Prkcd (protein kinase C, delta) - Rat Genome Database

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Gene: Prkcd (protein kinase C, delta) Rattus norvegicus
Analyze
Symbol: Prkcd
Name: protein kinase C, delta
RGD ID: 67383
Description: Enables TIR domain binding activity; diacylglycerol-dependent, calcium-independent serine/threonine kinase activity; and protein serine/threonine kinase binding activity. Involved in several processes, including D-aspartate import across plasma membrane; positive regulation of D-glucose import; and positive regulation of MAP kinase activity. Is active in postsynaptic cytosol. Used to study brain ischemia and hypertension. Biomarker of hyperinsulinism; hypertension; muscular disease; obesity; and restrictive cardiomyopathy. Human ortholog(s) of this gene implicated in autoimmune lymphoproliferative syndrome type 3 and steatotic liver disease. Orthologous to human PRKCD (protein kinase C delta); PARTICIPATES IN the extracellular signal-regulated Raf/Mek/Erk signaling pathway; vascular endothelial growth factor signaling pathway; ceramide signaling pathway; INTERACTS WITH (+)-pilocarpine; (S)-amphetamine; 1-(5-isoquinolinesulfonyl)-2-methylpiperazine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: nPKC-delta; Pkcd; protein kinase C delta type
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8165,775,681 - 5,806,122 (-)NCBIGRCr8
mRatBN7.2165,769,217 - 5,799,380 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl165,769,215 - 5,799,352 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx165,781,205 - 5,811,322 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0166,926,659 - 6,956,775 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0165,779,783 - 5,809,932 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0166,655,131 - 6,675,746 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl166,655,120 - 6,675,746 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0166,588,990 - 6,608,725 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4165,954,218 - 5,975,743 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1165,954,214 - 5,975,741 (-)NCBI
Celera169,398,816 - 9,419,806 (+)NCBICelera
Cytogenetic Map16p16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
PrkcdRatbrain ischemia  IMP 1642524 RGD 
PrkcdRatBurns  IEP 1642547protein:altered localization:cardiac muscle cellRGD 
PrkcdRatCardiomegaly  IEP 1581271associated with HypertensionRGD 
PrkcdRatCardiomegaly  IAGP 1581271 RGD 
PrkcdRatExperimental Diabetes Mellitus  IEP 1642532protein:increased expression:kidneyRGD 
PrkcdRathyperinsulinism  IEP 1625605 RGD 
PrkcdRathypertension  IAGP 1581271 RGD 
PrkcdRathypertension  IEP 1642534protein:increased expression:heart and fibroblastRGD 
PrkcdRatInsulin Resistance  IEP 729667protein:altered localization:nucleusRGD 
PrkcdRatInsulin Resistance  ISOPrkcd (Mus musculus)1642527associated with Obesity and protein:increased activity:adipocyteRGD 
PrkcdRatLeft Ventricular Hypertrophy  IDA 1581272 RGD 
PrkcdRatmuscular disease  IEP 1642535associated with Diabetes Mellitus more ...RGD 
PrkcdRatMyocardial Ischemia  IEP 1642550mRNA more ...RGD 
PrkcdRatMyocardial Reperfusion Injury  IEP 1642542protein:decreased expression:heartRGD 
PrkcdRatobesity  IEP 1642533protein:decreased expression:heart ventricleRGD 
PrkcdRatportal hypertension  ISOPRKCD (Homo sapiens)1642521mRNA:decreased expression:spleen and macrophageRGD 
PrkcdRatrestrictive cardiomyopathy  IEP 1642535associated with Diabetes Mellitus more ...RGD 
PrkcdRatRight Ventricular Hypertrophy  IDA 1581272 RGD 
PrkcdRatsteatotic liver disease  ISOPRKCD (Homo sapiens)1642523 RGD 
PrkcdRatStroke  IMP 1642524 RGD 
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PrkcdRatautoimmune lymphoproliferative syndrome type 3  ISOPRKCD (Homo sapiens)8554872ClinVar Annotator: match by term: Autoimmune lymphoproliferative syndrome and type IIIClinVarPMID:11976687 more ...
PrkcdRatgenetic disease  ISOPRKCD (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868 and PMID:28492532
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PrkcdRatChemical and Drug Induced Liver Injury  ISOPRKCD (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:30393195
PrkcdRatExperimental Diabetes Mellitus  ISOPRKCD (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12198386
PrkcdRatExperimental Liver Cirrhosis  ISOPRKCD (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25380136
PrkcdRatFever  ISOPRKCD (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:31422080 and PMID:32437895
PrkcdRathypertension  ISOPRKCD (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23973649
PrkcdRatHypothermia  ISOPRKCD (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:30366073
PrkcdRatIntestinal Neoplasms  ISOPRKCD (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:11983831
PrkcdRatmetabolic dysfunction-associated steatotic liver disease  ISOPRKCD (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:29341352
PrkcdRatParkinsonism  ISOPRKCD (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:15681813
PrkcdRattoxic encephalopathy  ISOPRKCD (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22512859
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PrkcdRatautoimmune lymphoproliferative syndrome type 3  ISOPRKCD (Homo sapiens)7240710 OMIM 

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PrkcdRat(+)-pilocarpine increases expressionEXP 6480464Pilocarpine results in increased expression of PRKCD proteinCTDPMID:15058486
PrkcdRat(-)-epigallocatechin 3-gallate multiple interactionsISOPRKCD (Homo sapiens)6480464epigallocatechin gallate inhibits the reaction [Histamine results in increased phosphorylation of PRKCD protein] and epigallocatechin gallate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of PRKCD protein]CTDPMID:23333628
PrkcdRat(S)-amphetamine increases expressionEXP 6480464Dextroamphetamine results in increased expression of PRKCD mRNA and Dextroamphetamine results in increased expression of PRKCD proteinCTDPMID:19497417
PrkcdRat(S)-nicotine decreases expressionISOPrkcd (Mus musculus)6480464Nicotine results in decreased expression of PRKCD mRNACTDPMID:21955143
PrkcdRat1,2-dimethylhydrazine multiple interactionsISOPrkcd (Mus musculus)6480464Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in increased expression of PRKCD mRNA]CTDPMID:22206623
PrkcdRat1,2-dimethylhydrazine increases expressionISOPrkcd (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of PRKCD mRNACTDPMID:22206623
PrkcdRat1-(5-isoquinolinesulfonyl)-2-methylpiperazine multiple interactionsEXP 64804641-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Heptachlor affects the localization of PRKCD protein] and 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCD protein]CTDPMID:14678745
PrkcdRat1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile multiple interactionsISOPRKCD (Homo sapiens)6480464Citalopram inhibits the reaction [convulxin results in increased phosphorylation of PRKCD protein]CTDPMID:30592962
PrkcdRat1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile increases expressionEXP 6480464Citalopram results in increased expression of PRKCD mRNACTDPMID:28467792
PrkcdRat17beta-estradiol decreases expressionISOPRKCD (Homo sapiens)6480464Estradiol results in decreased expression of PRKCD mRNACTDPMID:15757668 and PMID:32387340
PrkcdRat17beta-estradiol multiple interactionsISOPRKCD (Homo sapiens)6480464[Estradiol co-treated with TGFB1 protein] results in decreased expression of PRKCD mRNACTDPMID:30165855
PrkcdRat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOPrkcd (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with decitabine] results in increased expression of PRKCD mRNACTDPMID:15251184
PrkcdRat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOPrkcd (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of PRKCD mRNACTDPMID:21570461 and PMID:24680724
PrkcdRat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOPRKCD (Homo sapiens)6480464Tetrachlorodibenzodioxin results in increased expression of PRKCD mRNACTDPMID:23152189
PrkcdRat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of PRKCD mRNACTDPMID:20959002 more ...
PrkcdRat2,3,7,8-tetrachlorodibenzodioxine increases localizationEXP 6480464Tetrachlorodibenzodioxin results in increased localization of PRKCD proteinCTDPMID:17222441
PrkcdRat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOPrkcd (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of PRKCD mRNACTDPMID:15251184 and PMID:33956508
PrkcdRat2,6-dimethoxyphenol multiple interactionsISOPRKCD (Homo sapiens)6480464[Sodium Chloride co-treated with pyrogallol 1 and 3-dimethyl ether] results in increased expression of and affects the localization of PRKCD proteinCTDPMID:38598786
PrkcdRat2-butoxyethanol decreases expressionISOPrkcd (Mus musculus)6480464n-butoxyethanol results in decreased expression of PRKCD mRNACTDPMID:19812364
PrkcdRat2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid multiple interactionsEXP 6480464anacardic acid inhibits the reaction [Paraquat results in increased cleavage of and results in increased activity of PRKCD protein]CTDPMID:21777615

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Biological Process
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PrkcdRatactivation of protein kinase activity involved_inISOPRKCD (Homo sapiens)1624291 PMID:10713049RGDPMID:10713049
PrkcdRatapoptotic process involved_inISOPRKCD (Homo sapiens)1624291 PMID:10770950 and PMID:12649167RGDPMID:10770950 and PMID:12649167
PrkcdRatapoptotic process involved_inIMP 10047294PMID:21696630CACAO 
PrkcdRatapoptotic process involved_inISSUniProtKB:Q056551600115GO_REF:0000024UniProtGO_REF:0000024
PrkcdRatapoptotic process involved_inIEAUniProtKB-KW:KW-00531600115GO_REF:0000043UniProtGO_REF:0000043
PrkcdRatapoptotic process involved_inIEAUniProtKB:Q05655 and ensembl:ENSP000003316021600115GO_REF:0000107EnsemblGO_REF:0000107
PrkcdRatB cell proliferation acts_upstream_of_or_withinISOPrkcd (Mus musculus)1624291MGI:2179710 PMID:11976687RGDPMID:11976687
PrkcdRatB cell proliferation acts_upstream_of_or_withinIEAUniProtKB:P28867 and ensembl:ENSMUSP000001078291600115GO_REF:0000107EnsemblGO_REF:0000107
PrkcdRatcell chemotaxis involved_inIEAUniProtKB:Q05655 and ensembl:ENSP000003316021600115GO_REF:0000107EnsemblGO_REF:0000107
PrkcdRatcell chemotaxis involved_inISOPRKCD (Homo sapiens)1624291 PMID:24008408RGDPMID:24008408
PrkcdRatcellular response to angiotensin involved_inISSUniProtKB:Q056551600115GO_REF:0000024UniProtGO_REF:0000024
PrkcdRatcellular response to angiotensin involved_inISOPRKCD (Homo sapiens)1624291 PMID:18285462RGDPMID:18285462
PrkcdRatcellular response to angiotensin involved_inIEAUniProtKB:Q05655 and ensembl:ENSP000003316021600115GO_REF:0000107EnsemblGO_REF:0000107
PrkcdRatcellular response to glucose starvation  IEP 1642520 RGD 
PrkcdRatcellular response to hydrogen peroxide involved_inIEAUniProtKB:Q05655 and ensembl:ENSP000003316021600115GO_REF:0000107EnsemblGO_REF:0000107
PrkcdRatcellular response to hydrogen peroxide involved_inISOPRKCD (Homo sapiens)1624291 PMID:10713049RGDPMID:10713049
PrkcdRatcellular response to hydroperoxide involved_inIEAUniProtKB:Q05655 and ensembl:ENSP000003316021600115GO_REF:0000107EnsemblGO_REF:0000107
PrkcdRatcellular response to hydroperoxide involved_inISOPRKCD (Homo sapiens)1624291 PMID:19059439RGDPMID:19059439
PrkcdRatcellular response to insulin stimulus  IEP 1642545 RGD 
PrkcdRatcellular response to oxidative stress involved_inIDA 10047294PMID:21696630CACAO 
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Cellular Component
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PrkcdRatcell-cell junction located_inISOPrkcd (Mus musculus)1624291 PMID:10882525RGDPMID:10882525
PrkcdRatcell-cell junction located_inIEAUniProtKB:P28867 and ensembl:ENSMUSP000001078291600115GO_REF:0000107EnsemblGO_REF:0000107
PrkcdRatcytoplasm located_inISOPRKCD (Homo sapiens)1624291 PMID:15632189 more ...RGDPMID:15632189 more ...
PrkcdRatcytoplasm located_inIEAUniProtKB:Q05655 and ensembl:ENSP000003316021600115GO_REF:0000107EnsemblGO_REF:0000107
PrkcdRatcytoplasm located_inIEAUniProtKB:P28867 and ensembl:ENSMUSP000001078291600115GO_REF:0000107EnsemblGO_REF:0000107
PrkcdRatcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
PrkcdRatcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
PrkcdRatcytoplasm located_inISOPrkcd (Mus musculus)1624291 PMID:10882525RGDPMID:10882525
PrkcdRatcytosol located_inIEAUniProtKB:Q05655 and ensembl:ENSP000003316021600115GO_REF:0000107EnsemblGO_REF:0000107
PrkcdRatcytosol located_inTAS 1600115Reactome:R-RNO-8932373ReactomeReactome:R-RNO-8932373
PrkcdRatcytosol located_inISOPRKCD (Homo sapiens)1624291 PMID:10770950 more ...RGDPMID:10770950 more ...
PrkcdRatcytosol located_inISOPRKCD (Homo sapiens) and UniProtKB:Q05655-11624291 RGDGO_REF:0000052
PrkcdRatendolysosome located_inIEAUniProtKB:Q05655 and ensembl:ENSP000003316021600115GO_REF:0000107EnsemblGO_REF:0000107
PrkcdRatendolysosome located_inISOPRKCD (Homo sapiens)1624291 PMID:17303575RGDPMID:17303575
PrkcdRatendolysosome located_inISSUniProtKB:Q056551600115GO_REF:0000024UniProtGO_REF:0000024
PrkcdRatendomembrane system located_inIEAUniProtKB-SubCell:SL-01471600115GO_REF:0000044UniProtGO_REF:0000044
PrkcdRatendoplasmic reticulum located_inIEAUniProtKB:Q05655 and ensembl:ENSP000003316021600115GO_REF:0000107EnsemblGO_REF:0000107
PrkcdRatendoplasmic reticulum located_inISOPRKCD (Homo sapiens)1624291 PMID:15774464 and PMID:18556656RGDPMID:15774464 and PMID:18556656
PrkcdRatendoplasmic reticulum located_inISSUniProtKB:Q056551600115GO_REF:0000024UniProtGO_REF:0000024
PrkcdRatmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
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Molecular Function
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PrkcdRatATP binding enablesIEAUniProtKB-KW:KW-00671600115GO_REF:0000043UniProtGO_REF:0000043
PrkcdRatATP binding enablesIEAInterPro:IPR000719 more ...1600115GO_REF:0000002InterProGO_REF:0000002
PrkcdRatATP binding enablesIEAInterPro:IPR000719 more ...1600115GO_REF:0000002InterProGO_REF:0000002
PrkcdRatATP binding enablesIEAUniRule:UR0015033411600115GO_REF:0000104UniProtGO_REF:0000104
PrkcdRatdiacylglycerol-dependent serine/threonine kinase activity enablesEXP 729231PMID:12198130Reactome 
PrkcdRatdiacylglycerol-dependent serine/threonine kinase activity enablesIEAInterPro:IPR0143761600115GO_REF:0000002InterProGO_REF:0000002
PrkcdRatdiacylglycerol-dependent serine/threonine kinase activity enablesIEAInterPro:IPR014376 and InterPro:IPR0274361600115GO_REF:0000002InterProGO_REF:0000002
PrkcdRatdiacylglycerol-dependent serine/threonine kinase activity enablesIEAEC:2.7.11.131600115GO_REF:0000003UniProtGO_REF:0000003
PrkcdRatdiacylglycerol-dependent serine/threonine kinase activity enablesISOPRKCD (Homo sapiens)1624291 PMID:12391145 and PMID:18285462RGDPMID:12391145 and PMID:18285462
PrkcdRatdiacylglycerol-dependent, calcium-independent serine/threonine kinase activity  IDA 1642551 RGD 
PrkcdRatdiacylglycerol-dependent, calcium-independent serine/threonine kinase activity enablesIEAUniProtKB:P28867 and ensembl:ENSMUSP000001078291600115GO_REF:0000107EnsemblGO_REF:0000107
PrkcdRatdiacylglycerol-dependent, calcium-independent serine/threonine kinase activity enablesISOPrkcd (Mus musculus)1624291 PMID:22885697RGDPMID:22885697
PrkcdRatdiacylglycerol-dependent, calcium-independent serine/threonine kinase activity enablesISSUniProtKB:P288671600115GO_REF:0000024UniProtGO_REF:0000024
PrkcdRatenzyme activator activity enablesISOPRKCD (Homo sapiens)1624291 PMID:16611985RGDPMID:16611985
PrkcdRatenzyme activator activity enablesIEAUniProtKB:Q05655 and ensembl:ENSP000003316021600115GO_REF:0000107EnsemblGO_REF:0000107
PrkcdRatenzyme binding enablesISOPRKCD (Homo sapiens)1624291UniProtKB:Q02880 more ...RGDPMID:16611985 and PMID:18556656
PrkcdRatenzyme binding enablesIEAUniProtKB:Q05655 and ensembl:ENSP000003316021600115GO_REF:0000107EnsemblGO_REF:0000107
PrkcdRatinsulin receptor substrate binding enablesISOPrkcd (Mus musculus)1624291UniProtKB:P35570 and PMID:18285345RGDPMID:18285345
PrkcdRatinsulin receptor substrate binding enablesIEAUniProtKB:P28867 and ensembl:ENSMUSP000001078291600115GO_REF:0000107EnsemblGO_REF:0000107
PrkcdRatkinase activity enablesIEAUniProtKB-KW:KW-04181600115GO_REF:0000043UniProtGO_REF:0000043
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RGD Manual Annotations


  

Imported Annotations - KEGG (archival)


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#
Reference Title
Reference Citation
1. Protein kinase C translocation and PKC-dependent protein phosphorylation during myocardial ischemia. Albert CJ and Ford DA, Am J Physiol. 1999 Feb;276(2 Pt 2):H642-50.
2. Selective cyclooxygenase-2 inhibitors stimulate glucose transport in L6 myotubes in a protein kinase Cdelta-dependent manner. Alpert E, etal., Biochem Pharmacol. 2007 Feb 1;73(3):368-77. Epub 2006 Oct 13.
3. Microarray analysis of oxidative stress regulated genes in mesencephalic dopaminergic neuronal cells: relevance to oxidative damage in Parkinson's disease. Anantharam V, etal., Neurochem Int. 2007 May;50(6):834-47. Epub 2007 Feb 23.
4. Protein kinase D1 (PKD1) activation mediates a compensatory protective response during early stages of oxidative stress-induced neuronal degeneration. Asaithambi A, etal., Mol Neurodegener. 2011 Jun 22;6:43. doi: 10.1186/1750-1326-6-43.
5. Chronic activation of protein kinase C in soleus muscles and other tissues of insulin-resistant type II diabetic Goto-Kakizaki (GK), obese/aged, and obese/Zucker rats. A mechanism for inhibiting glycogen synthesis. Avignon A, etal., Diabetes. 1996 Oct;45(10):1396-404.
6. Effects of long-term elevated glucose on collagen formation by mesangial cells. Baccora MH, etal., Kidney Int. 2007 Aug 29;.
7. Regulation of protein kinase C isozymes in volume overload cardiac hypertrophy. Braun MU, etal., Mol Cell Biochem. 2004 Jul;262(1-2):135-43.
8. DeltaPKC mediates microcerebrovascular dysfunction in acute ischemia and in chronic hypertensive stress in vivo. Bright R, etal., Brain Res. 2007 May 4;1144:146-55. Epub 2007 Feb 2.
9. Protein kinase C-mediated modulation of glutamate transporter activity in rat retina. Bull ND, etal., Curr Eye Res. 2007 Feb;32(2):123-31.
10. Altered PKC expression and phosphorylation in response to the nature, direction, and magnitude of mechanical stretch. Bullard TA, etal., Can J Physiol Pharmacol. 2007 Feb;85(2):243-50.
11. A systems biology approach to the pathogenesis of obesity-related nonalcoholic fatty liver disease using reverse phase protein microarrays for multiplexed cell signaling analysis. Calvert VS, etal., Hepatology. 2007 Jul;46(1):166-72.
12. Mechanism of enhanced calcium sensitivity and alpha 2-AR vasoreactivity in chronic NOS inhibition hypertension. Carter RW and Kanagy NL, Am J Physiol Heart Circ Physiol. 2003 Jan;284(1):H309-16. Epub 2002 Sep 19.
13. Effect of hypoxia and aging on PKC delta-mediated SC-35 phosphorylation in rat myocardial tissue. Cataldi A, etal., Anat Rec (Hoboken). 2009 Aug;292(8):1135-42. doi: 10.1002/ar.20936.
14. Protein kinase Cdelta-dependent and -independent signaling in genotoxic response to treatment of desferroxamine, a hypoxia-mimetic agent. Clavijo C, etal., Am J Physiol Cell Physiol. 2007 Jun;292(6):C2150-60.
15. Skin immunosenescence: decreased receptor for activated C kinase-1 expression correlates with defective tumour necrosis factor-alpha production in epidermal cells. Corsini E, etal., Br J Dermatol. 2009 Jan;160(1):16-25. Epub 2008 Oct 11.
16. Nuclear import of PKCdelta is required for apoptosis: identification of a novel nuclear import sequence. DeVries TA, etal., EMBO J 2002 Nov 15;21(22):6050-60.
17. Protein kinase C delta activation and translocation to the nucleus are required for fatty acid-induced apoptosis of insulin-secreting cells. Eitel K, etal., Diabetes. 2003 Apr;52(4):991-7.
18. Altered cardiac endothelin receptors and protein kinase C in deoxycorticosterone-salt hypertensive rats. Fareh J, etal., J Mol Cell Cardiol. 2000 Apr;32(4):665-76.
19. Requirement of Ca(2+) and PKCdelta for Janus kinase 2 activation by angiotensin II: involvement of PYK2. Frank GD, etal., Mol Endocrinol 2002 Feb;16(2):367-77.
20. N-Acetylcysteine and alpha-cyano-4-hydroxycinnamic acid alter protein kinase C (PKC)-delta and PKC-zeta and diminish dysmorphogenesis in rat embryos cultured with high glucose in vitro. Gareskog M and Wentzel P, J Endocrinol. 2007 Jan;192(1):207-14.
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PMID:3691811   PMID:9447980   PMID:9677322   PMID:9687370   PMID:10431815   PMID:10446219   PMID:10617144   PMID:10708593   PMID:10713049   PMID:10721703   PMID:10770950   PMID:10882525  
PMID:11118818   PMID:11738801   PMID:11744693   PMID:11916978   PMID:11950946   PMID:11976687   PMID:11998977   PMID:12167703   PMID:12391145   PMID:12456804   PMID:12477932   PMID:12510148  
PMID:12566450   PMID:12606313   PMID:12619877   PMID:12700627   PMID:12809676   PMID:12826681   PMID:12878476   PMID:12893264   PMID:12904329   PMID:13679307   PMID:14555230   PMID:14561782  
PMID:14583092   PMID:14715667   PMID:15105418   PMID:15210825   PMID:15217780   PMID:15282327   PMID:15339931   PMID:15476586   PMID:15576445   PMID:15632189   PMID:15716854   PMID:15731106  
PMID:15769752   PMID:15774464   PMID:15817708   PMID:15838306   PMID:15935342   PMID:15961393   PMID:15963450   PMID:15978696   PMID:15991247   PMID:16118209   PMID:16361258   PMID:16361709  
PMID:16367743   PMID:16396499   PMID:16611985   PMID:16648180   PMID:16781675   PMID:16940418   PMID:16962999   PMID:16987961   PMID:17109817   PMID:17293847   PMID:17306383   PMID:17316401  
PMID:17531159   PMID:17569658   PMID:17728398   PMID:17825316   PMID:17901241   PMID:17938203   PMID:17959830   PMID:17978575   PMID:17989210   PMID:18097471   PMID:18158336   PMID:18180404  
PMID:18182053   PMID:18195168   PMID:18273864   PMID:18285345   PMID:18285462   PMID:18323529   PMID:18335519   PMID:18387943   PMID:18388183   PMID:18497307   PMID:18550549   PMID:18556656  
PMID:18583709   PMID:18668351   PMID:18725417   PMID:18836180   PMID:18991865   PMID:19056867   PMID:19057126   PMID:19059439   PMID:19063870   PMID:19246637   PMID:19249914   PMID:19279008  
PMID:19279011   PMID:19339511   PMID:19356729   PMID:19366211   PMID:19497417   PMID:19540196   PMID:19632305   PMID:19646462   PMID:19752773   PMID:19782747   PMID:19801500   PMID:19808702  
1 to 10 of 17 rows



Prkcd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8165,775,681 - 5,806,122 (-)NCBIGRCr8
mRatBN7.2165,769,217 - 5,799,380 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl165,769,215 - 5,799,352 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx165,781,205 - 5,811,322 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0166,926,659 - 6,956,775 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0165,779,783 - 5,809,932 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0166,655,131 - 6,675,746 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl166,655,120 - 6,675,746 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0166,588,990 - 6,608,725 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4165,954,218 - 5,975,743 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1165,954,214 - 5,975,741 (-)NCBI
Celera169,398,816 - 9,419,806 (+)NCBICelera
Cytogenetic Map16p16NCBI
PRKCD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38353,161,209 - 53,192,717 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl353,156,009 - 53,192,717 (+)EnsemblGRCh38hg38GRCh38
GRCh37353,195,225 - 53,226,733 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36353,170,263 - 53,201,773 (+)NCBINCBI36Build 36hg18NCBI36
Build 34353,170,262 - 53,201,771NCBI
Celera353,162,239 - 53,193,756 (+)NCBICelera
Cytogenetic Map3p21.1NCBI
HuRef353,210,511 - 53,276,026 (+)NCBIHuRef
CHM1_1353,146,796 - 53,178,291 (+)NCBICHM1_1
T2T-CHM13v2.0353,194,119 - 53,225,596 (+)NCBIT2T-CHM13v2.0
Prkcd
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391430,317,310 - 30,348,637 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1430,317,311 - 30,348,167 (-)EnsemblGRCm39 Ensembl
GRCm381430,595,353 - 30,626,414 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1430,595,354 - 30,626,210 (-)EnsemblGRCm38mm10GRCm38
MGSCv371431,408,555 - 31,423,498 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361429,424,378 - 29,447,560 (-)NCBIMGSCv36mm8
Celera1426,853,019 - 26,867,962 (-)NCBICelera
Cytogenetic Map14BNCBI
cM Map1418.82NCBI
Prkcd
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554303,124,738 - 3,153,274 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554303,125,066 - 3,151,857 (+)NCBIChiLan1.0ChiLan1.0
PRKCD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2253,157,598 - 53,189,084 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1353,162,376 - 53,193,855 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0353,104,137 - 53,135,588 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1354,330,328 - 54,357,910 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl354,330,328 - 54,357,910 (+)Ensemblpanpan1.1panPan2
PRKCD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12036,723,491 - 36,751,982 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2036,723,809 - 36,752,191 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2036,660,459 - 36,673,894 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02037,001,697 - 37,030,998 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2037,001,704 - 37,031,073 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12036,438,983 - 36,452,419 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02036,800,686 - 36,814,133 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02037,015,742 - 37,029,186 (-)NCBIUU_Cfam_GSD_1.0
Prkcd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118170,754,028 - 170,788,044 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364733,892,366 - 3,923,515 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364733,892,625 - 3,923,467 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRKCD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1335,290,610 - 35,323,356 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11335,290,835 - 35,323,245 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21338,361,707 - 38,390,508 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PRKCD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12214,561,401 - 14,592,877 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2214,565,282 - 14,592,873 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041152,302,998 - 152,334,406 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prkcd
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248224,033,130 - 4,059,555 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248224,035,819 - 4,062,907 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Prkcd
122 total Variants

Predicted Target Of
Summary Value
Count of predictions:459
Count of miRNA genes:255
Interacting mature miRNAs:306
Transcripts:ENSRNOT00000025858, ENSRNOT00000067639
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 30 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
1357403Slep4Serum leptin concentration QTL 43.91blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1619639137Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat

1 to 10 of 30 rows
D16Mgh7  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2165,769,407 - 5,769,550 (+)MAPPERmRatBN7.2
Rnor_6.0166,655,313 - 6,655,455NCBIRnor6.0
Rnor_5.0166,589,172 - 6,589,314UniSTSRnor5.0
RGSC_v3.4165,954,398 - 5,954,541RGDRGSC3.4
RGSC_v3.4165,954,399 - 5,954,541UniSTSRGSC3.4
RGSC_v3.1165,954,396 - 5,954,539RGD
Celera169,419,482 - 9,419,624UniSTS
Cytogenetic Map16p16UniSTS
D16Arb4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2165,769,278 - 5,769,666 (+)MAPPERmRatBN7.2
Rnor_6.0166,655,184 - 6,655,571NCBIRnor6.0
Rnor_5.0166,589,043 - 6,589,430UniSTSRnor5.0
RGSC_v3.4165,954,270 - 5,954,657UniSTSRGSC3.4
RGSC_v3.1165,954,266 - 5,954,655RGD
Celera169,419,366 - 9,419,753UniSTS
SHRSP x BN Map161.1599UniSTS
SHRSP x BN Map161.1599RGD
FHH x ACI Map165.3399RGD
Cytogenetic Map16p16UniSTS
AI044238  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2165,769,531 - 5,769,780 (+)MAPPERmRatBN7.2
Rnor_6.0166,655,437 - 6,655,685NCBIRnor6.0
Rnor_5.0166,589,296 - 6,589,544UniSTSRnor5.0
RGSC_v3.4165,954,523 - 5,954,771UniSTSRGSC3.4
Celera169,419,252 - 9,419,500UniSTS
RH 3.4 Map1631.5UniSTS
Cytogenetic Map16p16UniSTS
UniSTS:224276  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2165,769,421 - 5,769,611 (+)MAPPERmRatBN7.2
Rnor_6.0166,655,327 - 6,655,516NCBIRnor6.0
Rnor_5.0166,589,186 - 6,589,375UniSTSRnor5.0
RGSC_v3.4165,954,413 - 5,954,602UniSTSRGSC3.4
Celera169,419,421 - 9,419,610UniSTS
Cytogenetic Map16p16UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31


1 to 30 of 30 rows
RefSeq Transcripts NM_133307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275048 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF219629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ230615 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ230616 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ230617 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ230618 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ230619 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ230620 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ230621 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ230622 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ230623 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ230624 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ230625 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ230626 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ230627 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ230628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ230629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ230630 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ230631 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ230632 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ230633 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC076505 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235241 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M18330 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 30 of 30 rows

Ensembl Acc Id: ENSRNOT00000025858   ⟹   ENSRNOP00000025858
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl165,769,215 - 5,799,352 (-)Ensembl
Rnor_6.0 Ensembl166,655,120 - 6,675,746 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000067639   ⟹   ENSRNOP00000061108
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl165,772,620 - 5,799,352 (-)Ensembl
Rnor_6.0 Ensembl166,655,662 - 6,669,045 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000112103   ⟹   ENSRNOP00000083061
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl165,769,215 - 5,789,049 (-)Ensembl
RefSeq Acc Id: NM_133307   ⟹   NP_579841
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8165,775,681 - 5,805,839 (-)NCBI
mRatBN7.2165,769,217 - 5,799,380 (-)NCBI
Rnor_6.0166,655,131 - 6,675,746 (-)NCBI
Rnor_5.0166,588,990 - 6,608,725 (-)NCBI
RGSC_v3.4165,954,218 - 5,975,743 (-)RGD
Celera169,398,816 - 9,419,806 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063275048   ⟹   XP_063131118
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8165,775,686 - 5,806,122 (-)NCBI
RefSeq Acc Id: XM_063275049   ⟹   XP_063131119
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8165,775,686 - 5,805,853 (-)NCBI
RefSeq Acc Id: XM_063275050   ⟹   XP_063131120
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8165,775,686 - 5,805,853 (-)NCBI
RefSeq Acc Id: XM_063275051   ⟹   XP_063131121
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8165,775,686 - 5,790,451 (-)NCBI
RefSeq Acc Id: NP_579841   ⟸   NM_133307
- UniProtKB: Q9JL03 (UniProtKB/Swiss-Prot),   Q9JK29 (UniProtKB/Swiss-Prot),   Q6DG48 (UniProtKB/Swiss-Prot),   P09215 (UniProtKB/Swiss-Prot),   A0A140UHX0 (UniProtKB/TrEMBL),   A6KG32 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000061108   ⟸   ENSRNOT00000067639
Ensembl Acc Id: ENSRNOP00000025858   ⟸   ENSRNOT00000025858
Ensembl Acc Id: ENSRNOP00000083061   ⟸   ENSRNOT00000112103
RefSeq Acc Id: XP_063131118   ⟸   XM_063275048
- Peptide Label: isoform X1
- UniProtKB: Q9JL03 (UniProtKB/Swiss-Prot),   Q9JK29 (UniProtKB/Swiss-Prot),   Q6DG48 (UniProtKB/Swiss-Prot),   P09215 (UniProtKB/Swiss-Prot),   A0A140UHX0 (UniProtKB/TrEMBL),   A6KG32 (UniProtKB/TrEMBL)
AGC-kinase C-terminal   C2   Phorbol-ester/DAG-type   Protein kinase

Name Modeler Protein Id AA Range Protein Structure
AF-P09215-F1-model_v2 AlphaFold P09215 1-673 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 40 of 59 rows
Database
Acc Id
Source(s)
BIND 134041
BioCyc Gene G2FUF-12186 BioCyc
Ensembl Genes ENSRNOG00000016346 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000025858 ENTREZGENE
Gene3D-CATH 2.60.40.150 UniProtKB/Swiss-Prot
  3.30.60.20 UniProtKB/Swiss-Prot
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7099952 IMAGE-MGC_LOAD
InterPro AGC-kinase_C UniProtKB/Swiss-Prot
  C1-like_sf UniProtKB/Swiss-Prot
  C2_dom UniProtKB/Swiss-Prot
  C2_domain_sf UniProtKB/Swiss-Prot
  DAG/PE-bd UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  PE/DAG-bd UniProtKB/Swiss-Prot
  PKC_delta UniProtKB/Swiss-Prot
  Pkinase_C UniProtKB/Swiss-Prot
  Prot_kin_PKC_delta UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
KEGG Report rno:170538 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91512 IMAGE-MGC_LOAD
NCBI Gene 170538 ENTREZGENE
PANTHER RIBOSOMAL PROTEIN S6 KINASE UniProtKB/Swiss-Prot
Pfam C1_1 UniProtKB/Swiss-Prot
  PKC_C2 UniProtKB/Swiss-Prot
  Pkinase UniProtKB/Swiss-Prot
  Pkinase_C UniProtKB/Swiss-Prot
PhenoGen Prkcd PhenoGen
PIRSF PKC_delta UniProtKB/Swiss-Prot
  Protein_kin_C_delta UniProtKB/Swiss-Prot
PRINTS DAGPEDOMAIN UniProtKB/Swiss-Prot
PROSITE AGC_KINASE_CTER UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
  PS50004 UniProtKB/Swiss-Prot
  ZF_DAG_PE_1 UniProtKB/Swiss-Prot
1 to 40 of 59 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Prkcd  protein kinase C, delta      Symbol and Name status set to approved 70586 APPROVED

Note Type Note Reference
gene_cellular_localization translocates from cytosol into the nucleus upon treatment with etoposide; Intralipid + heparin (IH) induces translocation from the cytosolic to membrane fraction 729633
gene_cellular_localization translocates from cytosol into the nucleus upon treatment with etoposide; Intralipid + heparin (IH) induces translocation from the cytosolic to membrane fraction 729667
gene_expression expressed in pancreatic acini 631304
gene_function binds phorbol esters 61695
gene_function binds phorbol esters 628336
gene_pathway activation by the digitalis drug ouabain is linked to Na+/K+-ATPase through Src/EGFR, and is required for the activation of ERK1/2 631304
gene_process involved in proheparin-binding EGF-like growth factor (HBEGF) ectodomain shedding upon TPA stimulation 61695
gene_process involved in proheparin-binding EGF-like growth factor (HBEGF) ectodomain shedding upon TPA stimulation 628336
gene_regulation maximal activation requires phosphatidylserine and diacylglycerol 61695
gene_regulation maximal activation requires phosphatidylserine and diacylglycerol 628336
gene_regulation tyrosine phosphorylation results in increased instability leading to degradation 631304
gene_regulation administration of the digitalis drug ouabain with intact cardiac myocytes causes rapid translocation/activation from the soluble to the particulate pools of enzymes 631304
gene_regulation protein is tyrosine phosphorylated by activated Cholecystokinin A receptor (Cckar) in pancreatic acinar cells 631304