substanceISOCDKN1A (Homo sapiens)6480464CDKN1A protein results in increased susceptibility to epigallocatechin gallateCTDPMID:15764647
Cdkn1aRat(-)-noscapine multiple interactionsISOCDKN1A (Homo sapiens)6480464Noscapine promotes the reaction [Cisplatin results in increased expression of CDKN1A protein]CTDPMID:20674069
Cdkn1aRat(-)-noscapine increases expressionISOCDKN1A (Homo sapiens)6480464Noscapine results in increased expression of CDKN1A proteinCTDPMID:20674069
Cdkn1aRat(1S)-bornane-2,3-dione multiple interactionsISOCDKN1A (Homo sapiens)6480464Acetylcysteine inhibits the reaction [camphorquinone results in increased expression of CDKN1A protein]CTDPMID:26658076
Cdkn1aRat(1S)-bornane-2,3-dione increases expressionISOCDKN1A (Homo sapiens)6480464camphorquinone results in increased expression of CDKN1A mRNA and camphorquinone results in increased expression of CDKN1A proteinCTDPMID:26658076

1 to 20 of 1790 rows

Biological Process
1 to 20 of 70 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cdkn1aRatanimal organ regeneration  IEP 2289671 RGD 
Cdkn1aRatcellular response to amino acid starvation involved_inISOCdkn1a (Mus musculus)1624291 PMID:26102367RGDPMID:26102367
Cdkn1aRatcellular response to amino acid starvation involved_inISOCDKN1A (Homo sapiens)1624291 PMID:26102367RGDPMID:26102367
Cdkn1aRatcellular response to cell-matrix adhesion involved_inISOCDKN1A (Homo sapiens)1624291 PMID:17553787RGDPMID:17553787
Cdkn1aRatcellular response to gamma radiation acts_upstream_of_or_withinISOCdkn1a (Mus musculus)1624291 PMID:10710310RGDPMID:10710310
Cdkn1aRatcellular response to heat  IEP 8547793 RGD 
Cdkn1aRatcellular response to ionizing radiation involved_inISOCDKN1A (Homo sapiens)1624291 PMID:20160708RGDPMID:20160708
Cdkn1aRatcellular response to UV-B involved_inISOCdkn1a (Mus musculus)1624291 PMID:25329316RGDPMID:25329316
Cdkn1aRatcellular senescence involved_inISOCDKN1A (Homo sapiens)1624291 PMID:15149599RGDPMID:15149599
Cdkn1aRatcellular senescence acts_upstream_of_or_withinISOCdkn1a (Mus musculus)1624291MGI:104738 PMID:11551927RGDPMID:11551927
Cdkn1aRatcellular senescence acts_upstream_ofISOCDKN1A (Homo sapiens)1624291 PMID:17553787RGDPMID:17553787
Cdkn1aRatDNA damage response involved_inISOCDKN1A (Homo sapiens)1624291 PMID:20160708RGDPMID:20160708
Cdkn1aRatDNA damage response acts_upstream_of_or_withinISOCdkn1a (Mus musculus)1624291MGI:1933751 PMID:12952892RGDPMID:12952892
Cdkn1aRatDNA damage response involved_inIBAMGI:104556 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cdkn1aRatDNA damage response, signal transduction by p53 class mediator acts_upstream_of_or_withinISOCdkn1a (Mus musculus)1624291 PMID:10710310RGDPMID:10710310
Cdkn1aRatepidermis development acts_upstream_of_or_withinISOCdkn1a (Mus musculus)1624291MGI:104738 PMID:11551927RGDPMID:11551927
Cdkn1aRatfibroblast proliferation acts_upstream_of_or_withinISOCdkn1a (Mus musculus)1624291MGI:1924285 PMID:26334721RGDPMID:26334721
Cdkn1aRatheart development involved_inISOCdkn1a (Mus musculus)1624291 PMID:24380855RGDPMID:24380855
Cdkn1aRatimport into nucleus involved_inISOCDKN1A (Homo sapiens)1624291 PMID:12417334RGDPMID:12417334
Cdkn1aRatin utero embryonic development acts_upstream_of_or_withinISOCdkn1a (Mus musculus)1624291MGI:1924285 PMID:26334721RGDPMID:26334721
1 to 20 of 70 rows

Cellular Component
1 to 17 of 17 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cdkn1aRatcyclin-dependent protein kinase holoenzyme complex part_ofISOCDKN1A (Homo sapiens)1624291 PMID:17420273RGDPMID:17420273
Cdkn1aRatcyclin-dependent protein kinase holoenzyme complex part_ofISOCdkn1a (Mus musculus)1624291PR:P30285 more ...RGDPMID:12970760
Cdkn1aRatcyclin-dependent protein kinase holoenzyme complex part_ofIBAMGI:104556 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cdkn1aRatcytoplasm located_inISOCdkn1a (Mus musculus)1624291 PMID:11254359 and PMID:36689330RGDPMID:11254359 and PMID:36689330
Cdkn1aRatcytosol located_inISOCdkn1a (Mus musculus)1624291 PMID:15964824RGDPMID:15964824
Cdkn1aRatnuclear body located_inISOCDKN1A (Homo sapiens)1624291 RGDGO_REF:0000052
Cdkn1aRatnucleolus located_inISOCDKN1A (Homo sapiens)1624291 PMID:22869755RGDPMID:22869755
Cdkn1aRatnucleoplasm located_inISOCDKN1A (Homo sapiens)1624291 PMID:22869755RGDGO_REF:0000052 and PMID:22869755
Cdkn1aRatnucleus is_active_inISOCdkn1a (Mus musculus)1624291 PMID:12970760RGDPMID:12970760
Cdkn1aRatnucleus located_inISOCdkn1a (Mus musculus)1624291 PMID:11254359 more ...RGDPMID:11254359 more ...
Cdkn1aRatnucleus is_active_inIBAMGI:104556 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cdkn1aRatnucleus located_inISOCDKN1A (Homo sapiens)1624291 PMID:11343236 and PMID:23213251RGDPMID:11343236 and PMID:23213251
Cdkn1aRatnucleus located_inIEAInterPro:IPR0031751600115GO_REF:0000002InterProGO_REF:0000002
Cdkn1aRatPCNA-p21 complex part_ofISOCDKN1A (Homo sapiens)1624291 PMID:11595739 and PMID:18794347RGDPMID:11595739 and PMID:18794347
Cdkn1aRatPCNA-p21 complex is_active_inISOCDKN1A (Homo sapiens)1624291UniProtKB:P12004 and PMID:11463845RGDPMID:11463845
Cdkn1aRatperinuclear region of cytoplasm  IDA 8662307 RGD 
Cdkn1aRatprotein-containing complex part_ofISOCDKN1A (Homo sapiens)1624291 PMID:22869755RGDPMID:22869755
1 to 17 of 17 rows

Molecular Function
1 to 19 of 19 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cdkn1aRatcyclin binding enablesISOCdkn1a (Mus musculus)1624291 PMID:12124778 and PMID:24380855RGDPMID:12124778 and PMID:24380855
Cdkn1aRatcyclin-dependent protein kinase activating kinase activity enablesISOCDKN1A (Homo sapiens)1624291 PMID:9106657RGDPMID:9106657
Cdkn1aRatcyclin-dependent protein serine/threonine kinase inhibitor activity enablesISOCDKN1A (Homo sapiens)1624291 PMID:11463845RGDPMID:11463845
Cdkn1aRatcyclin-dependent protein serine/threonine kinase inhibitor activity enablesIEAInterPro:IPR0031751600115GO_REF:0000002InterProGO_REF:0000002
Cdkn1aRatcyclin-dependent protein serine/threonine kinase inhibitor activity enablesISOCdkn1a (Mus musculus)1624291 PMID:12130539RGDPMID:12130539
Cdkn1aRatmolecular function activator activity enablesISOCDKN1A (Homo sapiens)1624291 PMID:17553787RGDPMID:17553787
Cdkn1aRatmolecular function inhibitor activity enablesISOCDKN1A (Homo sapiens)1624291 PMID:8876165RGDPMID:8876165
Cdkn1aRatprotein binding  IPISkp2 (Rattus norvegicus)2315050 RGD 
Cdkn1aRatprotein binding enablesISOCdkn1a (Mus musculus)1624291PR:P11440 more ...RGDPMID:11022036 more ...
Cdkn1aRatprotein binding enablesISOCDKN1A (Homo sapiens)1624291UniProtKB:G5E9A7 more ...RGDPMID:10873631 more ...
Cdkn1aRatprotein kinase binding enablesISOCDKN1A (Homo sapiens)1624291UniProtKB:P24941 and PMID:8876165RGDPMID:8876165
Cdkn1aRatprotein kinase inhibitor activity enablesISOCDKN1A (Homo sapiens)1624291 PMID:8876165RGDPMID:8876165
Cdkn1aRatprotein kinase inhibitor activity enablesIEAUniProtKB-KW:KW-06491600115GO_REF:0000043UniProtGO_REF:0000043
Cdkn1aRatprotein kinase inhibitor activity enablesIBAMGI:104556 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cdkn1aRatprotein sequestering activity enablesISOCDKN1A (Homo sapiens)1624291 PMID:11595739RGDPMID:11595739
Cdkn1aRatprotein serine/threonine kinase binding enablesISOCDKN1A (Homo sapiens)1624291UniProtKB:P24941 and PMID:11463845RGDPMID:11463845
Cdkn1aRatprotein-containing complex binding  IPICcnd1 (Rattus norvegicus) and Cdk4 (Rattus norvegicus)2289148 RGD 
Cdkn1aRatprotein-containing complex binding enablesISOCDKN1A (Homo sapiens)1624291ComplexPortal:CPX-2006 PMID:8876165RGDPMID:8876165
Cdkn1aRatubiquitin protein ligase binding enablesISOCDKN1A (Homo sapiens)1624291UniProtKB:Q9BV68 and PMID:23026136RGDPMID:23026136
1 to 19 of 19 rows

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cdkn1aRatG1/S transition pathway  ISOCDKN1A (Homo sapiens)8694143 RGD 
Cdkn1aRatnuclear factor, erythroid 2 like 2 signaling pathway   ISOCDKN1A (Homo sapiens)11535066 RGD 

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

1 to 9 of 9 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cdkn1aRatcell cycle pathway, mitotic  IEA 6907045 KEGGrno:04110
Cdkn1aRatchronic myeloid leukemia pathway  IEA 6907045 KEGGrno:05220
Cdkn1aRatepidermal growth factor/neuregulin signaling pathway   IEA 6907045 KEGGrno:04012
Cdkn1aRatglioma pathway  IEA 6907045 KEGGrno:05214
Cdkn1aRathepatitis C pathway  IEA 6907045 KEGGrno:05160
Cdkn1aRatmelanoma pathway  IEA 6907045 KEGGrno:05218
Cdkn1aRatp53 signaling pathway   IEA 6907045 KEGGrno:04115
Cdkn1aRatprostate cancer pathway   IEA 6907045 KEGGrno:05215
Cdkn1aRaturinary bladder cancer pathway  IEA 6907045 KEGGrno:05219
1 to 9 of 9 rows

Imported Annotations - PID (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cdkn1aRatNotch signaling pathway   ISOCDKN1A (Homo sapiens)6484113 PIDPID:200015
Cdkn1aRatphosphatidylinositol 3-kinase-Akt signaling pathway   ISOCDKN1A (Homo sapiens)6484113 PIDPID:200197

1 to 20 of 109 rows
#
Reference Title
Reference Citation
1. P21-dependent protective effects of a carbon monoxide-releasing molecule-3 in pulmonary hypertension. Abid S, etal., Arterioscler Thromb Vasc Biol. 2014 Feb;34(2):304-12. doi: 10.1161/ATVBAHA.113.302302. Epub 2013 Dec 12.
2. Loss of p21WAF1/CIP1 accelerates Ras oncogenesis in a transgenic/knockout mammary cancer model. Adnane J, etal., Oncogene. 2000 Nov 9;19(47):5338-47.
3. Expression of p53, p16INK4A, pRb, p21WAF1/CIP1, p27KIP1, cyclin D1, Ki-67 and HPV DNA in sinonasal endophytic Schneiderian (inverted) papilloma. Altavilla G, etal., Acta Otolaryngol. 2009 Nov;129(11):1242-9. doi: 10.3109/00016480802620647.
4. Expression of p21WAF1/CIP1, p53, bcl-2 and Ki-67 in venous leg ulcers with and without squamous cell carcinoma. Baldursson B, etal., Acta Derm Venereol. 2000 Jul-Aug;80(4):251-5.
5. Intestinal cell cycle regulations. Interactions of cyclin D1, Cdk4, and p21Cip1. Beauchamp RD, etal., Ann Surg. 1996 May;223(5):620-7; discussion 627-8.
6. Analysis of the K-ras and p53 pathways in X-ray-induced lung tumors in the rat. Belinsky SA, etal., Radiat Res 1996 Apr;145(4):449-56.
7. Basic helix-loop-helix protein E47-mediated p21Waf1/Cip1 gene expression regulates apoptosis of intestinal epithelial cells. Bhattacharya S, etal., Biochem J. 2007 Oct 15;407(2):243-54.
8. Expression of the cell cycle regulators p53, p21(WAF1/CIP1) and p16(INK4a) in human endometrial adenocarcinoma. Buchynska LG and Nesina IP, Exp Oncol. 2006 Jun;28(2):152-5.
9. The degradation of cell cycle regulators by SKP2/CKS1 ubiquitin ligase is genetically controlled in rodent liver cancer and contributes to determine the susceptibility to the disease. Calvisi DF, etal., Int J Cancer. 2009 Jun 16.
10. Inhibition of GSK-3beta decreases NF-kappaB-dependent gene expression and impairs the rat liver regeneration. Chen H, etal., J Cell Biochem. 2007 Dec 1;102(5):1281-9.
11. Microbiota matures colonic epithelium through a coordinated induction of cell cycle-related proteins in gnotobiotic rat. Cherbuy C, etal., Am J Physiol Gastrointest Liver Physiol. 2010 Aug;299(2):G348-57. doi: 10.1152/ajpgi.00384.2009. Epub 2010 May 13.
12. p21(Cip1) restrains pituitary tumor growth. Chesnokova V, etal., Proc Natl Acad Sci U S A. 2008 Nov 11;105(45):17498-503. doi: 10.1073/pnas.0804810105. Epub 2008 Nov 3.
13. Arecoline-induced growth arrest and p21(WAF1) expression are dependent on p53 in rat hepatocytes. Chou WW, etal., Toxicology. 2008 Jan 14;243(1-2):1-10. Epub 2007 Sep 8.
14. Impairment of rat postnatal lung alveolar development by glucocorticoids: involvement of the p21CIP1 and p27KIP1 cyclin-dependent kinase inhibitors. Corroyer S, etal., Pediatr Res 2002 Feb;51(2):169-76.
15. Immunohistochemical expression of p16, p21, p27 and cyclin D1 in oral nevi and melanoma. de Andrade BA, etal., Head Neck Pathol. 2012 Sep;6(3):297-304. doi: 10.1007/s12105-012-0334-y. Epub 2012 Feb 5.
16. Tumorigenic activity of p21Waf1/Cip1 in thymic lymphoma. De la Cueva E, etal., Oncogene. 2006 Jul 6;25(29):4128-32. Epub 2006 Feb 6.
17. DNA damage and p21(WAF1/CIP1/SDI1) in experimental injury of the rat adrenal cortex and trauma-associated damage of the human adrenal cortex. Didenko VV, etal., J Pathol. 1999 Sep;189(1):119-26.
18. Association of single-nucleotide polymorphisms in the Cell Cycle genes with breast cancer in the British population. Driver KE, etal., Carcinogenesis. 2008 Jan 3;.
19. Topological control of p21WAF1/CIP1 expression in normal and neoplastic tissues. el-Deiry WS, etal., Cancer Res 1995 Jul 1;55(13):2910-9.
20. Phyllodes tumor: a clinicopathologic and immunohistochemical study of 30 cases. Esposito NN, etal., Arch Pathol Lab Med. 2006 Oct;130(10):1516-21.
1 to 20 of 109 rows
PMID:8876165   PMID:9054499   PMID:9106657   PMID:9190208   PMID:9372966   PMID:9811456   PMID:10208428   PMID:10710310   PMID:11254359   PMID:11343236   PMID:11595739   PMID:11981756  
PMID:12124778   PMID:12130539   PMID:12354776   PMID:12373555   PMID:12477932   PMID:12588994   PMID:12759355   PMID:12809946   PMID:12816757   PMID:12952892   PMID:12970760   PMID:14636896  
PMID:14712235   PMID:15084472   PMID:15127886   PMID:15149599   PMID:15219678   PMID:15389873   PMID:15616584   PMID:15789403   PMID:15814681   PMID:15831459   PMID:15958724   PMID:15964824  
PMID:16079240   PMID:16177030   PMID:16467127   PMID:16723699   PMID:16908950   PMID:17158337   PMID:17420273   PMID:17515607   PMID:17553787   PMID:17556661   PMID:18067863   PMID:18336467  
PMID:18356301   PMID:18408766   PMID:18794347   PMID:18850004   PMID:19136059   PMID:19224154   PMID:19387581   PMID:19587222   PMID:19628677   PMID:20022323   PMID:20032585   PMID:20160708  
PMID:20163460   PMID:20231440   PMID:20398565   PMID:21179739   PMID:21383775   PMID:21628527   PMID:21712954   PMID:22038224   PMID:22045811   PMID:22152918   PMID:22194422   PMID:22217517  
PMID:22258892   PMID:22322893   PMID:22344541   PMID:22869755   PMID:23026136   PMID:23131154   PMID:23213251   PMID:23549417   PMID:23719597   PMID:24223793   PMID:24380855   PMID:24772447  
PMID:25015661   PMID:25329316   PMID:25331946   PMID:25681685   PMID:25919700   PMID:25932965   PMID:26102367   PMID:26384650   PMID:26544695   PMID:27221738   PMID:27262357   PMID:27521891  
PMID:27553040   PMID:27600103   PMID:27652271   PMID:27703600   PMID:28746924   PMID:29039595   PMID:30511343   PMID:32309849   PMID:32423114   PMID:33010296   PMID:35232758  



Cdkn1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8207,150,820 - 7,161,373 (+)NCBIGRCr8
mRatBN7.2207,149,177 - 7,159,727 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl207,149,217 - 7,159,585 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx207,860,502 - 7,870,951 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0207,222,359 - 7,232,808 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0207,697,344 - 7,707,907 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0206,348,422 - 6,358,864 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl206,351,458 - 6,358,864 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0208,592,437 - 8,602,879 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4207,376,325 - 7,386,778 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1207,379,612 - 7,385,803 (+)NCBI
Celera208,699,290 - 8,709,718 (+)NCBICelera
Cytogenetic Map20p12NCBI
CDKN1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38636,676,463 - 36,687,332 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl636,676,460 - 36,687,397 (+)EnsemblGRCh38hg38GRCh38
GRCh37636,644,240 - 36,655,109 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36636,754,465 - 36,763,087 (+)NCBINCBI36Build 36hg18NCBI36
Build 34636,754,464 - 36,763,086NCBI
Celera638,201,500 - 38,210,146 (+)NCBICelera
Cytogenetic Map6p21.2NCBI
HuRef636,362,600 - 36,373,330 (+)NCBIHuRef
CHM1_1636,645,994 - 36,657,029 (+)NCBICHM1_1
T2T-CHM13v2.0636,497,108 - 36,508,013 (+)NCBIT2T-CHM13v2.0
Cdkn1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391729,309,953 - 29,319,696 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1729,309,950 - 29,319,701 (+)EnsemblGRCm39 Ensembl
GRCm381729,090,979 - 29,100,722 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1729,090,976 - 29,100,727 (+)EnsemblGRCm38mm10GRCm38
MGSCv371729,227,931 - 29,237,667 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361728,821,439 - 28,828,386 (+)NCBIMGSCv36mm8
Celera1729,647,617 - 29,657,304 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1715.12NCBI
Cdkn1a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554376,254,309 - 6,261,479 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554376,254,638 - 6,261,278 (-)NCBIChiLan1.0ChiLan1.0
CDKN1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2551,147,920 - 51,156,533 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1647,017,498 - 47,026,165 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0636,241,405 - 36,250,032 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1637,436,963 - 37,445,599 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl637,436,990 - 37,445,599 (+)Ensemblpanpan1.1panPan2
CDKN1A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1125,746,898 - 5,755,103 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl125,745,852 - 5,892,281 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha125,765,839 - 5,774,065 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0126,095,734 - 6,103,965 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1125,750,615 - 5,758,848 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0125,829,928 - 5,838,160 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0125,928,229 - 5,936,457 (+)NCBIUU_Cfam_GSD_1.0
Cdkn1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494641,235,060 - 41,242,922 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647622,717,260 - 22,725,182 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647622,717,308 - 22,725,127 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDKN1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl732,354,672 - 32,363,761 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1732,354,776 - 32,363,771 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2737,258,037 - 37,267,157 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CDKN1A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11735,445,668 - 35,454,334 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1735,445,223 - 35,454,342 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604436,625,094 - 36,634,245 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cdkn1a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475421,108,874 - 21,115,885 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475421,109,074 - 21,115,869 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Cdkn1a
111 total Variants

Predicted Target Of
Summary Value
Count of predictions:535
Count of miRNA genes:238
Interacting mature miRNAs:302
Transcripts:ENSRNOT00000000628
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 23 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20126123605Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20460660717617956Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)20362164910078919Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat

1 to 10 of 23 rows
PMC316389P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2207,157,322 - 7,157,741 (+)MAPPERmRatBN7.2
Rnor_6.0206,356,459 - 6,356,877NCBIRnor6.0
Rnor_5.0208,600,474 - 8,600,892UniSTSRnor5.0
RGSC_v3.4207,384,362 - 7,384,780UniSTSRGSC3.4
Celera208,707,313 - 8,707,731UniSTS
Cytogenetic Map20p12UniSTS
PMC85267P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2207,148,954 - 7,149,322 (+)MAPPERmRatBN7.2
Rnor_6.0206,348,091 - 6,348,458NCBIRnor6.0
Rnor_5.0208,592,106 - 8,592,473UniSTSRnor5.0
RGSC_v3.4207,375,994 - 7,376,361UniSTSRGSC3.4
Celera208,698,959 - 8,699,326UniSTS
Cytogenetic Map20p12UniSTS
RH130358  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2207,159,502 - 7,159,702 (+)MAPPERmRatBN7.2
Rnor_6.0206,358,640 - 6,358,839NCBIRnor6.0
Rnor_5.0208,602,655 - 8,602,854UniSTSRnor5.0
RGSC_v3.4207,386,554 - 7,386,753UniSTSRGSC3.4
Celera208,709,494 - 8,709,693UniSTS
Cytogenetic Map20p12UniSTS
PMC85267P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2207,149,834 - 7,150,254 (+)MAPPERmRatBN7.2
Rnor_6.0206,348,971 - 6,349,390NCBIRnor6.0
Rnor_5.0208,592,986 - 8,593,405UniSTSRnor5.0
RGSC_v3.4207,376,874 - 7,377,293UniSTSRGSC3.4
Celera208,699,825 - 8,700,244UniSTS
Cytogenetic Map20p12UniSTS
PMC114802P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2207,157,377 - 7,157,757 (+)MAPPERmRatBN7.2
Rnor_6.0206,356,514 - 6,356,893NCBIRnor6.0
Rnor_5.0208,600,529 - 8,600,908UniSTSRnor5.0
RGSC_v3.4207,384,417 - 7,384,796UniSTSRGSC3.4
Celera208,707,368 - 8,707,747UniSTS
Cytogenetic Map20p12UniSTS
PMC125030P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2207,157,376 - 7,157,757 (+)MAPPERmRatBN7.2
Rnor_6.0206,356,513 - 6,356,893NCBIRnor6.0
Rnor_5.0208,600,528 - 8,600,908UniSTSRnor5.0
RGSC_v3.4207,384,416 - 7,384,796UniSTSRGSC3.4
Celera208,707,367 - 8,707,747UniSTS
Cytogenetic Map20p12UniSTS
PMC126110P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8207,159,228 - 7,160,014 (+)Marker Load Pipeline
mRatBN7.2207,157,581 - 7,158,367 (+)MAPPERmRatBN7.2
Rnor_6.0206,356,718 - 6,357,503NCBIRnor6.0
Rnor_5.0208,600,733 - 8,601,518UniSTSRnor5.0
RGSC_v3.4207,384,621 - 7,385,406UniSTSRGSC3.4
Celera208,707,572 - 8,708,357UniSTS
Cytogenetic Map20p12UniSTS
PMC149170P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2207,157,407 - 7,158,435 (+)MAPPERmRatBN7.2
Rnor_6.0206,356,544 - 6,357,571NCBIRnor6.0
Rnor_5.0208,600,559 - 8,601,586UniSTSRnor5.0
RGSC_v3.4207,384,447 - 7,385,474UniSTSRGSC3.4
Celera208,707,398 - 8,708,425UniSTS
Cytogenetic Map20p12UniSTS
PMC307617P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2207,157,452 - 7,157,669 (+)MAPPERmRatBN7.2
Rnor_6.0206,356,589 - 6,356,805NCBIRnor6.0
Rnor_5.0208,600,604 - 8,600,820UniSTSRnor5.0
RGSC_v3.4207,384,492 - 7,384,708UniSTSRGSC3.4
Celera208,707,443 - 8,707,659UniSTS
Cytogenetic Map20p12UniSTS


The following Strains have been annotated to Cdkn1a
ACI.BUF-(D20Img2-Cdkn1a)/Ncc     BUF.ACI-(D20Img2-Cdkn1a)/Ncc    




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31


1 to 17 of 17 rows
RefSeq Transcripts NM_001434559 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001434560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001434561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_080782 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006256128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039098379 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039098380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB218281 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB218282 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB218283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC100620 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L41275 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U12526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U24172 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U24174 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 17 of 17 rows

Ensembl Acc Id: ENSRNOT00000000628   ⟹   ENSRNOP00000000628
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl206,356,423 - 6,358,864 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000091731   ⟹   ENSRNOP00000072242
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl207,149,217 - 7,159,585 (+)Ensembl
Rnor_6.0 Ensembl206,351,458 - 6,357,756 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000101862   ⟹   ENSRNOP00000084354
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl207,152,331 - 7,158,686 (+)Ensembl
RefSeq Acc Id: NM_080782   ⟹   NP_542960
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8207,150,932 - 7,161,373 (+)NCBI
mRatBN7.2207,149,286 - 7,159,727 (+)NCBI
Rnor_6.0206,348,422 - 6,358,864 (+)NCBI
Rnor_5.0208,592,437 - 8,602,879 (+)NCBI
RGSC_v3.4207,376,325 - 7,386,778 (+)RGD
Celera208,699,290 - 8,709,718 (+)RGD
Sequence:
RefSeq Acc Id: XM_006256128   ⟹   XP_006256190
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8207,153,768 - 7,161,373 (+)NCBI
mRatBN7.2207,152,255 - 7,159,727 (+)NCBI
Rnor_6.0206,351,439 - 6,358,864 (+)NCBI
Rnor_5.0208,592,437 - 8,602,879 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039098379   ⟹   XP_038954307
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8207,150,820 - 7,161,373 (+)NCBI
mRatBN7.2207,149,177 - 7,159,727 (+)NCBI
RefSeq Acc Id: XM_039098380   ⟹   XP_038954308
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8207,153,977 - 7,161,373 (+)NCBI
mRatBN7.2207,152,416 - 7,159,727 (+)NCBI
RefSeq Acc Id: NP_542960   ⟸   NM_080782
- UniProtKB: Q64315 (UniProtKB/TrEMBL),   A6JJT7 (UniProtKB/TrEMBL),   A0A8I5ZZ18 (UniProtKB/TrEMBL),   A0A0G2K2H2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256190   ⟸   XM_006256128
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000000628   ⟸   ENSRNOT00000000628
Ensembl Acc Id: ENSRNOP00000072242   ⟸   ENSRNOT00000091731
RefSeq Acc Id: XP_038954307   ⟸   XM_039098379
- Peptide Label: isoform X1
Cyclin-dependent kinase inhibitor

Name Modeler Protein Id AA Range Protein Structure
AF-Q64315-F1-model_v2 AlphaFold Q64315 1-164 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13701440
Promoter ID:EPDNEW_R11964
Type:single initiation site
Name:Cdkn1a_1
Description:cyclin-dependent kinase inhibitor 1A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0206,351,461 - 6,351,521EPDNEW


1 to 26 of 26 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-4391 BioCyc
Ensembl Genes ENSRNOG00000000521 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000091731 ENTREZGENE
  ENSRNOT00000091731.2 UniProtKB/TrEMBL
  ENSRNOT00000101862.1 UniProtKB/TrEMBL
Gene3D-CATH 4.10.365.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7938247 IMAGE-MGC_LOAD
InterPro CDI UniProtKB/TrEMBL
  CDI_dom_sf UniProtKB/TrEMBL
  CDKN1A_vertebrate UniProtKB/TrEMBL
KEGG Report rno:114851 UniProtKB/TrEMBL
MGC_CLONE MGC:124547 IMAGE-MGC_LOAD
NCBI Gene 114851 ENTREZGENE
PANTHER CYCLIN-DEPENDENT KINASE INHIBITOR 1 UniProtKB/TrEMBL
  PTHR46778 UniProtKB/TrEMBL
Pfam CDI UniProtKB/TrEMBL
PharmGKB CDKN1A RGD
PhenoGen Cdkn1a PhenoGen
RatGTEx ENSRNOG00000000521 RatGTEx
TIGR TC221101
UniProt A0A0G2K2H2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZZ18 ENTREZGENE, UniProtKB/TrEMBL
  A6JJT7 ENTREZGENE
  Q2WFZ6_RAT UniProtKB/TrEMBL
  Q64315 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A6JJT7 UniProtKB/TrEMBL
1 to 26 of 26 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-11-05 Cdkn1a  cyclin-dependent kinase inhibitor 1A  Cdkn1a  cyclin-dependent kinase inhibitor 1A (p21, Cip1)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-15 Cdkn1a  cyclin-dependent kinase inhibitor 1A (p21, Cip1)  Cdkn1a  cyclin-dependent kinase inhibitor 1A   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Cdkn1a  cyclin-dependent kinase inhibitor 1A       Name updated 70584 APPROVED

Note Type Note Reference
gene_domains upstream promoter region contains conserved p53-binding sites, shared by rat, human and mouse 68871
gene_domains upstream promoter region contains conserved p53-binding sites, shared by rat, human and mouse 68872
gene_function inhibits the activity of cyclin-CDK complexes 68871
gene_function inhibits the activity of cyclin-CDK complexes 68872
gene_process may play a role in cell senescence and in neoplasia 68871
gene_process may play a role in cell senescence and in neoplasia 68872
gene_process involved in glucocorticoid mediated lung development 1299184
gene_product member of the cell cycle regulator family