Usp17la2 (ubiquitin specific peptidase 17-like a2) - Rat Genome Database

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Gene: Usp17la2 (ubiquitin specific peptidase 17-like a2) Rattus norvegicus
Analyze
Symbol: Usp17la2 (Ensembl: Usp17l8)
Name: ubiquitin specific peptidase 17-like a2 (Ensembl:ubiquitin specific peptidase 17 like family member 8)
RGD ID: 6500127
Description: Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in several processes, including CAAX-box protein processing; protein deubiquitination; and regulation of defense response. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytosol and nucleus. Orthologous to several human genes including USP17L11 (ubiquitin specific peptidase 17 like family member 11); USP17L12 (ubiquitin specific peptidase 17 like family member 12); and USP17L13 (ubiquitin specific peptidase 17 like family member 13); INTERACTS WITH Cuprizon; 2-hydroxypropanoic acid (ortholog); benzo[a]pyrene (ortholog).
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC100910107; ubiquitin carboxyl-terminal hydrolase 17-like protein A; ubiquitin carboxyl-terminal hydrolase 17-like protein D; ubiquitin carboxyl-terminal hydrolase DUB-1-like; ubiquitin specific peptidase 17-like I; Usp17li
RGD Orthologs
Human
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81168,563,281 - 168,567,056 (+)NCBIGRCr8
mRatBN7.21159,151,417 - 159,155,192 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1159,151,432 - 159,155,192 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01169,720,247 - 169,721,788 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1169,720,253 - 169,721,758 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01175,856,225 - 175,857,588 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1156,977,121 - 156,978,662 (-)NCBICelera
Cytogenetic Map1q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 11 of 11 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Usp17la2Rat2-hydroxypropanoic acid decreases expressionISOUSP17L2 (Homo sapiens)6480464Lactic Acid results in decreased expression of USP17L2 mRNACTDPMID:30851411
Usp17la2Ratbenzo[a]pyrene decreases methylationISOUSP17L2 (Homo sapiens)6480464Benzo(a)pyrene results in decreased methylation of USP17L2 promoterCTDPMID:27901495
Usp17la2Ratbutanal increases expressionISOUSP17L2 (Homo sapiens)6480464butyraldehyde results in increased expression of USP17L2 mRNACTDPMID:26079696
Usp17la2Ratcadmium atom decreases expressionISOUSP17L2 (Homo sapiens)6480464Cadmium results in decreased expression of USP17L2 mRNACTDPMID:24376830
Usp17la2RatCuprizon decreases expressionEXP 6480464Cuprizone results in decreased expression of USP17L5 mRNACTDPMID:27523638
Usp17la2Ratparacetamol increases expressionISOUSP17L2 (Homo sapiens)6480464Acetaminophen results in increased expression of USP17L2 mRNACTDPMID:26690555
Usp17la2Ratrac-lactic acid decreases expressionISOUSP17L2 (Homo sapiens)6480464Lactic Acid results in decreased expression of USP17L2 mRNACTDPMID:30851411
Usp17la2Ratrifampicin decreases expressionISOUSP17L2 (Homo sapiens)6480464Rifampin results in decreased expression of USP17L2 mRNACTDPMID:24552687
Usp17la2Ratsodium arsenite increases expressionISOUSP17L2 (Homo sapiens)6480464sodium arsenite results in increased expression of USP17L2 mRNACTDPMID:38568856
Usp17la2Ratthiram increases expressionISOUSP17L2 (Homo sapiens)6480464Thiram results in increased expression of USP17L2 mRNACTDPMID:38568856
Usp17la2Ratvalproic acid increases methylationISOUSP17L2 (Homo sapiens)6480464Valproic Acid results in increased methylation of USP17L2 geneCTDPMID:29154799

1 to 11 of 11 rows

Biological Process
1 to 20 of 20 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Usp17la2RatCAAX-box protein processing involved_inISOUSP17L2 (Homo sapiens)1624291 PMID:19188362RGDPMID:19188362
Usp17la2Ratnegative regulation of GTPase activity involved_inISOUSP17L2 (Homo sapiens)1624291 PMID:19188362RGDPMID:19188362
Usp17la2Ratnegative regulation of protein processing involved_inISOUSP17L2 (Homo sapiens)1624291 PMID:19188362RGDPMID:19188362
Usp17la2Ratnegative regulation of protein targeting to membrane involved_inISOUSP17L2 (Homo sapiens)1624291 PMID:19188362RGDPMID:19188362
Usp17la2Ratpositive regulation of GTPase activity involved_inISOUSP17L2 (Homo sapiens)1624291 PMID:21448158RGDPMID:21448158
Usp17la2Ratpositive regulation of MDA-5 signaling pathway involved_inISOUSP17L2 (Homo sapiens)1624291 PMID:20368735RGDPMID:20368735
Usp17la2Ratpositive regulation of RIG-I signaling pathway involved_inISOUSP17L2 (Homo sapiens)1624291 PMID:20368735RGDPMID:20368735
Usp17la2Ratprotein deubiquitination involved_inISOUSP17L2 (Homo sapiens)1624291 PMID:20228808RGDPMID:20228808
Usp17la2Ratprotein deubiquitination involved_inIEAInterPro:IPR0013941600115GO_REF:0000002InterProGO_REF:0000002
Usp17la2Ratprotein deubiquitination involved_inIEAARBA:ARBA000278791600115GO_REF:0000117UniProtGO_REF:0000117
Usp17la2Ratprotein K48-linked deubiquitination involved_inISOUSP17L2 (Homo sapiens)1624291 PMID:19188362 and PMID:20368735RGDPMID:19188362 and PMID:20368735
Usp17la2Ratprotein K63-linked deubiquitination involved_inISOUSP17L2 (Homo sapiens)1624291 PMID:19188362 and PMID:20368735RGDPMID:19188362 and PMID:20368735
Usp17la2Ratproteolysis involved_inIEAUniProtKB-KW:KW-06451600115GO_REF:0000043UniProtGO_REF:0000043
Usp17la2Ratregulation of apoptotic process involved_inIBAFB:FBgn0260936 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Usp17la2Ratregulation of cell migration involved_inISOUSP17L2 (Homo sapiens)1624291 PMID:21448158RGDPMID:21448158
Usp17la2Ratregulation of cell population proliferation involved_inISOUSP17L2 (Homo sapiens)1624291 PMID:19188362RGDPMID:19188362
Usp17la2Ratregulation of defense response to virus by host involved_inISOUSP17L2 (Homo sapiens)1624291 PMID:20368735RGDPMID:20368735
Usp17la2Ratregulation of G2/MI transition of meiotic cell cycle involved_inISOUSP17L2 (Homo sapiens)1624291 PMID:20228808RGDPMID:20228808
Usp17la2Ratregulation of protein stability involved_inIBAFB:FBgn0016756 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Usp17la2Ratregulation of ruffle assembly involved_inISOUSP17L2 (Homo sapiens)1624291 PMID:21448158RGDPMID:21448158
1 to 20 of 20 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Usp17la2Ratcytosol is_active_inIBAFB:FBgn0016756 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Usp17la2Ratendoplasmic reticulum membrane located_inISOUSP17L2 (Homo sapiens)1624291 PMID:19188362RGDPMID:19188362
Usp17la2Ratnucleus is_active_inIBAFB:FBgn0016756 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Usp17la2Ratnucleus located_inISOUSP17L2 (Homo sapiens)1624291 PMID:21239494RGDPMID:21239494

Molecular Function
1 to 9 of 9 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Usp17la2Ratcysteine-type deubiquitinase activity enablesISOUSP17L2 (Homo sapiens)1624291 PMID:19188362 more ...RGDPMID:19188362 more ...
Usp17la2Ratcysteine-type deubiquitinase activity enablesIEAInterPro:IPR001394 and InterPro:IPR0182001600115GO_REF:0000002InterProGO_REF:0000002
Usp17la2Ratcysteine-type deubiquitinase activity enablesIEAUniRule:UR0008807561600115GO_REF:0000104UniProtGO_REF:0000104
Usp17la2Ratcysteine-type deubiquitinase activity enablesIBAFB:FBgn0005632 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Usp17la2Ratcysteine-type deubiquitinase activity enablesIEAARBA:ARBA000268801600115GO_REF:0000117UniProtGO_REF:0000117
Usp17la2Ratcysteine-type peptidase activity enablesIEAUniProtKB-KW:KW-07881600115GO_REF:0000043UniProtGO_REF:0000043
Usp17la2Rathydrolase activity enablesIEAUniProtKB-KW:KW-03781600115GO_REF:0000043UniProtGO_REF:0000043
Usp17la2Ratpeptidase activity enablesIEAUniProtKB-KW:KW-06451600115GO_REF:0000043UniProtGO_REF:0000043
Usp17la2Ratprotein binding enablesISOUSP17L2 (Homo sapiens)1624291UniProtKB:Q9H7L9 and PMID:21239494RGDPMID:21239494
1 to 9 of 9 rows


#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:8995226   PMID:19188362   PMID:20228808   PMID:20368735   PMID:21239494   PMID:21448158  



Usp17la2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81168,563,281 - 168,567,056 (+)NCBIGRCr8
mRatBN7.21159,151,417 - 159,155,192 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1159,151,432 - 159,155,192 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01169,720,247 - 169,721,788 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1169,720,253 - 169,721,758 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01175,856,225 - 175,857,588 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1156,977,121 - 156,978,662 (-)NCBICelera
Cytogenetic Map1q32NCBI
USP17L2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38812,136,435 - 12,138,849 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl812,136,435 - 12,138,849 (-)EnsemblGRCh38hg38GRCh38
GRCh37811,993,944 - 11,996,358 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36812,032,086 - 12,033,678 (-)NCBINCBI36Build 36hg18NCBI36
Celera811,194,744 - 11,196,336 (+)NCBICelera
Cytogenetic Map8p23.1NCBI
CHM1_1812,060,015 - 12,061,607 (-)NCBICHM1_1
T2T-CHM13v2.087,595,654 - 7,598,068 (+)NCBIT2T-CHM13v2.0

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Variants in Usp17la2
4 total Variants

1 to 10 of 78 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1121767634166767634Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383668Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat

1 to 10 of 78 rows



ectoderm
endocrine system
endoderm
exocrine system
hepatobiliary system
mesenchyme
mesoderm
nervous system
reproductive system
7 3 2 2 2 3 1 6 14



Ensembl Acc Id: ENSRNOT00000023213   ⟹   ENSRNOP00000023213
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1169,720,253 - 169,721,758 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000112361   ⟹   ENSRNOP00000095262
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1159,151,432 - 159,155,192 (+)Ensembl
RefSeq Acc Id: XM_039097825   ⟹   XP_038953753
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81168,563,281 - 168,567,056 (+)NCBI
mRatBN7.21159,151,417 - 159,155,192 (+)NCBI
Protein RefSeqs XP_038953753 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000095262.1
Ensembl Acc Id: ENSRNOP00000023213   ⟸   ENSRNOT00000023213
RefSeq Acc Id: XP_038953753   ⟸   XM_039097825
- UniProtKB: A0A8I6AMA7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000095262   ⟸   ENSRNOT00000112361
USP

Name Modeler Protein Id AA Range Protein Structure
AF-F1M413-F1-model_v2 AlphaFold F1M413 1-502 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 22 of 22 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-58068 BioCyc
Ensembl Genes ENSRNOG00000043303 Ensembl
  ENSRNOG00000066547 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000112361.1 UniProtKB/TrEMBL
Gene3D-CATH Cysteine proteinases UniProtKB/TrEMBL
InterPro Papain-like_cys_pep_sf UniProtKB/TrEMBL
  Peptidase_C19 UniProtKB/TrEMBL
  Peptidase_C19_UCH UniProtKB/TrEMBL
  USP_CS UniProtKB/TrEMBL
  USP_dom UniProtKB/TrEMBL
NCBI Gene LOC100910107 ENTREZGENE
PANTHER INACTIVE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 17-LIKE PROTEIN 7-RELATED UniProtKB/TrEMBL
  UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UniProtKB/TrEMBL
Pfam UCH UniProtKB/TrEMBL
PhenoGen Usp17la2 PhenoGen
PROSITE USP_1 UniProtKB/TrEMBL
  USP_2 UniProtKB/TrEMBL
  USP_3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000043303 RatGTEx
  ENSRNOG00000066547 RatGTEx
Superfamily-SCOP SSF54001 UniProtKB/TrEMBL
UniProt A0A8I6AMA7 ENTREZGENE, UniProtKB/TrEMBL
1 to 22 of 22 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-01-08 Usp17la2  ubiquitin specific peptidase 17-like a2  Usp17li  ubiquitin specific peptidase 17-like I  Name and Symbol changed 629549 APPROVED
2023-09-19 Usp17li  ubiquitin specific peptidase 17-like I  LOC100910107  ubiquitin carboxyl-terminal hydrolase DUB-1-like  Symbol and Name Changed 1299863 APPROVED
2012-07-05 LOC100910107  ubiquitin carboxyl-terminal hydrolase DUB-1-like      Symbol and Name status set to provisional 70820 PROVISIONAL