Usp15 (ubiquitin specific peptidase 15) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Usp15 (ubiquitin specific peptidase 15) Rattus norvegicus
Analyze
Symbol: Usp15
Name: ubiquitin specific peptidase 15
RGD ID: 628795
Description: Enables cysteine-type deubiquitinase activity. Involved in protein deubiquitination. Located in cytoplasm and nucleus. Orthologous to human USP15 (ubiquitin specific peptidase 15); PARTICIPATES IN mitochondrial autophagy pathway; INTERACTS WITH 2,6-dinitrotoluene; 6-propyl-2-thiouracil; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: deubiquitinating enzyme 15; deubiquitinating enzyme Ubp109; ubiquitin carboxyl-terminal hydrolase 15; ubiquitin carboxyl-terminal hydrolase of 109 kDa; ubiquitin specific protease 15; ubiquitin thioesterase 15; ubiquitin-specific-processing protease 15; Ubp109
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8760,643,611 - 60,805,137 (-)NCBIGRCr8
mRatBN7.2758,756,714 - 58,848,778 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl758,756,872 - 58,848,721 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx760,630,453 - 60,720,966 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0762,833,103 - 62,923,616 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0762,610,431 - 62,700,867 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0766,595,707 - 66,687,707 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl766,595,742 - 66,687,278 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0766,793,539 - 66,885,533 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4762,871,167 - 62,961,405 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1762,891,896 - 62,982,135 (-)NCBI
Celera755,929,201 - 56,019,813 (-)NCBICelera
Cytogenetic Map7q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Usp15Ratchronic myeloid leukemia  ISOUSP15 (Homo sapiens)151667904mRNA and protein:decreased expression:PBMC (human)RGD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Usp15Ratdiabetic neuropathy  ISOUSP15 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:35478295

1 to 20 of 109 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Usp15Rat1,2-dimethylhydrazine multiple interactionsISOUsp15 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of USP15 mRNACTDPMID:22206623
Usp15Rat1-nitropyrene increases expressionISOUSP15 (Homo sapiens)64804641-nitropyrene results in increased expression of USP15 mRNACTDPMID:19041380
Usp15Rat2,2',4,4'-Tetrabromodiphenyl ether decreases expressionISOUSP15 (Homo sapiens)64804642 more ...CTDPMID:31675489
Usp15Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOUsp15 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of USP15 mRNACTDPMID:21570461
Usp15Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOUsp15 (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of USP15 mRNACTDPMID:15034205
Usp15Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOUsp15 (Mus musculus)6480464AHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of USP15 mRNA]CTDPMID:15034205
Usp15Rat2,4,6-tribromophenol increases expressionISOUSP15 (Homo sapiens)64804642 more ...CTDPMID:31675489
Usp15Rat2,6-dinitrotoluene affects expressionEXP 64804642 and 6-dinitrotoluene affects the expression of USP15 mRNACTDPMID:21346803
Usp15Rat3-isobutyl-1-methyl-7H-xanthine multiple interactionsISOUSP15 (Homo sapiens)6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of USP15 mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of USP15 mRNACTDPMID:28628672
Usp15Rat4,4'-diaminodiphenylmethane affects expressionISOUsp15 (Mus musculus)64804644 and 4'-diaminodiphenylmethane affects the expression of USP15 mRNACTDPMID:18648102
Usp15Rat4-hydroxyphenyl retinamide decreases expressionISOUsp15 (Mus musculus)6480464Fenretinide results in decreased expression of USP15 mRNACTDPMID:28973697
Usp15Rat6-propyl-2-thiouracil increases expressionEXP 6480464Propylthiouracil results in increased expression of USP15 mRNACTDPMID:30047161
Usp15Ratacetohydrazide decreases expressionISOUsp15 (Mus musculus)6480464acetylhydrazine results in decreased expression of USP15 mRNACTDPMID:15282401
Usp15Ratacetylsalicylic acid increases expressionISOUSP15 (Homo sapiens)6480464Aspirin results in increased expression of USP15 mRNACTDPMID:11906190
Usp15Ratacrylamide increases expressionEXP 6480464Acrylamide results in increased expression of USP15 mRNACTDPMID:28959563
Usp15Ratacrylamide decreases expressionEXP 6480464Acrylamide results in decreased expression of USP15 mRNACTDPMID:28959563
Usp15Rataflatoxin B1 increases methylationISOUSP15 (Homo sapiens)6480464Aflatoxin B1 results in increased methylation of USP15 intronCTDPMID:30157460
Usp15Ratamitrole increases expressionEXP 6480464Amitrole results in increased expression of USP15 mRNACTDPMID:30047161
Usp15Ratammonium chloride affects expressionEXP 6480464Ammonium Chloride affects the expression of USP15 mRNACTDPMID:16483693
Usp15Ratantirheumatic drug decreases expressionISOUSP15 (Homo sapiens)6480464Antirheumatic Agents results in decreased expression of USP15 mRNACTDPMID:24449571

1 to 20 of 109 rows

Biological Process
1 to 20 of 35 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Usp15RatBMP signaling pathway involved_inIEAUniProtKB:Q9Y4E8 and ensembl:ENSP000002803771600115GO_REF:0000107EnsemblGO_REF:0000107
Usp15RatBMP signaling pathway involved_inISOUSP15 (Homo sapiens)1624291 PMID:21947082RGDPMID:21947082
Usp15RatBMP signaling pathway involved_inISSUniProtKB:Q9Y4E81600115GO_REF:0000024UniProtGO_REF:0000024
Usp15Ratmonoubiquitinated protein deubiquitination involved_inISSUniProtKB:Q9Y4E81600115GO_REF:0000024UniProtGO_REF:0000024
Usp15Ratmonoubiquitinated protein deubiquitination involved_inIEAUniProtKB:Q9Y4E8 and ensembl:ENSP000002803771600115GO_REF:0000107EnsemblGO_REF:0000107
Usp15Ratmonoubiquitinated protein deubiquitination involved_inISOUSP15 (Homo sapiens)1624291 PMID:21947082 and PMID:24399297RGDPMID:21947082 and PMID:24399297
Usp15Ratnegative regulation of antifungal innate immune response involved_inISOUSP15 (Homo sapiens)1624291 PMID:33093067RGDPMID:33093067
Usp15Ratnegative regulation of antifungal innate immune response involved_inISSUniProtKB:Q9Y4E81600115GO_REF:0000024UniProtGO_REF:0000024
Usp15Ratnegative regulation of antifungal innate immune response involved_inIEAUniProtKB:Q9Y4E8 and ensembl:ENSP000002803771600115GO_REF:0000107EnsemblGO_REF:0000107
Usp15Ratnegative regulation of transforming growth factor beta receptor signaling pathway involved_inISSUniProtKB:Q9Y4E81600115GO_REF:0000024UniProtGO_REF:0000024
Usp15Ratnegative regulation of transforming growth factor beta receptor signaling pathway involved_inISOUSP15 (Homo sapiens)1624291 PMID:22344298RGDPMID:22344298
Usp15Ratnegative regulation of transforming growth factor beta receptor signaling pathway involved_inIEAUniProtKB:Q9Y4E8 and ensembl:ENSP000002803771600115GO_REF:0000107EnsemblGO_REF:0000107
Usp15Ratpositive regulation of RIG-I signaling pathway involved_inIEAUniProtKB:Q9Y4E8 and ensembl:ENSP000002803771600115GO_REF:0000107EnsemblGO_REF:0000107
Usp15Ratpositive regulation of RIG-I signaling pathway involved_inISOUSP15 (Homo sapiens)1624291 PMID:24399297RGDPMID:24399297
Usp15Ratprotein deubiquitination involved_inIDA 634484PMID:10880343UniProt 
Usp15Ratprotein deubiquitination involved_inIEAUniProtKB:Q8R5H1 and ensembl:ENSMUSP000001512441600115GO_REF:0000107EnsemblGO_REF:0000107
Usp15Ratprotein deubiquitination involved_inIEAInterPro:IPR0013941600115GO_REF:0000002InterProGO_REF:0000002
Usp15Ratprotein deubiquitination involved_inIEAARBA:ARBA000278791600115GO_REF:0000117UniProtGO_REF:0000117
Usp15Ratprotein deubiquitination involved_inIEAUniProtKB:Q9Y4E8 and ensembl:ENSP000002803771600115GO_REF:0000107EnsemblGO_REF:0000107
Usp15Ratprotein deubiquitination involved_inISOUsp15 (Mus musculus)1624291 PMID:32101751RGDPMID:32101751
1 to 20 of 35 rows

Cellular Component
1 to 19 of 19 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Usp15Ratcytoplasm located_inIEAUniProtKB:Q9Y4E8 and ensembl:ENSP000002803771600115GO_REF:0000107EnsemblGO_REF:0000107
Usp15Ratcytoplasm located_inISOUSP15 (Homo sapiens)1624291 PMID:21947082 and PMID:24526689RGDPMID:21947082 and PMID:24526689
Usp15Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Usp15Ratcytoplasm located_inIDA 634484PMID:10880343UniProt 
Usp15Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Usp15Ratcytosol located_inISOUSP15 (Homo sapiens) more ...1624291 RGDGO_REF:0000052
Usp15Ratcytosol located_inIEAUniProtKB:Q9Y4E8 and ensembl:ENSP000002803771600115GO_REF:0000107EnsemblGO_REF:0000107
Usp15Ratmitochondrion located_inIEAUniProtKB-SubCell:SL-01731600115GO_REF:0000044UniProtGO_REF:0000044
Usp15Ratmitochondrion located_inIEAUniProtKB-KW:KW-04961600115GO_REF:0000043UniProtGO_REF:0000043
Usp15Ratnuclear body located_inIEAUniProtKB:Q9Y4E8 and ensembl:ENSP000002803771600115GO_REF:0000107EnsemblGO_REF:0000107
Usp15Ratnuclear body located_inISOUSP15 (Homo sapiens) more ...1624291 RGDGO_REF:0000052
Usp15Ratnucleoplasm located_inISOUSP15 (Homo sapiens) more ...1624291 RGDGO_REF:0000052
Usp15Ratnucleoplasm located_inIEAUniProtKB:Q9Y4E8 and ensembl:ENSP000002803771600115GO_REF:0000107EnsemblGO_REF:0000107
Usp15Ratnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
Usp15Ratnucleus located_inIEAUniProtKB:Q9Y4E8 and ensembl:ENSP000002803771600115GO_REF:0000107EnsemblGO_REF:0000107
Usp15Ratnucleus is_active_inIBAPANTHER:PTN002728652 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Usp15Ratnucleus located_inISOUSP15 (Homo sapiens)1624291 PMID:21947082 and PMID:24526689RGDPMID:21947082 and PMID:24526689
Usp15Ratnucleus located_inIDA 634484PMID:10880343UniProt 
Usp15Ratnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
1 to 19 of 19 rows

Molecular Function
1 to 20 of 33 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Usp15Ratcatalytic activity enablesIEAInterPro:IPR0137921600115GO_REF:0000002InterProGO_REF:0000002
Usp15Ratcysteine-type deubiquitinase activity  IDA 634484 RGD 
Usp15Ratcysteine-type deubiquitinase activity enablesIEAUniProtKB:Q8R5H1 and ensembl:ENSMUSP000001512441600115GO_REF:0000107EnsemblGO_REF:0000107
Usp15Ratcysteine-type deubiquitinase activity enablesIEAUniProtKB:Q9Y4E8 and ensembl:ENSP000002803771600115GO_REF:0000107EnsemblGO_REF:0000107
Usp15Ratcysteine-type deubiquitinase activity enablesIEAInterPro:IPR001394 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Usp15Ratcysteine-type deubiquitinase activity enablesIEAUniRule:UR0008807561600115GO_REF:0000104UniProtGO_REF:0000104
Usp15Ratcysteine-type deubiquitinase activity enablesISOUsp15 (Mus musculus)1624291 PMID:12532266RGDPMID:12532266
Usp15Ratcysteine-type deubiquitinase activity enablesIEAARBA:ARBA000268801600115GO_REF:0000117UniProtGO_REF:0000117
Usp15Ratcysteine-type deubiquitinase activity enablesIEAEC:3.4.19.121600115GO_REF:0000003UniProtGO_REF:0000003
Usp15Ratcysteine-type deubiquitinase activity enablesIDA 634484PMID:10880343UniProt 
Usp15Ratcysteine-type deubiquitinase activity enablesISOUSP15 (Homo sapiens)1624291 PMID:16005295 more ...RGDPMID:16005295 more ...
Usp15Ratcysteine-type endopeptidase activity enablesIEAUniProtKB:Q9Y4E8 and ensembl:ENSP000002803771600115GO_REF:0000107EnsemblGO_REF:0000107
Usp15Ratcysteine-type endopeptidase activity enablesISOUSP15 (Homo sapiens)1624291 PMID:21947082 and PMID:22344298RGDPMID:21947082 and PMID:22344298
Usp15Ratcysteine-type endopeptidase activity enablesISSUniProtKB:Q9Y4E81600115GO_REF:0000024UniProtGO_REF:0000024
Usp15Ratcysteine-type peptidase activity enablesIEAUniProtKB-KW:KW-07881600115GO_REF:0000043UniProtGO_REF:0000043
Usp15Ratdeubiquitinase activity enablesISOUSP15 (Homo sapiens)1624291 PMID:32839293RGDPMID:32839293
Usp15Ratdeubiquitinase activity enablesIEAUniProtKB:Q8R5H1 and ensembl:ENSMUSP000001512441600115GO_REF:0000107EnsemblGO_REF:0000107
Usp15Ratdeubiquitinase activity enablesISOUsp15 (Mus musculus)1624291 PMID:32101751RGDPMID:32101751
Usp15Ratdeubiquitinase activity enablesIEAUniProtKB:Q9Y4E8 and ensembl:ENSP000002803771600115GO_REF:0000107EnsemblGO_REF:0000107
Usp15Rathydrolase activity enablesIEAUniProtKB-KW:KW-03781600115GO_REF:0000043UniProtGO_REF:0000043
1 to 20 of 33 rows

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Usp15Ratmitochondrial autophagy pathway   ISOUSP15 (Homo sapiens)10401790 RGD 

1 to 9 of 9 rows
#
Reference Title
Reference Citation
1. The three 'P's of mitophagy: PARKIN, PINK1, and post-translational modifications. Durcan TM and Fon EA, Genes Dev. 2015 May 15;29(10):989-99. doi: 10.1101/gad.262758.115.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. De-regulated STAT5A/miR-202-5p/USP15/Caspase-6 regulatory axis suppresses CML cell apoptosis and contributes to Imatinib resistance. Nie ZY, etal., J Exp Clin Cancer Res. 2020 Jan 17;39(1):17. doi: 10.1186/s13046-019-1502-7.
6. Tissue-specificity, functional characterization and subcellular localization of a rat ubiquitin-specific processing protease, UBP109, whose mRNA expression is developmentally regulated. Park KC, etal., Biochem J 2000 Jul 15;349(Pt 2):443-53.
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
1 to 9 of 9 rows
PMID:12532266   PMID:16005295   PMID:21947082   PMID:22001210   PMID:22344298   PMID:24399297   PMID:24526689   PMID:25002582   PMID:27368102   PMID:31933062   PMID:34088152   PMID:35478295  
PMID:36635430  



Usp15
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8760,643,611 - 60,805,137 (-)NCBIGRCr8
mRatBN7.2758,756,714 - 58,848,778 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl758,756,872 - 58,848,721 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx760,630,453 - 60,720,966 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0762,833,103 - 62,923,616 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0762,610,431 - 62,700,867 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0766,595,707 - 66,687,707 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl766,595,742 - 66,687,278 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0766,793,539 - 66,885,533 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4762,871,167 - 62,961,405 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1762,891,896 - 62,982,135 (-)NCBI
Celera755,929,201 - 56,019,813 (-)NCBICelera
Cytogenetic Map7q22NCBI
USP15
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381262,260,404 - 62,416,389 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1262,260,338 - 62,417,431 (+)EnsemblGRCh38hg38GRCh38
GRCh371262,654,185 - 62,810,169 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361260,940,454 - 61,086,165 (+)NCBINCBI36Build 36hg18NCBI36
Build 341260,940,453 - 61,086,165NCBI
Celera1262,323,221 - 62,468,927 (+)NCBICelera
Cytogenetic Map12q14.1NCBI
HuRef1259,705,057 - 59,854,661 (+)NCBIHuRef
CHM1_11262,622,031 - 62,771,333 (+)NCBICHM1_1
T2T-CHM13v2.01262,239,218 - 62,395,185 (+)NCBIT2T-CHM13v2.0
Usp15
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910122,940,911 - 123,032,924 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10122,940,911 - 123,032,900 (-)EnsemblGRCm39 Ensembl
GRCm3810123,105,006 - 123,197,281 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10123,105,006 - 123,196,995 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710122,550,300 - 122,633,979 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610122,516,304 - 122,599,983 (-)NCBIMGSCv36mm8
Celera10125,493,807 - 125,579,763 (-)NCBICelera
Cytogenetic Map10D2NCBI
cM Map1072.31NCBI
Usp15
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554589,403,097 - 9,533,653 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554589,440,645 - 9,533,653 (+)NCBIChiLan1.0ChiLan1.0
USP15
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21031,944,328 - 32,090,448 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11231,937,511 - 32,086,939 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01226,533,441 - 26,682,964 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11226,808,337 - 26,954,099 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1226,808,337 - 26,954,099 (-)Ensemblpanpan1.1panPan2
USP15
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1105,510,759 - 5,634,954 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl105,510,022 - 5,634,202 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha105,502,702 - 5,627,025 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0105,544,390 - 5,667,454 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl105,544,428 - 5,668,750 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1105,485,628 - 5,610,126 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0105,734,844 - 5,859,330 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0105,874,448 - 5,998,972 (+)NCBIUU_Cfam_GSD_1.0
Usp15
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494553,015,395 - 53,131,801 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936545978,280 - 1,095,659 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936545978,318 - 1,094,729 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
USP15
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl526,964,553 - 27,097,444 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1526,964,380 - 27,082,549 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2529,580,789 - 29,800,904 (+)NCBISscrofa10.2Sscrofa10.2susScr3
USP15
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11158,154,905 - 58,300,431 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1158,154,919 - 58,300,522 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037187,509,595 - 187,654,699 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Usp15
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248025,560,574 - 5,682,300 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248025,559,107 - 5,682,338 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Usp15
348 total Variants

Predicted Target Of
Summary Value
Count of predictions:100
Count of miRNA genes:86
Interacting mature miRNAs:89
Transcripts:ENSRNOT00000031191
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 36 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72192119566921195Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
2293667Bss42Bone structure and strength QTL 427.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)74765143992651439Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74322875088228750Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat
1641885Alcrsp9Alcohol response QTL 9alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)72409960669099606Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72475184169751841Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72940968384928080Rat
10059605Kidm47Kidney mass QTL 472.910.05kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)74725178365728867Rat
2293678Bss24Bone structure and strength QTL 246.710.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)74765143992651439Rat

1 to 10 of 36 rows
RH131414  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2758,758,323 - 58,758,425 (-)MAPPERmRatBN7.2
Rnor_6.0766,685,996 - 66,686,097NCBIRnor6.0
Rnor_5.0766,883,822 - 66,883,923UniSTSRnor5.0
RH 3.4 Map7503.7UniSTS
Cytogenetic Map7q22UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31


1 to 30 of 36 rows
RefSeq Transcripts NM_001433837 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001433838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001433839 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001433840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001433841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001433842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001433843 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001433844 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001433845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001433846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001433847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001433848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001433849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001433850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_145184 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006241431 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008765376 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078350 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078351 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078353 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010052935 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010052936 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010052937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010052938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 30 of 36 rows

Ensembl Acc Id: ENSRNOT00000031191   ⟹   ENSRNOP00000034485
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl758,756,872 - 58,848,700 (-)Ensembl
Rnor_6.0 Ensembl766,595,742 - 66,686,198 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000079410   ⟹   ENSRNOP00000071983
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl758,757,067 - 58,848,721 (-)Ensembl
Rnor_6.0 Ensembl766,624,512 - 66,687,278 (+)Ensembl
RefSeq Acc Id: NM_145184   ⟹   NP_660185
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8760,643,613 - 60,734,099 (-)NCBI
mRatBN7.2758,758,223 - 58,848,721 (-)NCBI
Rnor_6.0766,595,742 - 66,686,198 (+)NCBI
Rnor_5.0766,793,539 - 66,885,533 (+)NCBI
RGSC_v3.4762,871,167 - 62,961,405 (-)RGD
Celera755,929,201 - 56,019,813 (-)RGD
Sequence:
RefSeq Acc Id: XM_006241431   ⟹   XP_006241493
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8760,643,611 - 60,735,305 (-)NCBI
mRatBN7.2758,756,714 - 58,848,778 (-)NCBI
Rnor_6.0766,595,711 - 66,687,707 (+)NCBI
Rnor_5.0766,793,539 - 66,885,533 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008765376   ⟹   XP_008763598
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8760,643,611 - 60,709,300 (-)NCBI
mRatBN7.2758,756,714 - 58,823,442 (-)NCBI
Rnor_6.0766,620,530 - 66,687,707 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039078350   ⟹   XP_038934278
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8760,643,611 - 60,684,187 (-)NCBI
mRatBN7.2758,756,714 - 58,798,800 (-)NCBI
RefSeq Acc Id: XM_039078351   ⟹   XP_038934279
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8760,643,611 - 60,708,034 (-)NCBI
mRatBN7.2758,756,714 - 58,822,656 (-)NCBI
RefSeq Acc Id: XM_039078353   ⟹   XP_038934281
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8760,643,611 - 60,670,346 (-)NCBI
mRatBN7.2758,756,714 - 58,784,959 (-)NCBI
RefSeq Acc Id: XM_063262953   ⟹   XP_063119023
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8760,643,611 - 60,805,137 (-)NCBI
RefSeq Acc Id: XM_063262954   ⟹   XP_063119024
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8760,653,027 - 60,734,172 (-)NCBI
RefSeq Acc Id: XM_063262955   ⟹   XP_063119025
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8760,653,029 - 60,734,167 (-)NCBI
RefSeq Acc Id: XM_063262956   ⟹   XP_063119026
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8760,643,611 - 60,708,034 (-)NCBI
RefSeq Acc Id: XM_063262957   ⟹   XP_063119027
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8760,689,660 - 60,735,305 (-)NCBI
RefSeq Acc Id: XM_063262958   ⟹   XP_063119028
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8760,689,660 - 60,735,305 (-)NCBI
RefSeq Acc Id: XR_010052935
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8760,662,405 - 60,735,956 (-)NCBI
RefSeq Acc Id: XR_010052936
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8760,662,405 - 60,735,305 (-)NCBI
RefSeq Acc Id: XR_010052937
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8760,662,405 - 60,735,305 (-)NCBI
RefSeq Acc Id: XR_010052938
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8760,662,405 - 60,735,305 (-)NCBI
RefSeq Acc Id: XR_010052939
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8760,674,796 - 60,735,305 (-)NCBI
1 to 30 of 33 rows
Protein RefSeqs NP_001420766 (Get FASTA)   NCBI Sequence Viewer  
  NP_001420767 (Get FASTA)   NCBI Sequence Viewer  
  NP_001420768 (Get FASTA)   NCBI Sequence Viewer  
  NP_001420769 (Get FASTA)   NCBI Sequence Viewer  
  NP_001420770 (Get FASTA)   NCBI Sequence Viewer  
  NP_001420771 (Get FASTA)   NCBI Sequence Viewer  
  NP_001420772 (Get FASTA)   NCBI Sequence Viewer  
  NP_001420773 (Get FASTA)   NCBI Sequence Viewer  
  NP_001420774 (Get FASTA)   NCBI Sequence Viewer  
  NP_001420775 (Get FASTA)   NCBI Sequence Viewer  
  NP_001420776 (Get FASTA)   NCBI Sequence Viewer  
  NP_001420777 (Get FASTA)   NCBI Sequence Viewer  
  NP_001420778 (Get FASTA)   NCBI Sequence Viewer  
  NP_001420779 (Get FASTA)   NCBI Sequence Viewer  
  NP_660185 (Get FASTA)   NCBI Sequence Viewer  
  XP_006241493 (Get FASTA)   NCBI Sequence Viewer  
  XP_008763598 (Get FASTA)   NCBI Sequence Viewer  
  XP_038934278 (Get FASTA)   NCBI Sequence Viewer  
  XP_038934279 (Get FASTA)   NCBI Sequence Viewer  
  XP_038934281 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119023 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119024 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119025 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119026 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119027 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119028 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF14188 (Get FASTA)   NCBI Sequence Viewer  
  EDM16532 (Get FASTA)   NCBI Sequence Viewer  
  EDM16533 (Get FASTA)   NCBI Sequence Viewer  
  EDM16534 (Get FASTA)   NCBI Sequence Viewer  
1 to 30 of 33 rows
1 to 5 of 14 rows
1 to 5 of 14 rows
RefSeq Acc Id: NP_660185   ⟸   NM_145184
- UniProtKB: Q9R085 (UniProtKB/Swiss-Prot),   E9PSP9 (UniProtKB/Swiss-Prot),   A0A0G2K1U1 (UniProtKB/TrEMBL),   A6HQN8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006241493   ⟸   XM_006241431
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008763598   ⟸   XM_008765376
- Peptide Label: isoform X4
- UniProtKB: Q9R085 (UniProtKB/Swiss-Prot),   E9PSP9 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071983   ⟸   ENSRNOT00000079410
Ensembl Acc Id: ENSRNOP00000034485   ⟸   ENSRNOT00000031191
DUSP   USP

Name Modeler Protein Id AA Range Protein Structure
AF-Q9R085-F1-model_v2 AlphaFold Q9R085 1-952 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13695238
Promoter ID:EPDNEW_R5762
Type:initiation region
Name:Usp15_1
Description:ubiquitin specific peptidase 15
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0766,595,766 - 66,595,826EPDNEW


1 to 40 of 45 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-33843 BioCyc
Ensembl Genes ENSRNOG00000023202 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000031191 ENTREZGENE
  ENSRNOT00000079410 ENTREZGENE
Gene3D-CATH 3.30.2230.10 UniProtKB/Swiss-Prot
  Cysteine proteinases UniProtKB/Swiss-Prot
  Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1 UniProtKB/Swiss-Prot
InterPro DUSP-like_sf UniProtKB/Swiss-Prot
  Papain-like_cys_pep_sf UniProtKB/Swiss-Prot
  Pept_C19_DUSP UniProtKB/Swiss-Prot
  Peptidase_C19_UCH UniProtKB/Swiss-Prot
  RNA3'P_cycl/enolpyr_Trfase_a/b UniProtKB/Swiss-Prot
  Ub_carboxyl-term_hydrolase UniProtKB/Swiss-Prot
  Ub_USP-typ UniProtKB/Swiss-Prot
  Ubiquitin-like_domsf UniProtKB/Swiss-Prot
  USP_C UniProtKB/Swiss-Prot
  USP_CS UniProtKB/Swiss-Prot
  USP_dom UniProtKB/Swiss-Prot
KEGG Report rno:171329 UniProtKB/Swiss-Prot
NCBI Gene 171329 ENTREZGENE
PANTHER UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UniProtKB/Swiss-Prot
  UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 15 UniProtKB/Swiss-Prot
Pfam DUSP UniProtKB/Swiss-Prot
  Ubiquitin_3 UniProtKB/Swiss-Prot
  UCH UniProtKB/Swiss-Prot
  USP7_C2 UniProtKB/Swiss-Prot
PhenoGen Usp15 PhenoGen
PROSITE DUSP UniProtKB/Swiss-Prot
  USP_1 UniProtKB/Swiss-Prot
  USP_2 UniProtKB/Swiss-Prot
  USP_3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000023202 RatGTEx
SMART DUSP UniProtKB/Swiss-Prot
Superfamily-SCOP SSF143791 UniProtKB/Swiss-Prot
  SSF54001 UniProtKB/Swiss-Prot
  SSF54236 UniProtKB/Swiss-Prot
  SSF55205 UniProtKB/Swiss-Prot
UniProt A0A0A0MY07 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K1U1 ENTREZGENE, UniProtKB/TrEMBL
  A6HQN8 ENTREZGENE, UniProtKB/TrEMBL
1 to 40 of 45 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Usp15  ubiquitin specific peptidase 15    ubiquitin specific protease 15  Name updated 1299863 APPROVED
2004-02-26 Usp15  ubiquitin specific protease 15      Symbol and Name status set to approved 625702 APPROVED
2003-02-27 Usp15  ubiquitin specific protease 15      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_expression expression is developmentally regulated in liver, spinal cord and brain 634484