Usp15 (ubiquitin specific peptidase 15) - Rat Genome Database

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Gene: Usp15 (ubiquitin specific peptidase 15) Rattus norvegicus
Analyze
Symbol: Usp15
Name: ubiquitin specific peptidase 15
RGD ID: 628795
Description: Enables cysteine-type deubiquitinase activity. Predicted to be involved in several processes, including monoubiquitinated protein deubiquitination; regulation of innate immune response; and transforming growth factor beta receptor superfamily signaling pathway. Predicted to act upstream of or within regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator. Located in cytoplasm and nucleus. Orthologous to human USP15 (ubiquitin specific peptidase 15); PARTICIPATES IN mitochondrial autophagy pathway; INTERACTS WITH 2,6-dinitrotoluene; 6-propyl-2-thiouracil; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: deubiquitinating enzyme 15; deubiquitinating enzyme Ubp109; ubiquitin carboxyl-terminal hydrolase 15; ubiquitin carboxyl-terminal hydrolase of 109 kDa; ubiquitin specific protease 15; ubiquitin thioesterase 15; ubiquitin-specific-processing protease 15; Ubp109
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8760,643,611 - 60,805,137 (-)NCBIGRCr8
mRatBN7.2758,756,714 - 58,848,778 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl758,756,872 - 58,848,721 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx760,630,453 - 60,720,966 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0762,833,103 - 62,923,616 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0762,610,431 - 62,700,867 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0766,595,707 - 66,687,707 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl766,595,742 - 66,687,278 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0766,793,539 - 66,885,533 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4762,871,167 - 62,961,405 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1762,891,896 - 62,982,135 (-)NCBI
Celera755,929,201 - 56,019,813 (-)NCBICelera
Cytogenetic Map7q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-nitropyrene  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-tribromophenol  (ISO)
2,6-dinitrotoluene  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetohydrazide  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-endorphin  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cobalt dichloride  (EXP,ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dicrotophos  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fumonisin B1  (ISO)
genistein  (ISO)
gentamycin  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
hypochlorous acid  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
leflunomide  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methapyrilene  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
morphine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
oxaliplatin  (EXP)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylmercury acetate  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
streptozocin  (EXP)
thioacetamide  (EXP)
topotecan  (EXP)
Tributyltin oxide  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The three 'P's of mitophagy: PARKIN, PINK1, and post-translational modifications. Durcan TM and Fon EA, Genes Dev. 2015 May 15;29(10):989-99. doi: 10.1101/gad.262758.115.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. De-regulated STAT5A/miR-202-5p/USP15/Caspase-6 regulatory axis suppresses CML cell apoptosis and contributes to Imatinib resistance. Nie ZY, etal., J Exp Clin Cancer Res. 2020 Jan 17;39(1):17. doi: 10.1186/s13046-019-1502-7.
6. Tissue-specificity, functional characterization and subcellular localization of a rat ubiquitin-specific processing protease, UBP109, whose mRNA expression is developmentally regulated. Park KC, etal., Biochem J 2000 Jul 15;349(Pt 2):443-53.
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12532266   PMID:16005295   PMID:21947082   PMID:22001210   PMID:22344298   PMID:24399297   PMID:24526689   PMID:25002582   PMID:27368102   PMID:31933062   PMID:34088152   PMID:35478295  
PMID:36635430  


Genomics

Comparative Map Data
Usp15
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8760,643,611 - 60,805,137 (-)NCBIGRCr8
mRatBN7.2758,756,714 - 58,848,778 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl758,756,872 - 58,848,721 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx760,630,453 - 60,720,966 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0762,833,103 - 62,923,616 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0762,610,431 - 62,700,867 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0766,595,707 - 66,687,707 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl766,595,742 - 66,687,278 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0766,793,539 - 66,885,533 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4762,871,167 - 62,961,405 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1762,891,896 - 62,982,135 (-)NCBI
Celera755,929,201 - 56,019,813 (-)NCBICelera
Cytogenetic Map7q22NCBI
USP15
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381262,260,404 - 62,416,389 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1262,260,338 - 62,417,431 (+)EnsemblGRCh38hg38GRCh38
GRCh371262,654,185 - 62,810,169 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361260,940,454 - 61,086,165 (+)NCBINCBI36Build 36hg18NCBI36
Build 341260,940,453 - 61,086,165NCBI
Celera1262,323,221 - 62,468,927 (+)NCBICelera
Cytogenetic Map12q14.1NCBI
HuRef1259,705,057 - 59,854,661 (+)NCBIHuRef
CHM1_11262,622,031 - 62,771,333 (+)NCBICHM1_1
T2T-CHM13v2.01262,239,218 - 62,395,185 (+)NCBIT2T-CHM13v2.0
Usp15
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910122,940,911 - 123,032,924 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10122,940,911 - 123,032,900 (-)EnsemblGRCm39 Ensembl
GRCm3810123,105,006 - 123,197,281 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10123,105,006 - 123,196,995 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710122,550,300 - 122,633,979 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610122,516,304 - 122,599,983 (-)NCBIMGSCv36mm8
Celera10125,493,807 - 125,579,763 (-)NCBICelera
Cytogenetic Map10D2NCBI
cM Map1072.31NCBI
Usp15
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554589,403,097 - 9,533,653 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554589,440,645 - 9,533,653 (+)NCBIChiLan1.0ChiLan1.0
USP15
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21031,944,328 - 32,090,448 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11231,937,511 - 32,086,939 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01226,533,441 - 26,682,964 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11226,808,337 - 26,954,099 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1226,808,337 - 26,954,099 (-)Ensemblpanpan1.1panPan2
USP15
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1105,510,759 - 5,634,954 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl105,510,022 - 5,634,202 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha105,502,702 - 5,627,025 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0105,544,390 - 5,667,454 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl105,544,428 - 5,668,750 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1105,485,628 - 5,610,126 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0105,734,844 - 5,859,330 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0105,874,448 - 5,998,972 (+)NCBIUU_Cfam_GSD_1.0
Usp15
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494553,015,395 - 53,131,801 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936545978,280 - 1,095,659 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936545978,318 - 1,094,729 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
USP15
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl526,964,553 - 27,097,444 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1526,964,380 - 27,082,549 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2529,580,789 - 29,800,904 (+)NCBISscrofa10.2Sscrofa10.2susScr3
USP15
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11158,154,905 - 58,300,431 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1158,154,919 - 58,300,522 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037187,509,595 - 187,654,699 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Usp15
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248025,560,574 - 5,682,300 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248025,559,107 - 5,682,338 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Usp15
303 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:100
Count of miRNA genes:86
Interacting mature miRNAs:89
Transcripts:ENSRNOT00000031191
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71557388960573889Rat
2317059Aia15Adjuvant induced arthritis QTL 152.46joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)71700459862004598Rat
10755451Coatc11Coat color QTL 110coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)71794435762944357Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)71965431784928080Rat
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72192119566921195Rat
1641885Alcrsp9Alcohol response QTL 9alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)72409960669099606Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72475184169751841Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72673740163902784Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)72940968374409683Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72940968384928080Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73111283276112832Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73429328279293282Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73429328279293282Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73796056982960569Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
634326Hc3Hypercalciuria QTL 32.1urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)74278731487787314Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74322875088228750Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)743747099102228765Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)74486753389867533Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74659007091590070Rat
10059605Kidm47Kidney mass QTL 472.910.05kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)74725178365728867Rat
2293696Bmd32Bone mineral density QTL 325.10.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)74765143992651439Rat
2293707Bss32Bone structure and strength QTL 327.640.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)74765143992651439Rat
2300178Bmd54Bone mineral density QTL 545.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)74765143992651439Rat
2293644Bmd29Bone mineral density QTL 295.40.0001femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)74765143992651439Rat
2293667Bss42Bone structure and strength QTL 427.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)74765143992651439Rat
2293678Bss24Bone structure and strength QTL 246.710.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)74765143992651439Rat
2293685Bmd21Bone mineral density QTL 214.20.0003femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)74765143992651439Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)753612714103945643Rat
61435Cia4Collagen induced arthritis QTL 45.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)75811322462004598Rat

Markers in Region
RH131414  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2758,758,323 - 58,758,425 (-)MAPPERmRatBN7.2
Rnor_6.0766,685,996 - 66,686,097NCBIRnor6.0
Rnor_5.0766,883,822 - 66,883,923UniSTSRnor5.0
RH 3.4 Map7503.7UniSTS
Cytogenetic Map7q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 42 57 41 19 41 8 10 74 35 41 11 8
Low 1 1
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_145184 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006241431 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008765376 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078350 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078351 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078353 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010052935 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010052936 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010052937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010052938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010052939 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_593438 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF106657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227117 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000031191   ⟹   ENSRNOP00000034485
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl758,756,872 - 58,848,700 (-)Ensembl
Rnor_6.0 Ensembl766,595,742 - 66,686,198 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000079410   ⟹   ENSRNOP00000071983
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl758,757,067 - 58,848,721 (-)Ensembl
Rnor_6.0 Ensembl766,624,512 - 66,687,278 (+)Ensembl
RefSeq Acc Id: NM_145184   ⟹   NP_660185
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8760,643,613 - 60,734,099 (-)NCBI
mRatBN7.2758,758,223 - 58,848,721 (-)NCBI
Rnor_6.0766,595,742 - 66,686,198 (+)NCBI
Rnor_5.0766,793,539 - 66,885,533 (+)NCBI
RGSC_v3.4762,871,167 - 62,961,405 (-)RGD
Celera755,929,201 - 56,019,813 (-)RGD
Sequence:
RefSeq Acc Id: XM_006241431   ⟹   XP_006241493
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8760,643,611 - 60,735,305 (-)NCBI
mRatBN7.2758,756,714 - 58,848,778 (-)NCBI
Rnor_6.0766,595,711 - 66,687,707 (+)NCBI
Rnor_5.0766,793,539 - 66,885,533 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008765376   ⟹   XP_008763598
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8760,643,611 - 60,709,300 (-)NCBI
mRatBN7.2758,756,714 - 58,823,442 (-)NCBI
Rnor_6.0766,620,530 - 66,687,707 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039078350   ⟹   XP_038934278
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8760,643,611 - 60,684,187 (-)NCBI
mRatBN7.2758,756,714 - 58,798,800 (-)NCBI
RefSeq Acc Id: XM_039078351   ⟹   XP_038934279
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8760,643,611 - 60,708,034 (-)NCBI
mRatBN7.2758,756,714 - 58,822,656 (-)NCBI
RefSeq Acc Id: XM_039078353   ⟹   XP_038934281
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8760,643,611 - 60,670,346 (-)NCBI
mRatBN7.2758,756,714 - 58,784,959 (-)NCBI
RefSeq Acc Id: XM_063262953   ⟹   XP_063119023
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8760,643,611 - 60,805,137 (-)NCBI
RefSeq Acc Id: XM_063262954   ⟹   XP_063119024
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8760,653,027 - 60,734,172 (-)NCBI
RefSeq Acc Id: XM_063262955   ⟹   XP_063119025
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8760,653,029 - 60,734,167 (-)NCBI
RefSeq Acc Id: XM_063262956   ⟹   XP_063119026
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8760,643,611 - 60,708,034 (-)NCBI
RefSeq Acc Id: XM_063262957   ⟹   XP_063119027
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8760,689,660 - 60,735,305 (-)NCBI
RefSeq Acc Id: XM_063262958   ⟹   XP_063119028
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8760,689,660 - 60,735,305 (-)NCBI
RefSeq Acc Id: XR_010052935
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8760,662,405 - 60,735,956 (-)NCBI
RefSeq Acc Id: XR_010052936
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8760,662,405 - 60,735,305 (-)NCBI
RefSeq Acc Id: XR_010052937
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8760,662,405 - 60,735,305 (-)NCBI
RefSeq Acc Id: XR_010052938
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8760,662,405 - 60,735,305 (-)NCBI
RefSeq Acc Id: XR_010052939
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8760,674,796 - 60,735,305 (-)NCBI
RefSeq Acc Id: NP_660185   ⟸   NM_145184
- UniProtKB: E9PSP9 (UniProtKB/Swiss-Prot),   Q9R085 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006241493   ⟸   XM_006241431
- Peptide Label: isoform X1
- UniProtKB: A0A0A0MY07 (UniProtKB/TrEMBL),   A6HQN9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008763598   ⟸   XM_008765376
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: ENSRNOP00000071983   ⟸   ENSRNOT00000079410
RefSeq Acc Id: ENSRNOP00000034485   ⟸   ENSRNOT00000031191
RefSeq Acc Id: XP_038934279   ⟸   XM_039078351
- Peptide Label: isoform X8
- UniProtKB: A6HQP0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934278   ⟸   XM_039078350
- Peptide Label: isoform X7
- UniProtKB: A6HQP0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934281   ⟸   XM_039078353
- Peptide Label: isoform X9
- UniProtKB: A6HQP0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119023   ⟸   XM_063262953
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063119026   ⟸   XM_063262956
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063119024   ⟸   XM_063262954
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063119025   ⟸   XM_063262955
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063119028   ⟸   XM_063262958
- Peptide Label: isoform X11
RefSeq Acc Id: XP_063119027   ⟸   XM_063262957
- Peptide Label: isoform X10
Protein Domains
DUSP   USP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9R085-F1-model_v2 AlphaFold Q9R085 1-952 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695238
Promoter ID:EPDNEW_R5762
Type:initiation region
Name:Usp15_1
Description:ubiquitin specific peptidase 15
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0766,595,766 - 66,595,826EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628795 AgrOrtholog
BioCyc Gene G2FUF-33843 BioCyc
Ensembl Genes ENSRNOG00000023202 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000031191.7 UniProtKB/TrEMBL
  ENSRNOT00000079410 ENTREZGENE
  ENSRNOT00000079410.2 UniProtKB/TrEMBL
Gene3D-CATH 3.30.2230.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cysteine proteinases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro DUSP-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Papain-like_cys_pep_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_C19_DUSP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_C19_UCH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNA3'P_cycl/enolpyr_Trfase_a/b UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ub_USP-typ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  USP_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  USP_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  USP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:171329 UniProtKB/Swiss-Prot
NCBI Gene 171329 ENTREZGENE
PANTHER UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 15 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DUSP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ubiquitin_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UCH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  USP7_C2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Usp15 PhenoGen
PROSITE DUSP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  USP_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  USP_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  USP_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000023202 RatGTEx
SMART DUSP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF143791 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54001 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54236 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55205 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0A0MY07 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K1U1_RAT UniProtKB/TrEMBL
  A6HQN8_RAT UniProtKB/TrEMBL
  A6HQN9 ENTREZGENE, UniProtKB/TrEMBL
  A6HQP0 ENTREZGENE, UniProtKB/TrEMBL
  E9PSP9 ENTREZGENE
  Q9R085 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary E9PSP9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Usp15  ubiquitin specific peptidase 15    ubiquitin specific protease 15  Name updated 1299863 APPROVED
2004-02-26 Usp15  ubiquitin specific protease 15      Symbol and Name status set to approved 625702 APPROVED
2003-02-27 Usp15  ubiquitin specific protease 15      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expression is developmentally regulated in liver, spinal cord and brain 634484