Gpx4 (glutathione peroxidase 4) - Rat Genome Database

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Gene: Gpx4 (glutathione peroxidase 4) Rattus norvegicus
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Symbol: Gpx4
Name: glutathione peroxidase 4
RGD ID: 69226
Description: Enables phospholipid-hydroperoxide glutathione peroxidase activity and selenium binding activity. Involved in response to estradiol. Is active in cytosol and mitochondrion. Biomarker of acute kidney failure. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma; colorectal cancer; and spondylometaphyseal dysplasia Sedaghatian type. Orthologous to human GPX4 (glutathione peroxidase 4); PARTICIPATES IN glutathione metabolic pathway; INTERACTS WITH 1,2,4-trimethylbenzene; 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrotoluene.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: Gpx-4; Gshpx-4; Phgpx; phospholipid hydroperoxide glutathione peroxidase; phospholipid hydroperoxide glutathione peroxidase, mitochondrial; phospholipid hydroperoxide glutathione peroxidase, nuclear; snGpx
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Gpx4-ps1   Gpx4-ps2   Gpx4-ps3  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,300,833 - 10,303,629 (-)NCBIGRCr8
mRatBN7.279,650,186 - 9,652,982 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,650,185 - 9,652,982 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx712,533,042 - 12,535,860 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,408,380 - 14,411,198 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,269,509 - 12,272,287 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0712,516,357 - 12,519,154 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,516,352 - 12,519,154 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0712,686,460 - 12,689,257 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4711,162,521 - 11,165,318 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1711,162,520 - 11,165,318 (-)NCBI
Celera77,826,041 - 7,828,838 (-)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Gpx4RatAcute Coronary Syndrome  ISOGPX4 (Homo sapiens)401827171mRNA more ...RGD 
Gpx4Ratacute kidney failure treatmentIEP 401827911 RGD 
Gpx4RatBinge Drinking  IEP 401827870protein:decreased expression:liverRGD 
Gpx4Ratcolon cancer disease_progressionISOGPX4 (Homo sapiens)152995496mRNA and protein:increased expression:colon (human)RGD 
Gpx4Ratcolorectal adenocarcinoma susceptibilityISOGPX4 (Homo sapiens)152998895DNA:SNP:3' utr:c.718T>C (human)RGD 
Gpx4Ratcolorectal cancer susceptibilityISOGPX4 (Homo sapiens)152995451DNA:silent mutation:CDS: (rs713041) (human)RGD 
Gpx4Ratgastric adenocarcinoma susceptibilityISOGPX4 (Homo sapiens)152998894mRNA:decreased expression:stomach more ...RGD 
Gpx4Ratnephrotic syndrome  ISOGPX4 (Homo sapiens)7205671mRNA:decreased expression:kidneyRGD 
Gpx4Ratoral squamous cell carcinoma disease_progressionISOGPX4 (Homo sapiens)9068941protein:increased expression:oral cavity (human)RGDPMID:28653098 and REF_RGD_ID:152995473
Gpx4Ratpre-eclampsia  ISOGPX4 (Homo sapiens)401827170protein:decreased expression:placentaRGD 
Gpx4Ratpre-eclampsia  ISOGPX4 (Homo sapiens)401827849mRNA:decreased expression:placentaRGD 
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Gpx4Ratcerebral creatine deficiency syndrome  ISOGPX4 (Homo sapiens)8554872ClinVar Annotator: match by term: Cerebral creatine deficiency syndromeClinVarPMID:28492532
Gpx4Ratcyclic hematopoiesis  ISOGPX4 (Homo sapiens)8554872ClinVar Annotator: match by term: Cyclical neutropeniaClinVarPMID:28492532
Gpx4Ratgenetic disease  ISOGPX4 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868 and PMID:28492532
Gpx4RatPeutz-Jeghers syndrome  ISOGPX4 (Homo sapiens)8554872ClinVar Annotator: match by term: Peutz-Jeghers syndromeClinVarPMID:14970844 more ...
Gpx4Ratspondylometaphyseal dysplasia Sedaghatian type  ISOGPX4 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:17576681 more ...
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Gpx4RatBreast Neoplasms  ISOGPX4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17634480
Gpx4RatCadmium Poisoning  ISOGPX4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20643113
Gpx4RatColorectal Neoplasms  ISOGPX4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18850177
Gpx4Ratcongestive heart failure  ISOGPX4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20304815
Gpx4Ratcryptorchidism  ISOGPX4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:26050606
Gpx4RatEmbryo Loss  ISOGPX4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12566075
Gpx4RatFibrosis  ISOGPX4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:26042203
Gpx4Ratglucose intolerance  ISOGPX4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:26042203
Gpx4Ratmale infertility  ISOGPX4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19417079 and PMID:19744930
Gpx4Ratspondylometaphyseal dysplasia Sedaghatian type  ISOGPX4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Gpx4Ratsteatotic liver disease  ISOGPX4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:26042203
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Gpx4Ratspondylometaphyseal dysplasia Sedaghatian type  ISOGPX4 (Homo sapiens)7240710 OMIM 

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Gpx4Rat(+)-dexrazoxane multiple interactionsISOGpx4 (Mus musculus)6480464Dexrazoxane inhibits the reaction [Cyclophosphamide results in decreased expression of GPX4 protein]CTDPMID:37690746
Gpx4Rat(1->4)-beta-D-glucan multiple interactionsISOGpx4 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of GPX4 mRNACTDPMID:36331819
Gpx4Rat(R,R,R)-alpha-tocopherol multiple interactionsISOGPX4 (Homo sapiens)6480464alpha-Tocopherol inhibits the reaction [Sodium Selenite results in increased expression of GPX4 mRNA]CTDPMID:14642406
Gpx4Rat(S)-ropivacaine multiple interactionsISOGPX4 (Homo sapiens)6480464[Ropivacaine results in increased susceptibility to Cisplatin] which results in decreased expression of GPX4 protein more ...CTDPMID:39053794
Gpx4Rat(S)-ropivacaine decreases expressionISOGPX4 (Homo sapiens)6480464Ropivacaine results in decreased expression of GPX4 proteinCTDPMID:36124980
Gpx4Rat1,2,4-trimethylbenzene decreases expressionEXP 6480464pseudocumene results in decreased expression of GPX4 proteinCTDPMID:17337753
Gpx4Rat1,2-dimethylhydrazine multiple interactionsISOGpx4 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of GPX4 mRNACTDPMID:22206623
Gpx4Rat1,3-dichloropropan-2-ol decreases expressionISOGPX4 (Homo sapiens)64804641 and 3-dichloro-2-propanol results in decreased expression of GPX4 proteinCTDPMID:35870111
Gpx4Rat1,3-dichloropropan-2-ol decreases expressionISOGpx4 (Mus musculus)64804641 and 3-dichloro-2-propanol results in decreased expression of GPX4 proteinCTDPMID:35870111
Gpx4Rat1,3-dichloropropan-2-ol multiple interactionsISOGPX4 (Homo sapiens)6480464[Thiazoles binds to indoline] promotes the reaction [1 more ...CTDPMID:35870111
Gpx4Rat1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine multiple interactionsISOGpx4 (Mus musculus)64804643-Hydroxybutyric Acid inhibits the reaction [1-Methyl-4-phenyl-1 more ...CTDPMID:36435477
Gpx4Rat1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine decreases expressionISOGpx4 (Mus musculus)64804641-Methyl-4-phenyl-1 more ...CTDPMID:36435477
Gpx4Rat1-nitropyrene decreases expressionISOGpx4 (Mus musculus)64804641-nitropyrene results in decreased expression of GPX4 proteinCTDPMID:37993079
Gpx4Rat1-nitropyrene decreases expressionISOGPX4 (Homo sapiens)64804641-nitropyrene results in decreased expression of GPX4 proteinCTDPMID:37993079
Gpx4Rat1-nitropyrene multiple interactionsISOGPX4 (Homo sapiens)6480464CYP1B1 protein promotes the reaction [1-nitropyrene results in decreased expression of GPX4 protein] and ferrostatin-1 inhibits the reaction [1-nitropyrene results in decreased expression of GPX4 protein]CTDPMID:37993079
Gpx4Rat12(S)-HPETE increases chemical synthesisISOGPX4 (Homo sapiens)6480464GPX4 protein results in increased chemical synthesis of 12-HPETECTDPMID:11115402
Gpx4Rat17beta-estradiol decreases expressionISOGPX4 (Homo sapiens)6480464Estradiol results in decreased expression of GPX4 mRNACTDPMID:23019147
Gpx4Rat2,2',4,4',5,5'-hexachlorobiphenyl multiple interactionsISOGpx4 (Mus musculus)6480464[2 more ...CTDPMID:25510870
Gpx4Rat2,2',4,4'-Tetrabromodiphenyl ether affects expressionISOGpx4 (Mus musculus)64804642 more ...CTDPMID:30294300
Gpx4Rat2,2',5,5'-tetrachlorobiphenyl multiple interactionsISOGpx4 (Mus musculus)6480464[2 more ...CTDPMID:25510870

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Biological Process
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Gpx4Ratapoptotic process acts_upstream_of_or_withinISOGpx4 (Mus musculus)1624291 PMID:24599700RGDPMID:24599700
Gpx4Ratapoptotic process acts_upstream_of_or_withinIEAUniProtKB:O70325 and ensembl:ENSMUSP000001010111600115GO_REF:0000107EnsemblGO_REF:0000107
Gpx4Ratarachidonate metabolic process involved_inISSUniProtKB:P369691600115GO_REF:0000024UniProtGO_REF:0000024
Gpx4Ratarachidonate metabolic process involved_inIEAUniProtKB:P36969 and ensembl:ENSP000003461031600115GO_REF:0000107EnsemblGO_REF:0000107
Gpx4Ratarachidonate metabolic process involved_inISOGPX4 (Homo sapiens)1624291 PMID:11115402RGDPMID:11115402
Gpx4Ratcellular oxidant detoxification involved_inIEAGO:00046011600115GO_REF:0000108GOCGO_REF:0000108
Gpx4Ratcellular oxidant detoxification involved_inIEAGO:00470661600115GO_REF:0000108GOCGO_REF:0000108
Gpx4Ratcellular oxidant detoxification involved_inIEAGO:00046021600115GO_REF:0000108GOCGO_REF:0000108
Gpx4Ratcerebellum development acts_upstream_of_or_withinISOGpx4 (Mus musculus)1624291 PMID:24599700RGDPMID:24599700
Gpx4Ratcerebellum development acts_upstream_of_or_withinIEAUniProtKB:O70325 and ensembl:ENSMUSP000001010111600115GO_REF:0000107EnsemblGO_REF:0000107
Gpx4Ratchromatin organization involved_inISSUniProtKB:O703251600115GO_REF:0000024UniProtGO_REF:0000024
Gpx4Ratchromatin organization acts_upstream_of_or_withinIEAUniProtKB:O70325 and ensembl:ENSMUSP000001010111600115GO_REF:0000107EnsemblGO_REF:0000107
Gpx4Ratchromatin organization acts_upstream_of_or_withinISOGpx4 (Mus musculus)1624291 PMID:11344099RGDPMID:11344099
Gpx4Ratdendrite development acts_upstream_of_or_withinISOGpx4 (Mus musculus)1624291 PMID:24599700RGDPMID:24599700
Gpx4Ratdendrite development acts_upstream_of_or_withinIEAUniProtKB:O70325 and ensembl:ENSMUSP000001010111600115GO_REF:0000107EnsemblGO_REF:0000107
Gpx4Ratlipid metabolic process involved_inIEAUniProtKB-KW:KW-04431600115GO_REF:0000043UniProtGO_REF:0000043
Gpx4Ratlipoxygenase pathway involved_inISSUniProtKB:P369691600115GO_REF:0000024UniProtGO_REF:0000024
Gpx4Ratlipoxygenase pathway involved_inIEAUniProtKB:P36969 and ensembl:ENSP000003461031600115GO_REF:0000107EnsemblGO_REF:0000107
Gpx4Ratlipoxygenase pathway involved_inISOGPX4 (Homo sapiens)1624291 PMID:11115402RGDPMID:11115402
Gpx4Ratmulticellular organism growth acts_upstream_of_or_withinISOGpx4 (Mus musculus)1624291 PMID:24599700RGDPMID:24599700
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Cellular Component
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Gpx4Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Gpx4Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Gpx4Ratcytosol located_inISOGPX4 (Homo sapiens)1624291 PMID:11115402RGDPMID:11115402
Gpx4Ratcytosol located_inISOGpx4 (Mus musculus)1624291 PMID:12566075 and PMID:19890015RGDPMID:12566075 and PMID:19890015
Gpx4Ratcytosol located_inIEAUniProtKB:P36969 and ensembl:ENSP000003461031600115GO_REF:0000107EnsemblGO_REF:0000107
Gpx4Ratcytosol located_inIEAUniProtKB:O70325 and ensembl:ENSMUSP000001010111600115GO_REF:0000107EnsemblGO_REF:0000107
Gpx4Ratcytosol located_inISSUniProtKB:P369691600115GO_REF:0000024UniProtGO_REF:0000024
Gpx4Ratcytosol is_active_inIDA 11553053PMID:8878533FlyBase 
Gpx4Ratmitochondrion is_active_inIDA 11553053PMID:8878533FlyBase 
Gpx4Ratmitochondrion located_inIEAUniProtKB-SubCell:SL-01731600115GO_REF:0000044UniProtGO_REF:0000044
Gpx4Ratmitochondrion located_inISOGpx4 (Mus musculus)1624291 PMID:12566075 and PMID:15888450RGDPMID:12566075 and PMID:15888450
Gpx4Ratmitochondrion is_active_inIBAMGI:104767 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Gpx4Ratmitochondrion located_inIEAUniProtKB:O70325 and ensembl:ENSMUSP000001010111600115GO_REF:0000107EnsemblGO_REF:0000107
Gpx4Ratmitochondrion located_inIEAUniProtKB-KW:KW-04961600115GO_REF:0000043UniProtGO_REF:0000043
Gpx4Ratnuclear envelope located_inISOGpx4 (Mus musculus)1624291 PMID:12566075RGDPMID:12566075
Gpx4Ratnuclear envelope located_inIEAUniProtKB:O70325 and ensembl:ENSMUSP000001010111600115GO_REF:0000107EnsemblGO_REF:0000107
Gpx4Ratnucleolus located_inIEAUniProtKB-SubCell:SL-01881600115GO_REF:0000044UniProtGO_REF:0000044
Gpx4Ratnucleus located_inIEAUniProtKB:O70325 and ensembl:ENSMUSP000001010111600115GO_REF:0000107EnsemblGO_REF:0000107
Gpx4Ratnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
Gpx4Ratnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
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Molecular Function
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Gpx4Ratglutathione peroxidase activity enablesISSUniProtKB:O703251600115GO_REF:0000024UniProtGO_REF:0000024
Gpx4Ratglutathione peroxidase activity enablesIEAUniProtKB:O70325 and ensembl:ENSMUSP000001010111600115GO_REF:0000107EnsemblGO_REF:0000107
Gpx4Ratglutathione peroxidase activity enablesIEARHEA:168331600115GO_REF:0000116RHEAGO_REF:0000116
Gpx4Ratglutathione peroxidase activity enablesISOGpx4 (Mus musculus)1624291 PMID:11344099 and PMID:19890015RGDPMID:11344099 and PMID:19890015
Gpx4Ratglutathione peroxidase activity enablesIBAMGI:104767 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Gpx4Ratglutathione peroxidase activity enablesIEAUniProtKB:P36969 and ensembl:ENSP000003461031600115GO_REF:0000107EnsemblGO_REF:0000107
Gpx4Ratglutathione peroxidase activity enablesISOGPX4 (Homo sapiens)1624291 PMID:17630701 and PMID:36608588RGDPMID:17630701 and PMID:36608588
Gpx4Ratidentical protein binding enablesISOGPX4 (Homo sapiens)1624291 PMID:17630701RGDPMID:17630701
Gpx4Ratidentical protein binding enablesIEAUniProtKB:P36969 and ensembl:ENSP000003461031600115GO_REF:0000107EnsemblGO_REF:0000107
Gpx4Ratoxidoreductase activity enablesIEAUniProtKB-KW:KW-05601600115GO_REF:0000043UniProtGO_REF:0000043
Gpx4Ratperoxidase activity enablesIEAInterPro:IPR0008891600115GO_REF:0000002InterProGO_REF:0000002
Gpx4Ratperoxidase activity enablesIEAUniProtKB-KW:KW-05751600115GO_REF:0000043UniProtGO_REF:0000043
Gpx4Ratphospholipid-hydroperoxide glutathione peroxidase activity  IDA 68791 RGD 
Gpx4Ratphospholipid-hydroperoxide glutathione peroxidase activity enablesIEAUniProtKB:P36969 and ensembl:ENSP000003461031600115GO_REF:0000107EnsemblGO_REF:0000107
Gpx4Ratphospholipid-hydroperoxide glutathione peroxidase activity enablesIEARHEA:190571600115GO_REF:0000116RHEAGO_REF:0000116
Gpx4Ratphospholipid-hydroperoxide glutathione peroxidase activity enablesIEAEC:1.11.1.121600115GO_REF:0000003UniProtGO_REF:0000003
Gpx4Ratphospholipid-hydroperoxide glutathione peroxidase activity enablesIBAMGI:104767 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Gpx4Ratphospholipid-hydroperoxide glutathione peroxidase activity enablesISOGpx4 (Mus musculus)1624291 PMID:25402683 and PMID:29290465RGDPMID:25402683 and PMID:29290465
Gpx4Ratphospholipid-hydroperoxide glutathione peroxidase activity enablesIEAUniProtKB:O70325 and ensembl:ENSMUSP000001010111600115GO_REF:0000107EnsemblGO_REF:0000107
Gpx4Ratphospholipid-hydroperoxide glutathione peroxidase activity enablesISOGPX4 (Sus scrofa)1624291 PMID:2386798 and PMID:8135530RGDPMID:2386798 and PMID:8135530
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Imported Annotations - KEGG (archival)

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Gpx4Ratglutathione metabolic pathway  IEA 6907045 KEGGrno:00480

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#
Reference Title
Reference Citation
1. Import into mitochondria of phospholipid hydroperoxide glutathione peroxidase requires a leader sequence. Arai M, etal., Biochem Biophys Res Commun. 1996 Oct 14;227(2):433-9.
2. Evidence that a polymorphism within the 3'UTR of glutathione peroxidase 4 is functional and is associated with susceptibility to colorectal cancer. Bermano G, etal., Genes Nutr. 2007 Nov;2(2):225-32. doi: 10.1007/s12263-007-0052-3. Epub 2007 Oct 13.
3. Sulforaphane prevents maleic acid-induced nephropathy by modulating renal hemodynamics, mitochondrial bioenergetics and oxidative stress. Briones-Herrera A, etal., Food Chem Toxicol. 2018 May;115:185-197. doi: 10.1016/j.fct.2018.03.016. Epub 2018 Mar 13.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Impaired glomerular and tubular antioxidative defense mechanisms in nephrotic syndrome. Granqvist A, etal., Am J Physiol Renal Physiol. 2010 Oct;299(4):F898-904. doi: 10.1152/ajprenal.00124.2010. Epub 2010 Aug 4.
7. Glutathione peroxidase activity and expression levels are significantly increased in acute coronary syndromes. Holley A, etal., J Investig Med. 2017 Jun;65(5):919-925. doi: 10.1136/jim-2016-000361. Epub 2017 Mar 15.
8. Molecular cloning and functional expression of a cDNA for rat phospholipid hydroperoxide glutathione peroxidase: 3'-untranslated region of the gene is necessary for functional expression. Imai H, etal., J Biochem (Tokyo) 1995 Nov;118(5):1061-7.
9. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
10. Decreased Expression of Selenoproteins as a Poor Prognosticator of Gastric Cancer in Humans. Lan X, etal., Biol Trace Elem Res. 2017 Jul;178(1):22-28. doi: 10.1007/s12011-016-0908-8. Epub 2016 Dec 13.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Reduced selenium concentrations and glutathione peroxidase activity in preeclamptic pregnancies. Mistry HD, etal., Hypertension. 2008 Nov;52(5):881-8. doi: 10.1161/HYPERTENSIONAHA.108.116103. Epub 2008 Oct 13.
13. Differential expression and distribution of placental glutathione peroxidases 1, 3 and 4 in normal and preeclamptic pregnancy. Mistry HD, etal., Placenta. 2010 May;31(5):401-8. doi: 10.1016/j.placenta.2010.02.011. Epub 2010 Mar 19.
14. Genetic variants in selenoprotein genes increase risk of colorectal cancer. Méplan C, etal., Carcinogenesis. 2010 Jun;31(6):1074-9. doi: 10.1093/carcin/bgq076. Epub 2010 Apr 8.
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. Binge drinking during adolescence disrupts Se homeostasis and its main hepatic selenoprotein expression. Ojeda ML, etal., Alcohol Clin Exp Res. 2015 May;39(5):818-26. doi: 10.1111/acer.12707. Epub 2015 Apr 10.
17. Identification of a specific sperm nuclei selenoenzyme necessary for protamine thiol cross-linking during sperm maturation. Pfeifer H, etal., FASEB J 2001 May;15(7):1236-8.
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. Rat phospholipid-hydroperoxide glutathione peroxidase. cDNA cloning and identification of multiple transcription and translation start sites. Pushpa-Rekha TR, etal., J Biol Chem 1995 Nov 10;270(45):26993-9.
20. GOA pipeline RGD automated data pipeline
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PMID:1556123   PMID:2386798   PMID:8135530   PMID:9988735   PMID:10464096   PMID:11115402   PMID:11903656   PMID:12533403   PMID:12724282   PMID:12819198   PMID:12865426   PMID:14575705  
PMID:14583338   PMID:14651853   PMID:15670826   PMID:15757501   PMID:15821744   PMID:15888450   PMID:15901730   PMID:16159880   PMID:17603929   PMID:17630701   PMID:17997296   PMID:18614015  
PMID:19056867   PMID:19398061   PMID:19723078   PMID:19890015   PMID:21630459   PMID:22614831   PMID:23376485   PMID:23816523   PMID:25402683   PMID:25922076   PMID:26071777   PMID:26163004  
PMID:28709976   PMID:29290465   PMID:30205109   PMID:31685805   PMID:32376803   PMID:33415582   PMID:34699317   PMID:35076866   PMID:35320827   PMID:35653908   PMID:37391124   PMID:37506966  
PMID:37710183   PMID:37968154   PMID:38029583   PMID:38494855   PMID:38686488   PMID:38871197   PMID:38943181   PMID:39175261   PMID:39354361  



Gpx4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,300,833 - 10,303,629 (-)NCBIGRCr8
mRatBN7.279,650,186 - 9,652,982 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,650,185 - 9,652,982 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx712,533,042 - 12,535,860 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,408,380 - 14,411,198 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,269,509 - 12,272,287 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0712,516,357 - 12,519,154 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,516,352 - 12,519,154 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0712,686,460 - 12,689,257 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4711,162,521 - 11,165,318 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1711,162,520 - 11,165,318 (-)NCBI
Celera77,826,041 - 7,828,838 (-)NCBICelera
Cytogenetic Map7q11NCBI
GPX4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38191,103,994 - 1,106,779 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl191,103,982 - 1,106,791 (+)EnsemblGRCh38hg38GRCh38
GRCh37191,103,993 - 1,106,778 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36191,054,936 - 1,057,787 (+)NCBINCBI36Build 36hg18NCBI36
Build 34191,054,965 - 1,057,778NCBI
Celera191,036,910 - 1,039,761 (+)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef19877,428 - 880,271 (+)NCBIHuRef
CHM1_1191,103,529 - 1,106,380 (+)NCBICHM1_1
T2T-CHM13v2.0191,068,660 - 1,071,445 (+)NCBIT2T-CHM13v2.0
Gpx4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391079,883,000 - 79,892,273 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1079,883,000 - 79,892,273 (+)EnsemblGRCm39 Ensembl
GRCm381080,047,166 - 80,056,439 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1080,047,166 - 80,056,439 (+)EnsemblGRCm38mm10GRCm38
MGSCv371079,516,255 - 79,519,184 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361079,456,617 - 79,459,567 (+)NCBIMGSCv36mm8
Celera1081,068,319 - 81,071,248 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Gpx4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554956,767,975 - 6,772,178 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554956,767,969 - 6,772,256 (-)NCBIChiLan1.0ChiLan1.0
GPX4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2205,439,232 - 5,443,396 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1194,675,807 - 4,679,965 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01920,904 - 23,828 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1191,082,917 - 1,085,538 (+)NCBIpanpan1.1PanPan1.1panPan2
GPX4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha2057,443,525 - 57,445,796 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02058,383,449 - 58,385,704 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2058,383,450 - 58,385,689 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12057,438,781 - 57,441,040 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02057,918,275 - 57,920,554 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02058,121,304 - 58,123,564 (-)NCBIUU_Cfam_GSD_1.0
Gpx4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118217,324,770 - 217,328,696 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936588506,147 - 508,101 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936588506,101 - 508,469 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPX4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl277,320,464 - 77,323,931 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1277,321,568 - 77,323,931 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2277,673,720 - 77,676,083 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GPX4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.16873,867 - 876,225 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660817,991,488 - 7,994,293 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gpx4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248287,534,449 - 7,536,586 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248287,534,251 - 7,536,675 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Gpx4
22 total Variants

Predicted Target Of
Summary Value
Count of predictions:88
Count of miRNA genes:72
Interacting mature miRNAs:87
Transcripts:ENSRNOT00000018691
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 15 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat

1 to 10 of 15 rows
RH137289  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21435,338,433 - 35,338,615 (+)MAPPERmRatBN7.2
mRatBN7.279,650,550 - 9,651,548 (+)MAPPERmRatBN7.2
Rnor_6.0712,516,723 - 12,517,720NCBIRnor6.0
Rnor_6.01437,904,806 - 37,904,987NCBIRnor6.0
Rnor_5.01437,715,064 - 37,715,245UniSTSRnor5.0
Rnor_5.0712,686,826 - 12,687,823UniSTSRnor5.0
RGSC_v3.41437,742,061 - 37,742,242UniSTSRGSC3.4
RGSC_v3.4711,162,887 - 11,163,884UniSTSRGSC3.4
Celera77,826,407 - 7,827,404UniSTS
Celera1434,593,349 - 34,593,530UniSTS
Cytogenetic Map14p11UniSTS
Cytogenetic Map7q11UniSTS
RH143516  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.279,652,690 - 9,652,829 (+)MAPPERmRatBN7.2
Rnor_6.0712,518,863 - 12,519,001NCBIRnor6.0
Rnor_5.0712,688,966 - 12,689,104UniSTSRnor5.0
RGSC_v3.4711,165,027 - 11,165,165UniSTSRGSC3.4
Celera77,828,547 - 7,828,685UniSTS
RH 3.4 Map740.6UniSTS
Cytogenetic Map7q11UniSTS
UniSTS:237712  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8710,301,048 - 10,301,218 (+)Marker Load Pipeline
mRatBN7.279,650,401 - 9,650,571 (+)MAPPERmRatBN7.2
Rnor_6.0712,516,574 - 12,516,743NCBIRnor6.0
Rnor_5.0712,686,677 - 12,686,846UniSTSRnor5.0
RGSC_v3.4711,162,738 - 11,162,907UniSTSRGSC3.4
Celera77,826,258 - 7,826,427UniSTS
Cytogenetic Map7q11UniSTS
Gpx4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21435,338,112 - 35,338,614 (+)MAPPERmRatBN7.2
Rnor_6.01437,904,485 - 37,904,986NCBIRnor6.0
Rnor_5.01437,714,743 - 37,715,244UniSTSRnor5.0
RGSC_v3.41437,741,740 - 37,742,241UniSTSRGSC3.4
Celera1434,593,028 - 34,593,529UniSTS
Cytogenetic Map14p11UniSTS
Cytogenetic Map7q11UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31


1 to 29 of 29 rows
RefSeq Transcripts NM_001039849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001368043 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_017165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB072798 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF274028 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ537598 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY570513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB582508 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ087247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210610 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219811 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221663 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221899 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230991 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233099 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234630 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L24896 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U37427 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X82679 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 29 of 29 rows

Ensembl Acc Id: ENSRNOT00000018691   ⟹   ENSRNOP00000018691
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl712,516,357 - 12,518,684 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000077681   ⟹   ENSRNOP00000072552
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl712,516,357 - 12,519,154 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000093137
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl712,516,359 - 12,517,335 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000093376   ⟹   ENSRNOP00000076198
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl79,650,185 - 9,652,982 (-)Ensembl
Rnor_6.0 Ensembl712,516,352 - 12,519,154 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000093426   ⟹   ENSRNOP00000076309
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl79,650,186 - 9,652,512 (-)Ensembl
Rnor_6.0 Ensembl712,516,363 - 12,518,684 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000093632
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl712,516,358 - 12,517,901 (-)Ensembl
RefSeq Acc Id: NM_001039849   ⟹   NP_001034938
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,300,833 - 10,303,159 (-)NCBI
mRatBN7.279,650,186 - 9,652,512 (-)NCBI
Rnor_6.0712,516,357 - 12,518,684 (-)NCBI
Rnor_5.0712,686,460 - 12,689,257 (-)NCBI
RGSC_v3.4711,162,521 - 11,165,318 (-)RGD
Celera77,826,041 - 7,828,368 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001368043   ⟹   NP_001354972
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,300,833 - 10,303,537 (-)NCBI
mRatBN7.279,650,186 - 9,652,890 (-)NCBI
RefSeq Acc Id: NM_017165   ⟹   NP_058861
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,300,833 - 10,303,629 (-)NCBI
mRatBN7.279,650,186 - 9,652,982 (-)NCBI
Rnor_6.0712,516,357 - 12,519,154 (-)NCBI
Rnor_5.0712,686,460 - 12,689,257 (-)NCBI
RGSC_v3.4711,162,521 - 11,165,318 (-)RGD
Celera77,826,041 - 7,828,838 (-)RGD
Sequence:
RefSeq Acc Id: NP_058861   ⟸   NM_017165
- Peptide Label: isoform A precursor
- UniProtKB: Q76LU9 (UniProtKB/Swiss-Prot),   Q6PZ55 (UniProtKB/Swiss-Prot),   Q91XR8 (UniProtKB/Swiss-Prot),   P36970 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001034938   ⟸   NM_001039849
- Peptide Label: isoform B
- UniProtKB: P36970 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000018691   ⟸   ENSRNOT00000018691
Ensembl Acc Id: ENSRNOP00000072552   ⟸   ENSRNOT00000077681
Ensembl Acc Id: ENSRNOP00000076198   ⟸   ENSRNOT00000093376


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13695040
Promoter ID:EPDNEW_R5561
Type:initiation region
Name:Gpx4_2
Description:glutathione peroxidase 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R5562  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0712,518,684 - 12,518,744EPDNEW
RGD ID:13695039
Promoter ID:EPDNEW_R5562
Type:initiation region
Name:Gpx4_1
Description:glutathione peroxidase 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R5561  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0712,519,059 - 12,519,119EPDNEW


1 to 35 of 35 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-34914 BioCyc
BioCyc Pathway PWY-4081 [glutathione-peroxide redox reactions] BioCyc
BioCyc Pathway Image PWY-4081 BioCyc
Ensembl Genes ENSRNOG00000013604 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000093376 ENTREZGENE
  ENSRNOT00000093376.2 UniProtKB/Swiss-Prot
  ENSRNOT00000093426.2 UniProtKB/Swiss-Prot
Gene3D-CATH Glutaredoxin UniProtKB/Swiss-Prot
InterPro Glutathione_peroxidase UniProtKB/Swiss-Prot
  GPX_AS UniProtKB/Swiss-Prot
  GPX_CS UniProtKB/Swiss-Prot
  Thioredoxin-like_sf UniProtKB/Swiss-Prot
KEGG Report rno:29328 UniProtKB/Swiss-Prot
NCBI Gene 29328 ENTREZGENE
PANTHER PHOSPHOLIPID HYDROPEROXIDE GLUTATHIONE PEROXIDASE UniProtKB/Swiss-Prot
  PTHR11592 UniProtKB/Swiss-Prot
Pfam GSHPx UniProtKB/Swiss-Prot
PhenoGen Gpx4 PhenoGen
PIRSF Glutathion_perox UniProtKB/Swiss-Prot
PRINTS GLUTPROXDASE UniProtKB/Swiss-Prot
PROSITE GLUTATHIONE_PEROXID_1 UniProtKB/Swiss-Prot
  GLUTATHIONE_PEROXID_2 UniProtKB/Swiss-Prot
  GLUTATHIONE_PEROXID_3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000013604 RatGTEx
Superfamily-SCOP SSF52833 UniProtKB/Swiss-Prot
UniProt A6K8S0_RAT UniProtKB/TrEMBL
  A6K8S1_RAT UniProtKB/TrEMBL
  A6K8S2_RAT UniProtKB/TrEMBL
  GPX4_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6PZ55 ENTREZGENE
  Q76LU9 ENTREZGENE
  Q91XR8 ENTREZGENE
UniProt Secondary Q6PZ55 UniProtKB/Swiss-Prot
  Q76LU9 UniProtKB/Swiss-Prot
  Q91XR8 UniProtKB/Swiss-Prot
1 to 35 of 35 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Gpx4  glutathione peroxidase 4      Name updated 70584 APPROVED

Note Type Note Reference
gene_mutations_overexpression overexpression inhibits synthesis of platelet activating factor 728699